This document provides information about helminths (parasitic worms) that infect humans. It begins with objectives and classifications of helminths. Nematodes (roundworms) are then described in more detail, including their general features, habitats, life cycles and diseases caused like ascariasis, pinworm infection and whipworm infection. Hookworms are also discussed. Platyhelminthes (tapeworms and flukes) are then introduced, with descriptions of cestodes (tapeworms) like Taenia saginata and Taenia solium, and preventive measures for helminth infections are mentioned.
Balantidium coli is a protozoan parasite that causes the disease balantidiasis in humans. It has two stages - a trophozoite stage where it reproduces and feeds, and an infective cyst stage. Humans typically become infected through ingesting cysts from fecally contaminated food or water. The cysts excyst in the small intestine and trophozoites take up residence in the large intestine, where they can cause symptoms like diarrhea, abdominal pain, and dysentery. Diagnosis is via stool examination or biopsy. Treatment involves antibiotics like tetracycline, metronidazole, or iodoquinol. Prevention focuses on sanitary disposal of human and pig feces to avoid
Cryptosporidiosis is caused by Cryptosporidium parasites and causes diarrhea in livestock and humans. It is transmitted through the fecal-oral route. There are 18 known Cryptosporidium species that can infect humans and animals. Some species only infect single host types while others can infect multiple species. Cryptosporidium forms oocysts that are resistant to chlorine and can lead to large waterborne outbreaks like the 1993 Milwaukee outbreak that infected 400,000 people. Symptoms in humans and livestock include watery diarrhea. There is no vaccine and treatment involves supportive care. Prevention involves handwashing and avoiding contact with infected individuals and young animals.
Fasciola hepatica, commonly known as the sheep liver fluke, is a parasitic flatworm that infects the livers of sheep and cattle. It can also infect humans. The adult fluke lives in the bile ducts of the liver and lays eggs that pass in the feces. The life cycle requires an intermediate snail host to continue development. People become infected by ingesting metacercariae encysted on aquatic plants like watercress. Clinical symptoms in humans range from fever and abdominal pain during migration to liver damage and obstruction of the bile ducts in chronic infections. Diagnosis is confirmed by finding characteristic eggs in stool or biopsy samples. Treatment involves medications like triclabendazole.
This document discusses Wuchereria bancrofti and Brugia malayi, the causative agents of lymphatic filariasis. It covers the pathogenesis, clinical manifestations, laboratory diagnosis, prevention and treatment of these parasitic roundworm infections. The key points are:
1. W. bancrofti and B. malayi are transmitted by mosquitoes and cause lymphatic obstruction and inflammation leading to lymphedema, elephantiasis, and hydrocele.
2. Clinical manifestations range from asymptomatic infections to lymphedema and elephantiasis of the legs, arms, breasts, and genitals.
3. Microfilariae can be detected by blood
Paramyxoviruses are larger RNA viruses that have a single piece of RNA genome and are not liable to antigenic variation. They include parainfluenza virus, mumps virus, measles virus, and respiratory syncytial virus (RSV). Parainfluenza viruses cause respiratory infections in children and adults. Mumps virus causes mumps or parotitis disease of childhood and can lead to complications like meningitis. Measles virus causes a highly infectious childhood disease and RSV is a major cause of bronchiolitis and pneumonitis in infants under 6 months old. These viruses are diagnosed through direct demonstration of viral antigens, virus isolation, and serological tests.
Microsporidia are obligate intracellular parasites with spores that range from 1-20 micrometers in length. They infect host cells through a unique polar tube structure. The microsporidian life cycle involves the spore injecting its contents into the host cell, proliferating within the cell, and then releasing new spores to infect other cells. Epidemiological data shows human microsporidia infections are often underreported but can be found worldwide, with transmission occurring through oral-fecal routes, inhalation, or possibly water sources. The host immune response plays a key role in controlling microsporidian infections.
The document discusses arboviruses, which are viruses transmitted by arthropod vectors like mosquitoes and ticks. It describes the characteristics and transmission cycles of arboviruses, examples of diseases they cause like dengue, yellow fever and Japanese encephalitis, and the viruses that cause these diseases including togaviruses and flaviviruses. Key information provided includes the virus families and genera, vectors involved in transmission, symptoms of associated diseases, and prevention and treatment methods.
Fasciola hepatica, also known as the common liver fluke, is a parasitic flatworm that infects the livers of sheep and cattle. Its complex life cycle involves freshwater snails acting as intermediate hosts. Humans can become accidentally infected by consuming raw freshwater plants containing the fluke larvae. The flukes mature and reproduce in the bile ducts of the liver, causing a disease called fascioliasis. Symptoms range from asymptomatic to abdominal pain and liver damage. Diagnosis involves examining stool samples for fluke eggs or conducting imaging tests and antibody tests. Treatment primarily involves administering deworming medications like triclabendazole or bithionol.
Balantidium coli is a protozoan parasite that causes the disease balantidiasis in humans. It has two stages - a trophozoite stage where it reproduces and feeds, and an infective cyst stage. Humans typically become infected through ingesting cysts from fecally contaminated food or water. The cysts excyst in the small intestine and trophozoites take up residence in the large intestine, where they can cause symptoms like diarrhea, abdominal pain, and dysentery. Diagnosis is via stool examination or biopsy. Treatment involves antibiotics like tetracycline, metronidazole, or iodoquinol. Prevention focuses on sanitary disposal of human and pig feces to avoid
Cryptosporidiosis is caused by Cryptosporidium parasites and causes diarrhea in livestock and humans. It is transmitted through the fecal-oral route. There are 18 known Cryptosporidium species that can infect humans and animals. Some species only infect single host types while others can infect multiple species. Cryptosporidium forms oocysts that are resistant to chlorine and can lead to large waterborne outbreaks like the 1993 Milwaukee outbreak that infected 400,000 people. Symptoms in humans and livestock include watery diarrhea. There is no vaccine and treatment involves supportive care. Prevention involves handwashing and avoiding contact with infected individuals and young animals.
Fasciola hepatica, commonly known as the sheep liver fluke, is a parasitic flatworm that infects the livers of sheep and cattle. It can also infect humans. The adult fluke lives in the bile ducts of the liver and lays eggs that pass in the feces. The life cycle requires an intermediate snail host to continue development. People become infected by ingesting metacercariae encysted on aquatic plants like watercress. Clinical symptoms in humans range from fever and abdominal pain during migration to liver damage and obstruction of the bile ducts in chronic infections. Diagnosis is confirmed by finding characteristic eggs in stool or biopsy samples. Treatment involves medications like triclabendazole.
This document discusses Wuchereria bancrofti and Brugia malayi, the causative agents of lymphatic filariasis. It covers the pathogenesis, clinical manifestations, laboratory diagnosis, prevention and treatment of these parasitic roundworm infections. The key points are:
1. W. bancrofti and B. malayi are transmitted by mosquitoes and cause lymphatic obstruction and inflammation leading to lymphedema, elephantiasis, and hydrocele.
2. Clinical manifestations range from asymptomatic infections to lymphedema and elephantiasis of the legs, arms, breasts, and genitals.
