etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Theileriosis Presented by Ahmed Abdulkadir Hassan
4th year student, college of veterinary medicine,
University of Bahri.
kadle010@gmail.com
khartoum, Sudan.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Theileriosis Presented by Ahmed Abdulkadir Hassan
4th year student, college of veterinary medicine,
University of Bahri.
kadle010@gmail.com
khartoum, Sudan.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
it consist of information regarding different species of theileria, their vectors, epidemiology, life cycle,pathogenesis ,clinical signs, gross lesions, microscopic lesions, control, prevention and treatment of theileriosis including pathognomic lesions of theileriosis
it consist of information regarding different species of theileria, their vectors, epidemiology, life cycle,pathogenesis ,clinical signs, gross lesions, microscopic lesions, control, prevention and treatment of theileriosis including pathognomic lesions of theileriosis
Streptococcus pyogenes
Streptococcus pyogenes.jpg
S. pyogenes bacteria at 900x magnification
Scientific classification
Kingdom: Eubacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: S. pyogenes
Binomial name
Streptococcus pyogenes
Rosenbach 1884
Streptococcus pyogenes is a species of Gram-positive bacteria. These bacteria are aerotolerant and an extracellular bacterium, made up of non-motile and non-sporing cocci. As expected with a streptococci, it is clinically important in human illness. It is an infrequent, but usually pathogenic, part of the skin microbiota. It is the predominant species harboring the Lancefield group A antigen, and is often called group A streptococcus (GAS). However, both Streptococcus dysgalactiae and the Streptococcus anginosus group can possess group A antigen. Group A streptococci when grown on blood agar typically produces small zones of beta-hemolysis, a complete destruction of red blood cells. (A zone size of 2–3 mm is typical.) It is thus also called group A (beta-hemolytic) streptococcus (GABHS), and can make colonies greater than 5 mm in size.[1]
Like other cocci, streptococci are round bacteria. The name is derived from Greek words meaning chain(Strepto) of berries (coccus) and pus(pyo)-forming(genes), because streptococcal cells tend to link in chains of round cells (see image) and a number of infections caused by the bacterium, produce pus. Streptococci are can be catalase positive or negative.[2] S. pyogenes can be cultured on blood agar plates. Under ideal conditions, it has an incubation period of 1 to 3 days.[3]
An estimated 700 million GAS infections occur worldwide each year. While the overall mortality rate for these infections is 0.1%, over 650,000 of the cases are severe and invasive, and have a mortality rate of 25%.[4] Early recognition and treatment are critical; diagnostic failure can result in sepsis and death.[5][6]
This Part 1 of 'Monsoon Illnesses affecting Lungs' covers an overview of leptospirosis, malaria and dengue. It base on Harrison's Textbook of Internal Medicine, 18th edition.
Tropical theileriosis or Mediterranean coast fever Ranjini Manuel
heileriases are a group of tickborne diseases caused by Theileria spp. A large number of Theileria spp are found in domestic and wild animals in tick-infested areas of the Old World. The most important species affecting cattle are T parva and T annulata, which cause widespread death in tropical and subtropical areas of the Old World. T lestoquardi, T luwenshuni, and T uilenbergi are important causes of mortality in sheep.
Definition, incidence, etiology, epidemiology, pathogenesis,
transmission, clinical findings, diagnosis, treatment, prevention and
control of Fasciolosis is lecturer notes for B.V.Sc & A.H. students.
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
Protozoan parasites characterized by the production of spore-like oocysts containing sporozoites were known as sporozoa.
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Tick paralysis is a parasitic disease of dogs, neurotoxin causes ascending paralysis. An inspirational note for dog lovers and veterinarians.Also available video on youtube.
Glaucoma is a condition that causes a build-up of fluid and pressure in the eye. If too much fluid (called aqueous humor fluid) is made or too little fluid is drained, the pressure of the eye increases and causes damage to the retina and the optic nerve, which ultimately leads to blindness
Anaphylaxis shock due to penicillin-DR.Jibachha SahDr. Jibachha Sah
Anaphylaxis shock due to penicillin is a case study for practicing veterinarians and students, who will able to describe the mode of action of prescribing drugs.
