The document discusses the properties, synthesis methods, reactions, and medicinal uses of thiophene. It describes thiophene's aromaticity and three synthesis methods: Paal-Knorr, from sodium succinate, and Hinsberg. Thiophene undergoes electrophilic substitution at the second position and can also be reduced. It has various medicinal uses.

1. TH I O PH EN E
Dr. Gurumeet C Wadhawa
Department of Chemistry
Karmaveer Bhaurao Patil ,College
Vashi, Navi Mumbai

2. Properties
1. Aromaticity
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3. Properties
1. Aromaticity
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4. Properties
1. Aromaticity
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5. Synthesis
1. Paal-Knorr synthesis of thiophene
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6. Synthesis
1. Paal-Knorr synthesis of furan
Mechanism
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7. Synthesis
2. From sod. succinate
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8. Synthesis
3. Hinsberg Synthesis
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9. Reactions
1. Electrophilic substitution
thiophene undergoes electrophilic substitution reaction
at 2nd position
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10. Reactions
1. Electrophilic substitution
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11. Reactions
1. Electrophilic substitution
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12. Reactions
2. Reduction
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13. Reactions
3. reaction
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14. Medicinal uses
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15. Medicinal uses
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