3. Microfilariae can be detected by blood
Paramyxoviruses are larger RNA viruses that have a single piece of RNA genome and are not liable to antigenic variation. They include parainfluenza virus, mumps virus, measles virus, and respiratory syncytial virus (RSV). Parainfluenza viruses cause respiratory infections in children and adults. Mumps virus causes mumps or parotitis disease of childhood and can lead to complications like meningitis. Measles virus causes a highly infectious childhood disease and RSV is a major cause of bronchiolitis and pneumonitis in infants under 6 months old. These viruses are diagnosed through direct demonstration of viral antigens, virus isolation, and serological tests.
Microsporidia are obligate intracellular parasites with spores that range from 1-20 micrometers in length. They infect host cells through a unique polar tube structure. The microsporidian life cycle involves the spore injecting its contents into the host cell, proliferating within the cell, and then releasing new spores to infect other cells. Epidemiological data shows human microsporidia infections are often underreported but can be found worldwide, with transmission occurring through oral-fecal routes, inhalation, or possibly water sources. The host immune response plays a key role in controlling microsporidian infections.
The document discusses arboviruses, which are viruses transmitted by arthropod vectors like mosquitoes and ticks. It describes the characteristics and transmission cycles of arboviruses, examples of diseases they cause like dengue, yellow fever and Japanese encephalitis, and the viruses that cause these diseases including togaviruses and flaviviruses. Key information provided includes the virus families and genera, vectors involved in transmission, symptoms of associated diseases, and prevention and treatment methods.
Fasciola hepatica, also known as the common liver fluke, is a parasitic flatworm that infects the livers of sheep and cattle. Its complex life cycle involves freshwater snails acting as intermediate hosts. Humans can become accidentally infected by consuming raw freshwater plants containing the fluke larvae. The flukes mature and reproduce in the bile ducts of the liver, causing a disease called fascioliasis. Symptoms range from asymptomatic to abdominal pain and liver damage. Diagnosis involves examining stool samples for fluke eggs or conducting imaging tests and antibody tests. Treatment primarily involves administering deworming medications like triclabendazole or bithionol.
Rhabdoviruses are a family of viruses that contain negative-stranded RNA and infect vertebrates including humans. They are transmitted primarily through animal bites. The most common rhabdovirus that infects humans is the rabies virus. Rabies virus causes an acute viral infection of the central nervous system that is nearly always fatal if post-exposure prophylaxis is not administered.
The document discusses Bartonella species, which are small Gram-negative bacteria transmitted by arthropods that can infect mammals. It provides details on several human pathogenic Bartonella species, including B. bacilliformis which causes Oroya fever, B. quintana which causes trench fever, and B. henselae which causes cat scratch disease. The document also examines the clinical manifestations, reservoirs, vectors, methods of transmission, diagnosis and treatment of diseases caused by different Bartonella species.
This document discusses cestodes (tapeworms) and provides information on their morphology, life cycles, and diseases they cause in humans. It describes the general characteristics of cestodes, including their segmented, tape-like shape and lack of digestive system. It separates cestodes into two main groups - pseudophyllidean and cyclophyllidean - and provides differences between them. Specific tapeworms discussed include Diphyllobothrium latum, Taenia solium, Taenia saginata, and Echinococcus granulosus. The larval forms and life cycles of these tapeworms are described, as well as the diseases they can cause, such as cysticercosis and hydat
Shigellosis = inflammation of intestines (especially the colon) with accompanying severe abdominal cramps, tenesmus and frequent, low-volume stools containing blood, mucus and fecal leukocytes.
Chickenpox is caused by the varicella-zirus, an enveloped virus 200nm in diameter and 300nm in length with linear, double-stranded segmented DNA. It spreads through coughing, sneezing or sharing food/drink and causes skin lesions and fever. Treatment can be done at home with calamine lotion but serious cases require seeing a doctor. The chickenpox vaccine can prevent it, especially for young children, and having it once makes one immune from getting it again.
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
Trichuris trichiura, also known as the whipworm, inhabits the large intestine of humans. The female produces 2,000-10,000 eggs per day which are passed in feces. Eggs become infective in soil after 2-3 weeks. People are infected by ingesting infective eggs from contaminated food, water, or hands. Worms attach to the intestinal mucosa and can live up to 5 years. Heavy infections may cause symptoms like bloody mucus stool. Diagnosis is by finding eggs in stool samples through sedimentation or flotation techniques.
This document discusses several types of mycoplasma bacteria. It describes their morphology, cultural characteristics, and the diseases they cause. The most common pathogenic mycoplasma are M. pneumoniae, M. hominis, M. urealyticum, and M. genitalium. M. pneumoniae causes atypical pneumonia. M. hominis and M. urealyticum can cause infections in the urogenital tract and lead to infertility. M. genitalium is associated with urethritis and pelvic inflammatory disease. Laboratory diagnosis involves culture studies, biochemical studies, and serological tests like complement fixation and ELISA. Tetracycline and erythromycin are commonly used for treatment
Clostridium is a genus of gram-positive, anaerobic, spore-forming bacteria. Some Clostridium species are pathogenic and can cause diseases like gas gangrene, tetanus, and botulism by producing toxins. Clostridium perfringens is a species that can cause gas gangrene through tissue destruction mediated by toxins and enzymatic activity. It is identified through culture, Gram staining, and tests like Nagler's reaction that detect lecithinase production. Treatment of gas gangrene involves prompt surgical debridement and antibiotics.
This document discusses coccidian protozoa, an obligate intestinal parasite found worldwide in subtropical and tropical regions. It has a complex life cycle involving both sexual and asexual reproduction. Symptoms in humans include diarrhea, abdominal pain, and weight loss. It is transmitted through the fecal-oral route due to ingestion of contaminated food or water in areas with poor sanitation. Diagnosis involves finding oocysts in stool samples under a microscope. Treatment involves antibiotics like trimethoprim/sulfamethoxazole. Prevention relies on proper sanitation and hygiene practices.
1. Hymenolepis nana, also known as the dwarf tapeworm, and Hymenolepis diminuta, also known as the rat tapeworm, are the two species of tapeworms that can infect humans.
2. H. nana has a direct life cycle and can re-infect its host without an intermediate host, while H. diminuta requires an arthropod intermediate host.
3. Symptoms of infection are usually mild but large numbers of worms can cause abdominal pain, diarrhea, and dehydration in humans, particularly children or those with weak immune systems. Treatment is with praziquantel.
Largest viruses that infect vertebrates
Can be seen under light microscope
Poxvirus diseases are characterized by skin lesions – localized or generalized
Important diseases caused by poxviruses are-
Smallpox
Monkeypox
Cowpox
Tanapox
Molluscum contagiosum
Hymenolepis nana, also known as the dwarf tapeworm, is the most common tapeworm infection in humans. It can be found worldwide but is most common in areas with poor sanitation. H. nana lives in the small intestine and can reproduce asexually inside the host, allowing infections to persist for years. Symptoms may include nausea, weakness, and diarrhea. Diagnosis is confirmed by finding H. nana eggs in stool samples. Treatment involves antiparasitic medications like praziquantel or niclosamide. Prevention focuses on good hygiene, sanitation, and eliminating rodent hosts.
This document describes the liver fluke Fasciola hepatica and Fasciola gigantica. It details their taxonomy, life cycle, transmission, symptoms, diagnosis and treatment. Fasciola species have a complex life cycle involving an aquatic snail as the first intermediate host and water plants as the second intermediate host. Humans and ruminants can become infected by ingesting metacercariae on contaminated water plants or water. Infection causes fascioliasis and symptoms range from asymptomatic to abdominal pain. Diagnosis involves finding eggs in stool or through serology. Treatment includes drugs like bithionol and triclabendazole.
