Excitable tissues are capable of generating and transmitting electrochemical impulses along cell membranes. The resting membrane potential in most neurons is around -70mV due to uneven distribution of ions like potassium and sodium across the cell membrane. When a threshold stimulus is reached, voltage-gated ion channels allow rapid sodium influx and potassium efflux, causing a brief reversal of the potential known as an action potential. This propagates the electrochemical signal along the membrane.
Receptor by Pandian M, Tutor, Dept of Physiology, DYPMCKOP, MH. This PPT for ...Pandian M
Introduction
SENSORY RECEPTORS
Structurally 3 types of receptors
Transducers
CLASSIFICATION OF RECEPTORS
A. Depending on the source of stimulus(Sherrington’s classification)
B. Depending upon type of stimulus
C. Clinical or anatomical classification of receptors
Production of receptor potential
Properties of receptors
Properties of receptor potential
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
Receptor by Pandian M, Tutor, Dept of Physiology, DYPMCKOP, MH. This PPT for ...Pandian M
Introduction
SENSORY RECEPTORS
Structurally 3 types of receptors
Transducers
CLASSIFICATION OF RECEPTORS
A. Depending on the source of stimulus(Sherrington’s classification)
B. Depending upon type of stimulus
C. Clinical or anatomical classification of receptors
Production of receptor potential
Properties of receptors
Properties of receptor potential
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
Action potential By Dr. Mrs. Padmaja R Desai Physiology Dept
To study the Concept of Action Potential and describe the stages of action potential.
Ionic basis of Action Potential & its Propogation.
Properties of Action Potential.
Types action Potential
Neural regulation of resp by Dr. Mrs Sunita M. Tiwale Professor Dept of Phys...Physiology Dept
Describe Nervous mechanism of regulation of respiration & significance of dual control.
Describe the different respiratory centres in brain stem with their interconnections & functions.
Describe the genesis of basic rhythm of respiration
Describe the clinical relevance of the nervous control of respiration
Action potential By Dr. Mrs. Padmaja R Desai Physiology Dept
To study the Concept of Action Potential and describe the stages of action potential.
Ionic basis of Action Potential & its Propogation.
Properties of Action Potential.
Types action Potential
Neural regulation of resp by Dr. Mrs Sunita M. Tiwale Professor Dept of Phys...Physiology Dept
Describe Nervous mechanism of regulation of respiration & significance of dual control.
Describe the different respiratory centres in brain stem with their interconnections & functions.
Describe the genesis of basic rhythm of respiration
Describe the clinical relevance of the nervous control of respiration
This presentation contains the basic information about nerve cells and action potential. This work is done for academic purpose only so if you are using give proper reference.
Hijama (Arabic: حجامة lit. "sucking") is the Arabic term for wet cupping, where blood is drawn by vacuum from a small skin incision for therapeutic purposes.The practice has Greek and Persian origin and is mentioned by Hippocrates.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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2. What is an excitable tissue?
• Tissues which are capable of
generation and transmission of
electrochemical impulses along the
membrane.
• An ability of specialized cells to
respond to certain stimuli by
producing electrical signals.
3. Excitable tissues in the
human body
Nerves
Muscles
Cardiac Muscle
Smooth Muscle
Skeletal Muscle
4. Understand excitable tissue
Suppose you have a dead frog. (Yes, that's kind of
gross, but let's just imagine it for a second.)
What would happen if you applied an electrical
stimulus to the nerve in the frog's leg? Creepily
enough, the dead leg would kick!
The Italian scientist Luigi Galvani discovered this fun
fact back in the 1700s, somewhat by accident during
a frog dissection.
Today, we know that the frog's leg kicks
because neurons (nerve cells) carry information via
electrical signals.
5. Resting Membrane Potential
• A potential difference exists across all cell
membranes
• This is called
– Resting Membrane Potential (RMP)
6. Resting membrane potential
explained
Imagine taking two electrodes
and placing one on the outside
and the other on the inside of the
plasma membrane of a living cell.
If you did this, you would
measure an electrical potential
difference, or voltage, between
the electrodes. This electrical
potential difference is called
the membrane potential.
7. Resting Membrane potential
For a cell’s membrane potential, the reference point
is the outside of the cell. In most resting neurons, the
potential difference across the membrane is
about 70 to 90 mV (1 mV is 1/1000 of avolt) with the
inside of the cell more negative than the outside.
That is, neurons have a resting membrane
potential (or simply, resting potential) of about -
70 to -90 mV.
8. Resting Membrane Potential
Because there is a potential difference across the cell
membrane, the membrane is said to be polarized.
If the membrane potential becomes more positive than it is at
the resting potential, the membrane is said to be depolarized.
If the membrane potential becomes more negative than it is at
the resting potential, the membrane is said to
be hyperpolarized.
9. Where does the resting membrane
potential come from?
The resting membrane potential is determined
by the
uneven distribution of ions (charged particles)
between the inside and the outside of the cell, and
by the different permeability of the membrane to
different types of ions.
10. Distribution of ions inside
and outside the cell
K+ and organic anions (such as those found in proteins
and amino acids) are present at higher concentrations
inside the cell than outside. In contrast, Na+
plus, Cl−
usually present at higher concentrations outside the cell.
11. How ions move across the cell
membrane
Because they are charged, ions can't pass
directly through the hydrophobic ("water-
fearing") lipid regions of the membrane.
