A multimodal strategy involves implementing several components together to improve outcomes and change behavior. For infection prevention and control, a multimodal approach is needed at both the national and hospital levels. It consists of system changes, education and training, monitoring practices and outcomes, reminders, and culture change. Hand hygiene is commonly addressed through multimodal strategies involving guidelines, education, automated monitoring, and reminders. Denmark has successfully used multimodal strategies including antimicrobial stewardship, isolation, communication, and establishing task forces to reduce antibiotic-resistant organisms like ESBL-producing Klebsiella pneumoniae in hospitals.