The advantage of goal setting is an inspirational matter to the young generation. Teach how to goal setting in his life, a case study of Yale University 1952.
Ethno veterinary medicine or traditional animal health care is based on folk beliefs, traditional knowledge, skills, methods and practices used for curing diseases and maintaining health of animals.
Antiseptic and disinfectant-Dr.Jibachha Sah,M.V.Sc,Lecturer,NPIDr. Jibachha Sah
Antiseptics• These are chemical substances which inhibit the growth or kill micro- organisms on living surfaces such as skin & mucous membrane .Disinfectants are used to kill or eliminate microorganisms and/or inactivate viruses on inanimate objects and surfaces (medical devices, instruments, equipment, walls, floors).
Babesiosis is the diseased state caused by the protozoal (single celled) parasites of the genus Babesia. Infection in a dog may occur by tick transmission, direct transmission via blood transfer from dog bites, blood transfusions, or transplacental transmission.
This 7-second Brain Wave Ritual Attracts Money To You.!nirahealhty
Discover the power of a simple 7-second brain wave ritual that can attract wealth and abundance into your life. By tapping into specific brain frequencies, this technique helps you manifest financial success effortlessly. Ready to transform your financial future? Try this powerful ritual and start attracting money today!
1.Wireless Communication System_Wireless communication is a broad term that i...JeyaPerumal1
Wireless communication involves the transmission of information over a distance without the help of wires, cables or any other forms of electrical conductors.
Wireless communication is a broad term that incorporates all procedures and forms of connecting and communicating between two or more devices using a wireless signal through wireless communication technologies and devices.
Features of Wireless Communication
The evolution of wireless technology has brought many advancements with its effective features.
The transmitted distance can be anywhere between a few meters (for example, a television's remote control) and thousands of kilometers (for example, radio communication).
Wireless communication can be used for cellular telephony, wireless access to the internet, wireless home networking, and so on.
Multi-cluster Kubernetes Networking- Patterns, Projects and GuidelinesSanjeev Rampal
Talk presented at Kubernetes Community Day, New York, May 2024.
Technical summary of Multi-Cluster Kubernetes Networking architectures with focus on 4 key topics.
1) Key patterns for Multi-cluster architectures
2) Architectural comparison of several OSS/ CNCF projects to address these patterns
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4) Some design recommendations & guidelines for adopting/ deploying these solutions.
ER(Entity Relationship) Diagram for online shopping - TAEHimani415946
https://bit.ly/3KACoyV
The ER diagram for the project is the foundation for the building of the database of the project. The properties, datatypes, and attributes are defined by the ER diagram.
2. INTRODUCTION
Bovine tropical theileriosis (Theileria annulata infection) is a protozoan disease
transmitted by several tick species, all belonging to the genus Hyalomma
Calf presented with bilateral pre scapular lymphnode enlargement,
petechiae on conjunctiva and bilateral exopthalmia with lacrymation
due to Tropical theileria
3. ETIOLOGY
●The two most virulent organisms in cattle are Theileria annulata, which causes
tropical theileriosis, and T. parva, which causes East Coast fever.
4. SPECIES AFFECTED
●T. annulata affects cattle, yaks and water buffalo.
●T. parva affects cattle and water buffalo (Bubalus bubalis). African buffalo (Syncerus caffer) and
cattle are important reservoir hosts for this organism.
●It can also infect sheep and goats, but does not cause significant illness in these animals.
5. GEOGRAPHICAL DISTRIBUTION
●T. annulata (tropical theileriosis) occurs in southern Europe, the Middle East and parts of
Asia.
●T. orientalis is widespread;
●T. parva (East Coast fever/ corridor disease) occurs in sub-Saharan
Africa
6. TRANSMISSION
●Theileria are transmitted by ticks acting as
biological vectors, and can be transmitted
transstadially. Transovarial transmission is not
thought to occur.
●Genera of ticks reported to act as vectors include
● Rhipicephalus (T. parva,), Hyalomma (T.
annulata,), Haemaphysalis (T. orientalis,) and
Amblyomma (T. mutans,).
●Transstadial transmission occurs when a
pathogen remains with the vector from one life
stage ("stadium") to the next.
