Epigenetics is the study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence. These changes can be caused by modifications to DNA and chromatin structure in response to environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and regulation by non-coding RNAs. Changes in epigenetic patterns can lead to changes in gene expression and phenotypic traits, and have been linked to diseases like cancer. While epigenetic changes are heritable, they are reversible and do not permanently alter the DNA sequence like mutations do.
This presentation on Epigenetics is most advanced and evidence based one. Its Very helpful for Genetics students and research fellows, Reproductive Medicine specialist, Reproductive Biologist, Infertility practitioners
Overview of epigenetics and its role in diseaseGarry D. Lasaga
Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes.
This presentation on Epigenetics is most advanced and evidence based one. Its Very helpful for Genetics students and research fellows, Reproductive Medicine specialist, Reproductive Biologist, Infertility practitioners
Overview of epigenetics and its role in diseaseGarry D. Lasaga
Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes.
Epigenetics is the study, in the field of genetics, of cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence. -Wikipedia
The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15
years. DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting regulate many biological processes that are fundamental to the genesis of cancer. Here, we
present the basic principles behind these epigenetic pathways and highlight the evidence suggesting that their misregulation can culminate in cancer. This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it
is time to embrace the central role of epigenetics in cancer.
"Epigenetics refers to genetic factors that change an organism’s appearance or biological functions without changing the actual DNA sequence. In other words, gene expression changes but the genes themselves don’t. Epigenetics adds an additional level of complexity to the genetic code." - Public Health Cafe
Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes. - [https://www.whatisepigenetics.com/fundamentals/]
Author of this presentation: The University of Western Australia
Short intro epigenetics & nutrigenomics& the early impact of nutrition Norwich Research Park
Our “genes” are not fixed: “Plasticity” of the genotype by epigenetic mechanisms => important for the phenotypic impact of nutrition.
• Histone and DNA modifications have impact on gene transcription efficiency. Methylation (more stable) and acetylation (more flexible) have impact on chromatin
structures.
• Epigenetic modifications have impact on offspring, embryo development, ageing and disease development or prevention => example: Dutch Hunger Winter.
Health status of future parents are very important for the future health of children.
Early healthy nutrition & lifestyle essential for successful healthy life & “ageing”.
Dna methylation ppt
definition of Dna methylation ppt
discovery of Dna methylation ppt
types of Dna methylation ppt
history of Dna methylation ppt
process of Dna methylation ppt
mechanism of Dna methylation ppt
methylation in cancer
cytosine methylation
genomic imprinting
Epigenetics definition, history of epigenetics, molecular basis of epigenetics, epigenetic modification, tools to study epigenetics, disease linked with epigenetics, DNA methylation demethylation and enzymes regulating DNA methylation
Epigenetics is the study, in the field of genetics, of cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence. -Wikipedia
The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15
years. DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting regulate many biological processes that are fundamental to the genesis of cancer. Here, we
present the basic principles behind these epigenetic pathways and highlight the evidence suggesting that their misregulation can culminate in cancer. This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it
is time to embrace the central role of epigenetics in cancer.
"Epigenetics refers to genetic factors that change an organism’s appearance or biological functions without changing the actual DNA sequence. In other words, gene expression changes but the genes themselves don’t. Epigenetics adds an additional level of complexity to the genetic code." - Public Health Cafe
Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes. - [https://www.whatisepigenetics.com/fundamentals/]
Author of this presentation: The University of Western Australia
Short intro epigenetics & nutrigenomics& the early impact of nutrition Norwich Research Park
Our “genes” are not fixed: “Plasticity” of the genotype by epigenetic mechanisms => important for the phenotypic impact of nutrition.
• Histone and DNA modifications have impact on gene transcription efficiency. Methylation (more stable) and acetylation (more flexible) have impact on chromatin
structures.
• Epigenetic modifications have impact on offspring, embryo development, ageing and disease development or prevention => example: Dutch Hunger Winter.
Health status of future parents are very important for the future health of children.
Early healthy nutrition & lifestyle essential for successful healthy life & “ageing”.
