Essential Trace elements
Definition of transition elements; Iron & haematenics; Functions of iron in the body, Causes of deficiency of iron. Focus on Compounds: Ferrous Fumarate; Ferrous Gluconate and Ferrous sulphate) Mineral Supplements (Cu, Zn, Cr, Mn, Sb, S, I).- Introduction, Role and deficiency.
Introduction about the mineral metabolism, function, classification, Role of minerals in life process such as calcium, potassium, phosphorous, chloride, magnesium, zinc, iodine, copper, cobalt some of the trace minerals. uses and their deficiency diseases and disorders. source of water, execration and water balance water process in life. acid-base balance, osmosis, concept of pH, concept of buffer, concept of electrolytes.
Introduction of Zinc, Zinc Chemistry, Zinc functions, Zinc metabolism , Role in diarrhea , role in wound healing, immunity , hormones , catalytic zinc atom structure zinc atom , zinc enzyme, acrodermatitis enteropathica, toxicity
role of metals in multivitamin Tabelets.pptxUnibaKhanam
This ppt involves role of cobalt, iron, magnesium, zinc and chromium in multivitamins
I made this ppt during my second semesterfor GE: chemistry and got full marks in presentation.
This module describes the types of minerals present in food. in nature we have several minerals which are generally classified into two as Major and Minor minerals. it also describes the recommended dietary allowance by ICMR 2020. Here you will be able to find the functions, sources and deficiency of each minerals.
Introduction about the mineral metabolism, function, classification, Role of minerals in life process such as calcium, potassium, phosphorous, chloride, magnesium, zinc, iodine, copper, cobalt some of the trace minerals. uses and their deficiency diseases and disorders. source of water, execration and water balance water process in life. acid-base balance, osmosis, concept of pH, concept of buffer, concept of electrolytes.
Introduction of Zinc, Zinc Chemistry, Zinc functions, Zinc metabolism , Role in diarrhea , role in wound healing, immunity , hormones , catalytic zinc atom structure zinc atom , zinc enzyme, acrodermatitis enteropathica, toxicity
role of metals in multivitamin Tabelets.pptxUnibaKhanam
This ppt involves role of cobalt, iron, magnesium, zinc and chromium in multivitamins
I made this ppt during my second semesterfor GE: chemistry and got full marks in presentation.
This module describes the types of minerals present in food. in nature we have several minerals which are generally classified into two as Major and Minor minerals. it also describes the recommended dietary allowance by ICMR 2020. Here you will be able to find the functions, sources and deficiency of each minerals.
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Multiparticulate dosage forms are pharmaceutical formulations in which the active substance is present as a number of small independent subunits. These sub units are compressed to form MUPS tablets
Introduction to CR/SR preparations, concept of controlled release formulation, challenges of CR drug delivery system, advantages and disadvantages, Factors influencing the design and performance of CR products (physiochemical properties: molecular size and diffusivity, aqueous solubility, ionization constant, partition coefficient, stability, pharmacokinetic and pharmacodynamic considerations: release rate and dose, Biological factors: Absorption, distribution, metabolism and elimination half life, therapeutic index, duration of action.
Kinetics of drug release from CRDS: Zero order, first order, Hixson-Crowell Release Model, Higuchi Release Model and Korsmeyer-Peppas Release Model
Oral controlled release systems: Dissolution controlled release (Matrix and encapsulated dissolution), diffusion controlled release (Reservoir and matrix system), dissolution and diffusion controlled release, Osmotically controlled release, pH independent formulations, Ion exchange resins.
Evaluation of CR formulations: Quality control methods( Identity, purity, strength, stability of the dosage form and drug in the dosage form, disintegration and dissolution, dosage form appearance, bioavailability of the drug from dosage form
Definition, role of gases in our body, focus on Oxygen, CO2 Inorganic anesthetics: Definition, Nitrous oxide Respiratory Stimulant: Definition, Ammonia solution, spirit of ammonia
Phr. Kabin Maleku
Introduction/ Concept of acid and base, Importance of acids and bases in Pharmacy, storage condition. Official acids: Phosphoric acid (Conc/dil), HCl (Conc/dil), Boric acid. Official Bases: NaOH, KOH, Ca (OH)2, dil. and strong NH3, Na2CO3, Acidosis and Alkalosis.