● Transmitt especially by Hyalomma anatolicum
anatolicum
Transovarial and transstadial transmission
of the Ixodes tick
7. Ticks
●Susceptibility to infection of Hyalomma ticks for Theileria annulata and it was reported that
female ticks have higher infection than male ticks .
8. INCUBATION PERIOD
●The incubation period for tropical theileriosis is approximately 1-3 weeks.
●The incubation period for East Coast fever is 7-12 days in experimentally infected animals,
although some cases might appear as late as 3 weeks.
9. Theileria lifecycle
●Lymphocyte stage: - In lymphocytes, schizonts, also known as Koch’s blue bodies, are formed.
Then these schizonts multiply, replicating the parasites and allow disease to proliferates.
● Schizonts then disseminate through the lymphoid tissues before differentiating into merozoites.
● The merozoites enter the erythrocytes and form piroplasms which are infective to ticks and
capable of sexual reproduction.
● Sexual reproduction occurs within the nymph and larval stages of the tick and the final infective
stage is present within the salivary glands and is transmitted to mammalian hosts when blood
feeding.
● Transmission in the tick is then trans-stadial.
10.
11. Infective sporozoitesTick feed and
transmit infectionInvade lymphocytes
(forms lymbhoblast)
Schixogony
Piroplasesses
in red blood cell
Tick feed and
become infected
Gametogcay in
Tick gut
Asexual multiplication
In salivary gland
Tick hostBovine host
12. Carrier Animals
●Indian native cows Sahiwal are resistant to Theileria because they are not affected by ticks and stand
by high temperature of 45°C. Cattle with subclinical infection are known as carrier animals as they have
low number of piroplasms in blood hence they act as a source of infection for the tick vectors.
● In carrier animals low numbers of piroplasms are present in erythrocytes and they become the source
for transmission of infection, the carrier animals were detected by Polymerase Chain Reaction test.
13. Pathogenesis
● After biting infected ticks the number of parasitized cells increases rapidly throughout the lymphoid
system, and from about day 14 onward, cells undergoing merogony are observed.
●This is associated with widespread lymphocytolysis, marked lymphoid depletion, and leukopenia.
●Piroplasms in RBCs infected by the resultant merozoites assume various forms, but typically they
are small and rod-shaped or oval.
●Typically, fever occurs 7–10 days after parasites are introduced by feeding ticks, continues
throughout the course of infection, and may be >106°F (41°C).
●Lymph node swelling becomes pronounced and generalized. Lymphoblasts in Giemsa-stained
smears of needle aspirates from lymph nodes contain multinuclear schizonts.
●Anorexia develops, and the animal rapidly loses condition; lacrimation and nasal discharge may
occur.
●Terminally, dyspnea is common. Just before death, a sharp decrease in body temperature is usual,
and pulmonary exudate pours from the nostrils.
●Death usually occurs 18–24 days after infection.
14. CLINICAL SIGNS
● A high temperature (41.2°C) is a common feature in acute cases.
● Diarrhoea with blood clots in a calf.
● Lymph node enlargement
● Theileria-annulata-piroplasms((pear shaped)- a stage that can infect or
transmit to other cattle.
● Pale, rather than healthy pink, vulva
● Increased respiratory and heart rate
15. ●Less commonly seen clinical signs that can be seen include: excessive salivation, diarrhoea,
constipation, swelling of lymph nodes, and brown urine.
● Sick cows not responding as expected to treatment for conditions such as milk fever
● Cows are off their food and appear hollow sided
● A decrease in milk production
● Sudden death especially in late pregnancy or early lactation.
● Lacrimation, corneal opacity, nasal discharge
● Cows have no strength or energy to do anything.
● Pale or yellow whites of eyes (a sign of jaundice)
● Lethargy – exercise intolerance, cows lagging on the walk to the shed
16. A high temperature (41.2°C) is a common feature in acute cases.
●The alteration of protein picture in animals after infection could be referred to decrease in
protein synthesis as a consequence of anorexia and fever
●The increases of body temperature occur due to the liberation of endogenous progeny
because cellular lysis and high level of parasitemia lead to the stimulation of thermoregulatory
center in the hypothalamus
17. ●Due to cellular lysis, endogenous pyrogen liberates in the blood stream causing raise of body
temperature which may leads inappetence (Glass et al. 2001)
Anorexia is a also common feature in tropical theileriosis acute cases.
