The document discusses biorisk management systems. It describes a biorisk management system as establishing principles to achieve biosafety and biosecurity objectives. It defines essential components for a framework that integrates biorisk management into an organization's governance, strategy, management, policies and culture. It also describes a comprehensive biorisk management process to mitigate biosafety and biosecurity risks and provides implementation guidance. The document then discusses assessing laboratory staff capabilities, identifying control measures, defining risk mitigation, and strategies for controlling risks.

1. Safety and biosecurity
Lecture 6:-Biorisk management system
Dr. Raghda Saad Mohammed

2. Biorisk management system
The biorisk management system:
 establishes the biorisk management principles that enable laboratories and
related facilities to achieve their biosafety and biosecurity objectives;
 defines the essential components of a biorisk management system
framework to be integrated into a laboratory or other related
organization’s overall governance, strategy and planning, management,
reporting processes, policies, values, and culture;
 describes a comprehensive biorisk management process that mitigates
biorisks (biosafety and biosecurity risks); and
 provides guidance on the implementation and use of the standard, where
appropriate.

3. Assess the capability of the laboratory staff to
control hazards
- training
- technical proficiency
- good habits of all members of the laboratory
- operational integrity of containment equipment
- facility safeguards

4. Mitigation control measures
After a risk has been assessed, analyzed and managed,
then measures should be put in place to prevent
recurrence. This is referred to as risk management and
is simply recognizing which events (hazards) may lead
to harm in the future and minimizing their likelihood
and consequence .
The preventative and control measures for work
related exposure are specific to the type of hazard.

5. Risk mitigation
Risk mitigation is the third step in the risk management process.
The first step - hazard identification - is carried out in order to
identify the hazards in the organisational systems and
operational environment, and to determine their effects. In the
second step - risk assessment - the probability of occurrence and
the severity of the hazard effects are analysed and assessed, the
magnitude of the risk and its acceptability are determined. The
purpose of the third step - risk mitigation - is to identify
measures which when implemented will minimise the risk or
even remove it from the system.

6. When a risk has been found to be unacceptable, control
measures need to be introduced. The level of risk can be
lowered by:
 Reducing the severity of potential consequences;
 Reducing the probability of occurrence harmful effects;
 Reducing the exposure to that risk.

7. Mitigation Strategies
An organization should identify the most appropriate strategy (or strategies)
to control the risks associated with the services provided. Examples of such
strategies are:
 Exposure avoidance. Risky task, practice, operation or activity is avoided
if the associated risk is determined to exceed the benefits.
 Loss reduction. Measures are taken to reduce the frequency of occurrence
of unsafe (unwanted) events or the severity of their effects (consequences).
 Control of exposure (by separation or duplication). Action is taken to
isolate the risks or to ensure redundancy to protect against the risks (e.g.
use of non-flammable insulation materials and partitions, back-up systems
to reduce the likelihood of total system failure, etc.)

8. Risk mitigation measures
Risk mitigation measures are introduced with the objective to:
 Eliminate the risk; or
 Mitigate the risk, if elimination is not feasible; or
 Cope with it, if neither elimination nor mitigation is feasible.
The identification of appropriate risk mitigation measures requires a good
understanding of the hazard and the factors contributing to its occurrence,
since any mechanism that will be effective in reducing risk will have to
modify one or more of these factors.

9. Safety Management Manual, the possible approaches to
risk mitigation include:
 Revision of the system design (before system
implementation);
 Modification of operational procedures;
 Changes to staffing arrangements; and
 Training of personnel to deal with the hazard

10. Thanks for
your
attention
12/10/2021 10