This is a brief overview of the Types of Mutation. I have compiled all the salient features of the Mutation and shared in this presentation, hope you guys like it.
Structural Chromosomal aberrations (Change in Structure of Chromosome)Asad Afridi
this presentation is about chromosomal aberration especially change in structure of chromosome. different types of structural chromosomal aberrations are also discussed. effects of different aberration are also included.
This is a brief overview of the Types of Mutation. I have compiled all the salient features of the Mutation and shared in this presentation, hope you guys like it.
Structural Chromosomal aberrations (Change in Structure of Chromosome)Asad Afridi
this presentation is about chromosomal aberration especially change in structure of chromosome. different types of structural chromosomal aberrations are also discussed. effects of different aberration are also included.
Cell Biology and genetics paper - Mutation a basic touch to b.sc students with examples. DNA, genome, gene level mutation and chromosome level with examples. Touched some of the mutation types.
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extra chromosomal DNA or other genetic elements.
Mutations result from errors during DNA replication (especially during meiosis) or other types of damage to DNA (such as may be caused by exposure to radiation or carcinogens), which then may undergo error-prone repair or cause an error during other forms of repair,
The slide include contents:
Mutation-Definition
Levels of Mutation
Features of Mutation
Types of Mutation
Mutations based on functional effects of the change
Genetic disorders
A chromosome abnormality, disorder, anomaly, aberration, or mutation is a missing, extra, or irregular portion of chromosomal DNA. It can be from an atypical number of chromosomes or a structural abnormality in one or more chromosomes
chromosomal aberrations
Variation in chromosomal structure or number
changes in the number of sets of chromosomes (ploidy), changes in the number of individual chromosomes (somy), or changes in appearance of individual chromosomes through mutation-induced rearrangements. They can be associated with genetic diseases or with species differences
Mujahid Hussain, Department of Botany, University of Sargodha, Sargodha, Punjab, Pakistan
Cell Biology and genetics paper - Mutation a basic touch to b.sc students with examples. DNA, genome, gene level mutation and chromosome level with examples. Touched some of the mutation types.
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extra chromosomal DNA or other genetic elements.
Mutations result from errors during DNA replication (especially during meiosis) or other types of damage to DNA (such as may be caused by exposure to radiation or carcinogens), which then may undergo error-prone repair or cause an error during other forms of repair,
The slide include contents:
Mutation-Definition
Levels of Mutation
Features of Mutation
Types of Mutation
Mutations based on functional effects of the change
Genetic disorders
A chromosome abnormality, disorder, anomaly, aberration, or mutation is a missing, extra, or irregular portion of chromosomal DNA. It can be from an atypical number of chromosomes or a structural abnormality in one or more chromosomes
chromosomal aberrations
Variation in chromosomal structure or number
changes in the number of sets of chromosomes (ploidy), changes in the number of individual chromosomes (somy), or changes in appearance of individual chromosomes through mutation-induced rearrangements. They can be associated with genetic diseases or with species differences
Mujahid Hussain, Department of Botany, University of Sargodha, Sargodha, Punjab, Pakistan
mutations Is a process that produces a gene or chromosome that differs from the wild type.
The mutation may result due to changes either on the gene or the chromosome itself.
Gene mutations – introduction – definition – a brief history – terminology –
classification of mutations – characteristic features of mutations – spontaneous
mutations and induced mutations
Gene mutations – artificial induction of mutations – physical and chemical
mutagens – molecular basis of mutations – detection of sex-linked lethals in
Drosophila by CLB technique – detection of mutations in plants – the importance of
mutation in plant breeding programmes –
Ecotoxicology is the science devoted to the study of the adverse effects of chemicals on ecosystems structure, functions, and biodiversity. It is a modern discipline, just developed during the last four decades, directly associated to the need to identify, predict, control, and minimize the negative environmental consequences of the recent human industrial development. Ecotoxicology has always been connected to toxicology, and is in part an extension of human/veterinary toxicology to the investigation of effects on wildlife. In parallel, it also linked ecotoxicology to ecology, from both conceptual and methodological viewpoints.
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine-disrupting chemicals, or endocrine-disrupting compounds are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.
A GENE is the basic physical and functional unit of heredity. Genes are made up of DNA. Some genes act as instructions to make molecules called proteins. However, many genes do not code for proteins. In humans, genes vary in size from a few hundred DNA bases to more than 2 million bases.
GENE MUTATIONS
A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes.
Carbohydrates are the sugars, starches and fibers found in fruits, grains, vegetables and milk products. Though often maligned in trendy diets, carbohydrates — one of the basic food groups — are important to a healthy life.
Ethoipian Region
Distribution of animals
Common Names
Scientific Names
Habitat
Feeding Habits
General Characteristics
Represented Images
Geographical region
Structural arrangement of teeth is known as dentition.
