Peste des Petits Ruminants (PPR) in India Epidemiology and ControlBhoj Raj Singh
PPR is endemic in India in sheep & goats. Mainly young stocks are more affected. Disease occurs throughout the year but more common in October & March. Though vaccination is the only method for control & eradication, even the institutes those developed the effective vaccine in India to control the disease fear to use it because many a time outbreaks ensue on vaccination. The other important reason for persistence of disease is undeclared Policy of suppressed reporting of PPR outbreaks.
Peste des Petits Ruminants (PPR) in India Epidemiology and ControlBhoj Raj Singh
PPR is endemic in India in sheep & goats. Mainly young stocks are more affected. Disease occurs throughout the year but more common in October & March. Though vaccination is the only method for control & eradication, even the institutes those developed the effective vaccine in India to control the disease fear to use it because many a time outbreaks ensue on vaccination. The other important reason for persistence of disease is undeclared Policy of suppressed reporting of PPR outbreaks.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Prevalence of canine leptospirosis has increased in recent years.
As many as 8.2% of dogs are shedding leptospires, some asymptomatically.49
Weather changes, population growth, and habitat encroachment have all increased human and canine exposure to pathogens and their carriers.
Transmission of leptospirosis can occur through direct contact or indirectly through environmental exposure.
Leptospires enter the body through mucous membranes in the mouth, eyes, or nose, or through abraded or water-softened skin.
Leptospires multiply in a host animal's bloodstream.
Leptospires move from the bloodstream to the kidneys and other tissues to continue reproducing.
Leptospires pass from the kidneys into the urine; then are shed back into the environment.
Other dogs, wild animals, or people can become infected through direct or indirect contact.
clinical signs
Fever
Lethargy
Weight loss
Anorexia
Depression
Acute renal failure
Jaundice
Abdominal discomfort
Vomiting and diarrhea
Blood in urine is uncommon, but may occur
Respiratory distress
Dogs at risk
Dogs at risk for developing leptospirosis include those with
Access to ponds, lakes, streams, or standing water
Exposure to urine from other infected animals, including:
Other dogs in shelters or other pet care facilities
Wildlife (e.g. rodents, racoons, opossum, deer), either through direct contact with urine or through contaminated water
Morbidity threats
As leptospirosis progresses, it can result in
Leptospiremia
Leptospires can multiply in the bloodstream and spread to many tissues and organs
Vascular damage/thrombocytopenia
Can lead to kidney failure and interfere with liver function
Contributes to coagulatory abnormalities and hemorrhages
Severe kidney and liver damage
Acute renal failure occurs in dogs with severe clinical signs
Acute hepatic dysfunction or chronic hepatitis have been caused by specific serovars
Poliovirus is a picornaviridae. it has 3 wildtypes, Wildtype 2 has been eradicated from the world. All countries have been declared polio free except Pakistan, Afghanistan and Nigeria. Global Polio Eradication Initiative has been discussed.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Prevalence of canine leptospirosis has increased in recent years.
As many as 8.2% of dogs are shedding leptospires, some asymptomatically.49
Weather changes, population growth, and habitat encroachment have all increased human and canine exposure to pathogens and their carriers.
Transmission of leptospirosis can occur through direct contact or indirectly through environmental exposure.
Leptospires enter the body through mucous membranes in the mouth, eyes, or nose, or through abraded or water-softened skin.
Leptospires multiply in a host animal's bloodstream.
Leptospires move from the bloodstream to the kidneys and other tissues to continue reproducing.
Leptospires pass from the kidneys into the urine; then are shed back into the environment.
