This document provides an overview of human reproduction, including the similarities and differences between male and female anatomy and the processes of conception, pregnancy, and birth. It explains that early in development, a fetus starts with parts that could develop into either gender, but DNA determines whether it becomes male or female. For females, it describes the menstrual cycle and role of hormones, as well as how one egg is released each month. For males, it outlines sperm production and the role of testes, vas deferens, and other structures. The document then explains fertilization, fetal development, and the different types of twins.
this video lets u understand the basic types of twins.useful for the school students in fact for every age group who wants to be aware of twins formation.just check it out
this video lets u understand the basic types of twins.useful for the school students in fact for every age group who wants to be aware of twins formation.just check it out
Turner & Sheek Pest Control offers a variety of services for home or business. Extensive training the identification and biology of home invading pests allows us to use pesticides more judicious AND more effective manner.
Turner & Sheek Pest Control offers a variety of services for home or business. Extensive training the identification and biology of home invading pests allows us to use pesticides more judicious AND more effective manner.
Pot and Portable Marijuana Breathalyzer, Canna Sense, Weed Maps and Detector vidyasagar555
BioCube has created two mobile applications with corresponding websites, American Cannabis and Canadian Cannabis, providing visitors with comprehensive information on medical marijuana, including its legal status, medical applications and location of doctors and dispensaries in the United States and Canada.
These are a mix of three different powerpoints that I found as public knowledge on the Internet. Some things have been added and credit was given if it was attached to the original powerpoint.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
4. Similarities
2 pouches
Testicles
Ovaries
Start out inside body
Testicles “descend” before birth
Fetus begins with “starter parts” that
could develop into either gender.
5. Around 7th Week…
Baby’s body is “told” by DNA to become
either male or female.
“Unused” parts disintegrate
“Used” parts continue development
(see overhead)
6. Male or Female???
DNA determines baby’s gender
XX = Female
XY = Male
Depends on which egg & sperm get
together.
Father determines baby’s gender.
7. Anatomy – similarities
Function – VERY different!
Male
Uncomplicated
Produce sperm
2-4 MILLION
every day
Female
Very Complicated!
One egg
Once a month
Careful coordination
of hormones & body
Timing perfect!
8. Females
Ovaries
2 pouches
Contain ova
Born with all of her eggs (~ 400,000)
Use up ~500
Won’t run out!
Ovulation
One egg released from ovary to oviduct
(fallopian tube)
9.
10. After Ovulation
Egg pushed along by cilia
Few days travel time to arrive in uterus
Cervix – Opening between uterus & vagina
Normally tiny
At birth – muscles pull open (dilation) cervix to
allow baby to pass through = Labor
11. Menstrual Cycle
Complex combination of 10-12
chemicals (hormones)
Usually one egg once a month
All about timing!!!
Uterus must be ready when egg gets there
in case it was fertilized
If no fertilization, tear down lining of uterus
and rebuild for next month
12. 28-Day Cycle (average)
Three Stages
1. Tear Down
2. Rebuild
3. Extra nutrients/blood for potential baby
No Baby?
Back to #1
13. Chemicals (hormones)
Regulate events in the body
Estrogen
Progesterone
LH (leuteinizing hormone)
FSH (follicle stimulating hormone)
Many others
14. Day 1
First menstrual blood & tissue
No baby = breaks down lining of uterus
5-7 days of blood/tissue exits body
Pre-Ovulation
15. ~Day 14
Ovulation = Egg released
Temp spikes slightly
Most fertile in next few days!
Able to get pregnant
Egg gets fertilized while traveling through
oviduct.
Post-Ovulation
16.
17. If fertilized…
Zygote begins to divide as it travels
through oviduct
Implants into lining of uterus
18. If not fertilized…
Egg travels through oviduct to uterus
Exits body with blood and tissues
during menstruation
19. Birth Control Pills
“Trick” body into thinking it’s pregnant
Extra hormones
No ovulation occurs
No ovulation = no egg = no fertilization = no baby!
No hormones taken for 7 days = menstruation
20. Male
Testes
Produce 2-4 million sperm every day
Outside body – why?
Sperm like temps 1-2° cooler than body temp
Vas Deferens
Tube sperm travel through
Vasectomy
Cut/tie off tube – sperm can’t get out!
21. Semen
Contains
300-500 million sperm
Sperm food
pH buffers
Allows sperm to survive for a couple of
days inside female’s body (hostile
environment)
22. What is sperm?
Then…
Used to think it was a tiny human
inside each cell
Spermists vs. Ovists
23. Now…
Contains Several
Parts:
Head
Chemical to dissolve
egg goo
Dad’s genetic
information (DNA)
Mitochondria
Energy
Tail Swimming
24. Prostate Gland
Adds non-sperm stuff to semen
pH buffers
Nourishment
Cancer very common
Slower-growing (usually)
Surgery for removal
27. Conception/Fertilization
Ejaculation
Release of 300-500 million sperm
Egg needs to be in oviduct
Sperm to egg, not an easy task
Go wrong direction : 2 paths – only 1 leads to an
egg
Get attacked by female’s white blood cells
Acidic environment
Current
28. Once egg is located…
Dissolve protective goo surrounding
egg
One gets through – enters egg
Instant biochemical change in zygote
No more sperm allowed in
30. Implants in uterine lining
Endometrium= outer lining of uterus
Becomes placenta
Uses mother’s nutrients
Continues development
31. Fetal Development
Anmion
Membrane surrounding baby
Contains amniotic fluid
Breaks just before birth = “water broke”
Amniotic Fluid
The “water” – surrounding baby
Buoyant cradle for baby
Protection
Free movement
32.
33. Fetal Dev (cont’d)
Umbilical Cord
Blood vessels from placenta to baby
Mom’s & baby’s blood do not circulate
together!
Can have 2 different blood types
Diffusion
36. Birth
Labor – muscles used to open cervix
Baby flips upside down
Head first!
Feet first = Breech (bad)
Cesarian Section (“C-section”) surgical removal
of baby
After baby is born mom delivers
placenta (“afterbirth”) that detaches
from uterus
37. Breastfeeding
Most nutritious option for baby
Milk changes as baby grows
Antibodies from mom create immunity
for baby
Studies have shown correlation
between breastfeeding and higher
intelligence in baby.
Bond w/baby is stronger
38. Twins/Multiple Births
Two types
Monozygotic
From one egg
Identical
Dizygotic
From two eggs
Fraternal
Not identical
39. Identical twins
One zygote
Splits in 2
No one knows why!
Completely random =
does NOT run in families
Same exact DNA
Nature’s clones
40. Fraternal Twins
2 separate eggs get fertilized
with 2 different sperm cells
More than one egg got released
during ovulation
Siblings
Can be sisters
Brothers
Brother and sister
Tends to run in families
41. Conjoined Twins
Used to be called “Siamese” twins
First well known case was in Siam
Identical twins that never completely
separated during development
Sometimes can be separated,
depending on what is shared.