1) The study used swept-source OCT to examine the 3D features of the dome-shaped macula (DSM) in highly myopic eyes over 2 years.
2) It found thinning of the sclera over time at the fovea and surrounding regions, with an average decline of 5-12 μm per year.
3) The height of the macular bulge increased on average by 20 μm over 2 years, suggesting dynamic changes in the posterior pole over time.
Presenters :
Jenil Shelsiya
Sisira PS
Gopika Jyothirmayan
Special Thanks To Sushma Shrestha
and Mentor Deepak Rai (Optometrist).
If any query,Viewers are requested to refer to book for detailed explanation or can ask me question directly in the comment box. Answers will be given from Presenter's side.
Congenital pit is an atypical coloboma usually located on the temporal edge of the disc, associated with irregular defects in the juxtapapillary choroid and pigment epithelium. Macular fibers passing through this area often are affected and corresponding changes in the retinal ganglion cell layer and in the visual field occur.
Presenters :
Jenil Shelsiya
Sisira PS
Gopika Jyothirmayan
Special Thanks To Sushma Shrestha
and Mentor Deepak Rai (Optometrist).
If any query,Viewers are requested to refer to book for detailed explanation or can ask me question directly in the comment box. Answers will be given from Presenter's side.
Congenital pit is an atypical coloboma usually located on the temporal edge of the disc, associated with irregular defects in the juxtapapillary choroid and pigment epithelium. Macular fibers passing through this area often are affected and corresponding changes in the retinal ganglion cell layer and in the visual field occur.
The presentation presents some treatment modalities as regards AI.This is to keep you thinking more on how to approach a case of AI in terms of management.
To know Humphrey visual field analyser
To know about various types of perimetry
To identify field defect
To recognize that field defect is due to glaucoma or neurological lesion
To know that field defect is progressive or not
Interpretation of HVFA
The presentation presents some treatment modalities as regards AI.This is to keep you thinking more on how to approach a case of AI in terms of management.
To know Humphrey visual field analyser
To know about various types of perimetry
To identify field defect
To recognize that field defect is due to glaucoma or neurological lesion
To know that field defect is progressive or not
Interpretation of HVFA
This ppt describe about the incidence, diagnosis and management of maculopathy in caaes of pathological myopia.
Data collected and created by Vivek Chaudhary
For queries : vivek977optom@gmail.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Am J Ophthalmol. 2014;158(5):1062-1070
Am J Ophthalmol. 2013;155(2):320-328.
3. Dome Shaped Macula
Study II: Dome Shaped Macular configuration: Longitudinal
Changes in The Sclera and Choroid by Swept-Source
Optical Coherence Tomography Over 2 Years
Study I: Three Dimensional Tomographic Features of Dome
Shaped Macula by Swept Source Optical Coherence
Tomography
Sclera
Choroid
Retina
4.
5. High myopia is often defined as a refractive error of - 6 Diopters or
more (Refractive definition) or an axial length of 26.5 mm or more
(Biometric definition). (Normal Axial length = 22-24 mm)
High myopia is associated with axial elongation of the globe with
concomitant thinning of the retina, choroid, and sclera and subsequent
development of macular pathologic features.
6. The progressive elongation of the globe can lead to scleral ectasia
“Staphyloma” which usually occur in the posterior pole, and may take
different patterns and shapes.
Posterior Staphyloma types (Curtin BJ 1977)
Staphyloma
7. 1 mm 1 cm 10 cm
Penetrat
ion
depth
(log)
1 mm
10 mm
100 mm
1 mm
Resolution
OCT
microscopy
Clinical Imaging
(CT, MRI, US)
Depth
The OCT fills the gap between clinical
imaging methods and microscopy with a
micrometer-scale resolution.
Over the past 2 decades, the introduction of optical
coherence tomography (OCT) has revolutionized the field of
ophthalmology; diagnosis and guided therapy.
