This study used swept-source optical coherence tomography (OCT) to examine the 3D tomographic features of dome-shaped maculas in highly myopic eyes. OCT imaging revealed that in all eyes, a horizontal ridge was formed within the posterior staphyloma by uneven thinning of the sclera, creating two outward concavities. In most eyes the ridge was band-shaped. The study provides new insights into the pathomorphology of dome-shaped maculas using 3D OCT imaging.
3D Tomgraphic features in dome shaped macula by swept source OCTAbdallah Ellabban
This study used swept-source optical coherence tomography (OCT) to examine the 3D tomographic features of dome-shaped maculas in highly myopic eyes. OCT imaging revealed that in all eyes, the retinal pigment epithelium within the posterior staphyloma had two outward concavities separated by a horizontal ridge. In most eyes the ridge was band-shaped. The study provides new insights into the topography and underlying pathomorphology of dome-shaped maculas.
This study prospectively examined 35 eyes with dome-shaped macular configuration using swept-source optical coherence tomography over a mean follow-up period of 24.8 months. The study found progressive asymmetric thinning of the sclera in the macular region. Scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase in macular bulge height over time. The choroid also showed generalized thinning within the staphyloma during follow-up. The ocular concavities deepened and macular bulge height increased significantly, indicating the progressive nature of the posterior pole changes in eyes with dome-shaped macular configuration.
Dome shaped macula in High myopia - Swept-source Optical coherence tomograph...Abdallah Ellabban
1) The study used swept-source OCT to examine the 3D features of the dome-shaped macula (DSM) in highly myopic eyes over 2 years.
2) It found thinning of the sclera over time at the fovea and surrounding regions, with an average decline of 5-12 μm per year.
3) The height of the macular bulge increased on average by 20 μm over 2 years, suggesting dynamic changes in the posterior pole over time.
Focal choroidal excavation in eyes with central serous chorioretinopathy Abdallah Ellabban
Focal choroidal excavation was detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavation were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroid, suggesting focal choroidal excavations may form from retinal pigment epithelium retraction caused by focal scarring of the choroid.
Inferior posterior staphyloma: choroidal maps and macular complications Abdallah Ellabban
Eyes with inferior posterior staphyloma showed marked choroidal thinning along the superior border of the staphyloma. As patient age increased, choroidal thinning progressed in the entire macular area. Eyes with neovascular complications associated with the staphyloma had significantly reduced macular choroidal thickness compared to eyes without complications. Reduction of the choroidal thickness with age seemed to be involved in the development of neovascularization associated with inferior posterior staphyloma.
Focal choroidal excavation in eyes with central serous chorioretinopathyAbdallah Ellabban
Focal choroidal excavations were detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavations were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroidal boundary. This study provides insights into the prevalence and 3D morphology of focal choroidal excavations in central serous chorioretinopathy.
This document discusses the application of anterior segment optical coherence tomography (AS-OCT) in diagnosing various ocular conditions. It provides an overview of AS-OCT imaging principles and compares it to ultrasound biomicroscopy. The document then examines the use of AS-OCT in diagnosing and monitoring conditions of the cornea, conjunctiva, and anterior chamber angle/glaucoma. Examples of pathologies that can be identified include corneal scars, Fuchs' dystrophy, graft rejection, angle closure, and bleb assessment after glaucoma surgery.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize and measure individual layers of the retina. OCT can detect various retinal pathologies through qualitative and quantitative analysis of the pre-retinal, overall retinal, foveal, and macular profiles. It is useful for diagnosing conditions like macular edema, retinal detachments, and glaucoma.
3D Tomgraphic features in dome shaped macula by swept source OCTAbdallah Ellabban
This study used swept-source optical coherence tomography (OCT) to examine the 3D tomographic features of dome-shaped maculas in highly myopic eyes. OCT imaging revealed that in all eyes, the retinal pigment epithelium within the posterior staphyloma had two outward concavities separated by a horizontal ridge. In most eyes the ridge was band-shaped. The study provides new insights into the topography and underlying pathomorphology of dome-shaped maculas.
