Focal choroidal excavations were found in 7.8% of eyes with central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (OCT). OCT revealed that in some eyes with focal excavations, unusual choroidal tissue bridged the bottom of the excavation to the outer choroid boundary, and in some cases a suprachoroidal space was present below the excavation. Eyes with focal excavations were more myopic and had thinner subfoveal choroidal thickness than eyes without excavations. The study suggests focal excavations in CSC may form from retinal pigment epithelium retraction caused by focal scarring of choroidal connective tissue.
Focal choroidal excavation in eyes with central serous chorioretinopathyAbdallah Ellabban
Focal choroidal excavations were detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavations were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroidal boundary. This study provides insights into the prevalence and 3D morphology of focal choroidal excavations in central serous chorioretinopathy.
Inferior posterior staphyloma: choroidal maps and macular complications Abdallah Ellabban
Eyes with inferior posterior staphyloma showed marked choroidal thinning along the superior border of the staphyloma. As patient age increased, choroidal thinning progressed in the entire macular area. Eyes with neovascular complications associated with the staphyloma had significantly reduced macular choroidal thickness compared to eyes without complications. Reduction of the choroidal thickness with age seemed to be involved in the development of neovascularization associated with inferior posterior staphyloma.
Tomographic fundus features in Pseudoxanthoma Elasticum Abdallah Ellabban
This study analyzed optical coherence tomography (OCT) scans of 52 eyes from 27 patients with pseudoxanthoma elasticum (PXE) and compared features between those with choroidal neovascularization (CNV) secondary to angioid streaks (AS) vs CNV secondary to age-related macular degeneration (AMD). Unique lesions were more common in PXE patients, including outer retinal tubulation (ORT) seen in 70.5% of eyes with CNV secondary to AS vs 34.1% of AMD eyes, and Bruch's membrane undulation seen in 70.8% vs 11.4% respectively. ORT appeared as round or ovoid structures beneath the outer plexiform layer.
Optical coherence tomography angiography optovue a very basic lecture detailing the new advancement of dyeless angiography by spectral domain OCT system and SSADA and Motion correction algorithm
This document discusses optical coherence tomography (OCT) and OCT angiography (OCTA). It provides background on OCT and how it can be used for in vivo optical biopsies. A brief history of OCT's development is given, along with principles of OCT variants like spectral domain OCT. Clinical applications of OCT and OCTA are explored through examples of interpreting OCT reports, identifying landmarks, and analyzing various retinal conditions and diseases. Potential research opportunities using OCT and OCTA data are also mentioned.
We can ultimately aim to obtain “optical biopsies” of cornea with the introduction of high resolution AS-OCT .
AS-OCT helps assess tissue anatomy and evaluate differences in cellular morphology and patterns to distinguish between divergent anterior segment conditions.
Optical Coherence Tomography (OCT) is a non-invasive imaging technique that examines living tissue using low coherence radiation. It provides high resolution cross-sectional images of the retina in real time. OCT allows for both qualitative and quantitative analysis of retinal thickness, volume, and nerve fiber layer thickness. Scans can be customized using different protocols like line, circle, or radial line scans to examine specific areas of interest like the macula or optic nerve.
Optic Coherence Tomography (OCT) is a non-invasive imaging technique used to screen superficial structures with micron-level resolution. OCT can be used to qualitatively and quantitatively analyze retinal layer thickness and detect anomalous structures. It has various applications in neurology, ophthalmology, and other fields to aid in diagnosis, treatment monitoring, and prognosis determination for conditions like multiple sclerosis, optic neuritis, glaucoma, and macular diseases. Newer OCT technologies continue to be developed with improvements in speed, resolution, and additional modalities.
Focal choroidal excavation in eyes with central serous chorioretinopathyAbdallah Ellabban
Focal choroidal excavations were detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavations were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroidal boundary. This study provides insights into the prevalence and 3D morphology of focal choroidal excavations in central serous chorioretinopathy.
Inferior posterior staphyloma: choroidal maps and macular complications Abdallah Ellabban
Eyes with inferior posterior staphyloma showed marked choroidal thinning along the superior border of the staphyloma. As patient age increased, choroidal thinning progressed in the entire macular area. Eyes with neovascular complications associated with the staphyloma had significantly reduced macular choroidal thickness compared to eyes without complications. Reduction of the choroidal thickness with age seemed to be involved in the development of neovascularization associated with inferior posterior staphyloma.
Tomographic fundus features in Pseudoxanthoma Elasticum Abdallah Ellabban
This study analyzed optical coherence tomography (OCT) scans of 52 eyes from 27 patients with pseudoxanthoma elasticum (PXE) and compared features between those with choroidal neovascularization (CNV) secondary to angioid streaks (AS) vs CNV secondary to age-related macular degeneration (AMD). Unique lesions were more common in PXE patients, including outer retinal tubulation (ORT) seen in 70.5% of eyes with CNV secondary to AS vs 34.1% of AMD eyes, and Bruch's membrane undulation seen in 70.8% vs 11.4% respectively. ORT appeared as round or ovoid structures beneath the outer plexiform layer.
Optical coherence tomography angiography optovue a very basic lecture detailing the new advancement of dyeless angiography by spectral domain OCT system and SSADA and Motion correction algorithm
This document discusses optical coherence tomography (OCT) and OCT angiography (OCTA). It provides background on OCT and how it can be used for in vivo optical biopsies. A brief history of OCT's development is given, along with principles of OCT variants like spectral domain OCT. Clinical applications of OCT and OCTA are explored through examples of interpreting OCT reports, identifying landmarks, and analyzing various retinal conditions and diseases. Potential research opportunities using OCT and OCTA data are also mentioned.
We can ultimately aim to obtain “optical biopsies” of cornea with the introduction of high resolution AS-OCT .
AS-OCT helps assess tissue anatomy and evaluate differences in cellular morphology and patterns to distinguish between divergent anterior segment conditions.
Optical Coherence Tomography (OCT) is a non-invasive imaging technique that examines living tissue using low coherence radiation. It provides high resolution cross-sectional images of the retina in real time. OCT allows for both qualitative and quantitative analysis of retinal thickness, volume, and nerve fiber layer thickness. Scans can be customized using different protocols like line, circle, or radial line scans to examine specific areas of interest like the macula or optic nerve.
Optic Coherence Tomography (OCT) is a non-invasive imaging technique used to screen superficial structures with micron-level resolution. OCT can be used to qualitatively and quantitatively analyze retinal layer thickness and detect anomalous structures. It has various applications in neurology, ophthalmology, and other fields to aid in diagnosis, treatment monitoring, and prognosis determination for conditions like multiple sclerosis, optic neuritis, glaucoma, and macular diseases. Newer OCT technologies continue to be developed with improvements in speed, resolution, and additional modalities.
Principles of optical coherence tomographyJagdish Dukre
OCT uses interferometry to perform non-invasive imaging of biological tissues. The first OCT images of the retina were obtained in 1990. Time domain OCT works by scanning a reference mirror to measure echo time delays, while Fourier domain OCT measures spectral interference patterns without scanning. Fourier domain OCT allows for much faster acquisition speeds compared to time domain OCT. Integrating OCT with scanning laser ophthalmoscopy enables localization of OCT scans on fundus images.
Wide field imaging techniques like ultra wide field imaging provide views of the peripheral retina beyond 100 degrees. This allows for better evaluation of pathologies in the retinal periphery. Techniques include non-contact lenses systems like Spectralis and Optos that provide wide field views up to 200 degrees without requiring pupillary dilation or contact lenses. OCT-Angiography is a new technique that uses motion contrast to generate high resolution images of the retinal microvasculature without requiring dyes. It has applications in evaluating diseases like AMD, diabetic retinopathy, and glaucoma. Autofluorescence imaging maps lipofuscin distribution in the retinal pigment epithelium and can detect accumulation associated with various retinal diseases.
optical coherence tomography is a new tool that makes retinal diagnosis easier. the above ppt includes a detailed and precise notes on OCT and its interpretation.
The document provides an overview of retinal optical coherence tomography (OCT). It discusses how OCT works using light to provide non-invasive, high resolution imaging of ocular structures. Examples of anterior segment, optic nerve, and retinal OCT scans are shown. Interpretation of macular OCT scans and quantitative thickness maps are described. Indications for retinal OCT include examining retinal layers, monitoring progression of diseases like age-related macular degeneration and diabetic macular edema, aiding treatment planning, and monitoring response to therapy. Case studies demonstrate how OCT enhanced diagnosis and treatment decisions for vitreoretinal interface disorders, retinal vascular diseases, and other retinal entities compared to other imaging tests.
Optical Coherance Tomography (OCT) in Vitreo Retina and Choroid Tahseen Jawaid
This document discusses optical coherence tomography (OCT) and its use in retinal imaging. OCT has become the most important test for diagnosing and managing retinal diseases. Several improvements to OCT technology over time, including Fourier domain detection and swept-source OCT, have provided faster scanning speeds and better visualization of the choroid and sclera. Both structural and quantitative analysis of OCT scans provide valuable information. While artifacts can occur, OCT remains a non-invasive and repeatable tool that will continue improving with advances in software.
