The document discusses the fetal membranes, which include the umbilical cord, amnion, amniotic fluid, yolk sac, and allantois. It describes the development, structure, function and abnormalities of each membrane. The umbilical cord connects the fetus to the placenta and transports nutrients. The amnion surrounds the fetus and amniotic fluid, protecting the fetus and allowing movement. The yolk sac provides early nutrition but later degenerates. The allantois contributes to blood and urinary system development. Abnormalities can impact fetal health.
Implantation and placentation , and overviewPranjal Gupta
Implantation and formation of placenta is an essential developmental process during human embryogenesis as it marks the connection between maternal and fetal blood, a condition specific to mammals more precisely eutherians. It works as a passage of required nutrients to the growing embryo and collection of its waste. It also discusses various types of placenta that are seen in mammals.
Implantation and placentation , and overviewPranjal Gupta
Implantation and formation of placenta is an essential developmental process during human embryogenesis as it marks the connection between maternal and fetal blood, a condition specific to mammals more precisely eutherians. It works as a passage of required nutrients to the growing embryo and collection of its waste. It also discusses various types of placenta that are seen in mammals.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
presentation on oogenesis of fertilisation process full details about it u will never find it anywhere else have full details about the ovum formation polar bodies and everything . so explore here
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
presentation on oogenesis of fertilisation process full details about it u will never find it anywhere else have full details about the ovum formation polar bodies and everything . so explore here
Giving overview of human embryonic development including spermatogenesis, oogenesis, fertilization, gastrulation, cleavage, extraembryonic layers and pregnancy
The skin is divided into two parts: the superficial part, the
epidermis; and the deep part, the dermis (Fig. 1.4). The
epidermis is a stratified epithelium whose cells become flat
tened as they mature and rise to the surface. On the palms of
the hands and the soles of the feet, the epidermis is extremely
thick, to withstand the wear and tear that occurs in these
regions. In other areas of the body, for example, on the ante
rior surface of the arm and forearm, it is thin. The dermis is
composed of dense connective tissue containing many blood
vessels, lymphatic vessels, and nerves. It shows considerable
variation in thickness in different parts of the body, tending
to be thinner on the anterior than on the posterior surface.
It is thinner in women than in men. The dermis of the skin
is connected to the underlying deep fascia or bones by the
superficial fascia, otherwise known as subcutaneous tissue.
The skin over joints always folds in the same place, the
SKIN CREASES (Fig. 1.5). At these sites, the skin is thinner
than elsewhere and is firmly tethered to underlying struc
tures by strong bands of fibrous tissue.
The appendages of the skin are the nails, hair follicles,
sebaceous glands, and sweat glands.
The nails are keratinized plates on the dorsal surfaces of
the tips of the fingers and toes. The proximal edge of the
plate is the root of the nail (see Fig. 1.5). With the exception
of the distal edge of the plate, the nail is surrounded and
overlapped by folds of skin known as nail folds. The sur
face of skin covered by the nail is the nail bed (see Fig. 1.5).
Hairs grow out of follicles, which are invaginations
of the epidermis into the dermis (see Fig. 1.4). The folli
cles lie obliquely to the skin surface, and their expanded
extremities, called hair bulbs, penetrate to the deeper part
of the dermis. Each hair bulb is concave at its end, and
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Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Home assignment II on Spectroscopy 2024 Answers.pdf
Fetal membranes
1.
2. By the end of the lecture the student should be able
to:
List the components of the fetal membranes.
Describe the stages of development of the
components.
Describe the structure and function of the
components.
Describe their fate and the possible congenital
anomalies.
4. It is a pathway which
connects the ventral aspect
of the embryo with the
placenta (chorion)
It is a soft tortuous cord
measuring (30- 90) cm in
length (average 55) ,(1-2)
cm in diameter.
It has a smooth surface
because it is covered by the
amnion
5. 1-Connecting stalk:
Alantois + two Umbilical arteries +
two Umbilical veins
The extra embryonic mesoderm
forms Wharton’s jelly
2-Yolk stalk (Vitello-intestinal duct):
A narrow, elongated duct which
connects gut to yolk sac
It contains Vitelline Vessels
Later on , it is obliterated and the
vitelline vessels disappear.
6. Normally, it is attached to
a point near the centre of
the fetal surface of the
placenta
7. (1) Abnormal Attachment:
a-Battledore placenta :
The UC is attached to the
margin of the placenta (it is
not dangerous).
b-Velamentous insertion of
the cord :
UC is attached to the
amnion away from
placenta, (It is dangerous
to the fetus due to rupture
of blood vessels during
labor)
8. (2) Abnormalities in Length:
a-Very Long Cord:
It is dangerous , it may
surround the neck of the
fetus and causes its death.
b-Very Short Cord:
It is dangerous because it
may cause premature
separation of placenta, or the
cord itself may rupture
9. (3) False and True knots
of umbilical cord:
a-False knots:
UC looks tortuous due to
twisting of umbilical
vessels (umbilical vessels
are longer than the cord),
these knots are normal and
do not cause any harm to
the fetus
b-True knots:
Are rare (1%) of
pregnancy, but very
dangerous because they
may cause obstruction to
blood flow in umbilical
vessels, leading to fetal
anoxia & fetal death
True Knots in 20-weeks fetus
10. 3rd week: Appears as a
diverticulum from caudal wall of
Y.S. that extends into connecting
stalk.
