The document discusses hormones, defining them as chemical messengers produced in one part of the body and carried via bloodstream to target tissues to modify their structure and function. It describes the major endocrine glands that secrete hormones, and classifies hormones based on their chemical composition and solubility. The mechanisms of hormone action are explained, distinguishing between water-soluble hormones that act via cell surface receptors and intracellular second messengers, and lipid-soluble hormones that directly enter cells and regulate gene expression. The processes of hormone synthesis, regulation, transport, and inactivation are also summarized.
Cells of the nervous system: Neurons & Glial cells
▫ Glial cells:
most abundant cells, are of 3 main types
A. Microglia: Phagocytic (immune) cells,
B. Astrocytes: Support & nutrition of the neurons
(provide neurons with lactate from glucose and
regulate the content of ECF by removing K+ &
excess neurotransmitters)
C. Oligodendrocytes: form myelin sheathe in CNS
Schwan cells form myelin sheaths in PNS
Ependymal cells: line brain & spinal cord cavities
using their cilia to allow for the circulation of the
Cells of the nervous system: Neurons & Glial cells
▫ Glial cells:
most abundant cells, are of 3 main types
A. Microglia: Phagocytic (immune) cells,
B. Astrocytes: Support & nutrition of the neurons
(provide neurons with lactate from glucose and
regulate the content of ECF by removing K+ &
excess neurotransmitters)
C. Oligodendrocytes: form myelin sheathe in CNS
Schwan cells form myelin sheaths in PNS
Ependymal cells: line brain & spinal cord cavities
using their cilia to allow for the circulation of the
medical #students #doctors #foodandnutrition #nurses #NEET #PCM #doctors #nutritioneducation #mscdfsm #dietician #nationaldieticians #RD #REGISTERED #DIETICIANS#NUTRITIONIST #INTERNATIONAL DIETICIANS This content is made for all student of medical ,nutrition ,doctors ,zoology ,chemistry ,medical who are still preparing for examination .feel free to give suggestion
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
medical #students #doctors #foodandnutrition #nurses #NEET #PCM #doctors #nutritioneducation #mscdfsm #dietician #nationaldieticians #RD #REGISTERED #DIETICIANS#NUTRITIONIST #INTERNATIONAL DIETICIANS This content is made for all student of medical ,nutrition ,doctors ,zoology ,chemistry ,medical who are still preparing for examination .feel free to give suggestion
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Introduction of Hormones
Most glands of the body deliver their
secretions by means of ducts. These are
called exocrine glands.
There are few other glands that produce
chemical substance that they directly
secrete into the bloodstream for
transmission to various target tissues.
These are ductless or endocrine glands.
The secretions of endocrine glands are
called as hormones.
3. Definition of Hormones
It is a chemical substance which is produced
in one part of the body, enters the
circulation and is carried to distant target
organs and tissues to modify their
structures and functions.
Hormones are strictly speaking stimulating
substances and act as body catalysts.
4. Properties of Hormones
They act as chemical messengers, are required
in small amounts.
They are secreted in blood prior to their use.
Site of synthesis and action is different except
autocrines.
Are not used up in reaction.
Their activity can be monitored by their blood
levels.
These can be proteins, amino acids or steroids.
5. Target Cell
Hormones circulate to all tissues but only
activate cells referred to as target cells.
Hormone can affect several different cell
types;
More than one hormone can affect a given cell
type;
Hormones can exert many different effects in
one cell or in different cells.
6. Hormone Receptors
Target cells must distinguish hormones (in
small amounts and similar molecules) by
binding receptors
(1) binding should be specific
(2) binding should be saturable
(3) binding should occur within the
concentration range of the expected
biologic response
7. Contd
Receptors are proteins, two functional
domains:
(1) A recognition domain binds the hormone
ligand;
(2) A second region generates a signal that
couples hormone recognition to some
intracellular function.
Receptors are located on the plasma
membrane and inside the cells (cytoplasm,
nucleus)
8. Contd
Target organs – Tissues with specific receptors
No receptors - Not a target organ
9. Target Cell Activation
Target cell activation depends on three
factors
Blood levels of the hormone
Relative number of receptors on the target cell
The affinity of those receptors for the
hormone
Up-regulation:target cells form more
receptors in response to the hormone
Down-regulation:target cells lose
receptors in response to the hormone
11. 1. Hypothalamus
2. Pituitary
3. Pineal gland
4. Thymus
5. Thyroid gland
6. Parathyroid glands
7. Langerhans’ islet of
pancreas
8. Adrenal glands
9. Sex glands
The major hormone
secreting glands are:
12. Contd
The major hormone secreting glands are:
Pituitary, hypothalamus, thyroid, adrenal,
pancreas, ovaries and testes.
