The document summarizes various drugs of abuse including their mechanisms of action, effects, dependence, tolerance, withdrawal and treatment approaches. It discusses stimulants like cocaine and amphetamines, opioids, cannabinoids, nicotine, depressants like alcohol, barbiturates and benzodiazepines. It describes how these drugs activate the brain's reward system and how chronic use leads to tolerance and dependence characterized by drug-seeking behavior and withdrawal symptoms when use is discontinued. Treatment involves managing withdrawal symptoms, replacing opioids with longer-acting alternatives, and addressing psychological aspects through counseling and support groups.

1. DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC

13. Dopamine Synapse DA L-DOPA Tyrosine Tyrosine

14. GABA-neuron

17. Dopamine receptor Dopamine reuptake pump

19. cAMP G-Protein cocaine

21. Cannabinoids/

23. cAMP G-Protein Cannabinoids

25. Positive actions Negative actions

28. Drugs of Abuse: Opiates

34. THE MESOLIMBIC DOPAMINERGIC REWARD PATHWAY

35. VTA Nucleus accumbens Prefrontal cortex Opioids

57. THANK YOU