This document discusses drugs used in de-addiction treatment. It describes addiction as a psychological and physiological dependence on substances that causes withdrawal symptoms when discontinued. Common addictive drugs include alcohol, opioids, cannabis, cocaine, and nicotine. The goals of de-addiction treatment are to control detoxification, withdrawal symptoms, reduce craving, and induce aversion. Several drugs are discussed that are used for different addictions, including disulfiram for alcohol dependence and buprenorphine for opioid withdrawal. Side effects of de-addiction medications include sedation, drowsiness, and nausea.