Canine pyometra is a uterine infection in intact female dogs that occurs during diestrus. It is caused by bacterial infection, usually E. coli, within the uterus under the influence of progesterone. Clinical signs include vaginal discharge, fever, lethargy, vomiting, and polyuria/polydipsia. Diagnosis involves abdominal palpation, ultrasonography, and clinical pathology. Treatment of choice is ovariohysterectomy, while antibiotics and prostaglandins may be used for medical management in some cases. Prognosis is good with early diagnosis and intervention to prevent systemic complications.
This is the case study of pyometra in bitch encountered in Central Veterinary Hospital.You will find the complete detail about the pyometra and related literature.
This is the case study of pyometra in bitch encountered in Central Veterinary Hospital.You will find the complete detail about the pyometra and related literature.
The fertility of a male is related to several phenomenon includes sperm production, viability and fertilizing capacity
of the ejaculated sperm, sexual desire and the ability to copulate. Reproductive problems causing absolute or relative
infertility in male animals mainly includes reduced to complete lack of sexual desire or libido, failure of normal
service and failure of conception after normal service. The sterile males are readily identified, but the males with
reduced fertility poses serious problems and causes economic losses to breeders and AI industry.
This slide will highlight the most important theoretical and practical concept regarding abortion. In this slide preparation the definition, types, clinical presentation, the magnitude and prevalence, types of abortion in different settings, managing of abortion based presentation are presented.
The fertility of a male is related to several phenomenon includes sperm production, viability and fertilizing capacity
of the ejaculated sperm, sexual desire and the ability to copulate. Reproductive problems causing absolute or relative
infertility in male animals mainly includes reduced to complete lack of sexual desire or libido, failure of normal
service and failure of conception after normal service. The sterile males are readily identified, but the males with
reduced fertility poses serious problems and causes economic losses to breeders and AI industry.
This slide will highlight the most important theoretical and practical concept regarding abortion. In this slide preparation the definition, types, clinical presentation, the magnitude and prevalence, types of abortion in different settings, managing of abortion based presentation are presented.
Please find the power point on Puerperal sepsis. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
The thin endometrium refers to the lining of the uterus, known as the endometrium, being insufficiently thick. This condition is typically characterized by a reduced thickness of the endometrial layer, which plays a crucial role in supporting the implantation and development of a fertilized egg during the menstrual cycle.
A thin endometrium is commonly associated with hormonal imbalances, such as low estrogen levels, which are vital for the growth and maintenance of the endometrial tissue. Inadequate blood flow to the uterus, chronic inflammation, or certain medical conditions can also contribute to this condition. Women with a thin endometrium may experience difficulties in achieving and maintaining pregnancy, as the thin lining may not provide an optimal environment for the embryo to implant and thrive.
Addressing the underlying causes of a thin endometrium often involves hormonal therapies to regulate estrogen levels, lifestyle modifications, and sometimes surgical interventions. Fertility treatments, such as in vitro fertilization (IVF), may be considered to overcome the challenges associated with a thin endometrium.
In conclusion, a thin endometrium can pose challenges to fertility and reproductive health, requiring a comprehensive approach to address the underlying factors and improve the chances of successful conception.
pregnancy induced pruritus,Polymorphic eruption of pregnancy,PEP,pruritic urt...statushigh5
Polymorphic eruption of pregnancy (PEP), pruritic urticarial papules and plaques of pregnancy (PUPPP),Polymorphic eruption of pregnancy (PEP) (syn., pruritic urticarial papules and plaques of pregnancy [PUPPP]) 3. Prurigo of pregnancy (PP) and 4. ... They included three conditions- eczema in pregnancy (EP), prurigo of pregnancy and pruritic folliculitis of pregnancy under AEP due to their overlapping features.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
6. CEH-Pyometra-ComplexCEH-Pyometra-Complex
CEH precedes pyometra
CEH & pyometra → two separate entities → clinical
manifestations & morphohistological differences
(De Bosschere et al, 2001)
Four gradations of CEH-Pyometra complex
(Dow, 1959)
7. Type I Type II Type III Type IV
thickened
endometrium
with
translucent
cysts
diffuse
plasma cell
infiltration
acute
endometritis
metritis or
pyometra
Chronic
endometritis,
squamous
metaplasia
8. ““Open” or “Closed” cervixOpen” or “Closed” cervix
1. Closed pyometra
2. Open pyometra
3. Stump pyometra
inflammation/ bacterial infection→uterine body
remnant
Severity of signs : cervix patency
11. Predisposing FactorsPredisposing Factors
Age
middle-aged or old bitches (> 4 years)
8.2 years (Dow, 1959)
2.4 years (Kersey, 2004)
Parity
nulliparous, intact bitches
Oestrous characteristics
long diestrus
12. Breed
wire-haired Dachshund/ Mongrels: ↓ risk
Rottweiler, rough-haired Collie,Cavalier King
Charles Spaniel/ Golden Retriever: ↑ risk
(Susi Arnold, 2006)
No breed influence on pyometra development
(Niskanen & Thrusfield, 1998)
13. PathogenesisPathogenesis
1) Hormonal influence on uterus
2) Virulence of infecting bacteria
3) Ability of bitch to combat infection
4) Individual sensitivity
Growth factors & their receptors (growth factors
receptors, GFs)
(Gama et al. 2009)
14. Hormonal influence on uterusHormonal influence on uterus
Progesterone in aetiology of canine pyometra & its
potentiation by estrogen
Teunissen (1952)
Prolonged stimulation of uterus by progesterone from cystic
corpora lutea
Hardy & Osborne (1974)
Steroid hormones influence conc. & distribution of steriod
receptors in uterus & cause pyometra
Dhaliwal et al (1999)
15.
