Heterocyclic Compounds, Nomenclature of Heterocycles, Classification of Heterocyclic Compounds, a) 5-membered Heterocyclic compounds, Preparation of Pyrrole:
THIS PRESENTATION COVER INTRODUCTION, STRUCTURE, AROMATICITY, RESONANCE, BASICITY, PHYSICAL PROPERTIES, SYNTHESIS, CHEMICAL PROPERTIES AND MEDICAL USES OF PYRIDINE AND PYRIMIDINE
THIS SLIDE HAVE GOOD CONTENT. THIS SLIDE CONTAIN INTRODUCTION, STRUCTURE, RESONANCE, AROMATICITY, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF QUINOLINE.
Heterocyclic chemistry - Fused ring systemsNaresh Babu
Fused hetero cyclic ring systems like Quinoline, Isoquinoline, Indole, Acridine, Benzimidzole & Phenothiazine - Structure, Aromaticity, Preparations, Acidity-Basicity and characteristic chemical reactions
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
THIS PRESENTATION COVER INTRODUCTION, STRUCTURE, AROMATICITY, RESONANCE, BASICITY, PHYSICAL PROPERTIES, SYNTHESIS, CHEMICAL PROPERTIES AND MEDICAL USES OF PYRIDINE AND PYRIMIDINE
THIS SLIDE HAVE GOOD CONTENT. THIS SLIDE CONTAIN INTRODUCTION, STRUCTURE, RESONANCE, AROMATICITY, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF QUINOLINE.
Heterocyclic chemistry - Fused ring systemsNaresh Babu
Fused hetero cyclic ring systems like Quinoline, Isoquinoline, Indole, Acridine, Benzimidzole & Phenothiazine - Structure, Aromaticity, Preparations, Acidity-Basicity and characteristic chemical reactions
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
Synthesis and characterization of resin copolymer derived from cardanol-furfu...ijceronline
International Journal of Computational Engineering Research (IJCER) is dedicated to protecting personal information and will make every reasonable effort to handle collected information appropriately. All information collected, as well as related requests, will be handled as carefully and efficiently as possible in accordance with IJCER standards for integrity and objectivity.
Hetero-cyclic compounds unit III as per PCI syllabus for second year B pharmacy students.
It covers all the details regarding Furan, Pyrrole and Thiophene ring
B. Sc. Part - I (Sem-II) Unit-IV (A) Phenols by Dr Pramod R Padolepramod padole
A) PHENOLS: Methods of formations a) from aniline & b) from cumene. Acidic character, Reaction of Phenols- a) Carboxylation (Kolbe’s reaction), b) Fries Rearrangement, c) Claisen Rearrengement and d) Reimer – Tiemann reaction.
B.Sc. Sem-II Unit-III (B) Aryl halides by Dr Pramod R Padolepramod padole
Aryl Halides: Synthesis chlorobenzene from benzene, phenol, and benzene diazonium chloride, Synthesis of benzyl chloride from toluene and benzyl alcohol, Reactions of both with aqueous KOH, NH3, and sodium ethoxide, Comparison of the reactivity of chlorobenzene and benzyl chloride. Benzyne intermediate mechanism.
B.Sc. (Sem-II) Unit-III (A) Alkenyl Halides by Dr Pramod R Padolepramod padole
Alkenyl Halides: Synthesis of vinyl chloride from acetylene and allyl chloride from propylene, Reactions of both with aqueous and alcoholic KOH, Comparison of the reactivity of vinyl and allyl chloride.
B. Sc. Sem - I Unit-IV (D) Orientation by Dr Pramod R Padolepramod padole
Orientation: Effect of substituent groups. Activating and deactivating groups. Theory of reactivity and orientation on the basis of inductive and resonance effects (-CH3, -OH, -NO2 and –Cl groups).