This study prospectively examined 35 eyes with dome-shaped macular configuration using swept-source optical coherence tomography over a mean follow-up period of 24.8 months. The study found progressive asymmetric thinning of the sclera in the macular region. Scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase in macular bulge height over time. The choroid also showed generalized thinning within the staphyloma during follow-up. The ocular concavities deepened and macular bulge height increased significantly, indicating the progressive nature of the posterior pole changes in eyes with dome-shaped macular configuration.
Dome shaped macula in High myopia - Swept-source Optical coherence tomograph...Abdallah Ellabban
1) The study used swept-source OCT to examine the 3D features of the dome-shaped macula (DSM) in highly myopic eyes over 2 years.
2) It found thinning of the sclera over time at the fovea and surrounding regions, with an average decline of 5-12 μm per year.
3) The height of the macular bulge increased on average by 20 μm over 2 years, suggesting dynamic changes in the posterior pole over time.
Focal choroidal excavation in eyes with central serous chorioretinopathy Abdallah Ellabban
Focal choroidal excavation was detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavation were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroid, suggesting focal choroidal excavations may form from retinal pigment epithelium retraction caused by focal scarring of the choroid.
Inferior posterior staphyloma: choroidal maps and macular complications Abdallah Ellabban
Eyes with inferior posterior staphyloma showed marked choroidal thinning along the superior border of the staphyloma. As patient age increased, choroidal thinning progressed in the entire macular area. Eyes with neovascular complications associated with the staphyloma had significantly reduced macular choroidal thickness compared to eyes without complications. Reduction of the choroidal thickness with age seemed to be involved in the development of neovascularization associated with inferior posterior staphyloma.
Focal choroidal excavation in eyes with central serous chorioretinopathyAbdallah Ellabban
Focal choroidal excavations were detected in 9 of 116 eyes (7.8%) with central serous chorioretinopathy using swept-source optical coherence tomography. The excavations were located within areas of choroidal hyperpermeability and retinal pigment epithelium leakage on angiography. Eyes with focal choroidal excavations were more myopic and had thinner subfoveal choroid compared to eyes without excavations. In some eyes, unusual choroidal tissue was observed beneath the excavation, bridging it to the outer choroidal boundary. This study provides insights into the prevalence and 3D morphology of focal choroidal excavations in central serous chorioretinopathy.
This document discusses the application of anterior segment optical coherence tomography (AS-OCT) in diagnosing various ocular conditions. It provides an overview of AS-OCT imaging principles and compares it to ultrasound biomicroscopy. The document then examines the use of AS-OCT in diagnosing and monitoring conditions of the cornea, conjunctiva, and anterior chamber angle/glaucoma. Examples of pathologies that can be identified include corneal scars, Fuchs' dystrophy, graft rejection, angle closure, and bleb assessment after glaucoma surgery.
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize and measure individual layers of the retina. OCT can detect various retinal pathologies through qualitative and quantitative analysis of the pre-retinal, overall retinal, foveal, and macular profiles. It is useful for diagnosing conditions like macular edema, retinal detachments, and glaucoma.
Optical Coherence Tomography (OCT) is a non-invasive imaging technique that examines living tissue using low coherence radiation. It provides high resolution cross-sectional images of the retina in real time. OCT allows for both qualitative and quantitative analysis of retinal thickness, volume, and nerve fiber layer thickness. Scans can be customized using different protocols like line, circle, or radial line scans to examine specific areas of interest like the macula or optic nerve.
The document discusses optical coherence tomography (OCT) and its role in ophthalmology. It provides details on:
- The history and development of OCT, how it works using interferometry and low coherence light, and its advantages over ultrasound.
- How OCT allows high-resolution, non-invasive cross-sectional imaging of the retina and other ocular structures.
- How OCT is used to detect and monitor various retinal pathologies like age-related macular degeneration, diabetic retinopathy, macular edema and more. Abnormal findings on OCT like fluid, exudates and neovascularization are summarized.
- The principles of different OCT technologies over time including time domain, spectral domain
We can ultimately aim to obtain “optical biopsies” of cornea with the introduction of high resolution AS-OCT .
AS-OCT helps assess tissue anatomy and evaluate differences in cellular morphology and patterns to distinguish between divergent anterior segment conditions.