Dna methylation ppt
definition of Dna methylation ppt
discovery of Dna methylation ppt
types of Dna methylation ppt
history of Dna methylation ppt
process of Dna methylation ppt
mechanism of Dna methylation ppt
methylation in cancer
cytosine methylation
genomic imprinting
Epigenetics definition, history of epigenetics, molecular basis of epigenetics, epigenetic modification, tools to study epigenetics, disease linked with epigenetics, DNA methylation demethylation and enzymes regulating DNA methylation
Epigenetics studies stably heritable traits that cannot be explained by changes in DNA sequence.
Covalent modifications in chromatin
DNA- DNA methylation (CpG); hydroxymethylation
Histone - lysine acetylation, lysine and arginine methylation, serine and threonine phosphorylation, and lysine ubiquitination and sumoylation
Epigenetic mechanisms:
Modified histones as post translational modification
DNA methylation – 5mC the 5th base, methyl transferases; genetic imprinting.
Epigenomics: complete set of epigenetic modifications on the genetic material of a cell.
Specific epigenetic regulation
RNA interference
X inactivation (Lyonization)
Genomic imprinting
Epigenetics in development and diseases.
Immerse yourself in a captivating world epigenetics with our comprehensive PDF guide, this document serves as an insightful resource for both beginners and seasoned enthusiasts seeking a deeper understanding of the molecular mechanisms that influence gene expression and cellular function.
Unlock the secrets behind the heritable changes in gene activity that go beyond the DNA sequence, as we explore the dynamic interplay between genetics and environmental factors. This PDF delves into the fascinating realm of epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA, shedding light on their pivotal roles in regulating gene expression and cellular identity.
Download "what is Epigenetics" document now and embark on a journey that transcends the traditional boundaries of genetics, exploring the intricate tapestry of epigenetic regulation that influences life at its very core.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
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http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
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2. Epigenetics at a glance
• It is a modern branch of genetics which
providing us with a basis for elucidating how
heritable changes other than those in DNA
sequence can influence phenotypic variation.
• Epigenetic gene regulation use reversible
modification of DNA &chromatin structure to
mediate interaction of the genome with a varity
of environmental factor & to generate change
pattern of gene expression in response to those
factor .
3. • Change may be transcription level or mRNA
level.
• Modified into different genome to become
complex & each modified genome called
epigenome.
• Epigenetic trait is stable both mitotically &
meotically heritable phenotype that capable to
change gene expression.
• Due to epigenetic modification different
diseases occur like dibetics,asthma&cancer etc.
4. What is intracellular signal to induce
epigenome?
• Cellular response pathway in epigenetics
organized three categories of change.
• 1.epigenetor(carcinogen,uv radiation &
environmental stress etc).
• 2.epigenetic initiators;-it includes protein
signal transduction pathway,DNA binding
protein,non coding RNA(siRNA).
• 3.epigenetic maintainers;-these are not
sequence specific in molecular level after
modification maintained by
DNAmethylase,DNAacetylase&deacetylase.
5.
6. Histone modification
• It is an important epigenetic mechanism of
gene regulation .
• Amino acid in N-terminal region of histone can
be covalently modified in several ways includes
acetylation ,phosphorylation,methylation.
• Normally histones are modified by acetylation
by histoneacetyl transferase(HAT) open for
transcription and deacetylase (HDAC) changing
the chromatin closed and silenced the gene
making unfevorable for transcription.
7.
8. Cntd..
• Other events also includes presence or absence
of methyl group on histones.
• Methylation in lysine4/27 in H3 causes
transcriptional activation while in lysine9
causes transcriptional silencing.
• Phosphorylation also occur if serine10
phosphorylation lysine9 methylation inhibited
if lysine14 deacetylated methylation of lysine9
is facilited.
• This pattern and interaction histone
modification called histone code
9. RNA interference
• During epigenetic regulation small noncoding
RNA(siRNA) participate in methylation
&histone modification .
• siRNA associate with protein to form RNA-
induced silencing complex(RISC).
• If siRNA perfectly complementary to mRNA
then it will cleave mRNA and destroyed then
gene silencing effectively occur .