2nd month: Its extra-
embryonic part degenerates.
3rd month: Its intra-embryonic
part extends from UB to UC as
thick tube , ‘(urachus) ’
After birth: the urachus is
obliterated and fibrosed to form
median umbilical ligament, that
extends from apex of UB to
umbilicus.
11. Blood formation in its wall
during 3rd to 5th week.
Its blood vessels persist as
the umbilical vein & arteries.
12. It is essential in the transfer
of nutrients to the embryo
during 2nd & 3rd weeks,
when the uteroplacental
circulation is not established.
It does not contain any yolk.
Its development passes
through three stages:
Primary yolk sac.
Secondary yolk sac.
Definitive yolk sac.
13. Appears in the Blastocyst
stage at 10-days, it lies
ventral to the embryonic
plate.
Its roof is formed by
hypoblast (primary
endoderm),
Its wall is formed by
exocoelomic membrane,
it lines the inner surface of
the cytotrophoblast, and
separated from it by the
extraembryonic
mesoderm
14. Appears in the chorionic
vesicle stage
Its roof is formed by
hypoblast (embryonic
endoderm), its wall is
formed by exocoelomic
membrane + inner layer
(splanchnic layer) of the
extraembryonic mesoderm.
At day 16: a diverticulum
appears from its dorsocaudal
end (Allantois) into the
substance of the connecting
stalk
15. After folding, part of Yolk Sac is
enclosed within the embryo to form the
Gut (Foregut, Midgut & Hindgut).
The remainder of Yolk Sac that remains
outside the embryo becomes the
Definitive Yolk Sac
The midgut is temporarily connected to
Definitive Yolk Sac by a narrow duct
Vitello-intestinal duct (Yolk stalk),
which is incorporated inside the
umbilical cord.
This is fibrosed and degenerated by
the end of (6th week)
16. 3rd week:
(a) Blood formationt
First formed in the extra-embryonic
mesoderm covering the wall of the yolk sac,
until hemopoietic activity begins in the liver
during 6th week
4th week: endoderm of yolk sac is
incorporated into the embryo to form
primordial gut
Epithelium of Respiratory system &G.I.T.
(b)Primordial germ cells in the endodermal lining of the wall of caudal end of
the yolk sac migrate into the developing sex glands to differentiate into germ
cells (spermatogonia or oogonia)
17. Yolk stalk detached from midgut by the
end of 6th week. In (2%) of adults, its
proximal intra-abdominal part persists as
ileal diverticulum (Meckel diverticulum).
At 10 week, small definitive yolk sac lies
in the chorionic cavity between amniotic
& chorionic sacs
At 20 weeks, as pregnancy advances,
definitive yolk sac atrophies and becomes
a very small cyst.
In unusual cases, it persists under the
amnion near the attachment of Umbilical
cord, on the fetal surface of the placenta.
Its persistence is of no significance
18. It is a thin, transparent & tough fluid-
filled, membranous sac surrounding the
embryo.
At First : It is seen as a small cavity lying
dorsal to the embryonic plate.
At Stage of Chorionic Vesicle: The
amnion becomes separated from the
chorion by chorionic cavity or extra
embryonic coelom.
After Folding: the amnion expands
greatly and is becomes on the ventral
surface of the embryo.
As a result of expansion of the amnion,
the extra embryonic coelom is gradually
obliterated and amnion forms the
epithelial covering of umbilical cord.
19. It is a watery fluid inside the
amniotic cavity (sac).
It has a major role in fetal growth &
development
It increases slowly, to become (700-
1000) ml by full term (37) weeks.
Composition:
99% of amniotic fluid is water
It contains un-dissolved material of
desquamated fetal epithelial cells +
organic + inorganic salts
As pregnancy advances,
composition of amniotic fluid
changes as fetal excreta (meconium
= fetal feces & urine) are added
20. Fetal & Maternal Sources:
Initially, some amniotic fluid
is secreted by amniotic cells.
Most of fluid is derived from
Maternal tissue by:
1-Diffusion across amnio-
chorionic membrane from
placenta.
2-Diffusion across chorionic
plate (chorionic wall related to
placenta) from the maternal
blood in the intervillous
spaces.