16. Virulence of infecting bacteriaVirulence of infecting bacteria
Bacterial infection- not primary cause
Predominant bacteria (in 82–100% of clinical cases):
Escherichia coli
E. coli isolates → O serogroups (O4, O6)
(Wadas et al, 1996)
Uropathogenic virulence factors (UVFs) for extra-intestinal
infection
(Yuri et al, 1999)
17. Genes Products
pap P fimbriae
fim Type1 fimbriae
sfa S fimbriae
hlyA α-haemolysin
cnf1 cytotoxic necrotising factor 1
iuc aerobactin
afa afimbrial adhesin 1 or Afa1
18. P fimbriae
PapGIII adhesin binds to Galα1–4Gal glycolipids &
Forssman Ag
bacterial adhesion & colonization
α-haemolysin/ CNF1 : tissue damage
E. coli isolates : 5, 3 or more UVF genes
genetic linkage- UVF genes & pathogenicity associated
islands (PAIs) : cnf1, hlyA; hlyA, pap; cnf1, hlyA, papGIII
19. Clinical signs Open-cervix Close-cervix
Vaginal discharge Watery- creamy;
light brown, green or
yellow
rare
Temperature normal/ slightly
elevated
elevated/ sub-normal
(toxemic bitch)
Lethargy/ depression + +
Vomiting + +
Polyuria/ polydipsia + +
Clinical signs : 4-8 wks following last standing heat
20. Diestrus bitch with purulent vaginal dischargeDiestrus bitch with purulent vaginal discharge
21. Mechanism of PolyuriaMechanism of Polyuria
Multifactorial
Reduced permeability for water in DCT of kidney
(Asheim, 1964)
Deposition of immune complexes in glomeruli causes
membranoproliferative glomerulonephropathy
(Sandholm et al, 1975)
Renal tubular insensitivity to ADH due to tubular
damage by E.coli endotoxins
22.
23. Abdominal palpationAbdominal palpation
Open-cervix pyometra
thickened, irregular & slightly turgid uterine horns
Closed-cervix pyometra
greater degree of uterine distension
visible abdominal enlargement
Care taken to avoid rupturing a distended uterus
24. UltrasonographyUltrasonography
In early diagnosis of canine pyometra
(Bigliardi et al; 2004)
Most valuable in closed-cervix pyometra
Uterine wall- increased thickness/ hypoechoic
Uterine lumen- grossly dilated/ anechoic fluid with
small echogenic particles
31. 1. Antibiotics1. Antibiotics
in every case
G(-) and G(+) efficacy
according resistogram as soon as possible
Quinolones (Enrofloxacin/Marbofloxacin)
Gentamicin
Cefalosporins
32. Natural PGF₂α Synthetic PGF₂α0.02 mg/kg SC bid 7-10 days 0.001– 0.002 mg/kg SC OD
7-10 days
Day 1 : 0.1 mg/kg
Day 2 : 0.2 mg/kg
Day 3-7 : 0.25 mg/kg OD
Longer duration of action
Dinoprost
(Lutalyse®)
Cloprostenol
(Cyclix®)
2. Prostaglandin F₂α/ PGE
37. ControlControl
1. O.H.
at 6 months of age or before
after breeding years
2. Post-partum reproductive system checking
3. Very rarely use contraceptive drugs
38. ConclusionConclusion
Canine pyometra : infectious cause of infertility
Occurrence : any bitch → clinical signs → after diestrus
regardless of age
Confirmatory diagnosis : combination of diagnostics
OH : therapy of choice
PGF₂α therapy : ↑ success rates in open-cervix pyometra