Cyclohexane exists in different conformations viz chair, boat, twist boat and half chair. These conformations possess different energies. Therefore they differ in energy.
Cyclohexane exists in different conformations viz chair, boat, twist boat and half chair. These conformations possess different energies. Therefore they differ in energy.
STEREOSPECIFIC REACTION, STEREOSELECTIVE REACTION, OPTICAL PURITY, ENANTIOMERIC EXCESS.. all these topics are explained in this slide with examples and formula.
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
Notes for Cellular Injury.
Prepared for B.pharm I year II sem students for study purpose.
Contact email : drxmathinanotech@gmail.com
Regards,
Mrs.S.Mathivanan., M.Pharm
Assistant Professor,
SMVEC Pharmacy college,
Puducherry.
STEREOSPECIFIC REACTION, STEREOSELECTIVE REACTION, OPTICAL PURITY, ENANTIOMERIC EXCESS.. all these topics are explained in this slide with examples and formula.
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
Notes for Cellular Injury.
Prepared for B.pharm I year II sem students for study purpose.
Contact email : drxmathinanotech@gmail.com
Regards,
Mrs.S.Mathivanan., M.Pharm
Assistant Professor,
SMVEC Pharmacy college,
Puducherry.
This slide discusses about basic indole nucleus, its chemistry, synthesis, reactions and medicinal uses of Indolyl derivatives..Indole is basically fused heterocyclic compound
This slide discusses about fused heterocyclic compound Acridine..the structural analogue of anthracene with one carbon group is replaced with nitrogen atom.
This slides discusses about Isoquinoline nucleus (fused heterocyclic compound). this ring contain benzene ring fused with pyridine nucleus with nitrogen atom
Pyridine is the six membered heterocyclic compounds with nitrogen as an hetero-atom..Its synthesis, reactions and medicinal uses were discussed in this ppt
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
3. Conformation of Ethane
• When an ethane molecule rotates about it's carbon-
carbon single bond two extreme conformations can
be result, the staggered and eclipsed conformation.
• Here we will use Newman projection to discuss the
confirmation.
H
H
H
H H
H
H H
H
HH
H
60°
0°
Staggered Eclipsed
4. Rotation around bond
• If one of the methyl group is allowed to rotate
keeping the rest of molecule undisturbed and
number of possible arrangement can be
obtained.
5. 60° 120°
360° 300°
240°
180°
H
HH
H
H
H
HH
H
H
H
H
H
H
H
HH
H
H
H H
H
H
H
H
H
HH
H
H
H
H
H
H H
H
H
H
H H
H
H
(I)- Eclipsed
Repulsion more
Energy more
Less stable
(II) - Staggered
Repulsion less
Energy less
More stable
(III)-Eclipsed
Repulsion more
Energy more
Less stable
(VI)-Staggered
Repulsion less
Energy less
More stable
(V)-Eclipsed
Repulsion more
Energy more
Less stable
(VII)-Eclipsed
Repulsion more
Energy more
Less stable
(IV)-Staggered
Repulsion less
Energy less
More stable
6. Energy level
• By doing so six possible confirmation can be
obtained out of which 3 are staggered (II,IV,VI)
and 3 are eclipsed form (I/VII,III,V).
• Potential energy of I,III,V,VII is greater than
that of II,IV,VI due to repulsive forces.
• Stability of II,IV,VI is greater than that of
I,III,V,VII.
I , III, V, VII > II , IV , VI
II, IV, VI > I , III , V , VII
8. n-Butane
CH3-CH2-CH3
C – C – C – C
H
H
HH
HH H
H
H
H
1 432
Kekule structure
Skeletal structure
condensed structure
9. Possible rotation for n-Butane
C – C – CH2-CH3
H
HH
HH
1 2
H3C – C – C – CH3
HH
H H
32
Rotation around C1 and C2
Rotation around C2 and C3
Structure I Structure II *
10. Conformations of n-Butane
• Butane has three carbon-carbon single bond
and molecule can rotate about each of them .
• If the rotation will be about C2 and C3 bond
then confirmation will be symmetrical.
• Different conformation of butane can be
obtained by rotating about its middle carbon-
carbon single bond.
11. 60° 120°
360° 300°
240°
180°
H3C
H3CH3C
H3C
CH3
CH3
CH3CH3
CH3
H3C
CH3
CH3
H3C
CH3
H
HH
H
H
H H
H
H
H
H
H
HH
H
H
H
H
H
H H
H
H
H
H H
H
H
(I)-Fully Eclipsed
Very high Repulsion
Very high Energy
Least stable
(II) – Staggered(Gauche)
Moderate Repulsion
Moderate Energy
Moderately stable
(III)-Partly Eclipsed
Repulsion high
Energy high
Less stable
(IV)-Staggered (Anti)
Repulsion less
Energy less
More stable
(VII)-Fully Eclipsed
Very high Repulsion
Very high Energy
Least stable
(VI) – Staggered(Gauche)
Moderate Repulsion
Moderate Energy
Moderately stable
(V)-Partly Eclipsed
Repulsion high
Energy high
Less stable
12. Conformers of n-Butane
• Butane has 3 staggered (II,IV,VI) conformer.
• IV (Anti conformer), in which the two methyl
group are as far apart as possible is more
stable and require very less energy.
• II , VI (Gauche conformer)
• Butane has 3 eclipsed (I/VII,III,V)
• I and VII are fully eclipsed
• III and V are Partly eclipsed
13. Energy level
• Potential energy of I,VII is greater followed by
III,V and II,VI. Conformer IV require very less
energy because bulky group CH3 is far apart.
• Stability of IV is greater than that of II,VI
followed by III, V and I,VII.
I ,VII > III, V > II, VI > IV
IV > II, VI > III, V > I, VII
16. 60° 120°
360°
300°
240°
180°
H3C
H3C
H3C
CH2-CH3
CH3
CH3
CH3
H3C-H2C
CH3
H
HH
H
H
H H
H
H
H
H
H
HH
H
H
H
H
H
H H
H
H
H
H H
H
H
CH2-CH3CH2-CH3
CH2-CH3
H3C-H2C
H3C-H2C
(I)- Eclipsed
Repulsion more
Energy more
Less stable
(II) - Staggered
Repulsion less
Energy less
More stable
(III)-Eclipsed
Repulsion more
Energy more
Less stable
(IV)-Staggered
Repulsion less
Energy less
More stable
(VI)-Staggered
Repulsion less
Energy less
More stable
(V)-Eclipsed
Repulsion more
Energy more
Less stable
(VII)-Eclipsed
Repulsion more
Energy more
Less stable
17. Energy level
• By doing so six possible confirmation can be
obtained out of which 3 are staggered (II,IV,VI)
and 3 are eclipsed form (I/VII,III,V).
• Potential energy of I,III,V,VII is greater than
that of II,IV,VI due to repulsive forces.
• Stability of II,IV,VI is greater than that of
I,III,V,VII.
I , III, V, VII > II , IV , VI
II, IV, VI > I , III , V , VII