• It acts directly preventing trancription factor
binding at initiation of transcription
TFiiB&RNA polymerase.
10. Cntd..
• Another process short RNA molecule can also
associate with protein complex to form RNA
induced transcriptional silent(RITS) complex
&induce formation of facultative
heterochromatin that silent gene.
11. Different non-coding RNA role in
Epigenetics
• miRNA-Micro RNA regulate gene expression by
blocking translation of specific mRNAs and cause
their degradation.
siRNA-Turn off gene regulation by directing
degradation of selective mRNA.
• piRNA-Bind piwi proteins &protect the germ line
from transposable element.
• lncRNA-long non-coding RNA many which
serves as scaffolds ,including X-chromosome
inactivation.
12. Environment impact &epigenome
• Different environment agents like
nutrient,chemicals &physical factors has
effect on epigenetic changes.
• In human it is very difficult to determine the
change in epigenome due to environmental
&learned behavior but has evidence mainly
that agents affect the endocrine system.
• For example:- mice coat colour(aghouti
&yellow) change due to affect allele.
13. Cntd..
• A drug(dietyl still bestol) used in USA several
decade for prevent complication of pregnancy
and miscarriage.
• It would increase high risk of vaginal &breast
cancer (female),in male it also affect in
neurological and behavioral alteration.
14. Epigenetic modification affect
behavior
• Epigenetic changes include alteration
methylation pattern and histone modification
may be important component in behavioral
change.
• Best example in case of honey bee worker.
• Worker and queen have same genome worker
is sterile but queen fertile .
• That epigenetic change occur by royal jelly ,it
was discovered by Ryszard Kucharski and
colleague in 2008.
15. Cntd..
• Royal jelly silence a key gene called Dnmt3
whose product add normally methyl group to
DNA with Dnmt3 silencing beeDNA is less
methylated that stimulate queen devlopment.
• In case human also seen that epigenetic changes
in case of neurodegenerative disorders
&neuropsychiatric with alter behavioural
phenotype.
16. Modification due to genome
imprinting
• Phenomenon of the differential expression of
genetic material depending either it is inherited
from male or female parents called genome
imprinting.
• Due to genome imprinting Mendels reciprocal
cross do not give identical result.
• Due to genome imprinting one Xchromosome
remain inactive and expression is balanced.
• During gamete formation differential CpG
methylation occur which helps in allele specific
imprinting & subsequent gene silencing.
17. Cntd..
• Different evolutionary point of view different
maternal& paternal gene affect in fetal growth
(gene conflict hypothesis).
• Best example fetal development of human both
maternal & paternal IGF2 gene have capable
to grow fetus but fetus use paternal IGF2 for
best growth.
• In maternal case H19 gene expressed and IGF2
gene blocked by CTCF(transcriptional
repressor protein)
18.
19. Epigenetics and cancer
• The relationship between cancer and Epigenetics was
first noted in 1980 by Feinberg and Vogelsten who
observed in colon cancer cell much lower level of
methylation than normal cells derived from same tissue.
• Studied that global hypermethylation(CpG) is property
of all cancer cell to date that selective
hypermethylation& gene silencing.
• DNA hypomethylation reverses the inactivation of
gene,leading to unrestricted transcription of many gene
sets including oncogene&mutation in histone modifying
gene seen in some case means dysfunctional
HAT&HDAC(Rubenstein-taybi syndrome).
20. Cntd..
• Hypomethylation of repetitive sequence leads
to transcriptional activation transposable DNA
sequences such as LINES(long interspersed
nuclear elements) & SINES further increase
genomic instability.
• Hypermethylation(CpG island) occur that silent
tumor supressing gene studied in some cancer
case.
• Now a day epigenetic therapy also use instead
of chemotherapy to express the silent gene.
22. How mutation differ from
Epigenetics
• Mutation directly affects DNA sequence and
occur permanent change but in epigenetic
changes temporary time period due to
different physical, chemical factors.
• In epigenetic changes recovered at time of
gamete formation but not in mutation.
• Epigenetics is reversible process but
mutation is irreversible process.