SlideShare a Scribd company logo
Immunoglobulins: Structure and Function
Immunoglobulins:Structure and Function ,[object Object],Immune serum Ag adsorbed  serum  1  2   + - albumin globulins Mobility Amount of protein
General Functions of Immunoglobulins ,[object Object],[object Object],[object Object],(Usually require Ag binding) ,[object Object],[object Object],[object Object]
Basic Immunoglobulin Structure ,[object Object],[object Object]
Immunoglobulin Structure ,[object Object],[object Object],[object Object],[object Object],C H1 V L C L V H C H2  C H3 Hinge Region Carbohydrate Disulfide bond
Immunoglobulin Structure ,[object Object],[object Object],[object Object],[object Object],C H1 V L C L V H C H2  C H3 Hinge Region Carbohydrate Disulfide bond
Immunoglobulin Structure ,[object Object],[object Object],[object Object],[object Object],C H1 V L C L V H C H2  C H3 Hinge Region Carbohydrate Disulfide bond
IgG molecule Used with permission from:  Dr. Mike Clark, Immunology Division, Department of Pathology Cambridge University, Cambridge, England
Structure of the Variable Region ,[object Object],[object Object],HVR3 FR1 FR2 FR3 FR4 HVR1 HVR2 Variability Index 25 75 50 100 Amino acid residue 150 100 50 0
Immunoglobulin Fragments: Structure/Function Relationships ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Papain Fc Fab
Immunoglobulin Fragments: Structure/Function Relationships Ag  Binding Complement Binding Site Placental Transfer Binding to Fc Receptors
Immunoglobulin Fragments: Structure/Function Relationships ,[object Object],[object Object],[object Object],[object Object],[object Object],Pepsin Fc Peptides F(ab’) 2
Human Immunoglobulin Classes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Human Immunoglobulin Subclasses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Human Immunoglobulin Light Chain Types ,[object Object],[object Object]
Human Immunoglobulin Light Chain Subtypes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Immunoglobulins ,[object Object],[object Object],[object Object],[object Object],[object Object]
IgG ,[object Object],[object Object],IgG1, IgG2 and IgG4 IgG3
IgG ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IgM ,[object Object],[object Object],[object Object],[object Object],C  4 J Chain
IgM ,[object Object],[object Object],[object Object],[object Object],[object Object]
Fixation of C1 by IgG and IgM Abs No activation Activation C1r C1s C1q C1r C1s C1q
IgM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Tail Piece
B Cell Antigen Receptor (BcR) Ig-  Ig-  Ig-  Ig- 
IgA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Chain Secretory Piece
Origin of Secretory Component of sIgA Y Y Y Y Y Y
IgA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IgD ,[object Object],[object Object],[object Object],Tail Piece
IgD ,[object Object],[object Object],[object Object],[object Object],[object Object]
IgE ,[object Object],[object Object],[object Object],C  4
IgE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

More Related Content

What's hot

Antibody (immunoglobulin) structures and types
Antibody  (immunoglobulin) structures and types Antibody  (immunoglobulin) structures and types
Antibody (immunoglobulin) structures and types
Jatin Anand
 
Antibody
AntibodyAntibody
Antibody
Praveen Garg
 
Immunoglobulins- Structure and function
Immunoglobulins- Structure and functionImmunoglobulins- Structure and function
Immunoglobulins- Structure and function
Namrata Chhabra
 
Immunoglobulin or antibody and their types
Immunoglobulin or antibody and their typesImmunoglobulin or antibody and their types
Immunoglobulin or antibody and their types
SoniaBajaj10
 
The complement system in immunology
The complement system in immunology The complement system in immunology
The complement system in immunology
tinasingh30
 
Antibodies
AntibodiesAntibodies
Antibodies
SHRUTHI VASAN
 
Innate immunity
Innate immunityInnate immunity
Innate immunity
Hari Sharan Makaju
 
Adaptive/Acquired Immunity
Adaptive/Acquired ImmunityAdaptive/Acquired Immunity
Adaptive/Acquired Immunity
Dr ABU SURAIH SAKHRI
 
Immunochemistry
ImmunochemistryImmunochemistry
Immunochemistry
Tapeshwar Yadav
 
Antibody Structure, Types & Functions
Antibody Structure, Types & Functions Antibody Structure, Types & Functions
Antibody Structure, Types & Functions
Srishti Pandey
 
Antibodies chpt 4
Antibodies chpt 4Antibodies chpt 4
Antibodies chpt 4
Fasil Taddese
 
Antibody: Structure and Function
Antibody: Structure and FunctionAntibody: Structure and Function
Antibody: Structure and Function
RAJENDRA SINGH
 