OCT is a great technology,Many ophthalmologist find very difficult to understand it ,SO I have tired to simplify it as much as possible .Hope everyone can understand now onwards the basic about OCT .
Every feedback s most welcomed sothat i can improve further in coming days
Please email your feedback to me in the following address
yourgyanu@gmail.com
OCT provides high-resolution, cross-sectional images of the retina and anterior eye using low-coherence interferometry. It allows detection of morphological changes and measurement of retinal thickness, volume, and nerve fiber layer thickness. Newer variants such as ultra-high resolution OCT, Doppler OCT, and anterior segment OCT provide additional structural and functional information. OCT is a non-invasive imaging technique that has become an essential tool for diagnosing and managing retinal diseases.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution cross-sectional images of the retina and anterior segment of the eye. OCT works by measuring the interference of light reflected from tissues to create 3D images. It is analogous to ultrasound imaging but uses light instead of sound. OCT is useful for diagnosing and monitoring various retinal conditions and diseases like macular degeneration as well as measuring eye structures. Some common applications of OCT include detecting macular holes, cysts, detachments and membranes in the retina.
This document summarizes a seminar on optical coherence tomography (OCT). OCT uses low-coherence interferometry to produce high-resolution, cross-sectional tomographic images of internal tissue microstructures. It has advantages over other imaging modalities like high resolution, rapid acquisition, and small catheter designs. The document outlines OCT applications in fields like cardiology, dermatology, and gastroenterology. It also discusses current limitations and future work to improve penetration depth, resolution, and acquisition rates to further clinical applications.
This document provides guidance on interpreting optical coherence tomography (OCT) scans of the macula in common retinal diseases. It discusses how to acquire high-quality OCT images and systematically evaluate the scans. Key steps in image acquisition include proper scan centration and verification of data quality. When evaluating scans, the document outlines examining scan quality, overall retinal profile, foveal contour, retinal layers, and identifying any abnormalities. Specific pathologies are demonstrated, such as macular edema, holes, detachments, and changes at the retinal pigment epithelium. Overall, the document serves as a guide for clinicians to optimize OCT image quality and systematically read scans to accurately diagnose and monitor macular diseases.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses low-coherence interferometry to produce high-resolution, cross-sectional images of biological tissues. OCT works by measuring the backscattered light from internal tissue microstructures. The basic setup uses a Michelson interferometer with a broadband light source, such as a superluminescent diode, to capture back-reflected light. There are different types of OCT systems, including time domain OCT, frequency domain OCT, and swept-source OCT. OCT has various medical applications for imaging the eye, skin, and detecting cancer or other abnormalities in human cells.
Operating an OCT & evaluating normal scan (Optom.Saptarshi Mehta).....Saptarshivision
Here you can understand the basic of OCT and how to interpreted a OCT scan. Alteration in retinal layers which shows in OCT, what is the correct terminology to describe them, and how to identify the artifacts which can induce errors in measurement making quantitative data inaccurate. I am trying to include all the essential information in this presentation. I hope, which helps you, for your clinical practice. Thank you.
OPTICAL COHERENCE TOMOGRAPHY (SKIN OCT)....
Optical coherence tomography (OCT) is an established medical imaging technique that uses light to capture micrometer-resolution, three dimensional images from within optical scattering media (e.g., biological tissue). Optical coherence media (e.g., biological tissue). Optical coherence tomography is based on low coherence interferometry, typically employing near-infrared light. The use of relative long wavelength light allows it to penetrate into the scattering medium. Confocal microscopy, another optical technique, typically penetrates less deeply into the sample but with higher resolution.
This document provides a brief history and overview of optical coherence tomography (OCT). It discusses that OCT was first used to image the retina in 1991 with a resolution of 17 μm. Commercially available OCT systems emerged in 1996 and provided cross-sectional retinal images with 10 μm resolution. The document then outlines the development and advantages of newer spectral domain OCT technology, which offers higher resolution, faster scanning speeds, and 3D imaging capabilities compared to earlier time domain OCT. A variety of clinical applications of OCT are also reviewed.
1. OCT imaging provides high-resolution cross-sectional images of coronary arteries and stents to assess plaque, guide stent sizing and placement, and confirm procedural success.
2. The OCT catheter is advanced to the region of interest and an automated pullback acquires images as flush media clears blood from the field of view. Images can be used to characterize plaque, measure vessel and stent dimensions, check apposition and expansion, and detect complications.
3. OCT has advantages over IVUS like superior resolution and ability to identify details like thin-cap fibroatheroma, but it also has limitations such as limited tissue penetration and the need for flush media that adds contrast load.
Flexible fiberoptic catheter used for light delivery
OCT enhances imaging resolution that may permit the evaluation of clinical (e.g., luminal measurements during PCI) and research (e.g., fibrous cap thickness and strut levelanalysis) parameters for the interventional cardiologist.
OCT-Angiography (OCT-A) uses motion contrast to non-invasively image the retinal and choroidal vasculature without the need for dye injection. It provides layer-by-layer 3D analysis and quantification. While it has advantages over fluorescein angiography like shorter acquisition time, OCT-A cannot image leakage or pooling and has limitations like motion artifacts and limited field of view. OCT-A is being used to evaluate diseases like diabetic retinopathy, macular degeneration, and vascular occlusions but currently serves as a complementary test rather than replacement for fluorescein angiography.
Reduction of retinal senstivity in eyes with reticular pseudodrusenAbdallah Ellabban
This study evaluated the effect of reticular pseudodrusen on retinal function using multiple imaging methods in 13 eyes with reticular pseudodrusen but no other macular abnormalities. Infrared reflectance imaging detected reticular pseudodrusen within the central macula in more eyes than color fundus photography or fundus autofluorescence. Retinal sensitivity across the macula was lower in eyes with reticular pseudodrusen compared to normal eyes. The number of reticular pseudodrusen detected by different imaging modalities correlated with reduced retinal sensitivity in specific macular areas.
OCT angiography allows visualization of the retinal and choroidal vasculature without dye injection. It uses amplitude decorrelation and phase variance techniques to detect blood flow. The retina and choroid can be segmented into different en face slabs. The superficial, deep, and outer retinal plexuses as well as the choriocapillaris can be visualized. OCTA is useful for diagnosing wet AMD by detecting type 1 CNV beneath the RPE that may not be clearly seen on FA. It can help classify CNV shape and branching patterns. Motion artifacts and projection artifacts can occur but many devices have correction software.
Focal choroidal excavation in eyes with central serous chorioretinopathy Abdallah Ellabban
Focal choroidal excavation was detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavation were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroid, suggesting focal choroidal excavations may form from retinal pigment epithelium retraction caused by focal scarring of the choroid.
This document summarizes research on accommodation presented to the Ophthalmology Department at Al-Azhar University. It defines accommodation as the eye's ability to change refractive power and focus on objects at different distances by altering the shape of the lens. The document discusses the mechanism of accommodation, theories around how it functions including Helmholtz's relaxation theory, and types of accommodation like tonic, proximal, and reflex accommodation. It also examines anomalies of accommodation such as presbyopia, insufficiency of accommodation, and their treatment.
Principles of optical coherence tomographyJagdish Dukre
OCT uses interferometry to perform non-invasive imaging of biological tissues. The first OCT images of the retina were obtained in 1990. Time domain OCT works by scanning a reference mirror to measure echo time delays, while Fourier domain OCT measures spectral interference patterns without scanning. Fourier domain OCT allows for much faster acquisition speeds compared to time domain OCT. Integrating OCT with scanning laser ophthalmoscopy enables localization of OCT scans on fundus images.
Wide field imaging techniques like ultra wide field imaging provide views of the peripheral retina beyond 100 degrees. This allows for better evaluation of pathologies in the retinal periphery. Techniques include non-contact lenses systems like Spectralis and Optos that provide wide field views up to 200 degrees without requiring pupillary dilation or contact lenses. OCT-Angiography is a new technique that uses motion contrast to generate high resolution images of the retinal microvasculature without requiring dyes. It has applications in evaluating diseases like AMD, diabetic retinopathy, and glaucoma. Autofluorescence imaging maps lipofuscin distribution in the retinal pigment epithelium and can detect accumulation associated with various retinal diseases.
optical coherence tomography is a new tool that makes retinal diagnosis easier. the above ppt includes a detailed and precise notes on OCT and its interpretation.
