Immunity is defined as the capacity of the body to resist pathogenic agents.
It is the ability of body to resist the entry of different types of foreign bodies like bacteria, virus, toxic substances, etc.
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
Cell mediated immunity also known as T cell immunity. it is developed by cell mediated responses and it does not involve any antibodies. Cell mediated immunity is offered by T lymphocytes and it starts developing when T cells come in contact with the antigens. In the Cell mediated immunity T cell plays one of the important role for the process of crosstalk with other immune system as well as to signal B cells to produce the antibody mediated immune response. Primary function of cell mediated response-
1) Eliminate intracellular pathogens.
2)Eliminate tumor cells.
T cells regulate proliferation and activity of other cells of the immune system : B cells, macrophages, neutrophil, etc.
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
Cell mediated immunity also known as T cell immunity. it is developed by cell mediated responses and it does not involve any antibodies. Cell mediated immunity is offered by T lymphocytes and it starts developing when T cells come in contact with the antigens. In the Cell mediated immunity T cell plays one of the important role for the process of crosstalk with other immune system as well as to signal B cells to produce the antibody mediated immune response. Primary function of cell mediated response-
1) Eliminate intracellular pathogens.
2)Eliminate tumor cells.
T cells regulate proliferation and activity of other cells of the immune system : B cells, macrophages, neutrophil, etc.
Difference between innate and adaptive immunitykamilKhan63
Adaptive Immunity : it is the immune response against a specific antigen.
Innate Immunity : it is the immediate protective response of the immune system that does not require previous exposure to the antigen.
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Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues. Any disease that results from such an aberrant immune response is termed an "autoimmune disease".
Antibodies are immune system-related proteins called immunoglobulins. Each antibody consists of four polypeptides– two heavy chains and two light chains joined to form a "Y" shaped molecule. ... This variable region, composed of 110-130 amino acids, give the antibody its specificity for binding antigen.
Difference between innate and adaptive immunitykamilKhan63
Adaptive Immunity : it is the immune response against a specific antigen.
Innate Immunity : it is the immediate protective response of the immune system that does not require previous exposure to the antigen.
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Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues. Any disease that results from such an aberrant immune response is termed an "autoimmune disease".
Antibodies are immune system-related proteins called immunoglobulins. Each antibody consists of four polypeptides– two heavy chains and two light chains joined to form a "Y" shaped molecule. ... This variable region, composed of 110-130 amino acids, give the antibody its specificity for binding antigen.
Human Anatomy and Physiology - Lymphatic system and body defensesJethro Baltazar
Human Anatomy and Physiology - Lymphatic System and body defenses.
This presentation was made by Jethro Baltazar showing the Lymphatic system, Parts of Lymphatic system, Function of Lymphatic System, The body defenses including the importance of Lymphatic System in defending our body, Disorders of immunity and Developmental Aspects of the Lymphatic System.
Email me at emulsifier1998@gmail.com and jethrobaltazar1998@yahoo.com for more information and permission to download. You can also text me at 09096530340.
IMMUNITY:
INTRODUCTION:
Our immune system is essential for our survival.
Without an immune system, our bodies would be open to attack from bacteria, viruses, parasites, and more.
It is our immune system that keeps us healthy as we drift through a sea of pathogens.
Nervous control of blood vessels regulation of arterial pressureAmen Ullah
The main function of the circulatory system is to give local blood flow to the tissue. There arespecial need of the tissue which is:
delivery of oxygen to the tissue
delivery of nutrients to the tissue
removal of carbon dioxide from tissue
maintaining of normal concentration of ions
transform of hormones and other substance to tissue
The study of movement of blood through circulatory system.
cardiovascular system is Responsible for to pump the blood and to circulate it through different parts of the body.
It is essential for the maintenance of pressure and other physical factors within the blood vessels
Lymphatic system, Human Lymphatic systemAmen Ullah
Tissue fluid (interstitial fluid) that enters the lymphatic vessels.
larger particles that escape into tissue fluid can only be removed via lymphatic system.
Hemo: Referring to blood cells
Poiesis: “The development or production of”
The word Hemopoiesis refers to the production & development of all the blood cells
Coagulation or clotting is defined as the process in which blood loses its fluidity and becomes a jelly-like mass few minutes after it is shed out or collected in a container
Factors responsible for erythropoiesis. Development and maturation of erythrocytes require mostly three types of factors
1. General factors 2. Maturation factors 3. Factors necessary for hemoglobin formation.
Cardiac murmur is an abnormal heart sounds. can be heard with stethoscope or auscultation. the etiology of the cardiac murmur may be septal defect, valvular defects or vascular defects. the two main causes that lead to cardiac murmur, like stenosis and incompetence.
Arrhythmia is also known as irregular heart beats. If SA node is not the pacemaker, any other part of the heart such as atrial muscle, AV node and ventricular muscle becomes the pacemaker. the beats may be fast, slow or miss beats.
Term and Definitions regarding microbiology, Pathogenicity and virulency, acute and chronic infection, primary and secondary infection, opportunistic infection.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Definitions
• Immune system = cells, tissues, and molecules that
mediate resistance to infections
• Immunology = study of structure and function of the
immune system
• Immunity = resistance of a host to pathogens and their
toxic effects
OR
• Immunity is defined as the capacity of the body to
resist pathogenic agents.