There are over 100,000 known fungal species that inhabit different environments. Only around 600 species can cause disease in humans. Historically, invasive fungal infections were rare in immunocompromised patients but have increased in recent decades due to factors like improved diagnostics and more immunosuppressed individuals. Fungi use various virulence factors like thermal tolerance, dimorphism, and production of toxins or extracellular enzymes to establish infections by evading or weakening the host's immune response.
Giardia duodenalis is a flagellated protozoan parasite that causes giardiasis. It has both a trophozoite and cyst stage. The trophozoite lives in the small intestine where it attaches to epithelial cells and feeds on mucus, interfering with absorption. It can cause diarrhea and malabsorption. The cyst forms when trophozoites pass through the large intestine and are excreted in feces. Cysts are hardy and infect new hosts when ingested. Giardiasis is common worldwide and transmitted through contaminated water. Treatment involves metronidazole antibiotics.
Strategies Novartis can use to GROW from a Billion Dollar Company to a Trillion Dollar Company like Alphabet Inc
Novartis is a leading healthcare company which is situated in Switzerland and uses digital technologies and innovative science to come up with transformative ways of treatment in areas of great medicinal needs. This article explains what Novartis strategies and what they should employ so that they can rise from a billion dollar company to a trillion dollar company like the Google Alphabet Inc.
Novartis was formed in March 1996 by the merging of pharmaceutical and agrochemical divisions of Ciba-Geigy and Sandoz companies. Thanks to the merging of the two companies, Novartis is one of the biggest pharmaceutical companies in the world. Novartis is one of the largest companies which achieved a great milestone within a few decades. Novartis as a whole is divided into three major divisions: Sandoz (generics), Innovative Medicines and Alcon (eyecare). Novartis is also involved in collaborative research projects that are publicly funded.
Below are some of Novartis best selling drugs and their revenue
1.Cosenty – This is the top selling drug with a revenue of 4.788 billion dollars
2.Enfresto – This has a revenue of 4.644 billions dollars
3.Promacta – This has a revenue 0f 2.088 billion dollars
Medicine manufactured by Novartis and their uses
Medicine Medicine use
Cosentyx Used to treat psoriatic arthritis
Entresto Used to treat heart failure
Lucentis Used to block abnormal vessel growth in the back of the eye
Tasigna Used to treat chronic myelogenous leukemia which has the Philadelphia chromosome
Jakavi Used to treat myelofibrosis, polycythemia vera and graft-versus-host disease
Promacta Used to treat patients with abnormal low platelet count
Sandostatin Used to treat patients with tumor experiencing symptoms like flushing and diarrhea
Xolair Used to treat moderate and severe asthma
Gilenya Used to treat multiple sclerosis
How Novartis became one of the biggest pharmaceutical companies in the world
1.Market control through partnership
Geigy, Sandoz and Ciba combined their power so that they can compete with strong foreign firms and formed a cartel called the Basal Syndicate or Basal IG. Basal IG secured most of the manufacturing facilities all over the US and across Europe. It later joined with IG Farben and other chemical companies to form a big cartel called the Quadrapartite Cartel which dominated all of the European market and enjoyed the profits made from the joint manufacturing.
2.Growth acceleration through mergers
Since competition was very rampant in the pharmaceutical industry, Ciba and Geigy decided to merge with Sandoz AG to form Novartis. With this merge, Novartis became one of the growing giants in the pharmaceutical industry. This made Novartis gain a lot of fame and build a strong reputation over other companies. Novartis majored on agrochemical and pharmaceutical industries which made it easy to focus on a specific mar
1. Tapeworms are parasitic flatworms that consist of a head called a scolex and a long segmented body called a strobila. They attach to the intestinal wall of their host and absorb nutrients.
2. Common tapeworms discussed include Diphyllobothrium latum, Taenia solium, Taenia saginata, Hymenolepis nana, Echinococcus granulosus, and Echinococcus multilocularis. Their life cycles involve an intermediate host and definitive host, usually transmitting between via ingestion of eggs from feces.
3. Symptoms from tapeworm infections can range from asymptomatic to abdominal pain, diarrhea, and nutritional deficiencies. Diagnosis
Rhabdoviruses are a family of viruses that contain negative-stranded RNA and infect vertebrates including humans. They are transmitted primarily through animal bites. The most common rhabdovirus that infects humans is the rabies virus. Rabies virus causes an acute viral infection of the central nervous system that is nearly always fatal if post-exposure prophylaxis is not administered.
The document discusses Bartonella species, which are small Gram-negative bacteria transmitted by arthropods that can infect mammals. It provides details on several human pathogenic Bartonella species, including B. bacilliformis which causes Oroya fever, B. quintana which causes trench fever, and B. henselae which causes cat scratch disease. The document also examines the clinical manifestations, reservoirs, vectors, methods of transmission, diagnosis and treatment of diseases caused by different Bartonella species.
This document discusses cestodes (tapeworms) and provides information on their morphology, life cycles, and diseases they cause in humans. It describes the general characteristics of cestodes, including their segmented, tape-like shape and lack of digestive system. It separates cestodes into two main groups - pseudophyllidean and cyclophyllidean - and provides differences between them. Specific tapeworms discussed include Diphyllobothrium latum, Taenia solium, Taenia saginata, and Echinococcus granulosus. The larval forms and life cycles of these tapeworms are described, as well as the diseases they can cause, such as cysticercosis and hydat
Shigellosis = inflammation of intestines (especially the colon) with accompanying severe abdominal cramps, tenesmus and frequent, low-volume stools containing blood, mucus and fecal leukocytes.
Chickenpox is caused by the varicella-zirus, an enveloped virus 200nm in diameter and 300nm in length with linear, double-stranded segmented DNA. It spreads through coughing, sneezing or sharing food/drink and causes skin lesions and fever. Treatment can be done at home with calamine lotion but serious cases require seeing a doctor. The chickenpox vaccine can prevent it, especially for young children, and having it once makes one immune from getting it again.
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
Trichuris trichiura, also known as the whipworm, inhabits the large intestine of humans. The female produces 2,000-10,000 eggs per day which are passed in feces. Eggs become infective in soil after 2-3 weeks. People are infected by ingesting infective eggs from contaminated food, water, or hands. Worms attach to the intestinal mucosa and can live up to 5 years. Heavy infections may cause symptoms like bloody mucus stool. Diagnosis is by finding eggs in stool samples through sedimentation or flotation techniques.
This document discusses several types of mycoplasma bacteria. It describes their morphology, cultural characteristics, and the diseases they cause. The most common pathogenic mycoplasma are M. pneumoniae, M. hominis, M. urealyticum, and M. genitalium. M. pneumoniae causes atypical pneumonia. M. hominis and M. urealyticum can cause infections in the urogenital tract and lead to infertility. M. genitalium is associated with urethritis and pelvic inflammatory disease. Laboratory diagnosis involves culture studies, biochemical studies, and serological tests like complement fixation and ELISA. Tetracycline and erythromycin are commonly used for treatment
Clostridium is a genus of gram-positive, anaerobic, spore-forming bacteria. Some Clostridium species are pathogenic and can cause diseases like gas gangrene, tetanus, and botulism by producing toxins. Clostridium perfringens is a species that can cause gas gangrene through tissue destruction mediated by toxins and enzymatic activity. It is identified through culture, Gram staining, and tests like Nagler's reaction that detect lecithinase production. Treatment of gas gangrene involves prompt surgical debridement and antibiotics.