The document provides an overview of retinal optical coherence tomography (OCT). It discusses how OCT works using light to provide non-invasive, high resolution imaging of ocular structures. Examples of anterior segment, optic nerve, and retinal OCT scans are shown. Interpretation of macular OCT scans and quantitative thickness maps are described. Indications for retinal OCT include examining retinal layers, monitoring progression of diseases like age-related macular degeneration and diabetic macular edema, aiding treatment planning, and monitoring response to therapy. Case studies demonstrate how OCT enhanced diagnosis and treatment decisions for vitreoretinal interface disorders, retinal vascular diseases, and other retinal entities compared to other imaging tests.
Optical Coherance Tomography (OCT) in Vitreo Retina and Choroid Tahseen Jawaid
This document discusses optical coherence tomography (OCT) and its use in retinal imaging. OCT has become the most important test for diagnosing and managing retinal diseases. Several improvements to OCT technology over time, including Fourier domain detection and swept-source OCT, have provided faster scanning speeds and better visualization of the choroid and sclera. Both structural and quantitative analysis of OCT scans provide valuable information. While artifacts can occur, OCT remains a non-invasive and repeatable tool that will continue improving with advances in software.
OCT is a great technology,Many ophthalmologist find very difficult to understand it ,SO I have tired to simplify it as much as possible .Hope everyone can understand now onwards the basic about OCT .
Every feedback s most welcomed sothat i can improve further in coming days
Please email your feedback to me in the following address
yourgyanu@gmail.com
OCT provides high-resolution, cross-sectional images of the retina and anterior eye using low-coherence interferometry. It allows detection of morphological changes and measurement of retinal thickness, volume, and nerve fiber layer thickness. Newer variants such as ultra-high resolution OCT, Doppler OCT, and anterior segment OCT provide additional structural and functional information. OCT is a non-invasive imaging technique that has become an essential tool for diagnosing and managing retinal diseases.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution cross-sectional images of the retina and anterior segment of the eye. OCT works by measuring the interference of light reflected from tissues to create 3D images. It is analogous to ultrasound imaging but uses light instead of sound. OCT is useful for diagnosing and monitoring various retinal conditions and diseases like macular degeneration as well as measuring eye structures. Some common applications of OCT include detecting macular holes, cysts, detachments and membranes in the retina.
This document summarizes a seminar on optical coherence tomography (OCT). OCT uses low-coherence interferometry to produce high-resolution, cross-sectional tomographic images of internal tissue microstructures. It has advantages over other imaging modalities like high resolution, rapid acquisition, and small catheter designs. The document outlines OCT applications in fields like cardiology, dermatology, and gastroenterology. It also discusses current limitations and future work to improve penetration depth, resolution, and acquisition rates to further clinical applications.
This document provides guidance on interpreting optical coherence tomography (OCT) scans of the macula in common retinal diseases. It discusses how to acquire high-quality OCT images and systematically evaluate the scans. Key steps in image acquisition include proper scan centration and verification of data quality. When evaluating scans, the document outlines examining scan quality, overall retinal profile, foveal contour, retinal layers, and identifying any abnormalities. Specific pathologies are demonstrated, such as macular edema, holes, detachments, and changes at the retinal pigment epithelium. Overall, the document serves as a guide for clinicians to optimize OCT image quality and systematically read scans to accurately diagnose and monitor macular diseases.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses low-coherence interferometry to produce high-resolution, cross-sectional images of biological tissues. OCT works by measuring the backscattered light from internal tissue microstructures. The basic setup uses a Michelson interferometer with a broadband light source, such as a superluminescent diode, to capture back-reflected light. There are different types of OCT systems, including time domain OCT, frequency domain OCT, and swept-source OCT. OCT has various medical applications for imaging the eye, skin, and detecting cancer or other abnormalities in human cells.
Operating an OCT & evaluating normal scan (Optom.Saptarshi Mehta).....Saptarshivision
Here you can understand the basic of OCT and how to interpreted a OCT scan. Alteration in retinal layers which shows in OCT, what is the correct terminology to describe them, and how to identify the artifacts which can induce errors in measurement making quantitative data inaccurate. I am trying to include all the essential information in this presentation. I hope, which helps you, for your clinical practice. Thank you.
OPTICAL COHERENCE TOMOGRAPHY (SKIN OCT)....
Optical coherence tomography (OCT) is an established medical imaging technique that uses light to capture micrometer-resolution, three dimensional images from within optical scattering media (e.g., biological tissue). Optical coherence media (e.g., biological tissue). Optical coherence tomography is based on low coherence interferometry, typically employing near-infrared light. The use of relative long wavelength light allows it to penetrate into the scattering medium. Confocal microscopy, another optical technique, typically penetrates less deeply into the sample but with higher resolution.
This document provides a brief history and overview of optical coherence tomography (OCT). It discusses that OCT was first used to image the retina in 1991 with a resolution of 17 μm. Commercially available OCT systems emerged in 1996 and provided cross-sectional retinal images with 10 μm resolution. The document then outlines the development and advantages of newer spectral domain OCT technology, which offers higher resolution, faster scanning speeds, and 3D imaging capabilities compared to earlier time domain OCT. A variety of clinical applications of OCT are also reviewed.
1. OCT imaging provides high-resolution cross-sectional images of coronary arteries and stents to assess plaque, guide stent sizing and placement, and confirm procedural success.
2. The OCT catheter is advanced to the region of interest and an automated pullback acquires images as flush media clears blood from the field of view. Images can be used to characterize plaque, measure vessel and stent dimensions, check apposition and expansion, and detect complications.
3. OCT has advantages over IVUS like superior resolution and ability to identify details like thin-cap fibroatheroma, but it also has limitations such as limited tissue penetration and the need for flush media that adds contrast load.
Flexible fiberoptic catheter used for light delivery
OCT enhances imaging resolution that may permit the evaluation of clinical (e.g., luminal measurements during PCI) and research (e.g., fibrous cap thickness and strut levelanalysis) parameters for the interventional cardiologist.
OCT-Angiography (OCT-A) uses motion contrast to non-invasively image the retinal and choroidal vasculature without the need for dye injection. It provides layer-by-layer 3D analysis and quantification. While it has advantages over fluorescein angiography like shorter acquisition time, OCT-A cannot image leakage or pooling and has limitations like motion artifacts and limited field of view. OCT-A is being used to evaluate diseases like diabetic retinopathy, macular degeneration, and vascular occlusions but currently serves as a complementary test rather than replacement for fluorescein angiography.
Reduction of retinal senstivity in eyes with reticular pseudodrusenAbdallah Ellabban
This study evaluated the effect of reticular pseudodrusen on retinal function using multiple imaging methods in 13 eyes with reticular pseudodrusen but no other macular abnormalities. Infrared reflectance imaging detected reticular pseudodrusen within the central macula in more eyes than color fundus photography or fundus autofluorescence. Retinal sensitivity across the macula was lower in eyes with reticular pseudodrusen compared to normal eyes. The number of reticular pseudodrusen detected by different imaging modalities correlated with reduced retinal sensitivity in specific macular areas.
OCT angiography allows visualization of the retinal and choroidal vasculature without dye injection. It uses amplitude decorrelation and phase variance techniques to detect blood flow. The retina and choroid can be segmented into different en face slabs. The superficial, deep, and outer retinal plexuses as well as the choriocapillaris can be visualized. OCTA is useful for diagnosing wet AMD by detecting type 1 CNV beneath the RPE that may not be clearly seen on FA. It can help classify CNV shape and branching patterns. Motion artifacts and projection artifacts can occur but many devices have correction software.
Focal choroidal excavation in eyes with central serous chorioretinopathy Abdallah Ellabban
Focal choroidal excavation was detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavation were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroid, suggesting focal choroidal excavations may form from retinal pigment epithelium retraction caused by focal scarring of the choroid.
This document summarizes research on accommodation presented to the Ophthalmology Department at Al-Azhar University. It defines accommodation as the eye's ability to change refractive power and focus on objects at different distances by altering the shape of the lens. The document discusses the mechanism of accommodation, theories around how it functions including Helmholtz's relaxation theory, and types of accommodation like tonic, proximal, and reflex accommodation. It also examines anomalies of accommodation such as presbyopia, insufficiency of accommodation, and their treatment.
Red eye can be caused by conditions affecting the conjunctiva, cornea, sclera, anterior chamber, or eyelids. Common causes include conjunctivitis (bacterial, viral, allergic), keratitis (infectious or non-infectious), corneal abrasion or ulcer, subconjunctival hemorrhage, episcleritis, iritis, hyphaema, glaucoma, entropion, ectropion, and orbital cellulitis. A thorough history and physical exam is needed to determine the cause and guide treatment.
The document summarizes several theories of accommodation, including Helmholtz's relaxation theory, Schachar's theory, and the catenary theory. It also discusses clinical assessment of accommodation and various anomalies such as insufficiency, excess, spasm, and infacility. Treatment options mentioned include spectacle correction, vision therapy exercises to stimulate or relax accommodation, and in rare cases, cycloplegic drugs.