Thymus, pineal gland and parathyroid gland.
Hormones can be classified according to
chemical composition, solubility, location of
receptors, and the nature of the signal used
to mediate hormonal action within the cell.
16. Hormones are synthesized & modified for full
activity in a variety of ways.
Some hormones are synthesized in final form
and secreted immediately.
Included in this class are steroid hormones.
Some, such as the catecholamines are
synthesized in final form and stored in the
producing cells.
Synthesis of Hormones
17. While others, like insulin, are synthesized
from precursor molecules in the producing
cell, and then are processed and secreted
upon a physiologic cue (plasma glucose
concentrations).
Finally, still others are converted to
active forms from precursor molecules in
the peripheral tissues (T3 and DHT).
Contd
18. Are secreted directly into the blood
Peptide and protein hormones are secreted
by exocytosis
Steroid (lipophilic) hormones continuously
penetrate the membrane (they are not
accumulated in cells, their concentration in
blood is determined by the speed of
synthesis)
Fate of Hormones in The Organism
19. Regulation of Hormone Secretion
Hormones reach target organs, exert their
metabolic effects, also reach their site of
production.
Here, they can inhibit the production of
hormone. This is called as feedback inhibition.
Sometimes the concentration of the hormone
is less, which stimulates the production of
hormone by a process of feedback
stimulation.
20.
21. Transport of Hormones in Blood
Protein and peptide nature – in free state
Steroid hormones and thyroid hormones –
bound with alpha-globulins or albumins
Catecholamines – in free state or bound
with albumins, sulphates or glucuronic acid
Reach the target organs
Cells have the specific receptors to certain
hormone
22. The Final Effects of Hormones Action
Change the permeability of cell membrane,
accelerate the penetration of substrates,
enzymes, coenzymes into the cell and out of
cell.
Acting on the allosteric centers affect the
activity of enzymes (Hormones penetrating
membranes).
23. Contd
Affect the activity of enzymes through the
second messengers (cAMP). (Hormones that can
not penetrate the membrane).
Act on the genetic apparatus of the cell
(nucleus, DNA) and promote the synthesis of
proteins (Steroid and thyroid hormones).
Induce secretory activity and stimulate mitosis
24. Inactivation of hormones
After biochemical effect hormones are
released and metabolized
Hormones are inactivated mainly in liver
Inactive metabolites are excreted mainly
with urine
Half-life
from several min to 20 min – for the majority
of hormones
till 1 h – for steroid hormones
till 1 week – for thyroid hormones
25. Factors Regulating Hormone
Action
Action of a hormone at a target organ is
regulated by four factors:
1. Rate of synthesis and secretion: The hormone
is stored in the endocrine gland.
2. In some cases, specific transport systems in
plasma.
3. Hormone-specific receptors in target cell
membranes which differ from tissue to tissue.
4. Ultimate degradation of the hormone usually
by the liver or kidneys.
26.
27. Mechanisms of Hormone Action
Two mechanisms, depending on their chemical
nature
1. Water-soluble hormones (all amino acid–
based hormones except thyroid hormone)
Cannot enter the target cells
Act on plasma membrane receptors
Coupled by G proteins to intracellular
second messengers that mediate the
target cell’s response
28. Contd
2. Lipid-soluble hormones (steroid and
thyroid hormones)
Act on intracellular (cytoplasm or
nucleus) receptors that directly
regulate gene expression.
30. Plasma Membrane Receptors and
Second-Messenger Systems
Intracellular second messenger is utilized
to implement the hormonal action and
involves:
1. G-protein-coupled adenylate cyclase cAMP
system.
2. G-protein-coupled phosphatidylinositol (PIP2)
Ca2+ pathway.
31. cAMP Signaling Mechanism
Hormone (first messenger) binds to
receptor
Receptor activates G protein
G protein activates adenylate cyclase
Adenylate cyclase converts ATP to cAMP
(second messenger)
cAMP activates protein kinases
32. Activated kinases phosphorylate various
proteins, activating some and inactivating
others
cAMP is rapidly degraded by the enzyme
phosphodiesterase
Intracellular enzymatic cascades have a
huge amplification effect
cAMP Signaling Mechanism
33. Figure 16.2
Hormone (1st messenger)
binds receptor.
Receptor
activates G
protein (GS).
G protein
activates
adenylate
cyclase.
cAMP acti-
vates protein
kinases.
Adenylate
cyclase
converts ATP
to cAMP (2nd
messenger).
Receptor
G protein (GS)
Adenylate cyclase
Triggers responses of
target cell (activates
enzymes, stimulates
cellular secretion,
opens ion channel,
etc.)
