1) Hormones are organic substances that regulate growth, metabolism and other functions by acting as biochemical messengers. They can be classified based on their chemical composition and target organs.
2) Hormone action involves processes like synergism, permissiveness, antagonism and feedback loops. Lipid-soluble hormones like steroids directly enter cells and activate genes, while water-soluble hormones trigger intracellular signaling cascades.
3) The document discusses the mechanisms and characteristics of hormone action, including the different classes of receptors, signal amplification pathways, and how lipid-soluble and water-soluble hormones elicit their effects on target cells and tissues. Negative and positive feedback loops help regulate hormone secretion.
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
Gastrointestinal Hormones by Pandian M, Dept of Physiology DYPMCKOP, for MBBS...Pandian M
Classify GIT hormones
List the source and functions of different GI hormones
Explain the mechanism of action and regulation of secretion of different GI Hormones
Describe the role of GI hormones in regulation of GI functions
Explain the dysfunctions produced by alteration in secretion of GIT hormones
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
Gastrointestinal Hormones by Pandian M, Dept of Physiology DYPMCKOP, for MBBS...Pandian M
Classify GIT hormones
List the source and functions of different GI hormones
Explain the mechanism of action and regulation of secretion of different GI Hormones
Describe the role of GI hormones in regulation of GI functions
Explain the dysfunctions produced by alteration in secretion of GIT hormones
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. There are many types of hormones that act on different aspects of bodily functions and processes.
Biochemistry Of Hormones
Contains All Important topics with best key points....
Made By Sanjay kumar (Student Of PharmD Faculty of Pharmacy Hamdard University)
Hormones are chemical messengers that are secreted directly into the blood, which carries them to organs and tissues of the body to exert their functions. There are many types of hormones that act on different aspects of bodily functions and processes.
Biochemistry Of Hormones
Contains All Important topics with best key points....
Made By Sanjay kumar (Student Of PharmD Faculty of Pharmacy Hamdard University)
This is a lecture I presented to the staff at the Edge of South Burlington about the importance of periworkout nutrition for hard trainers as well as ways to set up a diet around it.
High blood pressure causes many types of cardiovascular disease, such as stroke and heart failure, and renal disease. Peripheral arterial disease (PAD) is caused by atherosclerosis, which is the narrowing and / or blockage of the blood vessels in the legs.
Cells of the nervous system: Neurons & Glial cells
▫ Glial cells:
most abundant cells, are of 3 main types
A. Microglia: Phagocytic (immune) cells,
B. Astrocytes: Support & nutrition of the neurons
(provide neurons with lactate from glucose and
regulate the content of ECF by removing K+ &
excess neurotransmitters)
C. Oligodendrocytes: form myelin sheathe in CNS
Schwan cells form myelin sheaths in PNS
Ependymal cells: line brain & spinal cord cavities
using their cilia to allow for the circulation of the
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. WHAT ARE HORMONES?
• Natural organic substances, that regulate growth,
metabolism and other functions of an organism
• They are simply biochemical messengers
• They can be classified according to the chemical
composition, organs where they work e.g
reproductive hormones in the reproductive
organs, and if they either act on the same cell
producing them i.e. autocrine or paracrine
3. GENERAL PRINCIPLES OF HORMONE
ACTION
• Trophic hormone:- A hormone that has its primary function the regulation
of hormone secretion by another endocrine gland
• Synergism-when different hormones work together and have a greater
effect than individual hormone action
• Permissiveness-a small amount of one hormone allows a second hormone
to have its full effect on a target cell; i.e. first hormone ‘permits’ the full
action of the second hormone
• Antagonism-one hormone produces the opposite effect of the other
• The processes involve in both negative and positive feedback. For example,
if A>B>C>D, increase in D causes inhibition of A i.e. negative feedback. If D
decreases, A production is triggered, i.e. positive feedback.
4.
5. GENERAL CHARACTERISTICS
OF HORMONES
Not secreted at a uniform rate
Exert their effects in biocatalytic amounts
Turnover is varied and usually rapid
Exert multiple actions
Exhibit high degree of specificity
Different tissues may respond differently to a
given hormone
6. MECHANISM OF HORMONE ACTION
The hormones fall into two general classes based on
their solubility in water.
1. Hydrophilic Hormone: The water soluble hormone.
They are transported simply dissolved in blood
Examples: the catecholamines (epinephrine and
norepinephrine) and peptide/protein hormones.
2. Lipophilic Hormone: They are poorly soluble in water.
So they cannot be dissolved in watery blood. They bind to
plasma protein and present in the blood in protein bound
form. They are lipid soluble.