This document discusses coccidian protozoa, an obligate intestinal parasite found worldwide in subtropical and tropical regions. It has a complex life cycle involving both sexual and asexual reproduction. Symptoms in humans include diarrhea, abdominal pain, and weight loss. It is transmitted through the fecal-oral route due to ingestion of contaminated food or water in areas with poor sanitation. Diagnosis involves finding oocysts in stool samples under a microscope. Treatment involves antibiotics like trimethoprim/sulfamethoxazole. Prevention relies on proper sanitation and hygiene practices.
1. Hymenolepis nana, also known as the dwarf tapeworm, and Hymenolepis diminuta, also known as the rat tapeworm, are the two species of tapeworms that can infect humans.
2. H. nana has a direct life cycle and can re-infect its host without an intermediate host, while H. diminuta requires an arthropod intermediate host.
3. Symptoms of infection are usually mild but large numbers of worms can cause abdominal pain, diarrhea, and dehydration in humans, particularly children or those with weak immune systems. Treatment is with praziquantel.
Largest viruses that infect vertebrates
Can be seen under light microscope
Poxvirus diseases are characterized by skin lesions – localized or generalized
Important diseases caused by poxviruses are-
Smallpox
Monkeypox
Cowpox
Tanapox
Molluscum contagiosum
Hymenolepis nana, also known as the dwarf tapeworm, is the most common tapeworm infection in humans. It can be found worldwide but is most common in areas with poor sanitation. H. nana lives in the small intestine and can reproduce asexually inside the host, allowing infections to persist for years. Symptoms may include nausea, weakness, and diarrhea. Diagnosis is confirmed by finding H. nana eggs in stool samples. Treatment involves antiparasitic medications like praziquantel or niclosamide. Prevention focuses on good hygiene, sanitation, and eliminating rodent hosts.
This document describes the liver fluke Fasciola hepatica and Fasciola gigantica. It details their taxonomy, life cycle, transmission, symptoms, diagnosis and treatment. Fasciola species have a complex life cycle involving an aquatic snail as the first intermediate host and water plants as the second intermediate host. Humans and ruminants can become infected by ingesting metacercariae on contaminated water plants or water. Infection causes fascioliasis and symptoms range from asymptomatic to abdominal pain. Diagnosis involves finding eggs in stool or through serology. Treatment includes drugs like bithionol and triclabendazole.
There are over 100,000 known fungal species that inhabit different environments. Only around 600 species can cause disease in humans. Historically, invasive fungal infections were rare in immunocompromised patients but have increased in recent decades due to factors like improved diagnostics and more immunosuppressed individuals. Fungi use various virulence factors like thermal tolerance, dimorphism, and production of toxins or extracellular enzymes to establish infections by evading or weakening the host's immune response.
Giardia duodenalis is a flagellated protozoan parasite that causes giardiasis. It has both a trophozoite and cyst stage. The trophozoite lives in the small intestine where it attaches to epithelial cells and feeds on mucus, interfering with absorption. It can cause diarrhea and malabsorption. The cyst forms when trophozoites pass through the large intestine and are excreted in feces. Cysts are hardy and infect new hosts when ingested. Giardiasis is common worldwide and transmitted through contaminated water. Treatment involves metronidazole antibiotics.
Strategies Novartis can use to GROW from a Billion Dollar Company to a Trillion Dollar Company like Alphabet Inc
Novartis is a leading healthcare company which is situated in Switzerland and uses digital technologies and innovative science to come up with transformative ways of treatment in areas of great medicinal needs. This article explains what Novartis strategies and what they should employ so that they can rise from a billion dollar company to a trillion dollar company like the Google Alphabet Inc.
Novartis was formed in March 1996 by the merging of pharmaceutical and agrochemical divisions of Ciba-Geigy and Sandoz companies. Thanks to the merging of the two companies, Novartis is one of the biggest pharmaceutical companies in the world. Novartis is one of the largest companies which achieved a great milestone within a few decades. Novartis as a whole is divided into three major divisions: Sandoz (generics), Innovative Medicines and Alcon (eyecare). Novartis is also involved in collaborative research projects that are publicly funded.
Below are some of Novartis best selling drugs and their revenue
1.Cosenty – This is the top selling drug with a revenue of 4.788 billion dollars
2.Enfresto – This has a revenue of 4.644 billions dollars
3.Promacta – This has a revenue 0f 2.088 billion dollars
Medicine manufactured by Novartis and their uses
Medicine Medicine use
Cosentyx Used to treat psoriatic arthritis
Entresto Used to treat heart failure
Lucentis Used to block abnormal vessel growth in the back of the eye
Tasigna Used to treat chronic myelogenous leukemia which has the Philadelphia chromosome
Jakavi Used to treat myelofibrosis, polycythemia vera and graft-versus-host disease
Promacta Used to treat patients with abnormal low platelet count
Sandostatin Used to treat patients with tumor experiencing symptoms like flushing and diarrhea
Xolair Used to treat moderate and severe asthma
Gilenya Used to treat multiple sclerosis
How Novartis became one of the biggest pharmaceutical companies in the world
1.Market control through partnership
Geigy, Sandoz and Ciba combined their power so that they can compete with strong foreign firms and formed a cartel called the Basal Syndicate or Basal IG. Basal IG secured most of the manufacturing facilities all over the US and across Europe. It later joined with IG Farben and other chemical companies to form a big cartel called the Quadrapartite Cartel which dominated all of the European market and enjoyed the profits made from the joint manufacturing.
2.Growth acceleration through mergers
Since competition was very rampant in the pharmaceutical industry, Ciba and Geigy decided to merge with Sandoz AG to form Novartis. With this merge, Novartis became one of the growing giants in the pharmaceutical industry. This made Novartis gain a lot of fame and build a strong reputation over other companies. Novartis majored on agrochemical and pharmaceutical industries which made it easy to focus on a specific mar
1. Tapeworms are parasitic flatworms that consist of a head called a scolex and a long segmented body called a strobila. They attach to the intestinal wall of their host and absorb nutrients.
2. Common tapeworms discussed include Diphyllobothrium latum, Taenia solium, Taenia saginata, Hymenolepis nana, Echinococcus granulosus, and Echinococcus multilocularis. Their life cycles involve an intermediate host and definitive host, usually transmitting between via ingestion of eggs from feces.
3. Symptoms from tapeworm infections can range from asymptomatic to abdominal pain, diarrhea, and nutritional deficiencies. Diagnosis
Trichinella spiralis is a nematode that causes the disease trichinosis. It has a direct lifecycle between pigs and humans. Humans typically become infected by eating undercooked pork containing encysted larvae. The larvae are released in the stomach and penetrate the intestine to mature into adults. The females release larvae that travel through blood vessels to encyst in muscle tissue, where they can survive for years. Symptoms vary from none to severe muscle pain and inflammation depending on the infection level. Diagnosis involves muscle biopsy or serology. Treatment involves antiparasitic medication and corticosteroids for severe cases. Prevention focuses on properly cooking pork and controlling infection in pig populations.
