This PPT describes about Five membered heterocyclic compound with oxygen atom

2. Furan
• Furan is a heterocyclic organic compound,
consisting of a five-membered aromatic ring
with four carbon atoms and one oxygen. The
class of compounds containing such rings are
also referred to as furans.

5. Physical properties
• It is colorless, flammable and highly volatile
liquid.
• Melting point: -85.6°C
• Boiling Point: 31.3°C
• Soluble in alcohol, ether and acetone but
slightly soluble in water
• Toxic and may be carcinogenic.

6. Chemical properties

8. Acidity and Basicity
• The basicity of Furan is weaker than Pyrroles
as well as benzo derivatives.
• By comparing the basicity of pyrrole with that
of model used for non-aromatic compounds ,
their aromatic resonance energy can be
calculated.

9. SYNTHESIS OF FURAN

12. 4. Decarboxylation of furoic acid
5.At commercial level, furan is prepared by
utilising the agricultural waste containing
pentosans

13. • Furfural obtained from acid hydrolysis of
pentosans (C5 polysaccharides) results in the
synthesis of Furan.

17. Hydrogenation / Reduction
• At 125°C and 100 atm pressure.

19. For Pyrrole synthesis

21. Medicinal uses
• The Furan and its derivatives are used as
antimicrobial (antibacterial, antifungal and anti-
viral).
• Some of its derivatives show anti-inflammatory,
anti-depressant, anti-anxiolytics, analgesic,
Diuretics, anticholinergic and muscle relaxant.

23. 3.Furosemide : Loop diuretics (used in the
treatment of edema mainly in CHF, Kidney
failure and liver disease
4.Azidothymidine (AZT) : Also called Zidovudine.
Used for HIV/AIDS

24. Furfurex : Used as an appetite suppresant

25. Ask doubts if any.???
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