●The cytokines (TNF-a, IL-1, and IL-6) produced by infected mononuclear cells are responsible for
the diverse clinical symptoms of tropical theileriosis, such as depression, pyrexia, anorexia,
cachexia, and disseminated haemorrhages,Forsyth et al. (1997) and Glass et al. (2003) .
18. ● Diarrhoea with blood clots in a calf.
●As a result to inflammatory reaction and ulceration to abomasal and gastro intestinal tract
●In severe cases haemorrhagic diarrhoea is seen, this is due to ulcer formation in the gastrointestinal
tracts leading to blood mixed faeces.
●The decreased serum phosphorus and magnesium concentration in cattle with theileriosis is the
results of diarrhoea and renal wasting.
19. Lymph node enlargement
●The enlargement of superficial lymph node could be explained by lymphoid hyperplasia in early
stage of disease that occurs due to increases of proliferation of microschizonts inside the lymphocyte
caused inflammatory reaction in the infected lymph node(Jabbar et al. 2008).
Parotid Lymph node enlargementPrescapular Lymph node enlargement
21. ●The cells infected by schizonts induce massive and uncontrolled proliferation of both specific and
nonspecific T lymphocyte resulting in enlarged lymph nodes
Affected lymph nodes show reactive follicular hyperplasia, reticulo-
endothelial hyperplasia, enlarged germinal centers and slight increase
of interfollicular lymphoid tissue within the paracortical and cortical
regions
Prescapular lymph node enlargement
22. Recumbence
●The significant rises in the serum AST and ALT activities were due to muscle trauma caused by
prolonged recumbency in theileriosis.
23. Pale, rather than healthy pink, vulva
●One of the plausible reasons may be the oxidative damage to RBCs
● A significant feature of the disease is anemia owing to overproduction of cytokines and
reactive oxygen species.
●Immune-mediated mechanism such as erythrophagocytosis might be responsible RBCs count
reduction eventually
Haemolytic anaemia
24. ●The other importing cause to make the anemia in bovine theileriosis infection was the hemolytic
anemia caused by an immune– mediated hemolytic which is indicated by the presence
haemagglutinin.
● The modern research explains the mechanism of anemia that occurs due to the activity of
antioxidant enzymes such as superoxide dismutase (SOD) was effective by parasites and results
increased fragility of RBCs and thus ,acceleration of erythrocytes clearance by Phyagocytic cells.
●This anemia could be due to both an autoimmune reaction (Hooshmand-Rad 1976) and the effect of
intra-erythrocytic piroplasms (Preston et al. 1992).
●In addition, pro-inflammatory cytokines, particularly TNF-α, have been implicated in mediating
anemia associated with tropical theileriosis.
●The decrease in RBC could be due to increased levels of activated complement products.
Additionally, since oxidized erythrocytes may be destroyed easily by erythropagocytosis,
oxygen radicals may also be involved in the pathogenesis of anemia
25. Jaundice
●It could be also a resultant of biliary obstruction which resulted in obstructive
jaundice with a reflux of cholesterol into the blood stream from the liver and
stimulate hepatic cell membrane for synthesis of cholesterol.
26. Increased respiratory and heart rate
Normal Infected
Heart rate (bpm)(65 to 80) 122
Respiratory rate (cpm) (15 to 35) 75
bpm: beats per minute
cpm: cycles per minute
●Anemia associated with theileriosis and secondary hypoxia and vasculitis, leading to
some degree of cardiovascular injury.
●Cardiac troponin I is released from myocytes in both reversible and irreversible
myocardial injury.
●Respiratory signs occur due to the accumulation of edematous fluid inside the lung
and thoracic cavity
27. Ocular oedema in a cow
Lacrimation with visible ocular odema Ocular odema
Ocular odema
●it is strongly believed that T. annulata in the foetal circulation might have got access into
cerebral circulation and caused increased vascular permeability.
