The document summarizes the major histocompatibility complex (MHC), which screens T cells so that only those capable of binding to MHC molecules are maintained. It discusses MHC restriction, whereby a T cell only recognizes a peptide bound to a particular MHC variant. MHC molecules are highly polymorphic, affecting the range of bound peptides and interactions with T cell receptors. MHC class I presents intracellular peptides to cytotoxic T cells, while MHC class II presents extracellular peptides to T helper cells, leading to different immune responses.
Antigen processing and presentation by Dr K.Geetha, Associate Professor, Department of Biotechnology, Kamaraj College of Engineering & Technology, Near Virudhunagar, Madurai Dist.
Antigen processing and presentation by Dr K.Geetha, Associate Professor, Department of Biotechnology, Kamaraj College of Engineering & Technology, Near Virudhunagar, Madurai Dist.
cytokines play a key role in controlling the immune system. It facilitate other cells and organs to work, with this presentation you will be able to learn about what are cytokines, their types, & their biological roles along with diseases related to cytokines and cytokines based therapies.
IT CONTAINS THE LATEST INFORMATION ABOUT MHC MOLECULE WHICH WILL BE HELPFUL FOR B.SC /M.SC/CSIR-NET/DBT-JRF/GATE STUDENTS. THIS IS IN VERY SIMPLE AND LUCID MANNER TO UNDERSTAND AND ONE CAN EASILY OPT FOR THIS TO PREPARE NOTES.
cytokines play a key role in controlling the immune system. It facilitate other cells and organs to work, with this presentation you will be able to learn about what are cytokines, their types, & their biological roles along with diseases related to cytokines and cytokines based therapies.
IT CONTAINS THE LATEST INFORMATION ABOUT MHC MOLECULE WHICH WILL BE HELPFUL FOR B.SC /M.SC/CSIR-NET/DBT-JRF/GATE STUDENTS. THIS IS IN VERY SIMPLE AND LUCID MANNER TO UNDERSTAND AND ONE CAN EASILY OPT FOR THIS TO PREPARE NOTES.
Major Histocompatibility Complex (MHC) plays a cardinal role in T cell-mediated immunity. Modern immunogenetics largely depends on the research on the MHC complex.
This ppts file will give the students of biochemistry or biology, in general, a brief outlook on the structure and functions of MHC, as well as its mode of action.
I hope this work will help intermediate students grasping the topic.
it is related to immunology .. Major histo compatibility complex - a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions..
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
6. The process by which T
cells are screened so that
only those capable of
binding to MHC are kept
alive called positive
selection
A T cell recognizes antigen as a
peptide bound by a particular
allelic variant of an MHC
molecule, and will not recognize
the same peptide bound to other
MHC molecules. This behavior of T
cells is called MHC restriction
The outstanding feature of
the MHC molecules is their
extensive polymorphism
At least three properties of MHC
molecules are affected by MHC
polymorphism: the range of
peptides bound; the conformation
of the bound peptide; and the
direct interaction of the MHC
molecule with the T-cell receptor
The interaction between
TCRs and peptide-MHC
complex is significant in
maintaining the immune
system against foreign
antigens
13. 1. Antigen Processing
Before an antigen can be presented, it must first be processed.
Processing transforms proteins into antigenic peptides.
MHC Class I Molecules
1. Intracellular peptides for MHC class I presentation are made
by proteases and the proteasome in the cytosol.
2. Then transported into the endoplasmic reticulum via TAP
(Transporter associated with Antigen Processing) to be further
processed.
3. They are then assembled together with MHC I molecules and
travel to the cell surface ready for presentation.
Antigen Processing and Presentation
14. MCH Class II Molecules
1. The route of processing for exogenous antigens for MHC class
II presentation begins with endocytosis of the antigen.
2. Once inside the cell, they are enclosed within endosomes that
activate proteases, to degrade the antigen.
3. MHC class II molecules are transported into endocytic
vesicles where they bind peptide antigen, and then travel to the
cell surface.
Antigen Processing and Presentation
16. 2. Antigen Presentation
The antigen presented on MHCs is recognised by T
cells using a T cell receptor (TCR). These
are antigen-specific.
Co-receptors
As well as the TCR, another T cell molecule is required
for antigen recognition and is known as a co-receptor.
These are either a CD4 or CD8 molecule:
CD4 is present on T helper cells and only binds to
antigen-MHC II complexes.
CD8 is present on cytotoxic T cells and only binds to
antigen-MHC I complexes.
Antigen Processing and Presentation
17. This therefore leads to very different effects.
1. Antigens presented with MHC II will activate T helper cell.
2. Antigens presented with MHC I activate cytotoxic T cells.
Cytotoxic T cells will kill the cells that they recognise, whereas T
helper cells have a broader range of effects on the presenting cell such
as:
1. Activation to produce antibodies (in the case of B cells)
2. Activation of macrophages to kill their intracellular pathogens.
20. Antigen Presentation
Antigens are delivered to the surface of APCs by Major
Histocompatibility Complex (MHC) molecules.
