hetro

1. Oxazole & Thiazole
Dr. Gurumeet C Wadhawa
Department of Chemistry
Karmaveer Bhaurao Patil ,College
Vashi, Navi Mumbai

2. Properties
1. Aromaticity
O XA ZO LE
2018
2

3. Properties
1. Aromaticity
O XA ZO LE
3

4. Synthesis
1. Robinson-Gabriel synthesis
O XA ZO LE
4

5. Synthesis
1. Robinson-Gabriel synthesis
Mechanism
O XA ZO LE
5

6. Synthesis
2. From an α- Hydroxy - Carbonyl Component
O XA ZO LE
α- Hydroxy - Carbonyl Component ????
6

7. Synthesis
2. From an α- Hydroxy - Carbonyl Component
E.g.
O XA ZO LE
7

8. Synthesis
3. From Isocyanides
E.g.
O XA
ZO LE
8

9. O XA ZO LE
Reactions
1. Electrophilic addition to N
9

10. O XA ZO LE
Reactions
2. Electrophilic substitution to C
10

11. O XA ZO LE
Reactions
3. Diels-Alder Reaction
11

12. O XA ZO LE
Reactions
3. Diels-Alder Reaction
12

13. O XA ZO LE
Reactions
3. Diels-Alder Reaction
(2) Kondrat'eva pyridine synthesis
13

14. O XA ZO LE
Reactions
3. Diels-Alder Reaction
(2) Kondrat'eva pyridine synthesis
14

15. O XA ZO LE
Medicinal uses
15

16. Properties
1. Aromaticity
TH I A ZO LE
16

17. Properties
1. Aromaticity
TH I A ZO LE
17

18. Synthesis
1. Gabriel synthesis
TH I A ZO LE
18

19. Synthesis
1. Gabriel synthesis
Mechanism
TH I A ZO LE
19

20. Synthesis
2. From an α- Hydroxy - Carbonyl Component
( Hantzsch Thiazole Synthesis)
TH I A ZO LE
20

21. Synthesis
2. From an α- Hydroxy - Carbonyl Component
( Hantzsch Thiazole Synthesis)
Mechanism
TH I A ZO LE
21

22. Synthesis
3. From an thiocyanate salts
TH I A
ZO LE
22

23. TH I A ZO LE
23
Reactions
1. Electrophilic addition to N
a. Protonation (basic property)

24. TH I A ZO LE
2018 24
Reactions
2. Electrophilic substitution to C

25. TH I A ZO LE
25
Reactions
2. Electrophilic substitution to C

26. TH I A ZO LE
2018 26
Reactions

27. TH I A ZO LE
27
Medicinal uses

28. TH I A ZO LE
28
Medicinal uses