Nematoda, or roundworms, are bilaterally symmetrical unsegmented worms that can be free-living or parasitic. They live throughout the world in various environments. Ascaris lumbricoides is one of the most common parasitic nematodes infecting humans. It lives in the small intestine where the female lays eggs that are passed in feces. After ingestion of embryonated eggs, the larvae hatch and migrate through tissues before maturing into adults in the intestine. Heavy infections can cause malnutrition and other complications.
Trichinella spiralis is a parasitic nematode that causes the disease trichinosis. It has a direct lifecycle between pigs and humans. Humans typically become infected by eating undercooked pork containing encysted larvae. The larvae are released in the stomach and mature into adult worms in the small intestine. Female worms release larvae that migrate and encapsulate themselves in skeletal muscle tissue. Symptoms vary from none to severe depending on worm burden and include intestinal and muscle stage manifestations. Diagnosis involves muscle biopsy, serology, or history of eating undercooked pork. Treatment includes albendazole or mebendazole with corticosteroids for severe cases. Prevention focuses on proper cooking of pork and controlling infection in
Hookworms are parasitic roundworms that infect the small intestine of humans. The two main species are Necator americanus and Ancylostoma duodenale. They are transmitted when infective larvae penetrate the skin or are swallowed. In the intestine, the adult worms attach and feed on blood, causing iron-deficiency anemia. Over 500 million people worldwide are infected with hookworms, which is prevalent in tropical and subtropical regions. Symptoms include abdominal pain, diarrhea, and anemia. Diagnosis involves finding eggs in stool samples, and treatment involves anthelmintic medications to kill the worms and iron supplements to treat anemia.
The document provides information on tapeworm parasites (order Cestoidea), including their classification, morphology, life cycles, transmission, clinical features, diagnosis and treatment. It discusses several important tapeworm species that can infect humans, including Taenia saginata, Taenia solium, Hymenolepis nana, Echinococcus granulosus, and Diphyllobothrium latum. Key details on the morphology, life cycles, epidemiology and clinical manifestations of each species are provided.
1) Ascaris lumbricoides, or the roundworm, is a parasitic nematode that infects the small intestine of humans. It is widely distributed in tropical and subtropical regions.
2) The adult female worm is 20-35 cm long and lays up to 200,000 eggs per day that are passed in feces. The eggs can survive for weeks in the environment before hatching.
3) Infection occurs through ingestion of embryonated eggs. The larvae hatch in the intestine, migrate through the body, and mature into adults in the small intestine where they reproduce, completing the life cycle. Heavy infections can cause intestinal obstruction, pancreatitis and other complications.
Classes of Aschelminthes Powerpoint PresentationFaizRehman50
This presentation describes two classes of aschelminthes that are phylum nematoda and phylum kinorhyncha
This presentation gives us basic information of these two phylas.
Dear all MBBS student ,
Myself Dr. Manish Tiwari department of microbiology (SMC Medical college unnao) this presentation only for you not for PG students, if any doubt contact me on mail address..
Taenia spp. are tapeworms with three main species - T. saginata, T. solium, and T. asiatica. They have a scolex that attaches to the intestine and segments containing eggs. T. saginata uses cattle as an intermediate host and infects humans who eat undercooked beef. T. multiceps uses sheep as an intermediate host and infects dogs and humans. T. hydatigena uses sheep, goats, cattle and pigs as intermediate hosts and infects dogs. The parasites are diagnosed through imaging, biopsy or examining stool samples, and treated with praziquantel, albendazole or surgery depending on the specific species and location
Study of parasites Hymenolepis nana, Taenia Echinococcus(), & Pneumocystis carinii
Treatment
Morphology
Life cycle
Pathogenesis
Laboratory diagnosis
Parasites
Hymenolepis nana – Cestode (Dwarf Tapeworm)
Taenia Echinococcus – Cestode (Dog Tapeworm)
Pneumocystis carinii - Sporozoan parasite
Hymenolepis nana
Geographical Distribution
Habitat
Morphology of Hymenolepis nana
Adult Worm
Eggs
Larva
Life cycle of Hymenolepis nana
Direct Cycle
Indirect Cycle
Hymenolepis nana - Life cycle
Life cycle of Hymenolepis nana
Pathogenesis of Hymenolepis nana
Laboratory diagnosis of Hymenolepis nana
Treatment of Hymenolepis nana
Prevention (Prophylaxis) of H. nana
Taenia Echinococcus
Echinococcus Genus: Tapeworm with carnivorous and herbivorous hosts.
Morphology of Taenia Echinococcus
Life Cycle of Taenia Echinococcus
1. The document describes the life cycles of several parasitic roundworms (nematodes) that infect humans, including Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Strongyloides stercoralis, and Trichinella spiralis.
2. It provides details on the morphology, life stages, transmission, localization in the host, and clinical manifestations of each parasite.
3. The life cycles generally involve eggs passing in feces and developing into infective larvae in the soil, which then penetrate the skin or are ingested to develop into adult worms that reproduce sexually and release eggs to complete the
This is an overview about parasites infest or affect the human eyes & principles of the diseases thay cause
A medical-student-made presentation for Ain Shams University - Faculty of Medicine - Department of Parasitology
Hope it help you
Classification of medical parasitology Lec.2.pptxnedalalazzwy
Parasitology is the scientific discipline concerned with the study of the biology of parasites and parasitic diseases, including the distribution, biochemistry, physiology, molecular biology, ecology, evolution and clinical aspects of parasites, including the host response to these agents.
This document summarizes various intestinal and tissue parasites that can infect humans through contaminated food or water. It describes the clinical presentations, locations of infection, and histopathological findings for parasites such as Giardia lamblia, Strongyloides stercoralis, hookworm, Trichuris trichura, Cryptosporidium, Enterobius vermicularis, Entamoeba histolytica, Anisakis, Trichinella spiralis, Dracunculus medinensis, Schistosoma species, Echinococcus granulosus, Taenia saginata, cysticercosis, and filarial worms. Definitive diagnosis of many parasitic infections requires identification of eggs,
This document discusses two species of hookworm, Necator americanus and Ancylostoma duodenale. It describes their morphology, including size, shape, mouth structures, and sexual characteristics. It also covers their life cycles, which involve eggs passing in feces and developing through larval stages in soil before penetrating the skin of a new host. In the host, the larvae mature into adults that reside in the small intestine and suck blood, potentially causing anemia. Diagnosis is made by finding hookworm eggs on microscopic exam of stool samples. Treatment involves antihelminthic medications like albendazole and mebendazole to kill the parasites.
lab of medical and health sciences by Abd Al Salam Najmsalamkrbooly
The three main blood flukes (Schistosoma species) that infect humans are S. mansoni, S. hematobium, and S. japonicum. They reside in the blood vessels of the definitive host and have separate sexes. The lifecycle involves an intermediate snail host that varies by species. Cercariae emerge from snails and can penetrate human skin, migrating through tissues and eventually residing in veins, where they pair and produce eggs. Eggs cause pathology and are excreted, potentially continuing the lifecycle if they reach water. Diagnosis involves finding eggs in stool, urine, or tissues depending on the infecting species.
