The document discusses the properties, synthesis, reactions, and medicinal uses of oxazole and thiazole. It describes three common methods for synthesizing each heterocycle - the Robinson-Gabriel synthesis, from an alpha-hydroxy carbonyl component, and from isocyanides/thiocyanate salts. Key reactions include electrophilic addition and substitution. Oxazole and thiazole have various applications in medicinal chemistry.

1. Oxazole & Thiazole
Dr. Gurumeet C Wadhawa
Department of Chemistry
Karmaveer Bhaurao Patil ,College
Vashi, Navi Mumbai

2. Properties
1. Aromaticity
O XA ZO LE
2018
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3. Properties
1. Aromaticity
O XA ZO LE
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4. Synthesis
1. Robinson-Gabriel synthesis
O XA ZO LE
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5. Synthesis
1. Robinson-Gabriel synthesis
Mechanism
O XA ZO LE
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6. Synthesis
2. From an α- Hydroxy - Carbonyl Component
O XA ZO LE
α- Hydroxy - Carbonyl Component ????
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7. Synthesis
2. From an α- Hydroxy - Carbonyl Component
E.g.
O XA ZO LE
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8. Synthesis
3. From Isocyanides
E.g.
O XA
ZO LE
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9. O XA ZO LE
Reactions
1. Electrophilic addition to N
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10. O XA ZO LE
Reactions
2. Electrophilic substitution to C
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11. O XA ZO LE
Reactions
3. Diels-Alder Reaction
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12. O XA ZO LE
Reactions
3. Diels-Alder Reaction
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13. O XA ZO LE
Reactions
3. Diels-Alder Reaction
(2) Kondrat'eva pyridine synthesis
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14. O XA ZO LE
Reactions
3. Diels-Alder Reaction
(2) Kondrat'eva pyridine synthesis
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15. O XA ZO LE
Medicinal uses
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16. Properties
1. Aromaticity
TH I A ZO LE
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17. Properties
1. Aromaticity
TH I A ZO LE
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18. Synthesis
1. Gabriel synthesis
TH I A ZO LE
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19. Synthesis
1. Gabriel synthesis
Mechanism
TH I A ZO LE
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20. Synthesis
2. From an α- Hydroxy - Carbonyl Component
( Hantzsch Thiazole Synthesis)
TH I A ZO LE
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21. Synthesis
2. From an α- Hydroxy - Carbonyl Component
( Hantzsch Thiazole Synthesis)
Mechanism
TH I A ZO LE
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22. Synthesis
3. From an thiocyanate salts
TH I A
ZO LE
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23. TH I A ZO LE
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Reactions
1. Electrophilic addition to N
a. Protonation (basic property)

24. TH I A ZO LE
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Reactions
2. Electrophilic substitution to C

25. TH I A ZO LE
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Reactions
2. Electrophilic substitution to C

26. TH I A ZO LE
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Reactions

27. TH I A ZO LE
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Medicinal uses

28. TH I A ZO LE
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Medicinal uses