Different MHC molecules can bind different peptides. The MHC
is highly polygenic and polymorphic which equips us to
recognise a vast array of different antigens we might
encounter.
There are different classes of MHC, which have different
functions:
MHC class I molecules are found on all nucleated cells (not just
professional APCs) and typically present intracellular antigens
such as viruses.
MHC class II molecules are only found on APCs and typically
present extracellular antigens such as bacteria.
21. Endogenous Antigens
• Endogenous antigens are proteins found within the
cytosol of human cells. Examples of endogenous
antigens include:
1. Viral proteins produced during viral replication.
2. Proteins produced by intracellular bacteria such as
Rickettsias during their replication.
3. Proteins that have escaped into the cytosol from the
phagosome of phagocytes such as antigen-presenting
cells.
4. Tumor antigens produced by cancer cells.
5. Self-peptides from host cellular proteins.
Endogenous Antigens
22. ENDOGENOUS PATHWAY
• Endogenous antigens pass through proteasomes where they are
degraded into a series of peptides.
• The peptides are transported into the rough endoplasmic reticulum
(ER) by a transporter protein called TAP.
• The peptides then bind to the grooves of newly synthesized MHC-I
molecules.
• The endoplasmic reticulum transports the MHC-I molecules with
bound peptides to the Golgi complex.
• The Golgi complex, in turn, transports the MHC-I/peptide
complexes by way of an exocytic vesicle to the cytoplasmic
membrane where they become anchored.
• Here, the peptide and MHC-I/peptide complexes can be recognized
by by a complementary-shaped T-cell receptor (TCR) and a CD8
molecule, a co-receptor, on the surface of either a naive T8-
lymphocyte or a cytotoxic T-lymphocyte (CTL).
Endogenous Pathway
23. Factors required for Endogenous
Pathway
• Proteasomes are complex intracellular proteases that function
in regulated degradation of cellular proteins.
• Calreticulin and calnexin: Type of molecular chaperone
proteins, involved in the assembly of MHC-I and in the
processing of intracellular peptides.
• Transporter associated with antigen processing (TAP):
protein complex belongs to the ATP-binding-cassette
transporter family. essential for peptide delivery from the
cytosol into the lumen of the endoplasmic reticulum (ER),
where these peptides are loaded on major histocompatibility
complex (MHC) I molecules.
• TAP-associated glycoprotein or Tapasin is a critical cofactor.
It promotes the assembly of major histocompatibility complex
(MHC) class I molecules with peptides.
Factors required for Endogenous Pathway
24.
25. A Cytotoxic T-lymphocyte Recognizing a Virus-Infected Cell. Endogenous
antigens are those being produced within the cytosol of the cells of the body.
Examples include proteins from replicating viruses, proteins from intracellular
bacteria, and tumor antigens. The body marks infected cells and tumor cells
for destruction by placing peptide epitopes from these endogenous antigens
on their surface by way of MHC-I molecules. Cytotoxic T-lymphocytes (CTLs)
are then able to recognize peptide/MHC-I complexes by means of their T-cell
receptors (TCRs) and CD8 molecules and kill the cells to which they bind.
26. EXOGENOUS PATHWAY
Exogenous antigens, such as viruses, are engulfed and placed in a
phagosome.
Lysosomes fuse with the phagosome forming an phagolysosome.
Protein antigens are degraded into a series of peptides.
MHC-II molecules are synthesized in the endoplasmic reticulum. Within
the endoplasmic reticulum, a protein called the invarient chain (Ii)
attaches to the the peptide-binding groove of the MHC-II molecules and in
this way prevents peptides designated for binding to MHC-I molecules
within the ER from attaching to the MHC-II.
As the MHC-II molecules with bound Ii chain are transported to the Golgi
complex, the Ii is cleaved, leaving a short peptide called CLIP in the
groove of the MHC molecule.
The vesicles containing the MHC-II molecules fuse with the peptide-
containing phaglysosomes.
Exogenous Pathway
27. The CLIP peptide is removed from the MHC-II
molecules and the peptide epitopes are now free
to bind to the grooves of the MHC-II molecules.
The MHC-II molecules with bound peptides are
transported to the cytoplasmic membrane where
they become anchored.
Here, the peptide and MHC-II complexes can be
recognized by T4-lymphocytes by way of TCRs
and CD4 molecules having a complementary
shape.
Exogenous Pathway
28.
29.
30. MHC-II molecules with
bound peptides can be
recognized by a
complementary-shaped T-cell
receptor and a CD4 molecule,
a co-receptor, on the surface of
a T4-lymphocyte
T4-lymphocytes are the cells
the body uses to regulate both
humoral immunity and cell-
mediated immunity.
31. • The invariant chain (Abbreviated Ii) is a
polypeptide which plays a critical role in
antigen presentation. It is involved in the
formation and transport of MHC class II
peptide complexes for the generation of CD4+
T cell responses.
• Class II-associated invariant chain peptide
(CLIP): When Ii undergoes degradation and
leave a peptide fragment (85–101) in length.