Immunoglobulin,-Antibody structure, definition, structure, types, functions,
Immunoglobulin,-Antibody structure, definition, structure, types, functions,Immunoglobulin,-Antibody structure, definition, structure, types, functions,
Immunoglobulin,-Antibody structure, definition, structure, types, functions,
someshwar mankar
 
Natural and Artificial immunity
Natural and Artificial immunityNatural and Artificial immunity
Natural and Artificial immunity
Atifa Ambreen
 
Humoral immunity
Humoral immunityHumoral immunity
Humoral immunity
P Sn Raju
 
Antibodies and their types with functions
Antibodies and their types with functionsAntibodies and their types with functions
Antibodies and their types with functions
Ashokkumar Bollapalli
 
Immunoglobulins
ImmunoglobulinsImmunoglobulins
Immunoglobulins
Joanna Rose Navarro
 
Cell Mediated Immunity .pdf
Cell Mediated Immunity .pdfCell Mediated Immunity .pdf
Cell Mediated Immunity .pdf
Nandita Pandey
 
Antibodies immunoglobulins
Antibodies   immunoglobulinsAntibodies   immunoglobulins
Antibodies immunoglobulins
Meenakshi Sharma
 
Introduction to antigen
Introduction to  antigenIntroduction to  antigen
Introduction to antigen
Amjad Afridi
 

What's hot (20)

Antibody (immunoglobulin) structures and types
Antibody  (immunoglobulin) structures and types Antibody  (immunoglobulin) structures and types
Antibody (immunoglobulin) structures and types
 
Antibody
AntibodyAntibody
Antibody
 
Immunoglobulins- Structure and function
Immunoglobulins- Structure and functionImmunoglobulins- Structure and function
Immunoglobulins- Structure and function
 
Immunoglobulin or antibody and their types
Immunoglobulin or antibody and their typesImmunoglobulin or antibody and their types
Immunoglobulin or antibody and their types
 
The complement system in immunology
The complement system in immunology The complement system in immunology
The complement system in immunology
 
Antibodies
AntibodiesAntibodies
Antibodies
 
Innate immunity
Innate immunityInnate immunity
Innate immunity
 
Adaptive/Acquired Immunity
Adaptive/Acquired ImmunityAdaptive/Acquired Immunity
Adaptive/Acquired Immunity
 
Immunochemistry
ImmunochemistryImmunochemistry
Immunochemistry
 
Antibody Structure, Types & Functions
Antibody Structure, Types & Functions Antibody Structure, Types & Functions
Antibody Structure, Types & Functions
 
Antibodies chpt 4
Antibodies chpt 4Antibodies chpt 4
Antibodies chpt 4
 
Antibody: Structure and Function
Antibody: Structure and FunctionAntibody: Structure and Function
Antibody: Structure and Function
 
Immunoglobulin,-Antibody structure, definition, structure, types, functions,
Immunoglobulin,-Antibody structure, definition, structure, types, functions,Immunoglobulin,-Antibody structure, definition, structure, types, functions,
Immunoglobulin,-Antibody structure, definition, structure, types, functions,
 
Natural and Artificial immunity
Natural and Artificial immunityNatural and Artificial immunity
Natural and Artificial immunity
 
Humoral immunity
Humoral immunityHumoral immunity
Humoral immunity
 
Antibodies and their types with functions
Antibodies and their types with functionsAntibodies and their types with functions
Antibodies and their types with functions
 
Immunoglobulins
ImmunoglobulinsImmunoglobulins
Immunoglobulins
 
Cell Mediated Immunity .pdf
Cell Mediated Immunity .pdfCell Mediated Immunity .pdf
Cell Mediated Immunity .pdf
 
Antibodies immunoglobulins
Antibodies   immunoglobulinsAntibodies   immunoglobulins
Antibodies immunoglobulins
 
Introduction to antigen
Introduction to  antigenIntroduction to  antigen
Introduction to antigen
 

Viewers also liked

Immunoglobulins, complement and immunodefeciency disorders
Immunoglobulins, complement and immunodefeciency disordersImmunoglobulins, complement and immunodefeciency disorders
Immunoglobulins, complement and immunodefeciency disorders
Krishna Vasudev
 
Ch 6 the_complement_system
Ch 6 the_complement_systemCh 6 the_complement_system
Ch 6 the_complement_system
fadhili nyalusi
 
Immunoglobulins
ImmunoglobulinsImmunoglobulins
Immunoglobulins
Tapeshwar Yadav
 
Anigen antiboy reactions
Anigen antiboy reactionsAnigen antiboy reactions
Anigen antiboy reactions
iitsme
 