8. The OCT can acquire an “Optical biopsy” of retinal layers.
OCT scan of the normal retina
11. Reference
Beam
splitter
SLD
Detector
Time domain
Sample arm
Referencearm
OCT is analogous to ultrasound but uses light instead of sound.
Sample
It utilizes partial coherence interferometry to construct retinal images.
A-scan
Interference/
Signal
Processing
OCT image
Long wavelength 1050 nm
sweeping laser
Swept source
Fourier transform
12. Swept Source OCT => potential advantages for imaging highly myopic eyes:
1. High speed (>100,000 A scan / second)=>
allows for 3D imaging in less than 1 second with
minimal motion artifact.
2. Wide scan range up to 12 mm =>
covers wide area of the staphyloma.
3. Deeper penetration owing to its long
wavelength (1050 nm)=>
Imaging of choroid, even sclera in high myopia
13.
14. Dome-shaped macula (DSM) was first described by Gaucher et al. as an
unexpected inward bulge of the macula in highly myopic eyes within the
posterior staphyloma.
Dome Shaped macula Normal eye curvature
Steep curvature in High Myopia
Gaucher et al. (AJO 2008)
Dome Shaped macula
15. By using 3D MRI, Moriyama et al. ,
reported that 63 % of highly myopic eyes
had more than one ocular protrusion and
the presence of ocular protrusion may be
related the Dome shaped macula
tomographic appearance in OCT.
(Ophthalmology 2011)
3D MRI showing 3 protrusions at
the posterior pole.
Later, Imamura et al. reported that DSM
may be due to relative localized thickness
variation of the sclera at the fovea in
highly myopic eyes. (AJO 2010)
16. So far, it is still unknown:
•The actual 3D appearance of dome-shaped macula.
•Prevalence of vision threatening complications.
•The mechanisms underlying dome-shaped macula.
It is now recognized that dome shaped macular configuration is not rare,
with estimated prevalence between 9.3 - 10.7 % in highly myopic eyes.
Gaucher et al, AJO 2008
Ohsugi et al. AJO 2014
Our initial pilot study showed that dome shaped macula is associated with
multiple vision threatening complications in at least half of the patients.
17. To study the tomographic features and path-omorphology of dome-
shaped macula with Swept-Source Optical coherence Tomography
18. Prospective Cross-sectional study.
• 51 eyes .
• High myopia (> -6 Diopters or Axial Length > 26.5 mm).
• Dome shaped macula:
>50 µm
Dome shaped maculaRetinal Pigment Epith (RPE)
We defined dome shaped macula as “An inward bulge of the retinal pigment
epithelium (RPE) of more than 50 µm on the vertical sections of OCT above a
presumed line tangent to the outer surface of RPE at the bottom of the posterior
staphyloma”.
19. 3D Swept Source OCT.
Simultaneous Fluorescein and Indocyanine angiogram for eyes
with macular complications.
Axial length measurement using ocular biometry.
The type of staphyloma was classified by indirect ophthalmoscopy
according to Curtain BJ.
Curtin BJ. Trans Am Ophthalmol Soc 1977;75:67-86.
Visual acuity, Autorefractometry, and Color photography.
20. By Swept source OCT at 1050 nm
III- Segmentation of the RPE:
To create 3-D images of the topography of the
posterior pole.
I- Multi-averaged scan (12 mm)
Vertical and Horizontal scans → to confirm Diagnosis
Vertical scan
Horizontal scan
II- 3D imaging of the macula:
Raster scan protocol covering 12 x 8 mm2
3D scan
21. Fig 1
1- Retinal, choroidal, and scleral thicknesses at the fovea.
2- The height of the macular bulge above a presumed line tangent to the Retinal
pigment epithelium surface at the bottom of the posterior staphyloma.
2000 µm 2000 µm
3- Choroidal and scleral thicknesses at surrounding parafoveal regions at 2000µm
superiorly and inferiorly (vertical scan); temporally and nasally (horizontal scan).