B.Sc. Sem-I Unit-IV Mechanism of electrophilic aromatic substitution by Dr P...pramod padole
Mechanism of Electrophilic Aromatic Substitution: Nitration, Friedal Craft Alkylation and Acylation.Nuclear and Side Chain
Halogination, Birch Reduction
Sem - I Unit-III C) Aliphatic Hydrocarbons By Dr Pramod R Padolepramod padole
C) Aliphatic Hydrocarbons:
a) Alkanes: Methods of formation: i) Wurtz reaction & ii) Corey-House reaction. Chemical reactions: i) Halogenation (With mechanism),
ii) Aromatisation.
b) Alkenes: Methods of formation (With mechanism): i) Dehydrohalogenation of alkyl halides (E1 & E2), ii) Dehydration of alcohols.
Chemical reactions: Electrophilic & free radical addition of HX and X2 (With mechanism).
c) Alkynes: Preparation from vicinal and germinal dihalides. Chemical reactions: Hydrogenation.
d) Alkadienes : Classification, 1,3-Butadiene: Preparation from cycolhexene, Reactions: Addition of H2, Br2 & HBr.
Dyes, Drugs & Pesticides by Dr Pramod R Padolepramod padole
A] Dyes: Classification on the basis of structure and mode of application, Preparation and uses of Methyl orange, Crystal violet, Phenolphthalein , Alizarin and Indigo.
B) DRUGS:
Analgesic and antipyretics: Synthesis and uses of phenylbutazone. Sulpha drugs: Synthesis and uses of sulphanilamide and sulphadiazine. Antimalarials: Synthesis of chloroquine from 4,7-dichloroquinoline and its uses.
C] Pesticides: Insecticides: Synthesis and uses of malathion. Herbicides: Synthesis and uses of 2,4-dichloro phenoxy acetic acid (2,4-D). Fungicides: Synthesis and uses of thiram (tetramethyl thiuram disulphide).
Semester - I C) Aliphatic Hydrocarbons by Dr Pramod R Padolepramod padole
C) Aliphatic Hydrocarbons:
a) Alkanes: Methods of formation: i) Wurtz reaction & ii) Corey-House reaction. Chemical reactions: i) Halogenation (With mechanism),
ii) Aromatisation.
b) Alkenes: Methods of formation (With mechanism): i) Dehydrohalogenation of alkyl halides (E1 & E2), ii) Dehydration of alcohols.
Chemical reactions: Electrophilic & free radical addition of HX and X2 (With mechanism).
Semester - I C) Aliphatic Hydrocarbons by Dr Pramod R Padolepramod padole
C) Aliphatic Hydrocarbons:
a) Alkanes: Methods of formation: i) Wurtz reaction &
ii) Corey-House reaction. Chemical reactions: i) Halogenation (With mechanism), ii) Aromatisation.
b) Alkenes: Methods of formation (With mechanism): i) Dehydrohalogenation of alkyl halides (E1 & E2), ii) Dehydration of alcohols. Chemical reactions: Electrophilic & free radical addition of HX and X2 (With mechanism).
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
3. By Dr. Pramod R. Padole
Organic Chemistry
A]
Heterocyclic
compounds:
Unit - III
B]
Organometallic
compounds:
4. LOGO
Heterocyclic Compounds:
By Dr. Pramod R. Padole
(ii) Pyridine:
Synthesis from acetylene and
pentamethylene diamine
hydrochloride,
Basicity (Basic nature),
Electrophilic substitution
reactions (orientation) –
nitration, sulphonation,
Nucleophilic substitution
reactions (orientation)-
with
NaNH2, C6H5Li and KOH
(i) Pyrrole:
Synthesis from acetylene,
succinimide and furan,
Basicity (Basic & Acidic),
Electrophilic substitution
reactions (orientation) –
nitration, sulphonation,
acetylation and
halogenation,
Molecular
orbital structure.
