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Mitosis 
What is it? 
Why is it 
Important? 
What do I 
need to 
know?
Why more cells? 
 Populations of 
single-cell critters 
 Multicellularity? 
 We all start out as 
a single cell…? 
 The zygote… 
 & become/remain 
multicellular
Binary Fission…Monera
Binary Fission..DNA 
duplicates…why?
DNA separates & new cell 
wall divides cell in two
2 ‘new’ cells…identical?
Binary Fission
quiz 
 What happens to the size of bacteria 
after binary fission? 
 What has to happen before fission 
occurs? 
 What benefit(s) do bacteria derive 
from binary fission (as opposed to 
sexual reproduction)?
Eukaryotic cells?? 
 The nucleus? 
 Nuclear membrane 
 Chromosomes…not 
chromosome…? 
 All that ‘stuff’ in 
the cytoplasm?
Eukaryotic cell cycle 
 Cell is ‘born’ 
 Duplicates DNA?? 
 Grows to…size? 
 Prepares to divide 
 Divides=mitosis
Control of mitosis:CYCLIN
The nuclelus must first 
divide before the cell can 
 Why? 
 How? 
 How much time of 
the cell cycle/life 
can be spent in 
mitosis?
Chromosomes duplicate
Kinetochore (centromere)
Mitosis produces identical 
offspring (2N---2N)
Why some cells stop mitosis… 
differentiation 
 Muscle cells… 
 Nerve cells… 
 Critical functions 
might be disrupted 
 Adaptations to this 
condition
Importance??? 
 Growth 
 Replacement 
 Cancer 
 Regeneration of…
Cancer? 
 Unregulated 
mitosis 
 Benign 
 Malignant/ 
metastasis 
 How does it begin?
Normal cycle controls 
 Internal signals 
 External signals: 
growth factors 
fibronectin,etc 
carcinogens 
 Apoptosis 
 Immune functions 
 And…
Cell immortilization!! 
 Hayflick limit?? 
 Hela cells 
 Contact inhibition 
 Increased 
telomerase activity 
 = immortalization!
Immortalization??? 
 If you replaced… 
 Why not??…look at 
your shoestrings? 
 Telomerase & 
telomeres & …? 
 Recently… 
 Implications???
Mitosis quiz 
 Use two words to describe the 
importance of mitosis 
 Draw and label the cell cycle…include 
G1, S, G2, M and cytokinesis…what 
happens at each stage? 
 Why might telomerase be important? 
 What disease is associated with 
mitosis? 
 Are all organisms limited to 50 mitotic 
divisions?
Name stage of mitosis
Name stage of mitosis
Name stage of mitosis
Name stage of mitosis
Name stage of mitosis
Name stage of mitosis
Name stage of mitosis
Name stage of mitosis
These are bacteria 
 Watch the clip 
 What kind of 
reproduction is 
shown here? 
 What advantage 
does this confer on 
the organism?

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