Other dogs, wild animals, or people can become infected through direct or indirect contact.
clinical signs
Fever
Lethargy
Weight loss
Anorexia
Depression
Acute renal failure
Jaundice
Abdominal discomfort
Vomiting and diarrhea
Blood in urine is uncommon, but may occur
Respiratory distress
Dogs at risk
Dogs at risk for developing leptospirosis include those with
Access to ponds, lakes, streams, or standing water
Exposure to urine from other infected animals, including:
Other dogs in shelters or other pet care facilities
Wildlife (e.g. rodents, racoons, opossum, deer), either through direct contact with urine or through contaminated water
Morbidity threats
As leptospirosis progresses, it can result in
Leptospiremia
Leptospires can multiply in the bloodstream and spread to many tissues and organs
Vascular damage/thrombocytopenia
Can lead to kidney failure and interfere with liver function
Contributes to coagulatory abnormalities and hemorrhages
Severe kidney and liver damage
Acute renal failure occurs in dogs with severe clinical signs
Acute hepatic dysfunction or chronic hepatitis have been caused by specific serovars
Poliovirus is a picornaviridae. it has 3 wildtypes, Wildtype 2 has been eradicated from the world. All countries have been declared polio free except Pakistan, Afghanistan and Nigeria. Global Polio Eradication Initiative has been discussed.
Foot-and-mouth disease (FMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovids. The virus causes a high fever lasting two to six days, followed by blisters inside the mouth and near the hoof that may rupture and cause lameness.
FMD has very severe implications for animal farming, since it is highly infectious and can be spread by infected animals comparatively easily through contact with contaminated farming equipment, vehicles, clothing, and feed, and by domestic and wild predators.Its containment demands considerable efforts in vaccination, strict monitoring, trade restrictions, quarantines, and the culling of both infected and healthy (uninfected) animals.
Peste des-ruminants-is-a-rinderpest.doc pdfGudyne Wafubwa
Peste des petits ruminant virus (PPRV) is a disease mostly affecting goats and sheep. Since its first discovery, it has caused massive economic loss to most small pastoralists in Africa and other developing countries. It is the integral role of all stakeholders to join hands so as to eradicate the disease.
Polio mainly affects children
Polio is eradicated 99% globally
South Asian region declared to be polio-free since 2014
Afghanistan, Pakistan and Nigeria could never stop polio transmission
Unlike most diseases, polio can be eradicated with vaccination
Vaccines are cheap and effective
This Power Point Presentation is made by me for the Veterinary Students and Veterinary Graduates so that they can find data about Anthrax. i had searched for Anthrax on slide share but there were no any power point presentation regarding Bovine Anthrax. Now i am publishing it. Thanx
Regards:
Dr. Fasih ur Rehman
Veterinarian
Sindh Agriculture University, Tandojam.
Vaccine
Definition
History
Requirements for good immune response
Ideal characteristics of vaccine
Types
Adjuvants
Advantages & disadvantages
Comparison between live & killed vaccine
The study of animal viruses is important from a veterinary viewpoint and many of these viruses causes diseases that are economically devastating. Many animal viruses are also important from a human medical perspective. The emergence of the SARS virus in the human population, coming from an animal source, highlights the importance of animals in harbouring infectious agents; avian influenza viruses can directly infect humans. In addition research into animal viruses has made an important contribution to our understanding of viruses in general, their replication, molecular biology, evolution and interaction with the host.
The zoonotic and public health importance of fungus Ahmed Rafique
Fungus is accompanied with various diseases of human as well as animal.Normally fungal spores from decaying substances are the main source of infection.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
3. Talk Plan
Introduction
Origin and spread
Etiology
Physical and Chemical
Action
Economic importance
Transmission
Pathogenesis
Clinical signs
Post mortem lesion
Diagnosis
Differential diagnosis
Treatment
Prevention and
control
4. Introduction
• Included as List-A disease by OIE
• PPR ( Peste des Petits Ruminants) is also
known as Ovine Rinderpest or Goat Plague
• Acute , highly contagious transboundary
viral disease of goat and sheep
• Characterized by fever, sores in mouth,
oculo-nasal discharge, diarrhea,
pneumonia and ultimately death
5. Origin and Spread
• The first description of the disease was published in 1940
through an outbreak in Ivory Coast
• Pakistan and India: Early 1990s
• In Bangladesh, outbreaks of Peste des petits ruminants (PPR)
identified by British reference laboratory in goats since 1993.