●It is believed that the endothelial cells of the fine ocular blood vessels of the orbit were the
probable site of multiplication of the pathogen congenitally acquired from the dam during
gestation and consequential oedema of the orbits and eyelids(Vikrant Sudan et al 2012)
28. ●The cornel opacity was explained by as a result of white blood cells infiltration.
Theileria opacity Corneal opacity
29. ●The occurrence of parasites produces lesions in the endothelial lining of blood vessels, tissue
damage in organs, such as the liver, kidney, and lung, and multiple petechial haemorrhages
(Forsyth et al 1999), all of which play an important role in the development of coagulation defects
(Levi, et al.,1997)
30. Oedema of the jaw in a cow
●Oedematous jaw is due to decreased serum calcium concentration in infected cattle could be
attributed to the hypoalbuminaemia and kidney damage (Burtis and Ashwood, 1996).
●The reduction of serum protein level could be attributed to extra-vascular proteinaceous fluid in
body cavities due to infected lymph nodes, resulting in edema
●Hypoproteinaemia and hypoalboumineamia is possibly due to the harmful effect of toxic
metabolites of Theileria and also due to liver dysfunction.
Oedema
Theileria annulata induced brisket oedema in a bull
31. ●Mediastinal lymph nodes around the base of cranial and caudal vena cava returning blood
to the heart may be affected by Theileria species.
●In this condition, jugular engorgement, oedema, inappetence are the clinical signs.
Beisket oedema
32. ●Cutaneous nodules were perivascular infiltrate of lymphocytes,
macrophages and eosinophils
●Uilenberg and Zwart(1979) reported one case of cutaneous nodules in
which both T. parva schizonts and Demodex bovis were found.
Numerous skin nodules on the neck and shoulders
of a cow with bovine theileriosis
skin nodules
Innumerable skin nodules in calf
33. Nodules on medial thighs of a heifer Perivascular inflammatory infiltrate (lymphocytes,
macrophages and eosinophils) (haematoxylin)
35. CLINICOPATHOGY
●Reticulocyte count is an indicator of the
rate of erythrocyte production.
Reticulocytosis is caused by increased
RBC destruction.
● In theileriosis, the reason for this
imbalance is that anaemia causes a
greater stimulus for RBC production.
Singh et al. (2001).
●Activated partial thromboplastin time
(aPTT)) and PT were attributed to
impaired hepatic synthesis and the
consumption of several pro-coagulant
clotting factors in theileriosis.(Singh 2001)
●Marked decrease in both basophil and
monocyte counts in the infected group.
This variation could be due to
differences in stage and severity of
disease Omer et al. (2002),
36. ●High levels of fibrinogen in cows infected with Theileria annulata infection, pro-inflammatory
cytokines, including TNF-a, IL-1, and IL-6, are released systemically from schizont-infected
macrophages and monocytes (Brown,1990; Forsyth,1999).
●According to Stockham et al. (2000) and Omer et al. (2002), the decrease in RBC could be due to
increased levels of activated complement products. Additionally, since oxidised erythrocytes may be
destroyed easily by erythropagocytosis, oxygen radicals may also be involved in the pathogenesis
of the anaemia.
●MCV increased and MCHC decreased called macrocytic hypochromic anaemia). In other forms
of anemia in which the average size and hemoglobin content of the red blood cells are within
normal limits are called normocytic normochromic anemias. Increase MCV and decrease PCV due to
toxic metabolite of Theileria sp.cause harmful effect on bone marrow for that interfere
erythropossis.
●Leukocytosis result from lymphocytes proliferation in lymphoid organs as a defensive reaction to
the invasion and multiplication of T. annulata (Modi et al. 2015) while, leukopenia may be the
consequence of the destruction of white blood cells by the parasites.
● The decline in the values of Hb, TEC, and PCV may be attributed to the destruction of piroplasm
infected erythrocytes by macrophages in the lymph nodes, spleen and other organs of the monocyte
macrophage system coupled with reduced erythropoietic activity.
37. Source: Osama H Omer et al.,2003Biochemical analyze carried out in sera from 23 young
and 20 adult Friesian cattle infected from Theileria
annulata
38. ●Low serum total protein(hypoproteinaemia) concentration in cattle infected naturally from Theileria
annulata possible due to hypoalbuminaemia and hypoglobulinaemia arising from harmful effect of
toxic metabolite, liver failure and and sever lymphocytopaenia(Singh et al.,2001)
●The cardiac infracts and sever liver damage seen in rise in Aspartate aminotransferase (AST) and
Alkaline phosphate (AP) activity(Laiblin et al 1978).