This document summarizes flagellates, including their classification, morphology, and life cycles. It focuses on Giardia intestinalis and Trichomonas vaginalis. G. intestinalis has trophozoite and cyst stages, with the cyst being infective. It causes giardiasis by damaging the intestinal epithelium. T. vaginalis only exists as a trophozoite and causes trichomoniasis through overgrowth in the vagina when pH increases. Both can be diagnosed via microscopy of stool or vaginal samples and treated with metronidazole or tinidazole.
Unit 18 (B); Leukemia! A disease of white blood CellsRashidUllah7
Childhood leukemia is usually acute lymphocytic leukemia (ALL) which accounts for about 3/4 of childhood leukemia cases. Leukemia develops in the bone marrow where immature white blood cells are overproduced and do not mature correctly. The main types of childhood leukemia are ALL, AML, and rarely CML. ALL is the most common type and causes damaged by crowding out normal cells and spreading to other organs. Symptoms include fatigue, infections, bruising, and bone/joint pain. Testing of blood and bone marrow is used to diagnose leukemia and monitor treatment which aims to destroy leukemia cells through chemotherapy while supporting the patient.
Unit 18 (A); Paediatric Oncologyppt.pptxRashidUllah7
This document discusses cancer terminology, types, causes, symptoms, and medical management. It focuses on defining cancer and describing the etiology, pathophysiology, signs and symptoms. It discusses diagnostic tests and the medical and nursing approaches to treating patients with cancer, with specifics on breast cancer and ovarian cancer. Key points covered include the classification and naming of cancers based on origin, the differences between benign and malignant tumors, genetics and environmental factors that can cause cancer, and common nursing diagnoses and interventions for cancer patients.
Unit 16; CognitiveSensory dysfunctions and Rehabilitation.pptxRashidUllah7
This document defines and discusses several cognitive disorders: vision impairment, hearing impairment, and Down syndrome. It outlines the causes, signs/symptoms, diagnosis, treatment, nursing diagnoses, and interventions for each disorder. Vision impairment can be genetic, caused by infection or disease, trauma, or aging. Diagnosis involves visual acuity and field tests. Treatment includes glasses, contacts, eye drops or surgery. Hearing impairment is congenital or acquired from infection, disease, or injury. Diagnosis for infants uses brainstem response or emissions tests while older children have audiometry. Treatment includes hearing aids, cochlear implants, or surgery. Down syndrome is caused by a third copy of chromosome 21 and involves physical and developmental delays. Diagn
Unit 15; Neuro-muscular dysfunctions in Children.pptxRashidUllah7
The document provides information on the care of children with head injuries and cerebral palsy. It defines head injury and lists the most common causes as falls, motor vehicle accidents, bicycle accidents, and child abuse. It describes the types of head injuries such as skull fractures, concussions, and hematomas. It outlines the nursing management of head injuries which includes physical examination, monitoring neurological status, managing complications, and providing family support and education. It then discusses cerebral palsy, describing the types and outlining nursing care to address issues such as physical mobility, injury risk, communication problems, self-esteem, and family support.
Unit 14; Musculo-skeletal dysfunctions in Children.pptxRashidUllah7
This document provides an overview of pediatric musculoskeletal disorders including:
- Kyphosis, lordosis, and scoliosis - their causes, types, and treatment including bracing and spinal fusion surgery.
- Common fractures in children and their treatment involving reduction, retention with casting or traction.
- Rheumatoid arthritis in children including the different classifications of juvenile rheumatoid arthritis.
- Developmental dysplasia of the hip and its treatment with spica casting or Pavlik harness as well as nursing care.
10)Virus Properties Lecture Unit-I for stds.pptxRashidUllah7
Viruses are acellular organisms that contain either DNA or RNA as their genetic material. They come in a variety of shapes including spherical, helical, polyhedral, rod-shaped, brick-shaped, tadpole-shaped and bullet-shaped. Viruses must infect a host cell to replicate and use the host cell's machinery to produce more viruses. They have a protein coat called a capsid that may or may not be surrounded by a lipid envelope. Viruses are classified as DNA viruses or RNA viruses depending on whether their genetic material is DNA or RNA. Common DNA viruses include smallpox, herpes and hepatitis B viruses while common RNA viruses include polio, influenza, HIV and hepatitis C viruses.
4)Microbial Control Methods Unit-II 2.pptxRashidUllah7
This document discusses staining techniques used to visualize bacterial cells under a microscope. It describes simple staining, which uses a single dye to color all bacterial cells, and differential staining techniques like Gram staining that classify bacteria into groups. Gram staining involves staining cells with crystal violet dye, adding iodine as a mordant, washing with alcohol as a decolorizer, and counterstaining with safranin. This causes Gram-positive bacteria to appear violet and Gram-negative bacteria to appear pink based on differences in their cell wall structure. The document provides examples of staining Staphylococcus aureus, Bacillus subtilis and E. coli to demonstrate the staining results.
This document provides an overview of bacterial cell structure. It defines bacteria and lists their key characteristics, including being unicellular, prokaryotic, and reproducing through binary fission. It describes the three main shapes of bacteria and classifies them based on morphology, nutrition, temperature tolerance, and pH tolerance. The structure of bacterial cells is explained, including cellular components like the cell wall, flagella, pili, and endospores. Examples of medically important gram-positive and gram-negative bacteria are also provided.
Tuberculosis is a chronic infectious disease caused by the Mycobacterium tuberculosis bacterium. It primarily affects the lungs and is transmitted through airborne droplets. Common symptoms include cough, fever, weight loss and night sweats. Diagnosis involves sputum smear tests, chest x-rays and the Mantoux tuberculin skin test. Treatment consists of a multi-drug regimen over several months. Prevention focuses on vaccination, public education, isolation of infected individuals and improved sanitation.
This document summarizes information on four bacterial infections: cholera, diphtheria, pertussis, and tetanus. It provides definitions, symptoms, causative organisms, incubation periods, reservoirs, routes of entry, modes of transmission, occurrences, and methods of prevention, control, and treatment for each infection. Key details include that cholera causes rice watery stool through ingestion of contaminated food/water; diphtheria causes throat membrane through respiratory transmission; pertussis causes whooping cough through droplet transmission; and tetanus causes lockjaw through wound contamination. Prevention strategies include immunization, sanitation, and wound care.
The document classifies fungi into three main groups - Zygomycota, Ascomycota, and Basidiomycota. It then discusses fungal diseases (mycoses), classifying them into four types based on depth and mode of entry: systemic, cutaneous, subcutaneous, and opportunistic. Opportunistic mycoses often involve endogenous infections like candidiasis caused by the yeast Candida albicans in immunocompromised patients. The document also lists some common dermatomycoses (fungal skin infections) like tinea capitis, tinea faciei, and tinea pedis.
This document provides definitions and terminology related to anatomy and physiology. It defines key terms like anatomy, physiology, pathology, etiology, cells, tissues, organs, organ systems, and types of body movement. It also describes the levels of organization in the body from atoms to organ systems. Several anatomical directions, regions, and body cavities are outlined. The relationship between anatomy and physiology is described as anatomy explaining structure and physiology explaining function.
Meiosis is a type of cell division that produces gametes, such as sperm and egg cells, with half the number of chromosomes as the original parent cell. It involves two cell divisions: Meiosis I and Meiosis II. In Meiosis I, homologous chromosomes pair up and separate, reducing the chromosome number by half. Meiosis II then separates the sister chromatids, resulting in four haploid daughter cells each containing a single set of chromosomes. Meiosis introduces genetic variation through independent assortment and crossing over.
