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Membrana y transporte celular
Figureage 97
Cell interior
Plasma membranePlasma membrane
Outside cell 0.1 µm
Hydrophilic heads
Hydrophobic tails
(a) Phospholipids in water (b) Detergent in water
Figure 5-7
Page 100
E-face
P-face
Cytosol
Extracellular
fluid
E-face
P-face
(a)
(b)
Movimiento de fosfolípidos
Time
Glycoprotein
Hydrophilic
helixa
Cholesterol
Carbohydrate
chain
Extracellular fluid
Hydrophilic
Hydrophobic
Cytosol
Peripheral
protein
Carbohydrate
chains
Integral
proteins
Glycolipid
Funciones de las proteínas de la membrana
 Anclaje
 Transporte pasivo
 Transporte activo
 Actividad enzimática
 Comunicación
 Reconocimiento
 Unión
Outside
cell
Outside
cell
Inside
cell
Integrin
Outside
cell
Outside
cell
Outside
cell
Inside
cell
Inside
cell
Inside
cell
ATP
ADP
P
Na+
(a) Anchoring (b) Passive transport
(d) Enzymatic activity(c) Active transport
Outside
cell
Inside
cell
Outside
cell 1
Inside
cell 2
Outside
cell
Inside
bacterial
cell
Human
B
cell
Human
B
cell
Antigen
(e) Signal transduction (f) Cell recognition
(g) Intercellular junction
(g) Intercellular junction
Mecanismos de transporte celular
 Difusión
 Osmósis
 Difusión facilitada
 Transporte activo
 Endocitosis
 Exocitosis
Difusión
1 2 3
Osmosis
 Diferencia en concentración
 Membrana selectiva
 Presión osmótica
Figure 5-11
Page 104
Net movement
of water molecules
Pressure applied to piston to resist upward movement
Water
plus
solute
Pure water
Water
molecule
Molecule
of solute
Selectively
permeable
membrane
 Solución isotónica
 Solución hipertónica
 Solución hipotónica
Outside
cell
Outside
cell
Outside
cell
Inside
cell
Inside
cell
Inside
cell
No net water
movement
Net water movement
out of the cell
Net water movement
into the cell
Isotonic solution Hypertonic solution Hypotonic solution
10µm
(a)
(b)
(c)
Figure 5-13
Page 106
Plasma
membrane
Vacuole
Vacuolar
membrane
(tonoplast)
Cytoplasm
Plasma
membrane
Vacuole
Nucleus(a) (b) (c)
 Plasmólisis
 Turgencia
Transporte activo
a
Page 108
Higher
Higher
Lower
Lower
Outside
cell
Cytosol
Active
transport
channel
ATP
Sodium
concentrationgradient
Potassium
concentrationgradient
(a)
Outside cell Outside cell
Inside cell Inside cell
Low
concentration
of solute
High
concentration
of solute
Figure 5-15b
Page 108
ATP
ADP
1. Three sodium ions bind
to the transport protein
2. A phosphate group is
transferred from ATP to
the transport protein
3. The transport protein under-
goes a conformational
change, releasing three
sodium ions outside the cell.
6. The transport protein
returns to its original shape:
Two potassium ions are
released inside the cell
5. The phosphate is released
4. Two potassium ions bind
to the transport protein
(b)
Endocitosis
Figure 5-17
Page 110
0.25µm
1. A vesicle approaches the plasma membrane
2. fuses with it and
3. releases its contents outside the cell.
Figure 5-18(1)
Page 111
3. Lysosomes may fuse with the vacuole
and pour their potent enzymes onto the
ingested material.
2. The vacuole then pinches off inside the
cell.
1. Folds of the plasma membrane surround
the particle to be ingested, forming a
small vacuole around it.
Figure 5-18(2)
Page 111Nucleus
Lysosomes Large vacuole
Bacteria
Ingested bacteria
Glycogen (stored
nutrients)
2.5µm
Figure 5-19
Page 111
Microvilli Pinocytotic vesicle
Cytosol
Figure 5-20a
Page 112
Plasma
membrane
Cytosol
Uncoated
vesicle
Endosome
LDL receptor transported
to plasma membrane
and recycled
Free
cholesterol
Secondary
lysosome
Lysosome
Clathrin
Clathrin
recycled
Coated
pit
LDL
particle
LDL
receptor
(a)
Figure 5-20b
Page 112
0.25µm(b)
Fig. 5-23a, p. 126
Coated
pit
LDL attaches to specific
receptors in coated pits
on plasma membrane.
Vesicle containing LDL
particles fuses with a
lysosome, forming a
secondary lysosome.
Hydrolytic enzymes
then digest cholesterol
from LDL particles for
use by cell.
Endocytosis results in
formation of a coated
vesicle in cytosol.
Seconds later
coat is removed.
Uncoated vesicle
fuses with endosome.
Receptors are returned
to plasma membrane
and recycled.
(a) Uptake of low-density lipoprotein (LDL) particles, which transport cholesterol in the blood.
Endosome
Endosome
Primary
lysosome
Clathrin
recycled
Secondary
lysosome
Free
cholesterol
Clathrin
Cytosol
Uncoated
vesicle
Plasma
membrane
LDL
receptor
LDL
particle
1
2
3
4
5
1
2
3
4
5
Exocitosis
Fig. 5-20, p. 124
Exocitosis
Ciclo Celular
Fig. 10-5, p. 215
INTERPHASE
G1
(First gap phase)
S
(Synthesis phase)
G2
(Second gap
phase)
M PHASE
(Mitosis and cytokinesis)
Fig. 10-6a, p. 216
Fig. 10-6b, p. 217

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