Immunologic laboratory-tests
Immunologic laboratory-testsImmunologic laboratory-tests
Immunologic laboratory-testsdream10f
 
Antigen & Antibody Interactions
Antigen & Antibody InteractionsAntigen & Antibody Interactions
Antigen & Antibody Interactions
Guddeti Prashanth Kumar
 
Agglutination reactions
Agglutination reactionsAgglutination reactions
Agglutination reactions
Yeyeh Santos
 
Bio 151 lecture 4
Bio 151 lecture 4Bio 151 lecture 4
Bio 151 lecture 4
Marilen Parungao
 
Immunoglobulins
ImmunoglobulinsImmunoglobulins
Immunoglobulins
Victor Castilla
 
The Complement System
The Complement SystemThe Complement System
The Complement System
Ybeb18
 

Viewers also liked (12)

Immunoglobulins, complement and immunodefeciency disorders
Immunoglobulins, complement and immunodefeciency disordersImmunoglobulins, complement and immunodefeciency disorders
Immunoglobulins, complement and immunodefeciency disorders
 
Ch 6 the_complement_system
Ch 6 the_complement_systemCh 6 the_complement_system
Ch 6 the_complement_system
 
Immunoglobulins
ImmunoglobulinsImmunoglobulins
Immunoglobulins
 
Anigen antiboy reactions
Anigen antiboy reactionsAnigen antiboy reactions
Anigen antiboy reactions
 
Immunologic laboratory-tests
Immunologic laboratory-testsImmunologic laboratory-tests
Immunologic laboratory-tests
 
Antigen & Antibody Interactions
Antigen & Antibody InteractionsAntigen & Antibody Interactions
Antigen & Antibody Interactions
 
Agglutination reactions
Agglutination reactionsAgglutination reactions
Agglutination reactions
 
Bio 151 lecture 4
Bio 151 lecture 4Bio 151 lecture 4
Bio 151 lecture 4
 
Complement system
Complement systemComplement system
Complement system
 
Immunoglobulins
ImmunoglobulinsImmunoglobulins
Immunoglobulins
 
The Complement System
The Complement SystemThe Complement System
The Complement System
 
Vaccines
VaccinesVaccines
Vaccines
 

Similar to Immunoglobulins 2001

Lec8 immunoglobulins
Lec8 immunoglobulinsLec8 immunoglobulins
Lec8 immunoglobulins
DrShamimAkram
 
Lec8 Immunoglobulins aimec
Lec8 Immunoglobulins aimecLec8 Immunoglobulins aimec
Lec8 Immunoglobulins aimec
Shamim Akram
 
Stu ig
Stu igStu ig
Stu ig
mehr92
 
Immunoglobulins 2001
Immunoglobulins 2001Immunoglobulins 2001
Immunoglobulins 2001Kinza Ayub
 
Immunoglobulines
ImmunoglobulinesImmunoglobulines
Immunoglobulines
Meentu Prakash
 
Imunoglobulins-Basics
Imunoglobulins-Basics Imunoglobulins-Basics
Imunoglobulins-Basics
Dr.Prameswari Kasa
 
5th immunoglobulins 2 oct 2014
5th immunoglobulins 2 oct 20145th immunoglobulins 2 oct 2014
5th immunoglobulins 2 oct 2014
the university of lahore
 
Antibodies (immunoglobulin)
Antibodies (immunoglobulin)Antibodies (immunoglobulin)
Antibodies (immunoglobulin)
UMAMAHISHAQ
 
Immunoglobulins types
Immunoglobulins typesImmunoglobulins types
Immunoglobulins types
Navaneetha Krishnan J
 
Antigen structure and immunogenicity
Antigen structure and immunogenicityAntigen structure and immunogenicity
Antigen structure and immunogenicity
Microbiology
 
Immunoglobulin Structure and Classes.docx
Immunoglobulin Structure and Classes.docxImmunoglobulin Structure and Classes.docx
Immunoglobulin Structure and Classes.docx
King Lovepreet Singh Grewal
 
immunoglobuinstheirfunctions-150920084551-lva1-app6892.pdf
immunoglobuinstheirfunctions-150920084551-lva1-app6892.pdfimmunoglobuinstheirfunctions-150920084551-lva1-app6892.pdf
immunoglobuinstheirfunctions-150920084551-lva1-app6892.pdf
OsmanHassan35
 
Antibody Structure & Function
Antibody Structure & FunctionAntibody Structure & Function
Antibody Structure & Function
raj kumar
 
Antibody Structure & Function
Antibody Structure & FunctionAntibody Structure & Function
Antibody Structure & Functionraj kumar
 
