Gluconeogenesis is the synthesis of glucose from non-carbohydrate substrates like lactate, glycerol and certain amino acids. It occurs in the liver and kidneys when carbohydrate availability is low, such as during fasting or diabetes. While fatty acids can provide energy, glucose is still required by certain tissues and as a precursor for lactose production. Gluconeogenesis bypasses the irreversible steps of glycolysis using different enzymes and pathways that convert substrates like pyruvate and the Cori cycle transfers lactate from muscles to the liver for glucose synthesis. Gluconeogenesis is regulated both long-term through induction of enzymes by glucocorticoids and repression by insulin, and short-term through the
coordination between different metabolic pathways inside the body is called integration of metabolism. this presentation discuss about how metabolism can be regulated and integrated in liver, muscle and adipose tissue.
coordination between different metabolic pathways inside the body is called integration of metabolism. this presentation discuss about how metabolism can be regulated and integrated in liver, muscle and adipose tissue.
Triacylglycerol and compound lipid metabolismDipesh Tamrakar
Biosynthesis and metabolic regulation of triglyceride and other compound lipids: glycerophospholipids, sphingophospholipids, ether glycerolipids and glycolipids
Gluconeogenesis: Defined as biosynthesis of glucose from non-carbohydrate precursors
-Gluconeogenesis: an intro
-Thermodynamic Barriers (Each barrier detail explanation)
- Energetics of gluconeogenesis
-Substrates of gluconeogenesis (each substrate and pathway explained)
-Regulation of Gluconeogenesis, hormonal and transcriptional regulation
The glucuronic acid pathway is a quantitatively minor route of glucose metabolism. Like the pentose phosphate pathway, it provides biosynthetic precursors and inter-converts some less common sugars to ones that can be metabolized.
Gluconeogenesis- Steps, Regulation and clinical significanceNamrata Chhabra
Gluconeogenesis- Thermodynamic barriers, substrates of gluconeogenesis, reciprocal regulation of glycolysis and gluconeogenesis, biological and clinical significance
This PPT contains content of Gluconeogenesis, Steps involved in Gluconeogenesis, (Gluconeogenesis from Pyruvate, Gluconeogenesis from lactate, Gluconeogenesis from amino acids, Gluconeogenesis from glycerol, Gluconeogenesis from Propionate), Regulation and significance of Gluconeogenesis
Triacylglycerol and compound lipid metabolismDipesh Tamrakar
Biosynthesis and metabolic regulation of triglyceride and other compound lipids: glycerophospholipids, sphingophospholipids, ether glycerolipids and glycolipids
Gluconeogenesis: Defined as biosynthesis of glucose from non-carbohydrate precursors
-Gluconeogenesis: an intro
-Thermodynamic Barriers (Each barrier detail explanation)
- Energetics of gluconeogenesis
-Substrates of gluconeogenesis (each substrate and pathway explained)
-Regulation of Gluconeogenesis, hormonal and transcriptional regulation
The glucuronic acid pathway is a quantitatively minor route of glucose metabolism. Like the pentose phosphate pathway, it provides biosynthetic precursors and inter-converts some less common sugars to ones that can be metabolized.
Gluconeogenesis- Steps, Regulation and clinical significanceNamrata Chhabra
Gluconeogenesis- Thermodynamic barriers, substrates of gluconeogenesis, reciprocal regulation of glycolysis and gluconeogenesis, biological and clinical significance
This PPT contains content of Gluconeogenesis, Steps involved in Gluconeogenesis, (Gluconeogenesis from Pyruvate, Gluconeogenesis from lactate, Gluconeogenesis from amino acids, Gluconeogenesis from glycerol, Gluconeogenesis from Propionate), Regulation and significance of Gluconeogenesis
Glycogen is the storage form of Glucose which maintain the blood glucose level under various condition. Glycogen Metabolism is the important pathway of carbohydrate metabolism which gives the information about the glycogen synthesis (Glycogenesis), Glycogen breakdown (Glucogenolysis). Glycogen metabolism also gives the information how this pathway is regulated. Their are various diseases which are associated with this metabolism, commonly known as Glycogen storage diseases.
Multiple Choice Questions with Explanatory Answers on Chemistry of Carbohydrates for Medical, Biochemistry and Biology students - Chapter 1 of Multiple Choice Questions in Biochemistry by RC Gupta
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. Gluconeogenesis is synthesis of glucose
from non-carbohydrate substrates
Gluconeogenesis occurs when the
availability of carbohydrates is low
3. In diabetes mellitus, carbohydrates are
available but cannot be metabolized
During fasting, dietary carbohydrates are
not available
Availability of carbohydrates is low
during fasting and in diabetes mellitus
4. Though the energy requirements can be
met by lipids, provision of some amount of
carbohydrate is essential
Certain tissues, e.g. brain and erythro-
cytes, are dependent almost exclusively on
glucose as a source of energy
Adipose tissue requires glucose as a
source of glycerol-3-phosphate for esteri-
fication of fatty acids
5. Muscles require glucose as a source of
energy under anaerobic conditions
Glucose is also required for the synthesis
of lactose during lactation
Therefore, glucose requirement is met by
converting non-carbohydrates into glucose
6. EMB-RCG
The main substrates for gluconeogenesis
are:
• Lactate
• Glycerol
• Amino acids (except leucine & lysine)
• Intermediates of glycolysis
• Intermediates of citric acid cycle
The principal sites of gluconeogenesis are
liver and kidneys
7. Gluconeogenesis was believed in the past
to be a reversal of glycolysis
It was shown later that free energy is
released in some reactions of glycolysis
These functionally irreversible reactions are
energy barriers for gluconeogenesis
8. The energy barriers can be circumvented
by using different enzymes for catalysing
the reactions in backward direction
The reversible reactions are catalysed by
enzymes of the glycolytic pathway
9. EMB-RCG
The following reactions of glycolytic
pathway constitute energy barriers:
Conversion of glucose into glucose-
6-phosphate
Conversion of fructose-6-phosphate
into fructose-1,6-biphosphate
Conversion of phosphoenol pyruvate
into pyruvate
Energy barriers
10. EMB-RCG
In gluconeogenic pathway, the irreversible
glycolytic reactions are catalysed by:
Glucose-6-phosphatase
Fructose-1,6-biphosphatase
Pyruvate carboxylase
Phosphoenol pyruvate carboxykinase
Bypassing the energy barriers
11.