Examples: The lipid soluble hormones include thyroid
hormone, steroid hormones and Vitamin D3
7. Broad Classification (Structure)
Hydrophillic Lipophillic
Proteins, peptide hormones
& catecholamines
Steroid and thyroid hormones
Primarily act through second
messenger system
Activate genes on binding with
receptors in the nucleus
Circulate mainly dissolved in
the plasma
Largely bound to plasma proteins
8. Signal Amplification Via 2nd Messenger Pathways
Initial signal is in the form of hormone which acts
as ligand whose concentration is just one/per
receptor. The hormonal response has got multiple
steps, and each step multiplies the signal
(cascading effect) that finally leading to million
fold amplification, i.e. one hormone molecule
mediating its effect through million of molecules.
This process is known as signal amplification.
9.
10. MODE OF HORMONE ACTION
• Generally hormones work in two ways
1-synthesis of new protein molecules
2- changing cell permeability
• Lipid-soluble hormones involves in ‘
whereas water-soluble
hormones involves in ‘
12. MEMBRANE RECEPTOR
Receptors present in or on the surface of the
cell membrane.
Types
Ion channel-linked receptor
G –protein couple receptor
Enzyme –linked receptor
E.g., Proteins, peptides, & catecholamines
14. NUCLEAR RECEPTOR
Receptors present in nucleus &
there is direct association with one
or more chromosomes.
E.g., Thyroid hormones, Retinoid
hormones, Vitamin-D.
17. HOW LIPID-SOLUBLE HORMONES
WORK?
• Binding to specific cell receptor in the cell membrane
and form hormone-cell receptor complex, which
diffuses to nucleus
• The receptor is eventually released for re-use
• Steroid activates a specific gene to produce mRNA
• mRNA pass out into the cytoplasm and initiates
protein [enzyme] synthesis
why do they penetrate the cell?
the whole process is called mobile-receptor
hypothesis in which a steroid hormone is not attached
to the plasma membrane, but seem to move freely in
the nucleoplasm
18. HOW LIPID-SOLUBLE HORMONES
WORK?
Step1: Free lipophilic hormone (hormone not bound with its
plasma protein carrier) diffuses through the plasma membrane
of the target cell and binds with the receptor which is
intracellularly located inside the cytosol/or in the nucleus.
Step2. Each receptor has specific binding region with hormone
and another region with binding with DNA. Receptor alone
cannot bind to DNA unless it binds to hormone. Once the
hormone is bound to receptor, the hormone receptor complex
binds to specific region of DNA known as Hormone response
element(HRE).
Step3: Transcription of gene
Step4: m RNA transported out of nucleus into the cytoplasm
Step5: Translation at Ribosome
Step6: Protein/enzyme released from ribosome
Step7: protein/enzyme mediate ultimate response
24. HOW WATER-SOLUBLE HORMONES
WORK?
• ●1 A water-soluble hormone (the first messenger) diffuses from the
blood through interstitial fluid and then binds to its receptor at the
exterior surface of a target cell’s plasma membrane. The hormone–
receptor complex activates a membrane protein called a G protein. The
activated G protein in turn activates adenylate cyclase.
• ●2 Adenylate cyclase converts ATP into cyclic AMP (cAMP). Because the
enzyme’s active site is on the inner surface of the plasma membrane, this
reaction occurs in the cytosol of the cell.
• ●3 Cyclic AMP (the second messenger) activates one or more protein
kinases, which may be free in the cytosol or bound to the plasma
membrane. A protein kinase is an enzyme that phosphorylates (adds a
phosphate group to) other cellular proteins (such as enzymes). The donor
of the phosphate group is ATP, which is converted to ADP.
25. HOW WATER-SOLUBLE HORMONES
WORK?
• ●4 Activated protein kinases phosphorylate one or more cellular proteins.
Phosphorylation activates some of these proteins and inactivates others,
rather like turning a switch on or off.
• ●5 Phosphorylated proteins in turn cause reactions that produce
physiological responses. Different protein kinases exist within different
target cells and within different organelles of the same target cell. Thus,
one protein kinase might trigger glycogen synthesis, a second might cause
the breakdown of triglyceride, a third may promote protein synthesis, and
so forth. As noted in step ●4 phosphorylation by a protein kinase can also
inhibit certain proteins. For example, some of the kinases unleashed when
epinephrine binds to liver cells inactivate an enzyme needed for glycogen
synthesis
.
• ●6 After a brief period, an enzyme called phosphodiesterase inactivates
cAMP. Thus, the cell’s response is turned off unless new hormone
molecules continue to bind to their receptors in the plasma membrane
26. HOW WATER-SOLUBLE HORMONES
WORK?
• The whole process above is called
also called
. In this
instance, the first messenger delivers
message to fixed receptors in the target cell’s
plasma membrane. The message then is
passed to the cell where second messenger
triggers appropriate cellular changes