This document discusses mutation, which is a heritable change in genetic material or character of an organism. Mutations can be caused spontaneously or induced by mutagens like radiation. There are different types of mutations including point mutations, which change a single nucleotide, and chromosomal mutations, which involve changes in chromosome structure like deletions, inversions, duplications, and translocations. Mutations can occur in somatic cells or germ cells and be transmitted to offspring. Common gene mutations include point mutations, insertions, deletions, and frameshift mutations, which alter protein production. Mutation is an important source of genetic variation and has applications in crop improvement.
A mutation is a change that occurs in our DNA sequence, either due to mistakes when DNA is copied or as the result of environmental factors such as UV light. The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins. Mutations are two types that are Gene mutation and Chromosome mutation. Gene mutation are further divided into Point and frameshift mutation. Point mutation are three types ie. Silent mutation, Missense mutation and Nonsense mutation. Frameshift mutation are of two types that are addition and deletion. Chromosome mutations are further classified into Deletion, duplication, inversion and translocation.
A mutation is a change that occurs in our DNA sequence, either due to mistakes when DNA is copied or as the result of environmental factors such as UV light. The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins. Mutations are two types that are Gene mutation and Chromosome mutation. Gene mutation are further divided into Point and frameshift mutation. Point mutation are three types ie. Silent mutation, Missense mutation and Nonsense mutation. Frameshift mutation are of two types that are addition and deletion. Chromosome mutations are further classified into Deletion, duplication, inversion and translocation.
In biology, a mutation is an alteration in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA.
In biology, a mutation is an alteration in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA.
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extra chromosomal DNA or other genetic elements.
Mutations result from errors during DNA replication (especially during meiosis) or other types of damage to DNA (such as may be caused by exposure to radiation or carcinogens), which then may undergo error-prone repair or cause an error during other forms of repair,
Gene mutations – introduction – definition – a brief history – terminology –
classification of mutations – characteristic features of mutations – spontaneous
mutations and induced mutations
Gene mutations – artificial induction of mutations – physical and chemical
mutagens – molecular basis of mutations – detection of sex-linked lethals in
Drosophila by CLB technique – detection of mutations in plants – the importance of
mutation in plant breeding programmes –
mutations Is a process that produces a gene or chromosome that differs from the wild type.
The mutation may result due to changes either on the gene or the chromosome itself.
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2. Introduction
• Sudden heritable change in genetic material or character of an organism is
known as mutation
• Individuals showing these changes are known as mutants
• An individual showing an altered phenotype due to mutation are known as
variant
• Factor or agents causing mutation are known as mutagens
• Mutation which causes changes in base sequence of a gene are known as
gene mutation or point mutation
3. History
• English farmer Seth Wright recorded case of mutation first time in 1791 in
male lamb with unusual short legs
• The term mutation is coined by Hugo de Vries in 1900 by his observation
in Oenothera
• Systematic study of mutation was started in 1910 when Morgan
genetically analyzed white eye mutant of Drosophila
• H. J. Muller induced mutation in Drosophila by using X- rays in 1927 ; he
was awarded with Nobel prize in 1946
4. Characteristics of Mutation
• Generally mutant alleles are recessive to their wild type or normal alleles
• Most mutations have harmful effect, but some mutations are beneficial
• Spontaneous mutations occurs at very low rate
• Some genes shows high rate of mutation such genes are called as mutable
gene
• Highly mutable sites within a gene are known as hot spots.
• Mutation can occur in any tissue/cell (somatic or germinal) of an organism
5. Classification of mutation
• Based on the survival of an individual
1. Lethal mutation – when mutation causes death of all individuals undergoing
mutation are known as lethal
2. Sub lethal mutation - causes death of 90% individuals
3. Sub vital mutation– such mutation kills less than 90% individuals
4. Vital mutation -when mutation don’t affect the survival of an individual are
known as vital
5. Supervital mutation – This kind of mutation enhances the survival of
individual
6. • Based on causes of mutation
1. Spontaneous mutation-
Spontaneous mutation occurs naturally without any cause. The rate of
spontaneous mutation is very slow eg- Methylation followed by deamination of
cytosine.
Rate of spontaneous mutation is higher in eukaryotes than prokaryotes.
Eg. UV light of sunlight causing mutation in bacteria
2. Induced Mutation-
Mutations produced due to treatment with either a chemical or physical
agent are called induced mutation .
The agents capable of inducing such mutations are known as mutagen.
use of induced mutation for crop improvement program is known as mutation
breeding.
Eg. X- rays causing mutation in cereals
7. • Based on tissue of origin
1. Somatic mutation-
A mutation occurring in somatic cell is called somatic mutation.
In asexually reproducing species somatic mutations transmits from one
progeny to the next progeny
2. Germinal Mutation-
When mutation occur in gametic cells or reproductive cells are known as
germinal mutation.
In sexually reproductive species only germinal mutation are transmitted to the
next generation
8. • Based on direction of mutation
1. Forward mutation- When mutation occurs from the
normal/wild type allele to mutant allele are known as forward
mutation
2. Reverse mutation- When mutation occurs in reverse
direction that is from mutant allele to the normal/wild type allele
are known as reverse mutation
9. • Type of trait affected
1. Visible mutation- Those mutation which affects on
phenotypic character and can be detected by normal
observation are known as visible mutation
2. Biochemical mutation- mutation which affect the
production of biochemicals and which does not not show any
phenotypic character are known as biochemical mutation
10. Chromosome Mutations
• May Involve:
–Changing the
structure of a
chromosome
–The loss or gain
of part of a
chromosome
17. Nondisjunction
• Failure of chromosomes to
separate during meiosis
• Causes gamete to have too many
or too few chromosomes
• Disorders:
– Down Syndrome – three 21st chromosomes
– Turner Syndrome – single X chromosome
– Klinefelter’s Syndrome – XXY chromosomes
20. Point Mutation
• Change of a single
nucleotide
• Includes the deletion,
insertion, or substitution
of ONE nucleotide in a
gene
21. Point Mutation
• Sickle Cell disease is
the result of one
nucleotide
substitution
• Occurs in the
hemoglobin gene
22. Frameshift Mutation
• Inserting or deleting one or more
nucleotides
• Changes the “reading frame” like
changing a sentence
• Proteins built incorrectly