The document discusses oral disintegrating tablets (ODTs), which are oral solid dosage forms that dissolve or disintegrate rapidly in the mouth without water. ODTs offer advantages over traditional tablets like improved patient compliance and bioavailability. Key attributes of ODTs include rapid disintegration (within 30 seconds), good taste masking, and the use of superdisintegrants, sugars, and other excipients to facilitate quick dissolution. Common technologies for producing ODTs involve freeze-drying, direct compression, spray drying, and mass extrusion. Preformulation studies and tests of disintegration time and dissolution profile are important for developing an effective ODT formulation.
pharmaceutical technologists have developed a novel oral dosage form known as orally disintegrating tablets (odts) which disintegrate rapidly in saliva, usually in a matter of seconds, without the need to take it water. drug dissolution and absorption as well as onset of clinical effect and drug bioavailability may be significantly greater than those observed from conventional dosage forms ,
pharmaceutical technologists have developed a novel oral dosage form known as orally disintegrating tablets (odts) which disintegrate rapidly in saliva, usually in a matter of seconds, without the need to take it water. drug dissolution and absorption as well as onset of clinical effect and drug bioavailability may be significantly greater than those observed from conventional dosage forms ,
Formulation and evaluation of fast dissolving tabletsSURYAKANTVERMA2
ย
The concept of mouth dissolving drug delivery systems (MDDDS) or fast dissolving tablets emerged with an objective to improve patientโs compliance.
These dosage forms rapidly disintegrate and/or dissolve to release the drug as soon as they come in contact with saliva, thus obviating the need for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients.
The most common method of drug delivery is oral dosage
form of which tablet and capsule are predominant.
Tablet is more accepted as compared to capsule due to
many reason such as cost, tamper resistance, ease of
handling, ease of identification and manufacturing efficiency.
Tablet compression process understanding is resulted in
development of formulation.
Recent advances in the design of tablet compression
equipment has conducted resulted in higher efficiency,
minimized tablet variation, greater flexibility.
$ CONTENTS $
#Introduction
#Objective of granulation
#Essential properties of granules
#Mechanism of bond formation
#Mechanism of granule formation
#Method of granulation
#Modern equipments in granulation technology
Formulation and evaluation of fast dissolving tabletsSURYAKANTVERMA2
ย
The concept of mouth dissolving drug delivery systems (MDDDS) or fast dissolving tablets emerged with an objective to improve patientโs compliance.
These dosage forms rapidly disintegrate and/or dissolve to release the drug as soon as they come in contact with saliva, thus obviating the need for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients.
The most common method of drug delivery is oral dosage
form of which tablet and capsule are predominant.
Tablet is more accepted as compared to capsule due to
many reason such as cost, tamper resistance, ease of
handling, ease of identification and manufacturing efficiency.
Tablet compression process understanding is resulted in
development of formulation.
Recent advances in the design of tablet compression
equipment has conducted resulted in higher efficiency,
minimized tablet variation, greater flexibility.
$ CONTENTS $
#Introduction
#Objective of granulation
#Essential properties of granules
#Mechanism of bond formation
#Mechanism of granule formation
#Method of granulation
#Modern equipments in granulation technology
Novel Drug Delivery System is to provide a therapeutic amount of drug to the appropriate site in the body to accomplish promptly and then maintain the desired drug concentration
This presentation which highlights the various technology innovations and developments in targeted drug delivery as well as maps its applications in different therapeutic segments was presented at the Novel Drug Delivery Systems and Clinical Trial Management 2013 Conference at Shangai, China.
Excipients..different types of excipients and its applications in pharmacetical industry for manufacturing of dosage forms.
few examples of commercially available excipients in the market for the manufacturing purpose of intended dosage forms.
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17. Avg. particle size and flow index for industrially used superdisintegrants . Crospovidone A2 found to be best suited .
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23. Steps involved in zydis technology Active drug + carrier/polymer Poured in wells of blister packs Trays of blister packs passed though liq N2 freezing tunnels Aluminium foil backing is applied on blisters blisters are packed
52. Ion Exchange Resin Example Strong acid cation exchange resin Amberlite IRP-69, Indion-224 Weak acid cation exchange resin Amberlite IRP-65, Indion-204, Indion-234 Strong base anion exchange resin Amberlite IRP-276 Weak base anion exchange resin Dimethyl amine resin
53. 2.Forming Microgranuales Coating with taste masking material [ethylcellulose aquaous dispersion] SEED [Fine crystalline microcellulose sphere] Layering with drug
54. a) FMCS b) layered micro granules c) Coated micro granules
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