●AST and ALT are involved in amino acid and carbohydrate metabolism. These enzymes are present in
high concentrations in the muscles and liver. Elevation of these enzymes in the blood is indicator of
organ necrosis (Murray et al., 1996).
●Significant increase in bilurubin due to hepatic dysfunction and haemolytic anaemia (Singh et al 2001).
The increase in bilirubin levels is due to the destruction of parasitized erythrocytes by
erythrophagocytosis in the spleen, lymph nodes, and other organs of the reticuloendothelial system.
● Creatinine concentration decrease has no clinically significant. How ever muscle wasting and
rapidly emaciated associated with reduce the level of creatinine (Mehlhorn et al1994).
●Increase in BUN and uric acid due to the kidney damage, (Sandhu et al. (1998)
●The significant decrease in cholesterol and triglycerides may be attributed to anorexia associated
with the high rise of temperature and diarrhoea (Sharma et al. (1987)
39. Source: Osama H Omer et al.,2003Biochemical analyze carried out in sera from 23 young
and 20 adult Friesian cattle infected from Theileria
annulata
40. ●Decrease the serum copper and iron concentration is usually no clinical significance
●Decrease the serum phosphorus and magnesium associated with diarrhoea and renal wasting(Agus
et al,1982)
●Decrease the potassium concentration associated with inappetance,diarrhoea and
hypomaganesaemia(Yadave and Sharma,1986).
41. POSTMORTEM EXAMINATION
Bovine, lung.
The lung tissue is diffusely tan-brown, and
lobules are non-collapsed and rubbery
(interstitial pneumonia)
Bovine, popliteal lymph node.
The node is enlarged and diffusely pale, and
contains numerous petechiae.
42. Bovine, kidney.
There are multiple petechiae on the surface
of the cortex. The lymph node near the hilus
is markedly enlarged.
Bovine lymphoblasts contain intracytoplasmic Theileria
parva.
44. DIAGNOSTIC TEST
●PCR is often used in diagnosis as “gold standard test”, and can identify Theileria in the blood of
both carriers and clinical cases.
●Antibodies to T. parva and T. annulata can be detected with ELISAs, indirect fluorescent
antibody test (IFA) or other serological assays.
Theileria-annulata-piroplasms-cattle
46. MORBIDITY AND MORTALITY
●The mortality rate for tropical theileriosis is reported to be 40-90% in newly introduced cattle but <
5% in some indigenous animals.
●The morbidity rate in small ruminants infected with T. lestoquardi can approach 100%, with
reported mortality rates of 46-100%
47. ●In theileriosis, parasites invade to lymphoid cells and at a later stage of infection invade to
the erythrocytes and causes fever, anemia and leads to death (Soulsby 1982).
Death
●A leucocyte count below 1,000/mm3 is considered critical and fatal in a majority of the
cases (Mehlhorn and Armstrong 2001)
48. TREATMENT
●Parvaquone and buparvaquone are 2 effective drugs against tropical theileriosis.
●The recovery rate of animals treated with parvaquone was 60.7% and with buparvaquone it was
88.7% (Hashemi-Fesharki, 1991).
●Buparvaquone (Butalex) at a dose rate of 1 ml/20 kg (2.5 mg/kg) body weight intramuscularly along
with supportive therapy like inj. meloxicam,B-complex and fluid therapy. In severe and advanced
cases, a second treatment may be required at 48-72 hrs after the initial injection at the same dose
rate.
●Ascorbic acid was found better in treating clinical cases of bovine tropical theileriosis indicated
by decreased levels of oxidative stress such as plasma malondialdehyde (MDA), return to normal
activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) enzymes post
treatment( Ashwani Kumar,2014).
Note: Butalex should never be given by intravenous or subcutaneous injection
49. CONTROL
●Topical application of flumethrin 1 % pour-on preparation (Bayticol pour-on) over the vertebral
column is also advised.