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
Temple of Asclepius in Thrace. Excavation resultsKrassimira Luka
The temple and the sanctuary around were dedicated to Asklepios Zmidrenus. This name has been known since 1875 when an inscription dedicated to him was discovered in Rome. The inscription is dated in 227 AD and was left by soldiers originating from the city of Philippopolis (modern Plovdiv).
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.pptHenry Hollis
The History of NZ 1870-1900.
Making of a Nation.
From the NZ Wars to Liberals,
Richard Seddon, George Grey,
Social Laboratory, New Zealand,
Confiscations, Kotahitanga, Kingitanga, Parliament, Suffrage, Repudiation, Economic Change, Agriculture, Gold Mining, Timber, Flax, Sheep, Dairying,
Beyond Degrees - Empowering the Workforce in the Context of Skills-First.pptxEduSkills OECD
Iván Bornacelly, Policy Analyst at the OECD Centre for Skills, OECD, presents at the webinar 'Tackling job market gaps with a skills-first approach' on 12 June 2024
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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This document provides an overview of wound healing, its functions, stages, mechanisms, factors affecting it, and complications.
A wound is a break in the integrity of the skin or tissues, which may be associated with disruption of the structure and function.
Healing is the body’s response to injury in an attempt to restore normal structure and functions.
Healing can occur in two ways: Regeneration and Repair
There are 4 phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This document also describes the mechanism of wound healing. Factors that affect healing include infection, uncontrolled diabetes, poor nutrition, age, anemia, the presence of foreign bodies, etc.
Complications of wound healing like infection, hyperpigmentation of scar, contractures, and keloid formation.
2. OBJECTIVES
• At the end, the learners will be able to:
• Define key terms
• Discuss general characteristics of helminths
• Give their classification
• Identify helminthic diseases
• Discuss preventive measures
M. Iqbal
4. General Features of Nematodes
Nematodes (Nema= thread) are commonly known as
Round worms. They include pinworms or thread wor
ms, Hookworms, Whipworms.
Shape: unsegmented, Round, elongated and tapered
at both ends. Hooks and suckers are absent.
Size: from 5 mm to 30 cm in length.
Digestive system: complete alimentary tract present.
Sex: dioecious, means male and female are separate.
Males are smaller than females.
Reproduction: Mostly are oviparous but some are vivi
parous.
Life cycle: Almost monogenetic; may take about 60 da
ys to complete their life cycle.
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5. Habitat
Regarding habitat there are two groups of Nemato
des:
1. Intestinal, and 2. Tissue or somatic Nematodes
1. Intestinal Nematodes:
a. Small Intestinal Nematodes:
e.g: Ascaris lumricoides (Round worm)
Ancyclostoma duodenale (hookworm)
Necator americanus (hookworm)
b. Large Intestinal Nematodes:
e.g: Enteroboius vermicularis (pinworm)
Trichuris trichiura (whipworm)
Infective stage: either fertilized egg or larva
6. Roundworms
Different species like Ascaris lumbricoid, etc are found.
Gk. Askaris=intestinal worm
► Size: Males 15-30 cm and females from 20-40 cm in l
ength
► Habitat: Small intestine
► Transmission: by ingestion of fertilized eggs via food
and water
► S/S
• GIT disturbance, N/V, Colic pain, anorexia, malnutritio
n, paleness, intestinal obstruction in heavy infection, fe
ver, liver abscess, pancreatitis and Loeffler’s syndrom
e due to their migration (ectopic infection).
Most infections (about 85%) are mild and symptomless.
M. Iqbal
7. ► Diagnosis:
• The presence of adult worms in faeces or vomitus
• Microscopic stool examination for eggs and larvae
• Sputum microscopic examination
• Blood examination for Eosinophilia
► Treatment
1. Pharmacologic Treatment:
• Mebendazole and pyrantel pamoate are drugs of c
hoice. Other drugs are piperazine, albendazole, an
d Thiabendazole.
2. Surgery:
Is necessary in case of intestinal obstruction.
Note: Ascariasis in pregnancy should be treated afte
r 1st trimester.
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8. Pinworms
• Pinworm or threadworm is a common name. They in
clude different species like Enterobius vermicularis.
► Size: Small and can be seen with naked eyes. Male
s range from 2-5 mm and females from 8-12 mm in l
ength.
► Habitat: The adult worms remain attached to caecu
m, appendix and in ilium, ascending colon as well.
► Transmission: by Ingestion or inhalation of fertilize
d eggs.
• Female comes down and lays eggs in perianal area
during night which causes itching and irritation.
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9. Pinworm cont…
► S/S: perianal itching and irritation, pruritu
s ani.
►Laboratory Diagnosis:
• Graham sticky tape method for eggs on pe
rianal area.
• Microscopic stool examination
► Treatment: Mebendazole, pyrantel pamo
ate and should be repeated after two week
s
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10. Whipworms
• Whipworm (whip shaped) is a common name.
They include different species like Trichuris tri
chiura, etc.
► Size: Males range from 3-4 cm and females f
rom 4-5 cm in length.
• Females lay 2,000 to 6,000 eggs /day
► Habitat: Large intestine, caecum, appendex
► Transmission: Ingestion of food and water c
ontaminated with fertilized eggs.
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11. Whipworm cont…
► S/S: Abdominal pain, distention, mucous or
bloody diarrhea, anorexia, weight loss, eosin
ophilia, anemia.
► Laboratory Diagnoisis: Microscopic stool e
xamination.
► Treatment: Albendazole or Mebendazole
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14. Hookworm
• Hookworm is a common name. different speci
es are like Ancyclostoma duodenale (Gk. Anc
hylos=hooked), Necator americanus (Necator
=murderer means American murderer),etc. Ap
art from anthrophilic, there are zoophilic speci
es also.
► Habitat: duodenum and jejunum and ileum.
► Size: Male 10 mm and female 15 mm.
► Transmission: The entrance of rhabditiform
(rod shaped) larva through the skin of bare fo
oted man waking on contaminated soil.
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15. Hookworm cont…
► S/S: severe itching at penetration site known
as ground itch or ancylostoma dermatitis whic
h lasts for 2-4 weeks. Loeffler’s syndrome, an
emia as they suck blood and there secretions
also contain anticoagulant which leads to bloo
d loss.
► Laboratory diagnosis: Stool examination, S
tool occult blood, CBC.
► Treatment: Mebendazole or albendazole
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16. 2. Tissue or Somatic Nematodes
Somatic nematodes are filarial worms (Latin, filu
m means ‘thread’).
General features:
• Size: 2-10 cm in length
• Habitat: Lymphatic vessels, blood vessels, lung
s, and subcutaneous tissues
• Life cycle: They are digenetic, blood sucking in
sect.
• Vector: Filarial worms are transmitted by variou
s species of mosquitoes like Anopheles, Aedes,
and Culex. M. Iqbal
17. • Microfilaria: The adult females are vivipar
ous and give birth to larvae called microfila
ria. The vectors transmit microfilaria into h
uman blood.
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18. Lymphatic Filariasis
• Three filarial worms are responsible for lymph
atic filariasis. They are Wucheria bancrofti, Br
ugia malayi, Brugia timori. The most common
is Wucheria bancrofti which is responsible for
90 % of infections. It causes elephantiasis.