The greatest risk of excavation work is cave-ins. Employees can be protected from cave-ins through the use of protective systems like sloping, shielding, and shoring. A competent person must inspect excavations daily for hazards and ensure protective systems are adequately designed and installed. Other excavation hazards include oxygen deficiency, toxic gases, water accumulation, falls, and mobile equipment.
This document provides information about glaucoma, including:
- Glaucoma is a disease of the optic nerve that can cause vision loss and blindness if left untreated. It has no symptoms in its early stages.
- The two main types are open-angle glaucoma, which accounts for 95% of cases, and closed-angle glaucoma, which develops more rapidly.
- Risk factors include family history, age over 40 for African Americans and 60 for others, high eye pressure, thin corneas, and certain medical conditions.
- Regular eye exams including tonometry to measure pressure and examination of the optic nerve are important for early detection and treatment to prevent vision loss. Glau
This document discusses various theories and anomalies of accommodation. It begins by defining accommodation and related terms. It then discusses several theories of the accommodation mechanism, including Helmholtz's relaxation theory, Gullstrand's mechanical model, and Schachar's, Tsherning's, and Cotenary's theories. It also covers types of accommodation and anomalies such as presbyopia, insufficiency/ill-sustained accommodation, paralysis, excess accommodation, and spasm. Presbyopia is discussed in detail regarding pathophysiology, causes, symptoms, and treatment options like optical correction and surgery. Other anomalies are summarized briefly regarding their etiology, clinical features, and management.
This study used swept-source optical coherence tomography (OCT) to examine the 3D tomographic features of dome-shaped maculas in highly myopic eyes. OCT imaging revealed that in all eyes, a horizontal ridge was formed within the posterior staphyloma by uneven thinning of the sclera, creating two outward concavities. In most eyes the ridge was band-shaped. The study provides new insights into the pathomorphology of dome-shaped maculas using 3D OCT imaging.
3D Tomgraphic features in dome shaped macula by swept source OCTAbdallah Ellabban
This study used swept-source optical coherence tomography (OCT) to examine the 3D tomographic features of dome-shaped maculas in highly myopic eyes. OCT imaging revealed that in all eyes, the retinal pigment epithelium within the posterior staphyloma had two outward concavities separated by a horizontal ridge. In most eyes the ridge was band-shaped. The study provides new insights into the topography and underlying pathomorphology of dome-shaped maculas.
This study prospectively examined 35 eyes with dome-shaped macular configuration using swept-source optical coherence tomography over a mean follow-up period of 24.8 months. The study found progressive asymmetric thinning of the sclera in the macular region. Scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase in macular bulge height over time. The choroid also showed generalized thinning within the staphyloma during follow-up. The ocular concavities deepened and macular bulge height increased significantly, indicating the progressive nature of the posterior pole changes in eyes with dome-shaped macular configuration.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize and measure individual layers of the retina. OCT can detect various retinal pathologies through qualitative and quantitative analysis of the pre-retinal, overall retinal, foveal, and macular profiles. It is useful for diagnosing conditions like macular edema, retinal detachments, and glaucoma.
Optical Coherence Tomography - principle and uses in ophthalmologytapan_jakkal
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize detailed layers and structures within the retina. OCT can be used to qualitatively and quantitatively analyze the retina, detecting various pathological features and measuring retinal thickness. Anterior segment OCT also allows high-resolution imaging of the cornea, iris, angle, and anterior chamber.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize and measure individual layers of the retina. OCT can detect various retinal pathologies and abnormalities through qualitative and quantitative analysis of the pre-retinal, overall retinal, foveal, and macular profiles.
The document discusses optical coherence tomography (OCT) and its role in ophthalmology. It provides details on:
- The history and development of OCT, how it works using interferometry and low coherence light, and its advantages over ultrasound.
- How OCT allows high-resolution, non-invasive cross-sectional imaging of the retina and other ocular structures.
- How OCT is used to detect and monitor various retinal pathologies like age-related macular degeneration, diabetic retinopathy, macular edema and more. Abnormal findings on OCT like fluid, exudates and neovascularization are summarized.
- The principles of different OCT technologies over time including time domain, spectral domain
OCT provides high-resolution cross-sectional images of ocular structures. There are various types including time-domain OCT, spectral-domain OCT, and swept-source OCT. AS-OCT allows non-invasive imaging of the anterior segment at high speed. It is useful for imaging corneal thickness, lesions, infections, dystrophies, and deposits. AS-OCT also provides pre- and post-operative evaluation and measurement of procedures such as LASIK, DSEK, and intracorneal ring segments.
Optical Coherence Tomography(OCT) in posterior segment diseasesShagil Khan
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to generate high-resolution cross-sectional images of the retina and optic nerve. It provides detailed visualization of retinal structures on a microscopic scale. OCT is useful for diagnosing and monitoring various posterior segment diseases. It allows differentiation between stages of macular hole, detection of epiretinal membranes, and identification of fluid associated with neovascular age-related macular degeneration. Advances in spectral domain OCT technology have improved imaging speed and resolution, enabling clearer visualization of small retinal structures and layers.
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR sipij
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Optic Disc and Macula Localization from Retinal Optical Coherence Tomography ...IJECEIAES
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Optical coherence tomography (OCT) is a non-invasive imaging technique that uses infrared light to generate high-resolution cross-sectional images of the retina and anterior segment of the eye. OCT works by measuring the echo time and intensity of reflected light to create digital representations of tissue structures. There are two main types - time domain OCT and spectral domain OCT. OCT is useful for diagnosing and monitoring many eye conditions, such as glaucoma, age-related macular degeneration, and diabetic retinopathy. It allows detailed visualization of the retina, optic nerve, macula, and anterior segment structures.
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FOCAL CHOROIDAL EXCAVATION IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY
1. Focal Choroidal Excavation in Eyes With Central Serous
Chorioretinopathy
ABDALLAH A. ELLABBAN, AKITAKA TSUJIKAWA, SOTARO OOTO, KENJI YAMASHIRO, AKIO OISHI,
ISAO NAKATA, MASAHIRO MIYAKE, YUMIKO AKAGI-KURASHIGE, NAOKO UEDA-ARAKAWA,
SHIGETA ARICHIKA, SHIN YOSHITAKE, AYAKO TAKAHASHI, AND NAGAHISA YOSHIMURA
PURPOSE: To study the prevalence and 3-dimensional
(3-D) tomographic features of focal choroidal excavations
in eyes with central serous chorioretinopathy (CSC)
using swept-source optical coherence tomography
(OCT).
DESIGN: Prospective, cross-sectional study.
METHODS: We examined 116 consecutive eyes with
CSC with a prototype 3-D swept-source OCT. 3-D
images of the shape of the macular area, covering 6 3
6 mm2
, were reconstructed by segmentation of the outer
surface of the retinal pigment epithelium (RPE).
RESULTS: The 3-D swept-source OCT detected focal
choroidal excavations in 9 eyes (7.8%). The 3-D scan-
ning protocol, coupled with en face scans, allowed for
clear visualization of the excavation morphology. In 5
eyes with focal excavations, unusual choroidal tissue
was found beneath the excavation, bridging the bottom
of the excavation and the outer choroidal boundary. Addi-
tionally, 3 of those 5 eyes showed a suprachoroidal space
below the excavation, as if the outer choroidal boundary
is pulled inward by this bridging tissue. The focal
choroidal excavations were located within fluorescein
leakage points and areas of choroidal hyperpermeability.
Eyes with focal choroidal excavations were more myopic
(L4.42 ± 2.92 diopters) than eyes without excavations
(L0.27 ± 1.80 diopters, P [ .001). Subfoveal choroidal
thickness was significantly thinner (301.3 ± 60.1 mm) in
eyes with focal excavations than in eyes without the exca-
vations (376.6 ± 104.8 mm, P [ .036).
CONCLUSIONS: Focal choroidal excavations were
present in 7.8% of eyes with CSC. In these eyes, focal
choroidal excavations may have formed from RPE retrac-
tion caused by focal scarring of choroidal connective
tissue. (Am J Ophthalmol 2013;-:-–-. Ó 2013
by Elsevier Inc. All rights reserved.)
C
ENTRAL SEROUS CHORIORETINOPATHY (CSC) IS
characterized by serous retinal detachment in the
macular area, as confirmed by leakage on fluorescein
angiography (FA). In eyes with CSC, indocyanine green
angiography (ICGA) often shows choroidal vascular abnor-
malities, such as choroidal filling delay, dilated vasculature,
choroidal hyperpermeability, and punctate hyperfluorescent
spots.1–9
Recent advances in choroidal imaging with optical
coherence tomography (OCT), coupled with the enhanced
depth imaging technique,10
have revealed choroidal thick-
ening in eyes with CSC, and such thickening decreased
after the treatment with photodynamic therapy.11–17
These
observations suggest that the underlying pathogenesis of
CSC is primarily related to functional abnormalities of the
choroidal vasculature.