Retroocular
tissue
Retina
Choroid
Sclera
Macular
bulge
22. Characteristics of Eyes with a Dome-Shaped Macula
Number of eyes(patients) 51 (35)
Sex (male/female) 8/27
Visual acuity (logMAR) 0.36 ± 2.16
Age (yrs) 65.6 ± 11.3 (40 to 87)
Axial length (mm) 29.53 ± 2.16 (26.16 to 34.89)
Refractive error (diopters) −13.69 ± 5.86 (−6.75 to −31.0)
Type of posterior staphyloma
I 18
II 26
III 3
IX 4
23. 23
The reconstructed 3D images revealed the curvature of the posterior pole.
In all eyes, two outward concavities were seen within the posterior staphyloma
and a horizontal ridge was seen traversing the macula.
42 eyes (82.4 %): showed a
band-shaped configuration.
9 eyes (17.6 %): showed a
typical dome-like bulge.
2 concavities
2 concavities
Horizontal
ridge
Horizontal
ridge
OCT scans showed marked scleral thinning
consistent with the two outward concavities.
24. The vertical scan showed a convex configuration, but the horizontal scan
showed an almost flat RPE line.
Vertical scan Horizontal scan
Both vertical and horizontal OCT scans showed a convex configuration.
28. Comparison between the Two Types of Dome- Shaped Macula
Band-shaped
configuration
Typical dome-
shaped convexity
P value
Number of eyes 42 (82.4%) 9 (17.6%)
Sex (male/female) 11/31 0/9 0.09a
Age (years) 66.6 ± 10.6 61.1 ± 14.1 0.192b
Axial length (mm) 29.75 ± 2.26 28.52 ± 1.28 .121b
Refractive error (diopters) −14.19 ± 6.19 −11.54 ± 3.10 .277b
Visual acuity (logMAR) 0.32 ± 0.36 0.29 ± 0.28 .818b
Foveal retinal thickness (μm) 193.5 ± 90.6 178.6 ± 52.8 .638b
Foveal choroidal thickness (μm) 32.8 ± 26.9 42.7 ± 37.9 .358b
Foveal scleral thickness (μm) 501.5 ± 93.6 598.3 ± 76.8 .006b
Height of the inward bulge (μm) 151.9 ± 63.8 154.2 ± 27.3 .864b
aFischer’s exact test, bUnpaired t-test
29. Complications in the Eyes with a Dome-Shaped
Macula
Choroidal neovascularization 21 (41.2%)
Serous retinal detachment 3 (5.9%)
Patchy chorioretinal atrophy 4 (7.8%)
Lamellar macular hole 3 (5.9%)
Full-thickness macular hole 1 (1.9%)
Foveal schisis 1 (1.9%)
Extrafoveal retinal schisis 9 (17.6%)
About 58.8 % of eyes had vision
threatening complications.
Choroidal neovascularization
(growth of new blood vessels from the choroid to invade the retina.)
Serous macular detachment Lamellar macular hole
(partial defect at the center of the fovea)
Extrafoveal schisis
(splitting of the retinal layers)
Incidence of choroidal neovascularization
in High myopia is about 5.2% in USA and
11.3% in Japan. Grossenkalus HE et al Retina (1992)
Hayashi K et al. Ophthalmology (2010)
30. Table . Characteristics of Eyes with CNV vs. without CNV
Eyes without
CNV
Eyes with
CNV P value
Number of eyes (%) 30 (58.8%) 21 (41.2%)
Age (years) 65.5 ± 12.4 65.8 ± 10.0 .936b
Axial length (mm) 29.60 ± 2.13 29.45 ± 2.24 .816b
Refractive error (diopters) −13.61 ± 6.26 −14.06 ± 5.35 .806b
Visual acuity (logMAR) 0.24 ± 0.32 0.53 ± 0.42 .007b
Foveal retinal thickness (μm) 190.1 ± 62.0 191.9 ± 111.6 .943b
Foveal choroidal thickness (μm) 38.5 ± 32.8 28.8 ± 21.8 .212b
Foveal scleral thickness (μm) 518.0 ± 109.7 519.4 ± 79.6 .958b
Height of the inward bulge (μm) 167.3 ± 59.5 131.0 ± 51.7 .028b
The mean height of the macular bulge was significantly more in eyes without CNV (P = .028).