Ultrasound biomicroscopy (UBM) allows for high-resolution noninvasive imaging of the anterior segment of the eye. UBM can image structures like the ciliary body and zonules that were previously unseen. It provides qualitative and quantitative analysis of pathophysiologic changes to anterior segment architecture. UBM uses high frequency transducers between 50-100 MHz for fine resolution imaging of superficial structures to a depth of around 5mm. It produces real-time images of the anterior segment that can be recorded for later analysis. UBM is useful for diagnosing various causes of glaucoma by allowing visualization of the angle and how anterior segment structures interact.
Optical coherence tomography (OCT) provides high resolution, cross-sectional images of the retina. OCT uses light waves to generate tomographic scans. Early OCT systems had axial resolutions of 10 μm and scan speeds of 400 scans/second. Newer spectral domain OCT systems have higher resolutions of 1-15 μm and faster scan speeds of up to 52,000 scans/second, allowing better visualization of retinal layers and pathology. OCT is used to qualitatively and quantitatively evaluate retinal morphology and thickness.
This document discusses optical coherence tomography (OCT) and OCT angiography (OCTA). It provides background on OCT and how it can be used for in vivo optical biopsies. A brief history of OCT's development is given, along with principles of OCT variants like spectral domain OCT. Clinical applications of OCT and OCTA are explored through examples of interpreting OCT reports, identifying landmarks, and analyzing various retinal conditions and diseases. Potential research opportunities using OCT and OCTA data are also mentioned.
The document describes the MS-39 topographer, which provides comprehensive corneal and anterior segment analysis through a combination of Placido disk technology and spectral domain OCT. The MS-39 allows for accurate measurement of corneal thickness, curvature, elevation, aberrations, and other metrics. It also enables tear film analysis, pupillometry, and advanced lens imaging for cataract evaluations. Overall, the document emphasizes that the MS-39 is a comprehensive device for anterior segment analysis and monitoring of conditions like keratoconus through serial exams.
Optical coherence tomography angiography optovue a very basic lecture detailing the new advancement of dyeless angiography by spectral domain OCT system and SSADA and Motion correction algorithm
Optical Coherance Tomography (OCT) in Vitreo Retina and Choroid Tahseen Jawaid
This document discusses optical coherence tomography (OCT) and its use in retinal imaging. OCT has become the most important test for diagnosing and managing retinal diseases. Several improvements to OCT technology over time, including Fourier domain detection and swept-source OCT, have provided faster scanning speeds and better visualization of the choroid and sclera. Both structural and quantitative analysis of OCT scans provide valuable information. While artifacts can occur, OCT remains a non-invasive and repeatable tool that will continue improving with advances in software.
This document compares and contrasts AS-OCT (anterior segment optical coherence tomography) and ultrasound biomicroscopy (UBM) imaging techniques for evaluating the anterior eye segment.
It discusses that AS-OCT provides non-contact, high resolution cross-sectional imaging of the anterior segment structures without touching the eye. UBM uses high frequency ultrasound to generate detailed 2D images of the anterior segment, allowing visualization of structures like the iris and angle.
While both techniques allow qualitative and quantitative assessment of the anterior chamber angle and structures, AS-OCT has advantages of being non-contact, faster imaging, and less operator dependency compared to UBM. However, UBM can image deeper into the posterior iris and has greater penetration than
The document provides an overview of retinal optical coherence tomography (OCT). It discusses how OCT works using light to provide non-invasive, high resolution imaging of ocular structures. Examples of anterior segment, optic nerve, and retinal OCT scans are shown. Interpretation of macular OCT scans and quantitative thickness maps are described. Indications for retinal OCT include examining retinal layers, monitoring progression of diseases like age-related macular degeneration and diabetic macular edema, aiding treatment planning, and monitoring response to therapy. Case studies demonstrate how OCT enhanced diagnosis and treatment decisions for vitreoretinal interface disorders, retinal vascular diseases, and other retinal entities compared to other imaging tests.