• Wucheria bancrofti
• Habitat: lymph nodes and lymph vessels
• Size: male 2-4 cm x 0.1 mm
female 8-10 cm x 0.2 mm
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19. They affect different tissues as:
a. Lymphatic vessels as lymphatic filariasis cau
sed by, for example, Brugia malayi
b. Subcutaneous tissues (e.g Loa loa)
c. Conjunctiva (e.g Loa loa)
d. Lungs (e.g Trichinella spiralis)
Transmission:
Somatic nematodes are mostly transmitted to
man in the form of larvae by mosquito bite.
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22. Platyhelminthes
Cestodes Trematodes
1. Tape-like, segmented
2. Monocious /Hermaphrodite
3. Suckers often with hook
4. Alimentary canal absent
1. Leaf-like, unsegmented
2. Monocious except schistosomes
3. Suckers but no hook
4. Alimentary canal present but inco
mplete
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23. Cestodes
Gk. Kestos=ribbon, means tape-like
► General Features:
• Shape: dorsoventrally flattened.
• Habitat: Intestine and other body tissues.
• Size: ranges from 1 cm to 15 meters.
• Body structure: Consists of
a) scolex: containing suckers (organs of att
achment)
b) neck: (germinal centre from which new pr
oglottids or segments keep generating)
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24. Cestodes general features cont…
c) Strobila: Trunk or body of tapeworm
• Proglottid: three types ---immature, mature, gravid.
Each mature proglottid contains both male and fema
le reproductive organs
• Digestive system: No digestive system
• Sex: hermaphrodites
• Life cycle: Digenetic, using intermediate and
definitive host.
They cause both intestinal as well as systemic i
nfections
There are different species of cestodes.
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25. Taenia saginata (beef tapeworm)
• Distribution: Worldwide
• Size: usually 5-10 meters but may exceed ev
en 20 meters. It is white in color.
• Habitat: Adult tapeworms live in the small int
estine of man attached to the mucosa by sc
olex.
• Life span: It may live for about 10 years.
• Proglottids: The strobila (trunk) consists of
1000-2000 proglottids (segments). Each seg
ment has opening to discharge fertilized egg
s.
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26. Cont….
• Testes: 300-400 in each mature proglottid
• Ovaries: Two in number. Each segment contai
ns about 80,000 eggs.
• Life cycle: It requires two hosts to complete its
life cycle.
• Intermediate host: Cattle (cow or buffalow) har
bours larval stage
• Definitve host: Man who harbours adult worm.
• Transmission: Ingestion of cysticercus cyst lar
vae by man in raw or undercooked meat of cattl
e or contaminated food or water.
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27. • Development in man: the larvae cysticerci g
row into adult in man. They discharge fertilize
d eggs through human faeces. The eggs are
viable upto 8 weeks in soil and are infective f
or cattle only.
• Development in cattle: The cattle ingest the
eggs during grazing. The eggs pass from inte
stine into muscles via blood circulation. In mu
scles,the eggs develop into larvae called cyst
icercus bovis. This larva is ingested by man i
n raw or undercooked beef.
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28. • S/S: Nausea, abdominal discomfort, pain, i
ndigestion, diarrhea alternating with consti
pation.
• Diagnosis: Microscopic stool examination
for segments and eggs
• Treatment: Praziquantel or Niclosamide
M. Iqbal
29. Taenia solium (pork tapeworm)
• Size: 2-3 meters in length.
• Habitat: Small intestine.
• Life span: upto 25 years
• Transmission: Ingestion of cysticerci by ma
n (definitive host) in raw or undercooked pork
.
• Proglottids: 800-900
• Intermediate host: pig
• Defenitive host: man
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30. • Life cycle is similar to that of T. saginatta.
• Transmission is same with that of T. saginatta
• It causes both intestinal as well as systemic inf
ections
• S/S:
• In Intestinal taeniasis there is abdominal disco
mfort and pain.
• Systemic infections include subcutaneous tiss
ues, skeletal muscles and brain infection
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31. ►Diagnosis
a) For Intestinal taeniasis:
• Microscopic stool examination
b) Tissue cysticercosis (tissues affected by cyst
icercus larvae is called cysticercosis) is diagnos
ed by:
• Radiography, biopsy
• CT scan, MRI
• Treatment:
• Same as T. saginatta infection
• For cysticercosis, prazequantel and albendazol
e are effective.
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32. Other systemic/tissue cestodes
They ineter body tissues in larval forms.
Examples are:
• Echinococcus granulosus (dog tapeworm) cau
ses hydated disease
• Echinicoccus multilocularis (rodent tapeworm)
causes alveolar and hydated disease
- Hydatid disease occurs when the larval stage
s of these organisms are ingested
- The larvae may develop in man and cause le
sions in several organs, e.g. liver, brain
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33. Trematodes
• Trematodes have suckers with a hole (Gk. Trema, h
ole; edios, appearance) appears in the middle of suc
kers, and hence are called trematodes.
• General characteristics:
• Leaf-shaped
• Unsegmented
• Size is 1 mm to several cm
• Found in intestine, liver, lung, blood vessels
• They are mostly hermaphrodites
• Either monogenetic or digenetic
• Their infective larvae are cercaria, metacercaria and
miracidium. M. Iqbal
34. • They are named according to the organs t
hey infect like liver fluke, lung fluke, etc.
Liver fluke Lung fluke
35. Prevention
• Education
• Safe disposal of faeces
• Avoid contact with contaminated soil
• Good personal hygiene
• Adequate sanitation
• Avoid bare footed walking
• Control measures for mosquitoes and flies
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36. References
• Textbook of Medical Parasitology by P.Ch
akabrty
• Tortora, microbiology, ed 10th
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38. • Annelid worms such as leeches all have an anterior (oral) sucker for
med from the first six segments of their body, which is used to conne
ct to a host for feeding. It also releases an anaesthetic to prevent the
host from feeling pain while it sucks blood. They use a combination
of mucus and suction (caused by concentric muscles in those six se
gments) to stay attached and secrete an anti-clotting enzyme, hirudi
n, into the host's blood stream. The medicinal leech (Hirudo medicin
alis) has two suckers, one at each end, called the anterior and poste
rior sucker. The posterior is mainly used for leverage while the anteri
or sucker, consisting of the jaw and teeth, is where the feeding takes
place.[12] During locomotion directional movement of the body is don
e by successive attachment and detachment of the oral sucker and t
he acetabulum.[2]
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40. Schistosoma (blood fluke)
• Morphology
• Adult schistosomes share all the fundamental features of
the digenea. They have a basic bilateral symmetry, oral
and ventral suckers, a body covering of a syncytial tegu
ment, a blind-ending digestive system consisting of mout
h, oesophagusand bifurcated caeca; the area between th
e tegument and alimentary canal filled with a loose netw
ork of mesoderm cells, and an excretory or osmoregulat
ory system based on flame cells. Adult worms tend to be
10–20 mm (0.4–0.8 in) long and use globins from their h
osts' hemoglobin for their own circulatory system.
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Loffler's syndrome is a disease in which eosinophils accumulate in the lung in response to a parasitic infection
Aedes aegypti female mosquito
Anopheles /əˈnɒfɨliːz/[1] (Greek anofelís: good-for-nothing) is a genus ofmosquito first described and named by J. W. Meigen in 1818.