Later, it is derived from
Fetus through:
Skin, Fetal Respiratory
Tract & mostly by Excreting
Urine (at beginning of 11th
week)
21. Provides symmetrical external growth of the
embryo
Acts as a barrier to infection (it is an aseptic
medium)
Permits normal fetal lung development
Prevents adherence of embryo to amnion
It protects embryo against external injuries
Keeps the fetal body temperature constant
Allows the embryo to move freely, aiding
muscular development in the limbs
It is involved in maintaining homeostasis of
fluids & electrolytes
It permits studies on fetal enzymes, hormones and
diagnosis of fetal sex and chromosomal
abnormalities
22. Amniotic fluid remains constant & in balance
--Most of fluid is swallowed and few passes into lungs by fetus,
and absorbed into fetal blood, where it is metabolised
-- Part of fluid passes through placental membrane into
maternal blood in intervillus space,
Other part of fluid is excreted by fetal kidneys into amniotic
sac
23. (1) Oligohydramnios:
The volume is less than ½ liters
Causes :
Placental insufficiency with low
placental blood flow
Preterm rupture of amnio-chorionic
membrane occurs in 10% of
pregnancies
Renal Agenesis (failure of kidney
development)
Obstructive Uropathy (urinary tract
obstruction) lead to absence of fetal
urine (the main source)
Complications :
Fetal abnormalities (pulmonary,
facial & limb defects)
24. (2) Polyhydramnios
(Hydramnios):
The volume is more than 2
liters, it is diagnosed by
Ultrasonography.
Causes
Fetal ( 1-20% ) :
Esophageal atresia.
Maternal (2-20%) :
defects in maternal
circulation.
Idiopathic (3-60%)
25. 25
PLACENTA
This is a fetomaternal organ.
It has two components:
Fetal part – develops from the chorionic sac ( chorion
frondosum )
Maternal part – derived from the endometrium ( functional
layer – decidua basalis )
The placenta and the umbilical cord are a transport system for
substances between the mother and the fetus.( vessels in
umbilical cord )
Function Of The Placenta:
1. Protection
2. Nutrition
3. Respiration
4. Excretion
5. Hormone production
26. 26
DECIDUA
DECIDUA is the
endometrium of the
gravid (pregnant)
uterus.
It has four parts:
Decidua basalis: it
forms the maternal
part of the placenta
Decidua
capsularis: it covers
the conceptus
Decidua parietalis:
the rest of the
endometrium
Decidua reflexa:
Junction between
capsularis &
parietalis.
27. 27
DEVELOPMENT OF PLACENTA
Until the beginning of the
8th week, the entire
chorionic sac is covered
with villi.
After that, as the sac grows,
only the part that is
associated with Decidua
basalis retain its villi.
Villi of Decidua capsularis
compressed by the
developing sac.
Thus, two types of chorion
are formed:
Chorion frondosum
(villous chorion)
Chorion laeve – bare
(smooth) chorion
About 18 weeks old, it
covers 15-30% of the
decidua and weights
about 1 6 of fetus
28. 28
DEVELOPMENT OF PLACENTA
The villous chorion (
increase in number,
enlarge and branch )
will form the fetal
part of the placenta.
The decidua basalis
will form the
maternal part of the
placenta.
The placenta will grow
rapidly.
By the end of the 4th
month, the decidua
basalis is almost
entirely replaced by
the fetal part of the
placenta.
29. 29
FULL-TERM PLACENTA Cotyledons –about 15 to 20
slightly bulging villous areas.
Their surface is covered by shreds
of decidua basalis from the
uterine wall.
After birth, the placenta is always
inspected for missing
cotyledons. Cotyledons
remaining attached to the uterine
wall after birth may cause severe
bleeding.
Grooves – formerly occupied by
placental septa
Maternal side
30. 30
FULL-TERM PLACENTA
( Discoid shape -500- 600 gm- Diameter 15-20 cm –
Thickness of 2-3 cm) Fetal surface:
This side is smooth and
shiny. It is covered by
amnion.
The umbilical cord is
attached close to the
center of the placenta.
The umbilical vessels
radiate from the
umbilical cord.
They branch on the fetal
surface to form
chorionic vessels.
They enter the chorionic
villi to form
arteriocapillary-
venous system.
Fetal side
31. 31
PLACENTAL MEMBRANE
This is a composite
structure that consists of
the extra-fetal tissues
separating the fetal blood
from the maternal blood.
It has four layers:
Syncytiotrophoblast
Cytotrophoblast
Connective tissue of villus
Endothelium of fetal
capillaries
After the 20th week, the
cytotrophoblastic cells
disappear and the
placental membrane
consists only of three
layers.
33. Placental endocrine synthesis
The syncytiotrophoblast synthesizes protein &
steroid hormones
The protein hormones
1- human chorionic gonadotropin
2- human chorionic somatomammotropin
3- human chorionic thyrotropin
4- human chorionic corticotropin
The steroid hormones
Progesterone & Estrogens