Unit-III
A)
Heterocyclic Compounds
5. pramodpadole@gmail.com
By Dr. Pramod R. Padole
Organometallic compounds:
(i) Grignard reagents:
Methyl magnesium bromide-
Synthesis from methyl bromide
(only reaction)
Synthetic applications:
Electrophilic substitution reactions-
formation of alkanes, alkenes, higher
alkynes and other organometallic
compounds,
Nucleophilic substitution reactions-
Reaction with aldehydes and ketones,
ethylene oxide, acetyl chloride, methyl
cyanide and CO2.
Unit – III
B)
(ii) Methyl lithium:
Synthesis and
Reaction with water,
formaldehyde,
acetaldehyde, acetone,
ethylene oxide and
CO2.
9. Heterocyclic Compounds or Heterocycles:
Defination:
The cyclic compounds obtained by replacing
one or more carbon atom of a ring by
heteroatom, like, N, O or S, are called as
heterocyclic compounds.
OR
Heterocyclic compound, or heterocycles, is
cyclic compound in which one or more of the
atoms of the ring are heteroatoms.
A heteroatom (such as N, O, S, etc.) is an
atom other than carbon.
10. Heterocyclic Compounds or Heterocycles:
Examples:
The common names of heterocycles are-
N
H
2
34
5
1 O 1
2
34
5
S 1
2
34
5
N
1 2
3
4
5
6
Pyrrole Furan Thiophene Pyridine
11. Nomenclature of Heterocycles:
Most of the heterocyclic compounds are known by their common
names.
The name comes from the Greek word heterose, meaning “different”
variety of atoms, such as N, O, S, P, Si, B, Se (Selenium) and As
(Arsenic) can be incorporated (introduced) into ring structures.
For naming their derivatives, the hetero atom is always numbered as “1”.
As per Greek nomenclature, the carbon atom next to the hetero atom is
sometimes referred to as the α-carbon atom and those further away as
β- and Ɣ-carbon atoms.
N
H
2
34
5
1
NO2
N
1
2
3
4
5
6 OH
2-nitro Pyrrole (- nitro Pyrrole)
2-hydroxy Pyridine (-hydroxy Pyridine)
12. Nomenclature of Heterocycles:
Give the names of the following heterocyclic compounds:
2-acetyl-pyrrole 3-nitro-pyridine
N
H
C
O
CH3
(1) (2)
N
NO2
N NH2
(3)
2-amino pyridine
(4)
N C6H5
2-Phenyl pyridine
14. LOGO 5 – membered heterocyclic Compounds:
These type of compounds contain four
carbon atoms and one hetero atom in a
ring, i.e., total 5-atoms in a ring, are
called as 5-membered heterocyclic
compounds.
The nitrogen containing five membered heterocycle’s
names usually ends with –ole.
N
H
2
34
5
1 O 1
2
34
5
S 1
2
34
5
Pyrrole Furan Thiophene
Q.1) Pyrrole is a 5 membered hererocyclic compound. (S-13 & W-16, ½ Mark)
15. LOGO
6 – membered hetercyclic compounds:
These types of compounds contain five carbon
atoms and one hetero atom in a ring, i.e., total
6-atoms in a ring, are called as 6-membered
heterocyclic compounds.
Example:
The nitrogen containing six membered heterocycle’s names usually
ends with –ine.
Q.1) Pyridine is a 6 membered hererocyclic compound. (S-19 & W-19 , ½ Mark)
N
1 2
3
4
5
6
Pyridine
16. pramodpadole@gmail.com
By Dr. Pramod R. Padole
Condensed heterocyclic compounds:
These types of compounds contain five or
six membered heterocyclic ring condensed
(fused) with a benzene, are called as
condensed heterocyclic compounds.
Examples:
N 1
2
3
45
6
7
8
9
10
Quinoline
N
1
2
3
45
6
7
8
9
10
Isoquinoline
18. LOGO
Pyrrole or Azole: C4H5N
Pyrrole is a Greek word (Pyrros + Oleum)
meaning is that –
Pyrros = Fairy & Oleum = oil
Pyrrole is an important heterocyclic compound
having five - member ring containing
nitrogen as the heteroatom.