aFischer exact test, bUnpaired t-test
Choroidal neovascular membrane
RPE atrophy
31. We speculated that = > The bulge in eyes with DSM may act as a macular
buckle or ”indent” mechanism, indenting the fovea similar to a macular
exoplant, and thus change the tractional forces over the fovea.
Macular Buckle
(used previously for treatment for myopic foveoschisis and
myopic macular hole)
The incidence of extrafoveal schisis “splitting of the retina” was similar to reports on
high myopia while foveo-schisis “splitting of retinal layers at the fovea” was quite
low as compared to highly myopic eyes without dome shaped configuration.
High myopia with foveo-schisisSuperior schisis in DSM Inferior schisis in DSM
32. ◆ In highly myopic eyes with DSM , a horizontal ridge is formed within
the posterior staphyloma between two outward concavities of RPE.
◆ 3D reconstructed images showed that DSM may involve 2
configurations; more common Band shaped ridge and Less frequent
Dome shaped convexity.
◆ 3D reconstruction of the shape of the posterior pole using OCT is a
useful method to study the topography of the globe.
33.
34. Since the sclera is the primary determinant of eyeball shape and the
main changes in ocular elongation in high myopia take place at the
scleral coat, tracking changes in the sclera may help to elucidate the
mechanism underlying the formation of a dome-shaped macula.
Based on our previous 3D data, DSM has shown to be more complex
and the mechanisms that underlie DSM are still speculative.
Sclera
35. To study longitudinal changes in the posterior pole in eyes
with dome-shaped macular configuration.
2 years
36. 36
-Tracked the changes in sclera and choroid at the fovea and at 4 parafoveal
locations 2000 µm from the foveal center => Scleral thickness maps.
-Tracked changes in Macular bulge and dynamic changes in the posterior pole.
• 35 eyes with High myopia and Dome-shaped macula.
• Mean follow up 24.8 ± 2.5 months.
• Using Swept Source OCT
Prospective Cross-sectional study.
1 2
Macular bulge
*
A
Sclera
B
37. 1st scan (January 2011)
2nd Scan (July 2013)
A
B
A
B
Scleral thickness map
Scleral thickness map
38. Longitudinal changes in The Sclera Over 2 Years
At initial visit At the end of follow up P valuea
Visual acuity (logMAR) 0.37 ± 0.49 0.36 ± 0.45 .804
Foveal scleral thickness (μm) 496.1 ± 95.7 484.7 ± 96.2 < .001
Macular bulge height (μm)b 136.5 ± 60.9 157.6 ± 67.0 < .001
Parafoveal Scleral thicknesses
At 2000 µm superiorly (μm) 280.9 ± 87.1 258.2 ± 87.2 < .001
At 2000 µm inferiorly (μm) 263.1 ± 68.7 239.0 ± 66.7 < .001
At 2000 µm temporally (μm) 307.6 ± 97.3 286.3 ± 95.5 < .001
At 2000 µm nasally (μm) 372.7 ± 88.2 360.9 ± 90.1 < .001
aPaired t-test
40. Scleral thickness map (µm)
Sep 2013
A
B
151µm
November 2011
}}}}
A
B
Superior Inferior
Scleral thickness map (µm)
Nov 2011
41. Decline In Scleral Thickness Per Year at Various Macular Points
Scleral Thick.
decline over 2
years (μm)
Estimated Scleral
thickness decline/year
(μm)
P Valuea
Foveal center 11.2 5.62 -
At 2000 µm superiorly 22.7 11.14 .002
At 2000 µm inferiorly 24.1 12.11 <.001
At 2000 µm temporally 21.3 10.39 .009
At 2000 µm nasally 11.6 5.83 .907
aComparisons with the foveal center (using one-way analysis of variance with least significant difference post-hoc analysis).