Hormones that
act via cAMP
mechanisms:
Epinephrine
ACTH
FSH
LH
Inactive
protein kinase
Extracellular fluid
Cytoplasm
Active
protein
kinase
GDP
Glucagon
PTH
TSH
Calcitonin
1
2 3 4
5
34.
35. Binding of Hormone to Receptor Leads to:
Conformational change in the receptor and
G-protein (α, β, γ subunits).
It cleaves the trimeric form into activated
α-GTP complex.
G-protein is a peripheral protein; which
diffuses along the inner surface of the
plasma membrane to reach the effector
protein.
Through allosteric modification the message
is conveyed to the effector protein
36. Contd
Effectors are intracellular enzymes like
adenylate cyclase.
On activation they produce second
messengers like cAMP.
cAMP is formed from ATP by adenylate
cyclase action .
In turn it activates protein kinase A which
phosphorylates intracellular proteins.
37. c AMP binds to (R) of protein kinase A.
Catalytic units (C) are released as active enzyme.
39. Contd
GLUCAGON: This leads to inhibition of
glycogen synthase and activation of
glycogen phosphorylase, ultimately resulting
in inhibition of glycogenesis.
On the other hand the inhibitory system
comprises of receptors (Ri) and inhibitory
regulatory complex (Gi).
40.
41.
42.
43.
44. Used by some amino acid–based hormones in
some tissues
Involves a G protein
G protein activates phospholipase C (PLC)
phospholipase splits membrane phospholipid
phosphatidylinositol (PIP2) into two second
messengers: diacylglycerol (DAG) and
Inositol- 1, 4, 5, triphosphate(IP3)
PIP2-Ca Signaling Mechanism
45. Contd
Intracellular IP3 releases Ca2+. A calcium
binding protein, calmodulin binds Ca2+.The
complex activates a number of intracellular
enzymes. (Eg.Ca2+-calmodulin complex inhibits
glycogenesis, stimulates glycogenolysis.)
DAG activates protein kinase C which in turn
phosphorylates specific enzymes and other
proteins in the cytosol to modulate their
activities.
46.
47. Second Messengers
Second messengers: Ca2+, DAG are
identified for GnRH, TRH, Acetyl choline,
Angiotensin-II, Vasopressin, Oxytocin
The second messengers of Insulin, GH,
Prolactin are a kinase or phosphatase
cascade.
Hormone itself is first messenger.
The message is communicated to the cell Via.
second messengers
48. Intracellular Receptors and
Direct Gene Activation
Steroid hormones and thyroid hormones
1. Diffuse into their target cells and bind with
intracellular receptors
2. Receptor-hormone complex enters the
nucleus
3. Receptor-hormone complex binds to a
specific region of DNA
4. This prompts DNA transcription to produce
mRNA
5. The mRNA directs protein synthesis
51. Contd
Cytosolic receptors found for the following
steroid hormones:
a. Glucocorticoids.
b. Mineralocorticoids
c. Progestins.
d. Estrogens.
e. Calcitriol.
Nuclear receptors are identified for
Thyroxine, Triiodothyronine.
52.
53. Major Differences B/W Hormones
and Enzymes
Parameters Hormones Enzymes
Chemical nature May be Protein, Amino acid or
Steroids
Always Proteins except
Ribozyme
Delivery to blood circulation Delivered first to the circulation
prior to use
Not so
Site of synthesis and action Is Different Is the Same
Role
As chemical messenger B/W the
cells /tissues or organs
As catalyst to enhance rate of
reaction
Regulation Negative feedback mechanism
and CNS
Factors: pH; temperature;
conc. of enzyme and substrate
and inhibitors
Primary action Is on the target tissues through
receptors to express instructions
Is on the specific substrates for
catalysis
54.
55. References
Bain DL, Heneghan AF, Connaghan-Jones KD, et al: Nuclear receptor
structure: implications for function. Ann Rev Physiol 2007;69:201.
Bartalina L: Thyroid hormone-binding proteins: update 1994.Endocr Rev
1994;13:140
Cristina Casals-Casas C, Desvergne B: Endocrine disruptors:from
endocrine to metabolic disruption. Annu Rev Physiol 2011;73:23.135–162.
Taguchi A, White M: Insulin-like signaling, nutrient homeostasis, and
life span. Ann Rev Physiol 2008;70:191.
Lippincott’s’’ Illustrated Reviews Biochemistry
Harper's Illustrated Biochemistry
Path physiology of Endocrinology system Colorado State University
Basic and Clinical Endocrinology – Francis Greenspan – David
G.Gardner
Text book of Medical biochemistry – MN Chatterjea