On the basis of OCT imaging, focal choroidal excava-
tion18–24
was recently reported as a localized area of
excavation within the submacular choroid. Focal choroidal
excavation was first reported to occur in otherwise healthy
eyes without any ocular comorbidities.22,23
However, later
reports showed that focal choroidal excavations are
associated with vision-threatening diseases such as CSC,
polypoidal choroidal vasculopathy, and choroidal neovascu-
larization.18–20
Recently, Margolis and associates20
reported
a case of focal choroidal excavation in an eye with CSC
and suggested that there could be an association between
the 2 conditions. However, mechanisms underlying this
unusual excavation remain unknown. In addition, most
previously reported cases of focal choroidal excavations
were examined with unidirectional OCT scans18–23
and
little information is available on the 3-dimensional (3-D)
shape of the excavations. So far, the prevalence of focal
choroidal excavation remains unknown because previous
reports are either single case reports or small case series.
Recent advances in OCT technology include the utiliza-
tion of a swept-source laser as the light source.25–27
The
swept-source OCT with a longer-wavelength light source
provides better views of the choroid because of improved
light penetration into the choroid. Additionally, the
tunable laser source of the swept-source OCT shows lower
signal decay with depth, further improving the visibility of
choroidal details. Furthermore, the higher imaging speed
allows for dense scanning and subsequent 3-D image recon-
struction of the posterior pole. In the study described herein,
we prospectively examined the macular area in a group of
consecutive eyes with CSC using a 1-mm-wavelength
Supplemental Material available at AJO.com.
Accepted for publication May 9, 2013.
From the Department of Ophthalmology and Visual Sciences, Kyoto
University Graduate School of Medicine, Kyoto, Japan (A.A.E.,
A.Tsujikawa, S.O., K.Y., A.O., I.N., M.M., Y.A.K., N.U.A., S.A., S.Y.,
A.Takahashi, N.Y.); and Department of Ophthalmology, Faculty of
Medicine, Suez Canal University, Ismailia, Egypt (A.A.E.).
Inquiries to Akitaka Tsujikawa, Department of Ophthalmology and
Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-
ku, Kyoto 606-8507, Japan; e-mail: tujikawa@kuhp.kyoto-u.ac.jp
0002-9394/$36.00
http://dx.doi.org/10.1016/j.ajo.2013.05.010
1Ó 2013 BY ELSEVIER INC. ALL RIGHTS RESERVED.
2. swept-source OCT to highlight the prevalence,
morphology, and 3-D tomographic features of focal
choroidal excavation, and the possible correlation between
focal choroidal excavation and the pathogenesis of CSC.
METHODS
THE ETHICS COMMITTEE AT KYOTO UNIVERSITY GRADUATE
School of Medicine approved this prospective study, which
was conducted in accordance with the tenets of the Decla-
ration of Helsinki. Written informed consent was obtained
from each subject before any study procedures or examina-
tions were performed.
We prospectively examined 116 eyes from 99 consecu-
tive CSC patients who presented to the macula clinic at
Kyoto University Hospital between the beginning of June
2010 and the end of January 2013. All study subjects
were Japanese. All study participants underwent a compre-
hensive ocular examination, including autorefractometry,
best-corrected visual acuity measurement in a Landolt
chart, slit-lamp biomicroscopy, intraocular pressure
measurement, fundus photography (TRC-NW8F; Topcon
Corp, Tokyo, Japan), and 3-D swept-source OCT imaging
with a prototype system (Topcon Corp). Simultaneous FA
and ICGA, using the Spectralis HRAþOCT (Heidelberg
Engineering, Heidelberg, Germany), were performed in
most eyes as indicated by the clinical course of the CSC.
DIAGNOSIS AND CLASSIFICATION OF CENTRAL SEROUS
CHORIORETINOPATHY: CSC was diagnosed based on
medical history, serous retinal detachment seen on the
fundus examination and OCT, and angiographic leak-
age(s) at the level of retinal pigment epithelium (RPE) in
FA. Patients with other causes of fluorescein leakage (eg,
age-related macular degeneration, polypoidal choroidal
vasculopathy, idiopathic choroidal neovascularization,
other secondary neovascular maculopathy) or other causes
of serous retinal detachment unrelated to CSC (eg, intraoc-
ular inflammation, posterior segment tumors) were
excluded from the study.
All CSC cases were classified by FA results into 3 types:28
classic CSC, chronic CSC, and multifocal posterior
pigment epitheliopathy.29,30
Eyes showing only 1 or few
specific angiographic leakage points at the level of RPE
were classified as classic CSC. Eyes with broad areas
of granular hyperfluorescence on FA associated with
indistinct areas of leakage were classified as chronic CSC.
Multifocal posterior pigment epitheliopathy was defined
as multiple massive leakages from the choroid into the
subretinal space.29
All eyes were divided into active and resolved eyes on
the basis of the presence of serous retinal detachment at
the time of swept-source OCT examination. Active CSC
was defined as the presence of a serous retinal detachment
and resolved CSC was defined as the absence of a serous
retinal detachment. Eyes with resolved CSC that were
included in this study had active disease either at the initial
clinic visit or at other follow-up visits, but before swept-
source OCT examinations.
SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY
AND SCAN PROTOCOLS: The prototype swept-source
OCT used in the current study has been previously
described in detail.31–33
Briefly, this swept-source OCT
uses a light source of a wavelength-sweeping laser centered
at 1050 nm with a tuning range of 100 nm. This system has
a scanning speed of 100 000 A-scans per second and a scan
window depth of 2.6 mm. The axial and transverse resolu-
tions are 8 mm and 20 mm in tissue, respectively. The
optical power incident on the cornea with the current
swept-source laser system is less than 1 mW, which is below
the safety requirements for this laser class by the American
National Standards Institute.
Swept-source OCT examinations were performed by
trained examiners after pupil dilation. In each subject,
multi-averaged horizontal and vertical scans of 12 mm
were obtained. Fifty single images, where each image
consisted of 1024 A-scans, were registered and averaged
by software to create a multi-averaged single image. A
raster scan protocol of 512 (horizontal) 3 128 (vertical)
A-scans per data set was acquired in 0.8 seconds to create
3-D data sets (total: 65 536 axial scans/volume). Each raster
scan consisted of 128 B-scans and covered an area of 6 3
6 mm, centered on the fovea (Supplemental Movie, avail-
able at AJO.com). The centration of the scan was achieved
with internal fixation target and confirmed by a built-in
camera within the swept-source OCT system. Owing to
the high speed and the invisible scanning light wavelength,
eye movements during the 3-D image acquisition were
minimal. To decrease speckle noise, each image was de-
noised by the weighted moving average of 3 consecutive
original B-scans.
FOCAL CHOROIDAL EXCAVATION: Diagnosis of focal
choroidal excavation was based on the presence of an
excavated area into the choroid, along the RPE/Bruch
membrane complex line on OCT scans, without any
history of prior trauma, infection, or inflammatory episode.
Focal choroidal excavation was classified by OCT as
conforming, if photoreceptor tips were attached to the
apical surface of the RPE; or as nonconforming, if there
was a separation between the photoreceptor tips and the
RPE.20
In terms of location, focal choroidal excavations
were classified as foveal, if the foveal center was located
within the excavation; or as extrafoveal, if the foveal center
was located outside the excavation.
In eyes with focal choroidal excavations, 3-D topo-
graphic images were reconstructed from the OCT scans,
by segmentation of the line of the outer surface of RPE,
to highlight the shape of the excavation. In each B-scan,
the outer surface of RPE line was automatically determined
2 --- 2013AMERICAN JOURNAL OF OPHTHALMOLOGY
3. by the software and manual corrections were done, as
necessary, using the built-in segmentation-modifying
tool. The excavation depth and width were measured
manually from the 3-D data set in the scan that showed
the greatest dimensions. En face OCT scans along the
z-axis (C-scans) were obtained from the 3-D data set and
the scan showing the excavation at the level of the RPE
plane was selected. The excavation boundary in the en
face image was marked by a hyper-reflective band, repre-
senting the RPE.
TOMOGRAPHIC AND ANGIOGRAPHIC FEATURES: The
tomographic and angiographic features at the area of exca-
vation were examined. Additionally, the correlation
between the locations of the excavation and the leakage
areas in FA and areas of choroidal hyperpermeability and
punctate hyperfluorescent spots in ICGA were analyzed.
Choroidal hyperpermeability was defined as cloud-like
areas of hyperfluorescence with blurred margins within
the choroid in the mid to late phase of ICGA.4
Punctate
hyperfluorescent spots were defined as a cluster of tiny
hyperfluorescent spots in the late phase of ICGA within
the macular area.2
The retinal and choroidal thicknesses at the center of
the fovea were manually measured with a built-in caliber
tool within the software. Retinal thickness was defined as
the distance between the vitreoretinal interface and the
outer border of the RPE and choroidal thickness was
defined as the distance between the outer border of the
RPE and the chorioscleral interface. When the focal
choroidal excavation was located within the foveal center,
choroidal thickness measurements were made in nearby
choroid that was not affected by the excavation.