12.
13. Conversion of oxaloacetate into
phosphoenol pyruvate
Conversion of pyruvate into phosphoenol
pyruvate requires two reactions:
Conversion of pyruvate into oxalo-
acetate
EMB-RCG
14. Pyruvate enters mitochondria and is converted
into oxaloacetate by pyruvate carboxylase
Oxaloacetate comes out of mitochondria with
the help of malate shuttle
It is converted into phosphoenol pyruvate by
phosphoenol pyruvate carboxykinase
The phosphate group is provided by GTP
17. For converting pyruvate into glucose:
Some of the reactions are catalysed
by glycolytic enzymes
Some reactions are catalysed by
gluconeogenic enzymes
18.
19.
20. The substrates for gluconeogenesis enter
the pathway at different stages
Lactate is a major substrate for gluco-
neogenesis
It is formed in muscles during anaerobic
conditions
21. Lactate cannot be utilized in muscles as
gluconeogenic enzymes are not present
there
It is used for synthesis of glucose in liver
via Cori cycle
22. Cori cycle
This cycle transfers glucose from liver to
muscles
Glucose is converted into lactate by
glycolysis as the conditions are usually
anaerobic in muscles
Lactate is transferred to liver for
gluconeogenesis
23.
24. Glucose-alanine cycle
This cycle transfers glucose from liver to
muscles and alanine from muscles to liver
Alanine carries carbon atoms for glucose
synthesis and amino group for urea
synthesis from muscles to liver
25. Pyruvate formed in muscles by aerobic
glycolysis is transaminated to alanine
Alanine goes to liver via circulation
This transports carbon atoms of pyruvate and
amino groups of amino acids to liver
26. Alanine transfers its amino group to a-keto-
glutarate in liver
Amino group of glutamate is used to synthesize
urea
Pyruvate is converted into glucose by gluco-
neogenesis which goes back to liver via blood
Alanine is converted into pyruvate, and a-keto-
glutarate into glutamate
27.
28. Glycerol is released from triglycerides and
glycerophospholipids
It can be converted into dihydroxyacetone
phosphate via glycerol-3-phosphate
Dihydroxyacetone phosphate, a glycolytic inter-
mediate, can enter gluconeogenic pathway
29.
30. Gluconeogenic amino acids are converted into
intermediates of glycolysis or citric acid cycle
Intermediates of glycolysis enter the pathway
directly at the stages where they are formed
Intermediates of citric acid cycle are converted
into oxaloacetate
Oxaloacetate is converted into PEP which is an
intermediate of gluconeogenesis
31.
32. Regulation of gluconeogenesis is long-term
as well as short-term
Long-term regulation occurs through induction
and repression
Synthesis of gluconeogenic enzymes is
induced by glucocorticoids
The synthesis is repressed by insulin
EMB-RCG
Regulation
33. The immediate regulator is
fructose-2,6-biphosphate
The ultimate regulator is glucagon
Short-term regulation occurs by:
Covalent modification
Allosteric mechanism
34. Fructose-2,6-biphosphate is the allosteric
modifier of two enzymes
It activates phosphofructokinase-1 which
increases glycolysis
It inhibits fructose-1,6-biphosphatase which
decreases gluconeogenesis
EMB-RCG
35. Fructose-2,6-biphosphate is formed from
fructose-6-phosphate
EMB-RCG
The phosphate is removed from carbon 2
by fructose-2,6-biphosphatase
Phosphate is added to carbon 2 of fructose-
6-phosphate by phosphofructokinase-2
37. When it is phosphorylated, phosphofructo-
kinase-2 is inactive and fructose-2,6-
biphosphatase is active
EMB-RCG
When the enzyme is dephosphorylated,
phosphofructokinase-2 is active and
fructose-2,6-biphosphatase is inactive
38. EMB-RCG
In the absence of glucagon (as after a
meal), the enzyme is dephosphorylated
Phosphofructokinase-2 is active and
fructose-2,6-biphosphatase is inactive
Concentration of fructose-2,6-biphosphate
rises
40. The reverse occurs after secretion of
glucagon
Glycolysis is decreased and gluco-
neogenesis is increased
Short-term regulation of gluconeogenesis
and glycolysis is reciprocal
EMB-RCG