7. Etiology
• Caused by a Morbillivirus (ssRNA) in
the family of Paramyxoviridae
• Genetically characterized into 4
groups
• 6 Structural proteins: N, P, L, M, F, H
• Incubation period: 3-6 days
8. Physical and Chemical
Action
Destroyed at 60˚C/60 min.
Inactivation: pH < 4.0 or >
10.0
Susceptible to alcohol,
sodium hydroxide, ether,
phenol & detergents etc
Long survival time in chilled
and frozen tissue
PPRV
9. Economic Importance
Highly
Fatal in
young
Morbidity:
Up to 100%
Mortality:
Varying
Goat: 55-85 %
Sheep: 45-75%
Prevalence
is higher in
mixed
population
About 22
million at risk
population in
BD
Limits
Trade &
Export
Threatens
Food
security
Production
loss & culling
10. Transmission
The virus is secreted in tears, nasal or ocular discharge, coughing
and in the feces of infected individual
Susceptible animals inhale droplets and likely to be infected
There is no known carrier state
Virus may also present in semen and embryo
Offspring can also be infected through mother by milk sucking
11. PPR virus penetrate the
retropharyngeal mucosa
Viremia
Specifically damage the
Alimentary system Respiratory System Lymphoid
System
Pathogenesis
Entry
Diarrhea Pneumonia
Immuno
suppression
12. Symptoms
High body temperature ( Up to 41˚C)
Diarrhea, depression , anorexia
Ulcer in the gum (lower),dental pad,
hard palate, cheek and tongue
Serous/ foamy/ hemorrhagic discharge
from nose
Pneumonia
14. Post Mortem Lesion
Dehydrated carcass with fecal soiling
Congestion of the ileo-cecal valve
Blackening of the
folds of large
intestine ( Zebra
stripping)
Enlarged spleen
Edematous
lymphnode
Broncho
pneumonia
15. Diagnosis
Based on history
- Any recent outbreak in the case area
- Change in husbandry and trade practice
- Change in weather. i.e. Rainy season
- Movement history
Based on clinical signs
Post Mortem changes
Blood examination
Isolation and culture of virus
Serological tests:
- PCR - AGID
- ELISA - cDNA probe
17. Line of Treatment
Non specific symptomatic treatment
Antibiotic therapy to prevent secondary infection
Anti-diarrheal drug
Anti-inflammatory drug
Fluid therapy
18. A PPR Case Study at
CVASU
Species: Goat
(Jamunapari)
Age: 11 month
Weight: 13 kg
Client’s Complaint:
Diarrhea and
Increased temp.
Clinical History: Off
fed, Stomatitis and
Nasal discharge
Treatment Given:
1) Inj. Diadin – 30 ml vial × 1
Sig: Inject 8 ml IV on 1st day followed
by 4 ml IV for next 4 days.
2) Inj. Histavet – 10 ml vial × 1
Sig: Inject 1 ml IM daily for 4 days.
3) Pow. DD-4 – 100gm pack × 1
Sig: Adm. 25gm PO, bid for 3 days.
4) Inj. Cholera Saline – 500 ml bag × 1
Sig: Inject 250 ml IV daily for 2 days.
19. Prevention and control
In March 2015, the FAO and OIE officially announced the global
PPR control strategy. Training and information sharing are crucial
elements for the success of this strategy.
Strict isolation and quarantine facility
Movement control
Compulsory slaughter of affected animals
Sanitation and hygiene
Vaccination
- Ring vaccination
- Vaccination of high risk population
20. PPR Vaccine
Tissue culture Rinderpest vaccine TC ID50 at 12 month of age
Genetically engineered recombinant vaccine (under trial by
OIE)
French attenuated PPR vaccine ( Immunity for 3 years)
Live attenuated PPR vaccine by LRI 45 lakh doses per year
(Adopted in VERO cell culture) but poor thermal stability so cold
chain is to be maintained to preserve the potency
Protocol:
1ml S/C at 4 months of age
Booster at 6 amonth of age
Followed by yearly vaccination
Editor's Notes
Pest of small ruminants/pseudo-rinderpest of small ruminants