STATISTICAL ANALYSES: All values are expressed as
mean 6 standard deviation. The measured visual acuity
was converted to the logarithm of the minimal angle of
resolution (logMAR) for statistical analyses. Unpaired
t tests were used to compare numerical variable means
and Fisher exact tests were used to compare the distribution
of categorical variables. Statistical significance was defined
as a P .05.
RESULTS
OF THE 116 EYES EXAMINED (99 CONSECUTIVE PATIENTS WITH
CSC), 3-D swept-source OCT examination detected focal
choroidal excavation in 9 eyes (7.8%) from 8 patients. The
mean age of eyes with focal choroidal excavation was 54.9
6 13.6 years (range: 35-76 years) and all 9 eyes were myopic,
with a mean spherical equivalent of À4.42 6 2.92 diopters.
Mean foveal retinal thickness was 194.4 6 50.6 mm (range:
125-311 mm) and mean foveal choroidal thickness was
301.3 6 60.9 mm (range: 192-376 mm). Table 1 shows the
patient demographics and ocular tomographic features of
TABLE1.ClinicalCharacteristicsofEyesWithFocalChoroidalExcavationAssociatedWithCentralSerousChorioretinopathy
Patient
Age
(y)Sex
Visual
Acuityb
RefractiveError
Spherical
Equivalent(Diopters)Location
Excavation
Type
CSC
Type
CSC
Activity
FRT
(mm)
FChT
(mm)
Excavation
Depth(mm)
Excavation
Width
(mm)
Previous
Treatment
Durationof
Follow-upWith
OCTExamination(mo)
176M1.2À0.50ExtrafovealNonconformingChronicActive21333195725052
252F1.2À10.50FovealNonconformingClassicActive31126750902rfPDT12
360F1.2À2.75ExtrafovealNonconforming¼Conformingc
ClassicResolved18522887623058
4a
35M1.2À3.75ExtrafovealNonconformingChronicActive19037654580078
35M1.5À5.75FovealNonconforming¼Conformingc
ChronicResolved197328911237078
550M1.5À5.50ExtrafovealNonconformingChronicActive19535936414024
662F1.2À5.75ExtrafovealNonconformingd
ClassicResolved17319269337073
758M1.0À1.75ExtrafovealNonconformingChronicActive1613285954704
866M0.1À3.50FovealNonconforming¼Conformingc
ChronicResolved125303821178rfPDT6
CSC¼centralserouschorioretinopathy;FChT¼fovealchoroidalthickness;FRT¼fovealretinalthickness;OCT¼opticalcoherencetomography;rfPDT¼reduced-fluencephotodynamic
therapy.
a
Patient4hasbilateralfocalchoroidalexcavation.
b
Landoltvisualacuity.
c
Thefocalchoroidalexcavationchangedfromnonconformingtoconformingtypeupontheresolutionofserousdetachmentin3eyes.
d
Inpatient6,theserousdetachmentcompletelyresolved,butthephotoreceptortipsremainedseparatedfromtheretinalpigmentepitheliumattheareaofexcavationonly.
VOL. -, NO. - 3FOCAL CHOROIDAL EXCAVATION
4. eyes with focal choroidal excavations. Microperimetry data
were available in 3 eyes, all of which had decreased retinal
sensitivity at the excavation area.
TOMOGRAPHIC FEATURES OF EYES WITH FOCAL
CHOROIDAL EXCAVATION: The 3-D scanning protocol
and en face OCT scans allowed us to detect focal choroidal
excavations in the macular area and to clearly visualize
their morphology. The focal choroidal excavation had
a foveal location in 3 eyes and an extrafoveal location in
the remaining 6 eyes. In 2 eyes, extrafoveal excavations
were detected with the 3-D scanning protocol, but not
with the line scanning protocol (Figure 1). In addition,
the 3-D reconstructed images of the macular area showed
that focal choroidal excavations can vary in shape, ranging
between small dimple-like excavations (Figure 2) to broad
irregular excavations (Figure 3). En face images at the level
of the RPE showed whether the excavation was filled with
outer retinal tissue (conforming excavation) or if the exca-
vation was optically empty, possibly filled with subretinal
fluid (nonconforming excavation).
The mean depth of the excavation in the 9 eyes was
69.2 6 20.7 mm (range: 36-95 mm) and mean excavation
width was 727.0 6 318.0 mm (range: 337-1237 mm). In
all 9 eyes, the inner retinal layers appeared physiologically
normal and even when the focal choroidal excavation was
FIGURE 1. Extrafoveal focal choroidal excavation examined with swept-source optical coherence tomography (OCT) in 4 eyes with
central serous chorioretinopathy. (Left column) Fundus photographs of 4 eyes with focal choroidal excavations. (Second column)
Magnified fundus images (23) of the dashed green square in the left column. Focal excavations were detected in fundus photographs
as either indistinct yellowish lesions or pigmentary mottling (white arrows). (Third column) Reconstructed 3-dimensional (3-D) 6 3
6-mm images (dashed green squares in fundus photographs) of the retinal pigment epithelium showing the shape of the excavations.
(Right column) The 3-D volumetric data set of a scan positioned over the focal choroidal excavation (dashed green lines in fundus
photographs). The focal choroidal excavations in the first and second rows were extrafoveal and were detectable only on 3-D scans.
The white asterisks indicate the foveal center and the black arrows indicate OCT scan direction.
4 --- 2013AMERICAN JOURNAL OF OPHTHALMOLOGY
5. located subfoveally, the foveal contour remained nearly
well preserved. At the excavation, the line of the external
limiting membrane was preserved in 8 eyes and disrupted in
1 eye. The line of the junction between the inner and outer
segments of the photoreceptors remained continuous in 3
eyes, was partially disrupted in 5 eyes, and was completely
disrupted in 1 eye. The RPE line was intact in all 9 eyes,
despite some thinning or attenuation.
Swept-source OCT allowed visualization of choroidal
structures. Multi-averaged scans often showed an inner
choroidal layer with medium-diameter blood vessels and
an outermost choroidal layer with larger-diameter blood
vessels. In 5 eyes with focal choroidal excavation,
unusual choroidal tissue without large vessels was
detected beneath the excavation, bridging between the
bottom of the excavation and the outer choroidal
boundary (Figure 3). In addition, the suprachoroidal
space below the focal excavation was observed in 3 of
these 5 eyes, as if the outer choroidal boundary was pulled
inward by the bridging tissue (Figure 4). The chorioscl-
eral interface was physiologically smooth, with no ecta-
sia, in all 9 eyes.
FIGURE 2. A small dimple-like focal choroidal excavation seen in an eye with central serous chorioretinopathy (CSC). (Top row,
left) Fundus photograph of the right eye of a 60-year-old female with resolved CSC (Patient 3). Pigmentary mottling at the area corre-
sponding to the focal choroidal excavation can be seen (white arrowhead). The dashed green square outlines the area (6 3 6 mm2
)
scanned by the swept-source optical coherence tomography (OCT). (Top, middle) Reconstructed 3-dimensional (3-D) image by
segmentation of the retinal pigment epithelium (RPE) shows the 3-D shape of the excavation. (Top, right) En face image at the level
of RPE shows the transverse shape of the excavation. (Second row, left) Horizontal and (Bottom, left) vertical OCT sections through
the focal choroidal excavation. (Second row, right) Magnified image in the area outlined by the dashed red square. The external
limiting membrane was preserved, the photoreceptor inner/outer segment junction line was partially disrupted, and the RPE was
almost preserved. The chorioscleral interface appears normal, without any ectasia. (Bottom, right) Horizontal OCT section at the
fovea (upper) shows a nonconforming focal choroidal excavation at the time of active CSC with serous retinal detachment. With
the resolution of the serous retinal detachment (lower), the retina reattached to the RPE surface. No remarkable changes in the focal
choroidal excavation size or shape occurred during the follow-up. The white asterisk indicates the foveal center and the white arrows
indicate the direction of the OCT scan. FCE [ focal choroidal excavation.
VOL. -, NO. - 5FOCAL CHOROIDAL EXCAVATION
6. The mean follow-up duration of eyes with focal
choroidal excavation by OCT examination was 42.8 6
31.4 months (range: 4-78 months). In all 9 eyes, the exca-
vations were located within the serous retinal detachment
during the active stage (nonconforming excavation).
During the follow-up period, 3 eyes showed resolution of
the serous retinal detachment and the photoreceptor tips
reattached to the RPE, thus converting the focal choroidal
excavation from the nonconforming to the conforming
type. In 1 eye, the serous retinal detachment completely
resolved, but the photoreceptor tips remained separated
from the RPE at the area of excavation. In the 5 eyes
that were followed for more than 4 years with OCT, no
remarkable changes in excavation size or shape were
detected. Additionally, no eye developed new focal
choroidal excavation and no eye showed disappearance of
the excavation in the macular area during the follow-up.