Dental Formula,
Dentition in Herbivores
Dentition in Carnivores
Dentition in Omnivores
Arrangement of teeth
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Lateral Ventricles.pdf very easy good diagrams comprehensive
Mutation Chromosomal Abberation
1.
2. Definition
Cause of mutations (mutagen)
Mutation frequency
Types of mutations
Chromosome mutations
Point mutations
Gene mutations
Somatic mutations
Kinds of gene mutation
3. “A mutation is a change in
amount or structure of DNA of an
organism.”
A mutation may result in the
change in appearance of a
characteristic in a population.
4. There are certain physical and
chemical agents which cause an
Inheritable changes in a gene
and thus produce its allele. These
are Called Mutagens.
These are three main categories
of mutagens.
5. These are high energy radiations
like Alpha, beta, gamma and
cosmic rays. They are called
ionizing b/c they penetrate the
tissues deeply causing ionization
of molecules encountered.
6. As they penetrate the cells,
electrons are forced to flow out of
molecules, thus stable molecules
and atoms are transferred into free
radicals and reactive ions. These
radiation affect the genetic material
altering the purines and
pyrimidines in the DNA and
resulting in point mutation.
7. These include UV rays.
These cannot ionize the
target tissue. The UV light
effect pyrimidines mainly
to cause a change in DNA.
8. Certain chemicals such as nitrous
acid hydroxylamine, dimethyl
Sulfonate etc act as mutagens. In
addition a variety of other Chemical
substances including Mustard gas,
caffeine, formaldehyde, certain
components of tobacco & an
increasing no. of drugs, food
preservatives and pesticides also
cause mutation.
9. Mutation occurs randomly and
spontaneously, therefore any
gene can undergoes mutation at
any time. The rates at which
occur also vary from species to
species. The factors that alter
mutation frequency include
temperature, aging and
malnutrition.
10. The work of H.J Miller (1920)
showed that frequency can be
increased by X –rays. Since it
has been shown the rate of
mutation can by increased by
the effect of different
mutagens.
12. These changes may involve the
loss or gain of single
chromosomes, a condition
called aneuploidy (2n-1 or 2n+1),
or the increase in whole sets of
chromosomes, a condition
called euploidy (Polyploidy –3n,
4n, 5n & so on).
13. Zygotes containing less than the
diploid no. of chromosomes
(aneuploidy) usually fail to develop,
but those with polysomic
chromosomes may develop. In most
cases where aneuploidy occurs in
animals, it produces severe
abnormalities. Chromosomal
mutation in human are:
22. During these changes
the no. of gene loci on
chromosomes is
changed and this has
profound effect on
phenotypes.
23. These changes result in
change in allele sequence of
parental linkage group and
produced recombinant.But
no change loci are lost.These
produced profound effect of
phenotype.
26. “A change in nucleotides sequence
of DNA molecule in a particular
region of the chromosome is called
a point mutation”.
Such a change in the base sequence
of a gene is transmitted to mRNA
during transcription
27. and may result in a change in the
amino acid sequence of polypeptide
chain produced from it during
translation in ribosome .Since point
mutations are changes in DNA, some
occurs in any type of cell, somatic
(somatic mutation)as well as germ
cells (gene mutation).
28.
29. Somatic mutation tends to remains
undetected because dominant allele is
present at that locus of
homologous chromosome. They affect the
organism in which these occur and lost on
the death of an organism. In case of
human mutation may produce cells with
increased rate of growth and division.
32. Gene mutations occurring
during gamete formation are
transmitted to all the cells of
the offspring and from one
generation to next therefore
may be significant for the
future of the species.
33. Most minor gene mutations are
recessive; therefore pass unnoticed
in the phenotype. However, there are
cases where a change in single base
have a profound effect on the
phenotype, for example “sickle cell
anemia” in humans, where mutation
affect only single base in one of
genes involved in the production of
hemoglobin.
36. “The mutation which arises for no
apparent reason and cause a genetic
alteration is called spontaneous
mutation.”
Spontaneous mutation is a random
and natural. It may occur at any site
of chromosome. It is found that
majority of them produces just a
slight effect and is harmful.
37. The frequency of
spontaneous mutations
is 1-10/million gametes,
but it should not be
underestimated, as any
higher organism
contains thousands of
gene loci.
38. Total mutation rate in
Drosophila indicate in
one generation there is
probability that 5% of the
gamete will contain a
mutation which arose in
that generation time.
43. “It may not kill the
individual possessing it,
but the gene is adversely
affected him in some way
and is decreasing his
probability of survival”.
44. Once a gene has mutated to an
allelic form, this mutant gene
will continue to duplicate itself
until it is eliminated together.
However, at times the mutant
gene may mutate back to the
original or wild form of the
gene.
45. This is called back
mutation or reverse
mutation. The frequency
of back mutation is rare
than the forward
mutation, the change from
wild to mutant.