42. 42
22.7
11.2
24.1
21.3 11.6
Decline of scleral thickness over 2 years
11.2 11.6
The relatively preserved sclera at the fovea and nasal side may
act as a macular pillar to support the expanding globe.
43. The sclera becomes entirely thinner over time in eyes with dome-
shaped macular configuration.
The scleral thinning is asymmetric and the progression of such
asymmetric scleral thinning leads to the dome-shaped tomographic
appearance.
Dome Shaped macular configuration is an independent scleral change
related to regional difference in the structural integrity of the sclera.
Editor's Notes
My thesis theme is about 3D Tomographic features of DSM by SSOCT
OCT is analogous to ultrasound imaging but uses infrared light instead of sound. It uses partial coherence interferometry to construct images of the retina.
#C# In the current study we used The 3rd generation SSOCT which uses wavelength sweeping laser at 1050 nanometer wavelength as a scanning light.
In the current research we used the SSOCT because it has potential advantages in imaging of highly myopic eyes.
1. High speed (>100,000 A scan / second) #C# => allows for 3D imaging in less than 1 second with minimal motion artifact.
#C# 2. Wide scan range up to 12 mm => covers wide area of the retia.
#C# 3. The long wavelength of the laser has ability to image deep ocular layers as the choroid and even sclera especially in HM
Dome-shaped macula (DSM) was first described by Gaucher et al. as an unexpected inward bulge of the macula in highly myopic eyes within the posterior staphyloma.
In normal eyes, the curve of the posterior pole is slightly convex. In highly myopic eyes the curvature of the posterior pole is more steeper. In eyes with DSM they have an inward convexity within the curvature of the posterior pole.
Later, Imamura et al. by reported that DSM may be due to relative localized thickness variation of the sclera at the fovea in highly myopic eyes.
By using 3D MRI, Moriyama et al. , reported that 63 % of highly myopic eyes had more than one ocular protrusion and the presence of ocular protrusion may be related the DSM tomographic appearance in OCT.
It is now recognized that dome-shaped macular configuration is not rare, with estimated prevalence between 9.3 - 10.7 % in highly myopic eyes.
#C# Our initial pilot study showed that dome-shaped macula is associated with multiple vision threatening complications.
#C# So far, the actual 3D appearance of DSM and the prevalence of vision threatening complications are still unknown. Furthermore, the mechanisms underlying DSM are rather speculative.
The aim of the current study is to reveal the tomographic features and pathomorphology of eyes with DSM by using long wavelength swept source OCT.
Our scanning protocol included;
** multi averaged 12 mm vertical and horizontal line scans to confirm the diagnosis of DSM.
** Then we captured 3D data over an area of 12 by 8 square mm.
** By segmentation of the RPE line in the 3D data set, we constructed a 3D image representing the curvature of the post pole.
On the contrary to the common concept, most eyes showed a band shaped ridge configuration
We compared between the demographic and tomographic features between both configurations, There were no difference between the 2 types except that the scleral was relatively thicker at the fovea in the dome shaped type.
As text.
Our two years results showed that the scleral thinning was asymmetric and there was greater thinning in the superior, inferior, and temporal regions as compared to the subfoveal and nasal regions. We also calculated the estimated decline of scleral thickness per year.
We found that the decline in scleral thickness was less marked at the foveal center and nasal region as compared to other measurement points. This is probably due to regional difference in structural strength of the sclera at the macula. We speculated that the relatively preserved sclera at the fovea and nasal side may act as a macular pillar to support the expanding globe.