UNDERSTANDING GENERIC VS INNOVATOR BUSINESSKabin Maleku
This presentation includes the basic difference between generic and innovator medicines and outline about various filling pathways for US FDA and Exclusivity and few case studies
“Pellets Technology: Special focus on Wruster Coating and Extruder
spheronization”
Basic introduction, various methods of pellets technology, Wruster process, equipments, various process parameters and equipment parameters, Extrusion-Spheronization, Equipments, process and equipment parameters
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
5. Copper
• Cu is an essential nutrient.
• Rapid growth increases Cu demands in infancy.
• The adult body contains approximately 100 mg of copper – the
highest concentrations are in liver, kidney, and hearth.
• The absorption in gastrointestinal tract requires a specific
mechanism - metal binding protein metallothionein
(Cu2+ ions are highly insoluble).
• Ceruloplasmin (CP) is a glycoprotein, copper-dependent
ferroxidase (95% of the total copper in human plasma), oxidizes
Fe2+ to Fe3+ in gastrointestinal iron absorption mechanism.
6. Copper metabolism
• Cu is an essential cofactor in a number of critical enzymes in
metabolism:
• superoxide dismutase (Cu/Zn-SOD)
• cytochrome c oxidase (COX)
• tyrosinase
• monoamino oxidase
• lysyloxidase
•
• Cu metabolism is altered in inflammation, infection, an cancer.
• In infection, Cu is essential for production of Ile-2 by activated
lymphocytes.
• In cancer, plasma CP is positively correlated with disease
stage.
8. Molybdenum
• Metal required for the function of the metalloenzymes:
• xantine oxydase
• aldehyde oxidase
• sulfite oxidase
• Nitrous acid oxidase
• Some evidence that Mo can interfere with Co metabolism
by the diminishing the efficiency of copper utilization.
• (the foot content of Mo is highly dependent upon the soil
type in which the foodstuff are grown).
11. Manganese
• High concentration of Mn2+ is present in mitochondria
• Functions as a necessary factor for activation of
glycosyltransferases (enzymes responsible for the synthesis
of oligosaccharides, glycoproteins, proteoglycans.
• Required for superoxid dismutase activity, for activity of
metalloenzymes:
• hydrolases
• kinases
• decarboxylases
• transferases.
• Deficiency of Mn extensively reduce glycoprotein and
proteoglycan formation.
12. Manganese Diseases
• Deficiency
Reduced serum cholesterol
Reduced coagulation
Hair reddening
Dermatitis
Growth retardation
Excess State
Parkinsonian syndrome
Impotence, loss of vigor, edema, myalgia, headache,
Extrapyramidal disorder
13. Iron
•Introduction
•Iron is an essential element for blood production.
About 70 percent of your body's iron is found in the
red blood cells of your blood called hemoglobin and in
muscle cells called myoglobin. Hemoglobin
is essential for transferring oxygen in your blood from
the lungs to the tissues.
17. Iron- haematenics
• HAEMATINICS
• are the agents used for formation of blood
• to treat various types of anaemia’s.
• These include: Iron, Vitamin B12 and Folic AcidA hematinic is a
nutrient required for the formation of blood cells in the process of
hematopoiesis
19. Iron- Deficiency
• The primary sources of heme iron are hemoglobin and myoglobin from
consumption of meat, poultry, and fish, whereas nonheme iron is obtained
from cereals, pulses, legumes, fruits, and vegetables
• GROUPS AT HIGH RISK: Poor, infants and adolescents, women of
reproductive age, pregnancy,
• Iron deficiency anemia
• Anemia of chronic disease-due to elevated hepcidin
• Anemia from active bleeding
• Anemia related to kidney disease-deficiency of erythropoietin
• Anemia related to pregnancy
• Anemia related to poor nutrition
• Thalassemia