FUNDUS AND ANGIOGRAPHIC FEATURES IN EYES WITH
CENTRAL SEROUS CHORIORETINOPATHY AND FOCAL
CHOROIDAL EXCAVATION: All eyes with focal choroidal
excavations showed changes in color fundus photographs
FIGURE 3. Broad, irregular focal choroidal excavation in an eye with central serous chorioretinopathy (CSC). (Top row, left)
Fundus photograph of the left eye of a 35-year-old man (Patient 4). Best-corrected visual acuity was 1.5 (Snellen: 20/13). Fundus
photograph showing pigmentary mottling in the area corresponding to the focal choroidal excavation (white arrowhead). The dashed
green square outlines the area (6 3 6 mm2
) scanned by the swept-source optical coherence tomography (OCT). (Top row, second)
Fundus autofluorescence image obtained at the active phase of CSC shows mixed areas of hyper- and hypo-autofluorescence in the
area of focal choroidal excavation. (Top row, third) Fluorescein angiography obtained at the active phase of CSC shows chronic
pattern of leakages. (Top row, fourth) Late-phase indocyanine green angiography obtained at the active phase of CSC showing
multiple areas of choroidal hyperpermeability and punctate hyperfluorescent spots. The focal choroidal excavation was located within
one of the areas of choroidal hyperpermeability and punctate hyperfluorescent spots. (Top row, right) Interpolated color map of
microperimetry data shows decreased retinal sensitivity at the area of excavation. (Second row) Horizontal (left) and vertical (right)
OCT sections at the fovea showing a conforming focal choroidal excavation with a broad, irregular shape. Beneath the focal choroidal
excavation, no large choroidal vessels are visible. Unusual choroidal tissue (yellow arrow) is seen bridging between the bottom of the
focal excavation and the outer choroidal boundary. (Bottom row, left) Reconstructed image by the segmentation of the retinal pigment
epithelium (RPE) shows the 3-dimensional shape of the excavation. (Bottom row, middle) En face image at the level of the RPE shows
the transverse shape of the excavation. (Bottom row, right) Consecutive horizontal (left) and vertical (right) OCT scans obtained at
follow-up visits; the focal choroidal excavation changed from nonconforming to conforming type with the resolution of the serous
detachment. There were no remarkable changes in the dimensions or the shape of the excavation over the follow-up period of 6 years.
The white arrows indicate the direction of the OCT scan. FCE [ focal choroidal excavation.
6 --- 2013AMERICAN JOURNAL OF OPHTHALMOLOGY
7. at the area of the excavation (Table 2). The focal choroidal
excavations appeared either as a yellowish lesion with
indistinct margins (n ¼ 3 eyes) or as a pigmentary distur-
bance, which often extended beyond the area of excavation
(n ¼ 6 eyes). FA was performed in all 9 eyes, 3 of which
showed classic CSC and the remaining 6 with chronic-
type leakage. In 8 of the 9 eyes, the focal excavation was
located within the area of fluorescein leakage, either as
a focal leak (classic CSC) or within the area of granular
hyperfluorescence (chronic CSC). In the remaining eye,
the focal choroidal excavation was located just adjacent
to the focal leakage area in FA. ICGA was performed in
7 eyes, all of which showed choroidal hyperpermeability
and punctate hyperfluorescent spots. In all 7 eyes, the focal
choroidal excavations were seen within the area of
choroidal hyperpermeability (Figure 3).
COMPARISON BETWEEN CENTRAL SEROUS CHORIORE-
TINOPATHY WITH AND WITHOUT FOCAL CHOROIDAL
EXCAVATION: Table 3 shows data comparisons of CSC
eyes with and without focal choroidal excavation. There
were no significant differences in age, visual acuity, or sex
distribution between the 2 groups. However, eyes with
focal choroidal excavations were more myopic (À4.42 6
2.92 diopters) than eyes without the excavations (À0.27
6 1.80 diopters, P ¼ .001). The foveal retinal thickness
in eyes without focal choroidal excavation (270.8 6
108.7 mm) was significantly greater than in eyes with the
excavations (194.4 6 50.6 mm, P ¼ .040). The subfoveal
choroid was significantly thinner in eyes with focal
choroidal excavations (301.3 6 60.9 mm) than in eyes
without the excavations (376.6 6 104.8 mm, P ¼ .036).
The foveal choroidal thickness in the fellow eyes of
patients with focal choroidal excavation was 269.4 6
97.0 mm. There was no statistical difference in the foveal
choroidal thickness between both eyes (P ¼ .418).
DISCUSSION
THE CURRENT STUDY SHOWED THAT FOCAL CHOROIDAL
excavations are seen in 7.8% of eyes with CSC. Focal
choroidal excavation could be suspected by careful
FIGURE 4. Suprachoroidal space under the focal choroidal excavation in an eye with central serous chorioretinopathy (CSC). (Top
row, left) Fundus photograph of the left eye of a 76-year-old man (Patient 1). Best-corrected visual acuity was 1.2 (Snellen: 20/16).
(Top row, second). Magnified fundus image in the area outlined by the dashed green square shows an indistinct yellowish lesion at the
location of the irregular-shaped excavation (white arrowhead). (Top row, third) Reconstructed image by the segmentation of the
retinal pigment epithelium (RPE) shows the 3-dimensional (3-D) shape of the excavation. (Top row, right) En face image at the level
of the RPE shows the transverse shape of the excavation. (Middle, left) Horizontal OCT section through the fovea shows a serous
retinal detachment under the fovea. (Bottom, left) Vertical OCT section through the fovea shows a nonconforming focal choroidal
excavation. (Bottom, right) A 3-D volumetric data set with scan positioned at the area involving the focal choroidal excavation (along
the dashed green line in fundus photograph). Beneath the focal choroidal excavation, unusual choroidal tissue, devoid of large vessels,
is seen bridging the bottom of the excavation and the outer choroidal boundary (yellow arrows). The suprachoroidal space (red
arrows) is seen under the focal choroidal excavation and the chorioscleral interface appears normal, with no ectasia. The white
asterisk indicates the foveal center. FCE [ focal choroidal excavation.
VOL. -, NO. - 7FOCAL CHOROIDAL EXCAVATION
8. ophthalmoscopic examination, appearing as an indistinct
yellowish lesion or as pigmentary mottling, but only
confirmed by OCT examination. 3-D reconstructed OCT
images showed that the excavations often have irregular
shapes and dip variably into the choroid, and the en face
scans highlighted the actual transverse shape of the excava-
tion. Additionally, 3-D OCT scanning of the macula helps
to detect tiny focal choroidal excavations that could be
easily missed in a routine OCT examination. Because all
eyes with focal choroidal excavation had a normal-
appearing inner scleral surface with no outpouching, we
believe that focal choroidal excavation is essentially a focal
choroidal abnormality.
Recent OCT image analysis revealed choroidal thick-
ening in eyes with CSC, especially in the active phase.12,13
In the current study, subfoveal choroidal thickness in eyes
with focal choroidal excavation (301.3 6 60.9 mm; mean
age, 54.9 6 13.6 years) was greater than that observed in
normal Japanese subjects of the same age group (240.2 6
66.8 mm; mean age, 54.1 6 3.1 years).34
In addition, Jirar-
attanasopa and associates11
reported a local choroidal
thickening in areas of choroidal vascular hyperpermeability
and in punctate hyperfluorescent spots. In our patients, 3-D
OCT and ICGA images showed that focal choroidal exca-
vations were located within these areas of choroidal abnor-
malities and that focal choroidal excavation may be
a feature associated with choroid thickening.
The foveal retinal thickness in CSC eyes without focal
choroidal excavation (270.8 6 108.7 mm) was significantly
greater than that in eyes with the excavations (194.4 6
50.6 mm). The reason for this difference is uncertain. In
our patients with CSC, the eyes without excavations
have higher percentages of active CSC with serous retinal
detachment (64.5%), as compared to eyes with excavations
(44.4%) at the time of swept-source OCT examination.
The percentage of active CSC may be involved in this
difference in the foveal retinal thickness. Additionally,
the difference in the height of the serous detachment in
both groups may have contributed to this difference.
