This document discusses the junctions found in oral mucosa, including the muco-cutaneous junction, muco-gingival junction, and dento-gingival junction. It provides detailed information on the histology and development of the dento-gingival junction. Specifically, it describes the non-keratinized stratified squamous epithelial attachment to the tooth, the basal lamina, and the process of passive eruption by which the junction migrates along the tooth surface from enamel to cementum with age.
Coronal and radicular pulp
Apical foramen
Accessory canal
Functions of dental pulp
Components of dental pulp
Functions of pulpal extracellular matrix
Organization of cells in the pulp
The principle cells of the pulp
The pathways of collagen synthesis
Matrix and ground substances
Vasculature and lymphatic supply
Innervation of Dentin- pulp complex
Disorders of the dental pulp
Advances in pulp vitality testing
Coronal and radicular pulp
Apical foramen
Accessory canal
Functions of dental pulp
Components of dental pulp
Functions of pulpal extracellular matrix
Organization of cells in the pulp
The principle cells of the pulp
The pathways of collagen synthesis
Matrix and ground substances
Vasculature and lymphatic supply
Innervation of Dentin- pulp complex
Disorders of the dental pulp
Advances in pulp vitality testing
To watch full lecture video please click the link
https://youtu.be/ZXcq3pweLjg
My youtube channel - Dr. deNto
We are discussing only the basics of oral mucosa membrane.
Definition
Classification
Components
1) Basement membrane
2) Lamina porpria
3) Submucosa
4) Epithelium
Keratinized and Nonkeratinized epithelium
Nonkeratinocytes
To watch full lecture video please click the link
https://youtu.be/ZXcq3pweLjg
My youtube channel - Dr. deNto
We are discussing only the basics of oral mucosa membrane.
Definition
Classification
Components
1) Basement membrane
2) Lamina porpria
3) Submucosa
4) Epithelium
Keratinized and Nonkeratinized epithelium
Nonkeratinocytes
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
• Introduction
• Definitions
• Macroscopic Features
• Microscopic Features
• Blood supply
• Nerve supply
• Lymphatic drainage
• Role of epithelium in defence mechanism
• Oxygen consumption of gingiva
• Correlation of Macroscopic with microscopic features
• Conclusion
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Histology of oral mucous membrane including gingiva/certified fixed orthodon...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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oral mucous membranes-2 /certified fixed orthodontic courses by Indian dental...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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Upload By : Ahmed Ali Abbas
Babylon University College of Dentistry
download this file from Website on google theoptimalsmile.wix.com/dentistry
Oral histology
Odontogenic cysts i / dental implant courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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Macroscopic features of Gingiva.
This presentation will help and let u know about the Development and Macroscopic features of gingiva in detail. Thank you.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
I. Definition
II. Properties
A. Physical
B. Chemical
III. Dentin formation
1. Odontoblast
A. Differentiation
B. Histology
2. Dentinogenesis
A.Matrix formation
B. Mineralization
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
8. Junctions in Oral Mucosa
I. Muco-cutaneous Junction.
K. st. sq. epith.
Lamina propira
Thin k. st. sq. epith.
Lamina propira
Para k. st. sq. epith.
Lamina propira
Thick nonk. st. sq. epith.
Lamina propira
13. Junctions in Oral Mucosa
II. Muco-gingival Junction.
Thick nonk. St. sq.
epith.
Lamina propria
with elastic fibers.
Parak. St. sq.
epith.
Lamina propria
with course
collagen fibers.
14. Junctions in Oral Mucosa
I. Muco-cutaneous
II. Muco-gingival
III. Dento-gingival
15. Junctions in Oral Mucosa
III. Dento-gingival Junction.
Collar around the tooth.
Thick at the coronal
end…. Bottom of the
gingival sulcus.
Tapers apically… at the
enamel surface.
16. Junctions in Oral Mucosa
III. Dento-gingival Junction… Histology
Epithelium..
Nonk. St. sq. epith.
Basal cell layer
I. Cuboidal cells
II. Attachment.. desmosomes &
hemi-desmosomes.
Supra-basal and superficial cells
a) Polyhedral then spindle or
flattened.
b) 3-4 layers apically to 15-30
layers coronaly.
c) Prominent intercellular spaces.
d) Obliquely directed to reach
tooth surface parallel to it.
17. Basal lamina..
External basal lamina
i. Lamina lucida.
ii. Lamina densa.
Internal basal lmaina
i. Lamina lucida .
ii. Lamina densa.
Epithelial attachment..
Submicroscopic, 40 nm extracellular
amorphous substance.
Formed and maintained by the superficial
layer of the attachment epith.
Formed of…
i. Lamina lucida .
ii. Lamina densa.
Junctions in Oral Mucosa
III. Dento-gingival Junction… Histology
18. Cells of junctional epith. differ in
I. High rate of cell division.
II. High rate of turnover.
III. Large amount of cytoplasm, rER and golgi.
IV. Less tonofilaments and desmosomes.
V. Larger inter-cellular spaces contain lymphocytes,
plasme cells and macrophages.
Junctions in Oral Mucosa
III. Dento-gingival Junction… Histology
19. Lamina propria..
Less collagen fibers
Contains inflammatory cells.
Integrity of the dento-gingival
junction.
Junctions in Oral Mucosa
III. Dento-gingival Junction… Histology
20. Junctions in Oral Mucosa
III. Dento-gingival Junction.
Let’s remember
22. Junctions in Oral Mucosa
III. Dento-gingival Junction… Gingival Sulcus
Capillary cleft found between the inner
surface of the free gingival and the
tooth surface.
Lined by nonk. epith.
Its depth varies from 0-6 mm and the
average depth 1-8 mm.
The more shallow the sulcus the more
favorable the condition of the gingival
margin.
23. Junctions in Oral Mucosa
III. Dento-gingival Junction… Migration
• Active eruption.. The tooth
actually moves from its crypt to
the oral cavity ; about 13- 14
of the crown is still covered by
the gingival.
• Passive eruption.. Gradual
exposure of the remaining
portion of the crown and may
even cementum.
24. Junctions in Oral Mucosa
III. Dento-gingival Junction… Migration
The bottom of the gingival sulcus is located on
enamel.
Apical end of attachment epithelium stays on
the CEJ.
In primary dentition almost up to one year of
age before shedding.
In permanent dentition up to one year of age
before shedding, and in permanent dentition
usually to the age of 20 or 30 years.
Anatomical crown is larger than the clinical
crown.
25. Junctions in Oral Mucosa
III. Dento-gingival Junction… Migration
The bottom of the gingival sulcus is still on enamel.
The apical end of the attachment epithelium has shifted to
cementum surface.
Till the age of 40 years of age or may even later.
The anatomical crown is still larger than the clinical crown.
26. Junctions in Oral Mucosa
III. Dento-gingival Junction… Migration
The bottom of the gingival sulcus is at the CEJ.
Epithelial attachment is entirely on cementum.
The anatomical crown is equal to the clinical
crown.
27. Junctions in Oral Mucosa
III. Dento-gingival Junction… Migration
The entire attachment epithelium and the
gingival sulcus lie in cementum.
The age at which this stage is variable.
The gingival recession is related to the
advancement of the previous stage.
The anatomical crown is less than clinical
crown.