Optical Coherence Tomography - principle and uses in ophthalmologytapan_jakkal
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize detailed layers and structures within the retina. OCT can be used to qualitatively and quantitatively analyze the retina, detecting various pathological features and measuring retinal thickness. Anterior segment OCT also allows high-resolution imaging of the cornea, iris, angle, and anterior chamber.
The document discusses the five layers of the cornea - epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. It describes the function of each layer. It also discusses corneal topography, which provides a 3D view of the cornea and is used to diagnose corneal conditions. Key measurements from topography include K readings to determine astigmatism and pachemetry readings to measure corneal thickness. Abnormal topography findings can indicate conditions like keratoconus, where the cornea protrudes in a cone shape. The document demonstrates how to properly perform corneal topography and pachymetry ultrasound scans.
Tomographic fundus features in Pseudoxanthoma Elasticum Abdallah Ellabban
This study analyzed optical coherence tomography (OCT) scans of 52 eyes from 27 patients with pseudoxanthoma elasticum (PXE) and compared features between those with choroidal neovascularization (CNV) secondary to angioid streaks (AS) vs CNV secondary to age-related macular degeneration (AMD). Unique lesions were more common in PXE patients, including outer retinal tubulation (ORT) seen in 70.5% of eyes with CNV secondary to AS vs 34.1% of AMD eyes, and Bruch's membrane undulation seen in 70.8% vs 11.4% respectively. ORT appeared as round or ovoid structures beneath the outer plexiform layer.
The document discusses considerations for selecting premium intraocular lenses (IOLs). It emphasizes listening to patients' desires and managing expectations. Various IOL options are suitable for different patients depending on their visual needs, personality, and ocular health factors. Careful preoperative evaluation, surgical technique, and postoperative management can help optimize outcomes and patient satisfaction.
optical coherence tomography is a new tool that makes retinal diagnosis easier. the above ppt includes a detailed and precise notes on OCT and its interpretation.
Ophthalmology Lectures ; Anterior segment OCT has been used widely in diagnosis of corneal disease, & in assessment of anterior segment surgery & keratoplasty
1. OCT imaging provides high-resolution cross-sectional images of coronary arteries and stents to assess plaque, guide stent sizing and placement, and confirm procedural success.
2. The OCT catheter is advanced to the region of interest and an automated pullback acquires images as flush media clears blood from the field of view. Images can be used to characterize plaque, measure vessel and stent dimensions, check apposition and expansion, and detect complications.
3. OCT has advantages over IVUS like superior resolution and ability to identify details like thin-cap fibroatheroma, but it also has limitations such as limited tissue penetration and the need for flush media that adds contrast load.
International Refereed Journal of Engineering and Science (IRJES)irjes
International Refereed Journal of Engineering and Science (IRJES) is a leading international journal for publication of new ideas, the state of the art research results and fundamental advances in all aspects of Engineering and Science. IRJES is a open access, peer reviewed international journal with a primary objective to provide the academic community and industry for the submission of half of original research and applications
FOCAL CHOROIDAL EXCAVATION IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY Abdallah Ellabban
Focal choroidal excavations were found in 7.8% of eyes with central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (OCT). OCT revealed that in some eyes with focal excavations, unusual choroidal tissue bridged the bottom of the excavation to the outer choroid boundary, and in some cases a suprachoroidal space was present below the excavation. Eyes with focal excavations were more myopic and had thinner subfoveal choroidal thickness than eyes without excavations. The study suggests focal excavations in CSC may form from retinal pigment epithelium retraction caused by focal scarring of choroidal connective tissue.
Multimodal evaluation of macular function in age related macularAbdallah Ellabban
- The study evaluated macular function in eyes with age-related macular degeneration (AMD) using visual acuity testing, microperimetry, and focal macular electroretinography (fmERG).
- Eyes with neovascular AMD showed marked deterioration of macular function on all tests as well as changes in the neurosensory retina.
- Eyes with large drusen only showed minimal retinal changes but decreased retinal sensitivity at the central point on microperimetry testing.
- Eyes with drusenoid pigment epithelial detachment (PED) had preserved retinal structure but significantly increased foveal thickness and decreased visual acuity, fmERG amplitudes, and retinal sensitivity,
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize and measure individual layers of the retina. OCT can detect various retinal pathologies and abnormalities through qualitative and quantitative analysis of the pre-retinal, overall retinal, foveal, and macular profiles.
