This document provides an overview of the heterocyclic compound pyrrole. Pyrrole is a five-membered heterocyclic compound containing one nitrogen atom. It plays an important role in living organisms as the structural feature of chlorophyll and heme contains four linked pyrrole rings. Pyrrole has weak acidic properties similar to acetylene. It can be synthesized through various methods including the reaction of acetylene and ammonia at high temperatures. Pyrrole undergoes characteristic reactions like oxidation, reduction, alkylation and acylation. It is involved in the synthesis of important drugs like Obatoclax which is used to treat various cancers.

1. Heterocyclic compounds -
Pyrrole
Lecture by
S.Mathivanan., M.Pharm
Assistant professor
Pharmacy

2. Introduction
Pyrrole is an important five membered
heterocyclic compound possessing a
nitrogen atom as hetero atom.
plays important role in the chemistry of
living organisms.
The essential structural feature of
chlorophyll and heme is porphyrin,
which consists of four Pyrrole rings
held together by bridges.
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3. Heterocyclic compounds

4. Properties of Pyrrole
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5. Resonance of Pyrrole
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6. Heterocyclic compounds

7. Acidic character
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 The acidic strength of pyrrole is very
weak, which is similar to acetylene.

8. Synthesis of Pyrrole
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9. Heterocyclic compounds

10. Mechanism
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12. Mechanism
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15. 5.Mixture of acetylene and ammonia
are passed through red-hot tube to
yield Pyrrole.
6.From distillation of Succinamide
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2C2H2 + NH3 C4H5N +
H2

16. Reactions of Pyrrole
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21. Grignard Reaction
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23.  Obatoclax : It is used to treat
Leukaemia, Lymphoma, Myelofibrosis
and mastocytosis
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24. Browse to know more
Thank you dear students...!!!!
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