06. ag receptor immunoglobulins
06. ag receptor   immunoglobulins06. ag receptor   immunoglobulins
06. ag receptor immunoglobulins
Yahyea Laskar
 
Immunoglobulin
ImmunoglobulinImmunoglobulin
Immunoglobulin
Arunkumar Durairaj
 

Similar to Immunoglobulins 2001 (20)

Lec8 immunoglobulins
Lec8 immunoglobulinsLec8 immunoglobulins
Lec8 immunoglobulins
 
Lec8 Immunoglobulins aimec
Lec8 Immunoglobulins aimecLec8 Immunoglobulins aimec
Lec8 Immunoglobulins aimec
 
Stu ig
Stu igStu ig
Stu ig
 
Immunoglobulins 2001
Immunoglobulins 2001Immunoglobulins 2001
Immunoglobulins 2001
 
Immunoglobulines
ImmunoglobulinesImmunoglobulines
Immunoglobulines
 
Imunoglobulins-Basics
Imunoglobulins-Basics Imunoglobulins-Basics
Imunoglobulins-Basics
 
5th immunoglobulins 2 oct 2014
5th immunoglobulins 2 oct 20145th immunoglobulins 2 oct 2014
5th immunoglobulins 2 oct 2014
 
Antibodies (immunoglobulin)
Antibodies (immunoglobulin)Antibodies (immunoglobulin)
Antibodies (immunoglobulin)
 
Immunoglobulins types
Immunoglobulins typesImmunoglobulins types
Immunoglobulins types
 
Antigen structure and immunogenicity
Antigen structure and immunogenicityAntigen structure and immunogenicity
Antigen structure and immunogenicity
 
Immunoglobulins (2)
Immunoglobulins (2)Immunoglobulins (2)
Immunoglobulins (2)
 
G.2014-immuno~ (3.antibody-lyj)
 G.2014-immuno~ (3.antibody-lyj) G.2014-immuno~ (3.antibody-lyj)
G.2014-immuno~ (3.antibody-lyj)
 
Immunoglobulin Structure and Classes.docx
Immunoglobulin Structure and Classes.docxImmunoglobulin Structure and Classes.docx
Immunoglobulin Structure and Classes.docx
 
L5 immunoglobulins
L5 immunoglobulinsL5 immunoglobulins
L5 immunoglobulins
 
immunoglobuinstheirfunctions-150920084551-lva1-app6892.pdf
immunoglobuinstheirfunctions-150920084551-lva1-app6892.pdfimmunoglobuinstheirfunctions-150920084551-lva1-app6892.pdf
immunoglobuinstheirfunctions-150920084551-lva1-app6892.pdf
 
Antibody Structure & Function
Antibody Structure & FunctionAntibody Structure & Function
Antibody Structure & Function
 
Antibody Structure & Function
Antibody Structure & FunctionAntibody Structure & Function
Antibody Structure & Function
 
06. ag receptor immunoglobulins
06. ag receptor   immunoglobulins06. ag receptor   immunoglobulins
06. ag receptor immunoglobulins
 
Lecture 5
Lecture 5Lecture 5
Lecture 5
 
Immunoglobulin
ImmunoglobulinImmunoglobulin
Immunoglobulin
 

More from guest08e813

Ab Formation 2001
Ab Formation 2001Ab Formation 2001
Ab Formation 2001guest08e813
 
Innate Immunity06
Innate Immunity06Innate Immunity06
Innate Immunity06guest08e813
 
Iso Allo Idio 2001
Iso Allo Idio 2001Iso Allo Idio 2001
Iso Allo Idio 2001guest08e813
 
Ig Genetics 2001
Ig Genetics 2001Ig Genetics 2001
Ig Genetics 2001guest08e813
 

More from guest08e813 (10)

Ab Formation 2001
Ab Formation 2001Ab Formation 2001
Ab Formation 2001
 
Innate Immunity06
Innate Immunity06Innate Immunity06
Innate Immunity06
 
Iso Allo Idio 2001
Iso Allo Idio 2001Iso Allo Idio 2001
Iso Allo Idio 2001
 
Complement 2
Complement 2Complement 2
Complement 2
 
Complement06
Complement06Complement06
Complement06
 
Ig Genetics 2001
Ig Genetics 2001Ig Genetics 2001
Ig Genetics 2001
 
Antigens
AntigensAntigens
Antigens
 
0616 Immuniz
0616 Immuniz0616 Immuniz
0616 Immuniz
 
Innate 1
Innate 1Innate 1
Innate 1
 
15 Mhc
15 Mhc15 Mhc
15 Mhc
 

Immunoglobulins 2001