• It is the ability of body to resist the entry of different
types of foreign bodies like bacteria, virus, toxic
substances, etc.
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3. Definitions
Immune response = Involves production of antibodies
and generation of specialized lymphocytes against
specific antigens.
Antigen: Molecules from a pathogen or foreign organism
that provoke a specific immune response.
Immunogen: An immunogen refers to a molecule that is
capable of eliciting an immune response by an organism’s
immune system
Allergen: An allergen is any substance (any harmless
substance), most often eaten or inhaled, that is
recognized by the immune system and causes an allergic
reaction.
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4. Immune System
(Made by three components)
Organs Cells Molecules
• Tonsils and adenoids
• Thymus
• Lymph nodes
• Spleen
• Payer’s patches
• Appendix
• Lymphatic vessels
• Bone marrow
Lymphocytes
o T-lymphocytes
o B-Lymphocytes,
plasma cells
o natural killer
lymphocytes
Monocytes, Macrophage
Granulocytes
o neutrophils
o eosinophils
o basophils
• Antibodies
• Complement
• Cytokines
• Interleukines
• Interferons
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5. Types of immunity
Immunity is of two types:
•I. Innate immunity.
•II. Acquired immunity.
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6. Innate Immunity
(Non-specific Immunity)
• Innate immunity is the inborn capacity of the
body to resist pathogens.
• By chance, if the organisms enter the body,
innate immunity eliminates them before the
development of any disease. It is otherwise
called the natural or non-specific immunity.
• It is a first line of defense against any type of
pathogens.
• Therefore, it is also called non-specific immunity.
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7. Acquired Immunity
(Specific Immunity)
• Acquired immunity is the resistance developed in
the body against any specific foreign body like
bacteria, viruses, toxins, vaccines or transplanted
tissues. So, this type of immunity is also known
as specific immunity.
• It is the most powerful immune mechanism that
protects the body from the invading organisms
or toxic substances.
• Lymphocytes are responsible for acquired
immunity
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8. Types of Acquired Immunity
There are Two types of acquired immunity
1.Cellular immunity (Cell mediated immunity).
2.Humoral immunity. (anti-bodies mediated
immunity)
Lymphocytes are responsible for the
development of these two types of immunity.
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9. Development and Processing
of Lymphocytes
• In fetus, lymphocytes develop from the bone
marrow.
• All lymphocytes are released in the Circulation
The two categories are:
• 1. T lymphocytes or T cells, which are
responsible for the development of cellular
immunity
• 2. B lymphocytes or B cells, which are
responsible for humoral immunity.
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10. T Lymphocytes
• T lymphocytes are processed in thymus.
• The processing occurs mostly during the period
between just before birth and few months after
birth.
• Thymus secretes a hormone called thymosin,
which plays an important role in immunity. It
accelerates the proliferation and activation of
lymphocytes in thymus.
• It also increases the activity of lymphocytes in
lymphoid tissues.
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11. Types of T Lymphocytes
• During the processing, T lymphocytes are
transformed into four types:
• 1. Helper T cells or inducer T cells. These cells are
also called CD4 cells because of the presence of
molecules called CD4 on their surface.
• 2. Cytotoxic T cells or killer T cells. These cells are
also called CD8 cells because of the presence of
molecules called CD8 on their surface.
• 3. Suppressor T cells.
• 4. Memory T cells.
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12. Storage of T Lymphocytes
• After the transformation, all the types of T
lymphocytes leave the thymus and are stored
in lymphoid tissues of lymph nodes, spleen,
bone marrow and GI tract.
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13. B Lymphocytes
• B lymphocytes were first discovered in the bursa of
Fabricius in birds, hence the name B lymphocytes.
• Bursa of Fabricius is a lymphoid organ situated near the
cloaca of birds.
• Bursa is absent in mammals, So processing of B
lymphocytes takes place in liver (during fetal life) and bone
marrow (after birth).
Types of B Lymphocytes
• After processing, the B lymphocytes are transformed into
two types:
• Plasma cells.
• Memory cells.
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14. Storage of B Lymphocytes
• After transformation, the B lymphocytes are
stored in the lymphoid tissues of lymph
nodes, spleen, bone marrow and the GI tract.
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17. Antigens
• Antigens are the substances which induce
specific immune reactions in the body.
Antigens are of two types:
• 1. Autoantigens or self antigens present on
the body’s own cells such as ‘A’ antigen and
‘B’ antigen in RBCs.
• 2. Foreign antigen s or non-self antigens that
enter the body from outside.
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19. Types of Non-self Antigens
• Non-self antigens are classified into two types,
depending upon the response developed against
them in the body:
• 1. Antigens, which induce the development of
immunity or production of antibodies
(immunogenicity).
• 2. Antigens, which react with specific antibodies and
produce allergic reactions (allergic reactivity).
• Antigens are mostly the conjugated proteins like
lipoproteins, glycoproteins and nucleoproteins
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