N
H
2
34
5
1
Pyrrole
Molecular Formula of Pyrrole is C4H5N or C4H4NH
19. Methods of Synthesis
or Preparation of Pyrrole:
From
Acetylene
Preparation of Pyrrole
From
Succinimide
From
Furan
Reactions that produce a particular functional group are called preparations
2 acetylene and ammonia
enol form, which on distillation
with Zinc dust
Furan + NH3
heated alumina
400oC - 500oC
20. Preparation of Pyrrole from Acetylene:
From Acetylene:
When mixture of acetylene (2 equivalents)
and ammonia is passing through a red
hot tube; to form pyrrole.
CH
HC
HC
CH
H-N H
Red Hot Iron Tube
N
H
H2
Pyrrole
H
(or NH3)
Q.1) How will you prepare / obtain pyrrole from acetylene? (S-13 & W-19, 2 Mark)
Q.2) What happens when mixture of acetylene and ammonia is passed through red hot tube?
(S-14 & W-16, 2 Mark)
21. Preparation of Pyrrole
from Succinimide:
H2C
C
H2C
C
O
O
N H
Succinimide ( Keto form)
H2C
C
H2C
C
O
O
OH
OH
Succinic acid
+
H
H
N H
?
22. Preparation of Pyrrole from Succinimide:
Or By distillating Succinimide with Zn-dust:
From Succinimide:
When Succinimide (Keto form) isomerizes to enol form,
which on distillation with Zinc dust; to form pyrrole.
Q.1) How will you obtain: Pyrrole form succinimide? (S-16 & S-17, 2 Mark)
Q.2) Pyrrole can be synthesized by distilling Succinimide with zinc dust. (S-17, ½ Mark)
Q.3) How will you prepare: Pyrrole form succinimide? (W-17, 2 Mark)
Q.4) Give the synthesis of Pyrrole from succinimide. (W-18, 2 Mark)
Q.5) Write method of synthesis of Pyrrole from succinimide. (S-19, 2 Mark)
H2C
C
CH2
C
O O
N
H
HC CH
C C
N
HO OH
H
HC CH
HC CH
N
H
Succinimide ( Keto form)
(Enol form) Pyrrole
+ 2 Zn-dustIsomerisation
+ 2 ZnO
On distillation
with
23. LOGOPreparation of Pyrrole from Furan:
Or Reaction with Furan and NH3 over alumina:
Or Industrial / Commercial Method of Pyrrole:
From Furan:
When mixture of furan and ammonia is passed over heated alumina
(Al2O3) as a catalyst at about 400oC - 500oC; to form pyrrole.
O
H2 N-H
or NH3
Furan
Al2O3
N
H
Pyrrole
H2O
Ammonia
400-500o
C
Catalyst
Q.1) How will you obtain Pyrrole from Furan? (W-11, S-12 & S-18, 2 Mark)
Q.2) How will you convert Furan to pyrrole? (W-13, 2 Mark)
Q.3) How will you synthesize Pyrrole from Furan? (W-15, 2 Mark)
Q.4) Write method of synthesis of Pyrrole from Furan. (S-19, 2 Mark)
24. LOGOPreparation of Pyrrole from Furan:
Or Reaction with Furan and NH3 over alumina:
Or Industrial / Commercial Method of Pyrrole:
From Furan:
When mixture of furan and ammonia is passed over heated alumina
(Al2O3) as a catalyst at about 400oC - 500oC; to form pyrrole.
Q.1) How will you obtain Pyrrole from Furan? (W-11, S-12 & S-18, 2 Mark)
Q.2) How will you convert Furan to pyrrole? (W-13, 2 Mark)
Q.3) How will you synthesize Pyrrole from Furan? (W-15, 2 Mark)
Q.4) Write method of synthesis of Pyrrole from Furan. (S-19, 2 Mark)
OFuran
Ammonia
H2
N
H
or NH3
+ N
H
Pyrrole
H2OAl2O3
400-500o
C
Catalyst
heated