Theoretically, there are 2 possible directional forces that
can lead to the formation of the focal choroidal excavation,
either forces pushing the retinal parenchyma and RPE into
the choroid or pulling forces causing traction on the RPE
toward the choroid. In 5 eyes with focal choroidal excava-
tions, unusual choroidal tissue, hyper-reflective on OCT
TABLE 2. Angiographic Characteristic of Eyes With Focal Choroidal Excavation Associated With Central Serous Chorioretinopathy
Patient Color Photography
Fundus
Autofluorescence
Correlation Between
Focal Choroidal Excavation
and Leakage Area
Choroidal
Hyperpermeability
Punctate
Hyperfluorescent
Spots
Correlation Between Focal
Choroidal Excavation and Choroidal
Hyperpermeability
1 Yellowish lesion Hypo Within leakage area NA NA NA
2 Yellowish lesion Hyper Adjacent to leakage area Yes Yes Within choroidal hyperpermeability
3 Pigmentary mottling NA Within leakage area NA NA NA
4a
Pigmentary mottling Hyper Within leakage area Yes Yes Within choroidal hyperpermeability
Pigmentary mottling Mixed Within leakage area Yes Yes Within choroidal hyperpermeability
5 Pigmentary mottling Hyper Within leakage area Yes Yes Within choroidal hyperpermeability
6 Pigmentary mottling Hypo Within leakage area Yes Yes Within choroidal hyperpermeability
7 Yellowish lesion Mixed Within leakage area Yes Yes Within choroidal hyperpermeability
8 Pigmentary mottling Mixed Within leakage area Yes Yes Within choroidal hyperpermeability
NA ¼ not available.
a
Patient 4 has bilateral focal choroidal excavation.
TABLE 3. Eyes With and Without Focal Choroidal Excavation
Associated With Central Serous Chorioretinopathy
CSC With Focal
Choroidal Excavation
CSC Without Focal
Choroidal Excavation P Value
N (eyes) 9 107
Sex (male/female) 6/3 92/15 .144a
Age (y) 54.9 6 13.6 55.7 6 12.6 .871b
Refractive error
(diopters)
À4.42 6 2.92 À0.27 6 1.80 .001b
Visual acuity
(logMAR)
À0.03 6 0.37 0.07 6 0.28 .731b
CSC subtype, n (%) (eyes)
Classic 3 (33.3%) 53 (49.5%)
Chronic 6 (67.7%) 45 (42.1%)
MPPE 0 9 (8.4%)
CSC status, n (%) (eyes)
Active 4 (44.4%) 69 (64.5%)
Resolved 5 (55.6%) 38 (35.5%)
Foveal retinal
thickness (mm)
194.4 6 50.6 270.8 6 108.7 .040b
Foveal choroidal
thickness (mm)
301.3 6 60.9 376.6 6 104.8 .036b
CSC ¼ central serous chorioretinopathy; LogMAR ¼ logarithm
of minimal angle of resolution; MPPE ¼ multifocal posterior
pigment epitheliopathy.
a
Fisher exact test.
b
Unpaired t test.
8 --- 2013AMERICAN JOURNAL OF OPHTHALMOLOGY
9. and devoid of large choroidal vessels, was detected beneath
the excavation, bridging the bottom of the focal excava-
tion and the outer choroidal boundary. Additionally, in 3
of these 5 eyes, the suprachoroidal space was seen below
the focal choroidal excavation, as if the outer boundary
of the choroid was pulled inward by this bridging tissue.
The nature of this unusual tissue is unknown; however, it
may represent focal scarring in the choroidal connective
tissue, and subsequent contraction of such scar results in
focal retraction of the RPE, leading to the formation of
the focal excavation.
In addition, the shape of most excavations was irregular
and often pointed externally, rather than being a smooth
outpouching. The presence of an outward traction on the
RPE would explain this shape. Alternatively, such
choroidal scarring can cause a contractive force on the
RPE when the choroid is thickened because of CSC during
the active stage of the disease, and such abnormal trac-
tional force may lead to focal choroidal excavation devel-
opment. However, this unusual choroidal tissue was
detected in only 5 of 9 eyes with focal excavation and,
therefore, other pathogenic mechanisms may be involved
in the formation of the focal choroidal excavation.
It is unknown whether focal choroidal excavation is
a congenital choroidal malformation or an acquired insult.
Previously, Margolis and associates20
and Abe and associ-
ates22
suggested that focal choroidal excavation may result
from a pre-existing congenital malformation. Such lesion
can cause visual disturbances if secondary changes occur
later in life. In our patients, no patient developed new focal
excavation during the course of the disease and no eyes
showed the resolution of the focal excavation during the
follow-up. In addition, in 5 eyes with follow-up of more
than 4 years, the focal choroidal excavation remained
almost stable, without any remarkable change in size or
shape during the OCT follow-up period.
In the current study, all focal choroidal excavations were
located withinor adjacent toareasof fluoresceinleakage and
in all 7 eyes examined with ICGA, the focal excavations
were located within areas of choroidal hyperpermeability.
One can speculate that focal choroidal excavation has
a possiblerole in the pathogenesis of CSC; however, because
the prevalence of focal choroidal excavationwas low (7.8%)
in CSC, the role would be limited only to some eyes.
Although eyes with CSC are often emmetropic or
slightly hyperopic, all 9 eyes in our study with focal
choroidal excavation associated with CSC were myopic.
The reason for this observation is unknown. However,
this observation is consistent with previous case
reports.18,19,21–23
In the current study, subfoveal choroidal
thickness in eyes with focal choroidal excavation was
greater than in normal Japanese subjects of the same age
group.34
However, foveal choroidal thickness in CSC
eyes with focal choroidal excavation has been shown to
be significantly thinner than in CSC eyes without the exca-
vation.11,13
One possible explanation is the myopic trend
seen in eyes with CSC and focal choroidal excavations,
and previous studies have shown that choroidal thickness
is negatively correlated with refractive error.35,36
Focal choroidal excavation was initially reported as an
incidental finding in patients complaining of metamorphop-
sia.21–23
It was later shown that focal choroidal excavations
are associated with vision-threatening diseases, including
choroidal neovascularization18
and polypoidal choroidal
vasculopathy,19
and these previous reports showed that focal
choroidal excavations were located within the areas of
pathology. In the current study, focal choroidal excavations
were also located within areas of angiographic leakage and
choroidal hyperpermeability in eyes with CSC. The patho-
genesis of these aforementioned diseases is thought to be
choroidal in nature and focal choroidal excavations are
thought of primarily as a choroidal abnormality. However,
itis stillunclear whetherfocal choroidal excavation is a plat-
form for the development of such complications.
The current study had some limitations. First, the
number of eyes with focal choroidal excavation was small.
Second, all subjects were Asian and it is possible that the
prevalence of focal choroidal excavation is different in
other ethnicities. Third, little is known about the natural
progression of focal choroidal excavation and it remains
unclear whether focal choroidal excavation is a congenital
or acquired abnormality. So far, the histopathologic nature
of the focal choroidal excavation is not known, and further
speculation into its pathogenic mechanisms is difficult. In
addition, the lack of normal control eyes without CSC
does not prove a true association between CSC and focal
choroidal excavation.
In conclusion, focal choroidal excavation is not very rare
in eyes with CSC, with a prevalence of approximately
7.8%. Although the focal choroidal excavation might be
partly related to the pathogenesis of CSC, its role is likely
to be limited to some eyes. The diagnosis of focal choroidal
excavation can only be made with OCT; however, it could
be suspected by careful fundus examination. The 3-D
reconstructed images revealed the shape of the focal exca-
vations and provided more insight into their morphology.
However, the clinical importance of focal choroidal exca-
vation is still unclear.
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST.
Financial disclosures: N. Yoshimura, Topcon Corporation (financial support), Nidek (financial support, consultant), Canon (financial support); A. Tsuji-
kawa, Pfizer (grant support). This study was supported, in part, by the Japan Society for the Promotion of Science (JSPS), Tokyo, Japan (Grant-in-Aid for
Scientific Research, no. 21592256), and by the Japan National Society for the Prevention of Blindness, Tokyo, Japan. Contributions of authors: conception
and design of the study (A.A.E., A. Tsujikawa, N.Y.); analysis and interpretation (A.A.E., A. Tsujikawa, K.Y., A.O., S.O., I.N., M.M., Y.A.-K., N.U.-A.,
S.A., S.Y., A. Takahashi); writing of the article (A.A.E., A. Tsujikawa); critical revision of the article (K.Y., A.O., S.O., I.N., M.M., Y.A.-K., N.U.-A.,
VOL. -, NO. - 9FOCAL CHOROIDAL EXCAVATION
10. S.A., S.Y., A. Takahashi, N.Y.); final approval of the article (A.A.E., A. Tsujikawa, S.O., K.Y., A.O., I.N., Y.A.-K., M.M., N.Y.); and data collection
(A.A.E., K.Y., A.O., S.O., I.N., M.M., Y.A.-K., N.U.-A., S.A., S.Y., A. Takahashi).
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12. Biosketch
Abdallah A. Ellabban, MD, graduated from the Suez Canal University (Egypt) and obtained his MD in 2003. He completed
a residency program and obtained a masters degree in ophthalmology from the Suez Canal University in 2007. Dr Ellabban
is now in a PhD program in the Department of Ophthalmology and Visual Sciences at Kyoto University (Japan). His
interests are imaging of the choroid and three-dimensional imaging of ocular structures.
11.e1 --- 2013AMERICAN JOURNAL OF OPHTHALMOLOGY