The document provides an overview of the immune system, including its innate and adaptive components. It defines key terms like antigens, immunogens, epitopes, and antibodies. It describes factors that influence antigen immunogenicity, such as physical and chemical properties, dose, and route of administration. It also outlines the characteristics of different antigen types including T-independent, T-dependent, and super antigens. Finally, it discusses the differences between antigens recognized by the adaptive immune system versus pattern recognition receptors of the innate immune system.

1. Eugene P. Mayer Office: Bldg. #2, Rm. B19 Phone: 733-3281 Email: MAYER@MED.SC.EDU

2. Overview of the Immune System Immune System Innate (Nonspecific) Adaptive (Specific) Cellular Components Humoral Components Cell-Mediated Humoral (Ab)

3. Antigens

21. Macrophage activation; Secretion of inflammatory cytokines TLR-2 (Toll-like receptor 2) Lipoproteins of Gram + bacteria Yeast cell wall components Phagocytosis Scavenger receptors Polyanions Opsonization; Complement activation Mannose-binding protein Mannose-containing carbohydrates Opsonization; Complement activation Complement Microbial cell wall components Biological Consequence of Interaction PRR PAMP

22. Production of interferon (antiviral) TLR-3 Double stranded RNA Macrophage activation; Secretion of inflammatory cytokines TLR-5 Flagellin (bacterial flagella) Macrophage activation; Secretion of inflammatory cytokines TLR-4 LPS (lipopolysaccharide of Gram – bacteria Biological Consequence of Interaction PRR PAMP

23. Macrophage activation; Secretion of inflammatory cytokines TLR-9 CpG containing DNA Production of interferon (antiviral) TLR-7 U-rich single stranded viral RNA Biological Consequence of Interaction PRR PAMP