Instead, they have to use specialized channel
proteins that provide a hydrophilic ("water-
loving") tunnel across the membrane.
Some channels, known as leak channels, are
open in resting neurons. Others are closed in
resting neurons and only open in response to
a signal.
12. • Ion channels that mainly allow K+
to pass are
called potassium channels, and ion channels that mainly
allow Na+ to pass are called sodium channels.
• The resting membrane potential depends mainly on movement
of K+ through potassium leak channels. Howevr both Na+ and K+
contribute to resting potential.
13. • Potassium concentration intracellular is
more
• Membrane is freely permeable to K+
• There is an efflux of K+
Flow of Potassium
K+ K+
K+
KK
+
+
K+
K
+
K
+
K+
K+
14. Entry of positive ions in to the extracellular fluid
creates positivity outside and negativity inside
Flow of Potassium
K+ K+
K+
KK
+
+
K+ K+ K+
K+
K+
15. • Outside positivity resists efflux of K+
• (since K+ is a positive ion)
• At a certain voltage an equilibrium is reached
and K+ efflux stops
Flow of Potassium
K+ K+
K+
KK
+
+
K+ K+ K+
K+
K+
16. Nernst potential (Equilibr ium potential)
The potential across the cell membrane at which the
net diffusion of ions across the cell membrane due to
concentration gradient stops.
• Nernst equation determines this potential
Where R= Universal Gas constt
T = Absolute Temp,
z = ion Valence
F = Faraday, an electrical Const
17. Nernst potential for K+ ions
Nernst Equation:
EMF = (RT/zF) x log (Cin / Cout)
RT/zF = -61
Conc of K+ ions inside the cell=140 mEq/l
Conc of K+ ions outside the cell= 4 mEq/l
EMF(mv)= - 61 log 140/4
= -61 log 35
= - 94mv
18. Nernst potential for Na+ ions
Nernst Equation:
EMF = (RT/zF) x log (Cin / Cout)
RT/zF = -61
Conc of K+ ions inside the cell=14 mEq/l
Conc of K+ ions outside the cell= 142 mEq/l
EMF(mv)= - 61 log 14/142
= +61 mv
19. The Goldman Equation
• When the membrane is permeable to several
ions the equilibrium potential that develops
depends on
– Polarity of each ion
– Membrane permeability
– Ionic concentration
• This is calculated using Goldman Equation
(or GHK Equation)
20. In the normal nerve fiber, the permeability of the
membrane to potassium is about 100 times as great
as its permeability to sodium.
Goldman equation gives a potential inside the
membrane of −86 millivolts, which is near the
potassium potential
21. Contribution of Na/K PUMP:-
- This is a powerful electrogenic pump on the cell
membrane.
- It Pump 3 Na to outside & 2 K to inside, causing →
loss of +ve ions ,loss of + ve charge from inside ,
negativity about - 4mV inside
-4mv
22. Nernst potential for Potassium -94mv
Nernst potential for Sodium +61mv
Putting these values in Gold man equation, gives a value of -
86mv
Which is nearer to K+ diffusing potential
Na- K pump provides - 4mv
i.e adding -86 and -4mv= -90mv
Resting membrane potential in nerves is -90 mv
23. Resting Membrane Potential in
Various Excitable Tissues
Large Myelinated Nerve fibers
Skeletal Muscle Fibers = - 90mv
Ventricular Muscle fibers
Smooth Muscle fiber & } = -55 to -60 mv
Self Excitatory Tissues
24. Action potential
Definition:
Abrupt / sudden Change (reversal) in resting
membrane potential in response to a threshold
stimulus.
Stimulus:
“Any Change in the environment”
TYPES: a. Electrical
b. Mechanical
c. Chemical
25. Action Potential (A.P.)
• When an impulse is generated
– Inside becomes positive
– Causes depolarisation
– Nerve impulses are transmitted as AP
27. Inside of the membrane is
• Negative
– During RMP
• Positive
– When an AP is generated
-90
+30
28. • Initially membrane is slowly depolarised
• Until the threshold level is reached
– (This may be caused by the stimulus)
Threshold level
-90
+30
29. • Then a sudden
change in polarisation
causes sharp
upstroke
(depolarisation) which
goes beyond the zero
level up to +30 mV
-90
+30
30. • Then a sudden
decrease in
polarisation causes
initial sharp down
stroke (repolarisation)
-90
+30
31. • When reaching the
Resting level rate
slows down
• Can go beyond the
resting level
– hyperpolarisation
-90
+30
32. • Spike potential
– Sharp upstroke and
downstroke
• Time duration of AP
– 1 msec
-90
+30
33. Ion channels called volted gated
channels responsible for action potential
Two types of channel:
Na+ channel
K+ channel
Physiological basis of AP
35. • When the threshold level is reached
– Voltage-gated Na+ channels open up
– Since Na conc outside is more than the inside
– Na influx will occur
– Positive ion coming inside increases the
positivity of the membrane potential and
causes depolarisation
– When it reaches +30, Na+ channels closes
– Then Voltage-gated K+ channels open up
– K+ efflux occurs
– Positive ion leaving the inside causes more
negativity inside the membrane
– Repolarisation occurs
36. • Since Na+ has come in and K+ has
gone out
• Membrane has become negative
• But ionic distribution has become
unequal
• Na+/K+ pump restores Na+ and K+
conc slowly
By pumping 3 Na+ ions outward and
2 K+ ions inward