Optical Coherence Tomography (OCT) is a non-invasive imaging technique that examines living tissue using low coherence radiation. It provides high resolution cross-sectional images of the retina in real time. OCT allows for both qualitative and quantitative analysis of retinal thickness, volume, and nerve fiber layer thickness. Scans can be customized using different protocols like line, circle, or radial line scans to examine specific areas of interest like the macula or optic nerve.
The document discusses optical coherence tomography (OCT) and its role in ophthalmology. It provides details on:
- The history and development of OCT, how it works using interferometry and low coherence light, and its advantages over ultrasound.
- How OCT allows high-resolution, non-invasive cross-sectional imaging of the retina and other ocular structures.
- How OCT is used to detect and monitor various retinal pathologies like age-related macular degeneration, diabetic retinopathy, macular edema and more. Abnormal findings on OCT like fluid, exudates and neovascularization are summarized.
- The principles of different OCT technologies over time including time domain, spectral domain
We can ultimately aim to obtain “optical biopsies” of cornea with the introduction of high resolution AS-OCT .
AS-OCT helps assess tissue anatomy and evaluate differences in cellular morphology and patterns to distinguish between divergent anterior segment conditions.
Ultrasound biomicroscopy (UBM) allows for high-resolution noninvasive imaging of the anterior segment of the eye. UBM can image structures like the ciliary body and zonules that were previously unseen. It provides qualitative and quantitative analysis of pathophysiologic changes to anterior segment architecture. UBM uses high frequency transducers between 50-100 MHz for fine resolution imaging of superficial structures to a depth of around 5mm. It produces real-time images of the anterior segment that can be recorded for later analysis. UBM is useful for diagnosing various causes of glaucoma by allowing visualization of the angle and how anterior segment structures interact.
Optical coherence tomography (OCT) provides high resolution, cross-sectional images of the retina. OCT uses light waves to generate tomographic scans. Early OCT systems had axial resolutions of 10 μm and scan speeds of 400 scans/second. Newer spectral domain OCT systems have higher resolutions of 1-15 μm and faster scan speeds of up to 52,000 scans/second, allowing better visualization of retinal layers and pathology. OCT is used to qualitatively and quantitatively evaluate retinal morphology and thickness.
This document discusses optical coherence tomography (OCT) and OCT angiography (OCTA). It provides background on OCT and how it can be used for in vivo optical biopsies. A brief history of OCT's development is given, along with principles of OCT variants like spectral domain OCT. Clinical applications of OCT and OCTA are explored through examples of interpreting OCT reports, identifying landmarks, and analyzing various retinal conditions and diseases. Potential research opportunities using OCT and OCTA data are also mentioned.
The document describes the MS-39 topographer, which provides comprehensive corneal and anterior segment analysis through a combination of Placido disk technology and spectral domain OCT. The MS-39 allows for accurate measurement of corneal thickness, curvature, elevation, aberrations, and other metrics. It also enables tear film analysis, pupillometry, and advanced lens imaging for cataract evaluations. Overall, the document emphasizes that the MS-39 is a comprehensive device for anterior segment analysis and monitoring of conditions like keratoconus through serial exams.
Optical coherence tomography angiography optovue a very basic lecture detailing the new advancement of dyeless angiography by spectral domain OCT system and SSADA and Motion correction algorithm
Optical Coherance Tomography (OCT) in Vitreo Retina and Choroid Tahseen Jawaid
This document discusses optical coherence tomography (OCT) and its use in retinal imaging. OCT has become the most important test for diagnosing and managing retinal diseases. Several improvements to OCT technology over time, including Fourier domain detection and swept-source OCT, have provided faster scanning speeds and better visualization of the choroid and sclera. Both structural and quantitative analysis of OCT scans provide valuable information. While artifacts can occur, OCT remains a non-invasive and repeatable tool that will continue improving with advances in software.
This document compares and contrasts AS-OCT (anterior segment optical coherence tomography) and ultrasound biomicroscopy (UBM) imaging techniques for evaluating the anterior eye segment.
It discusses that AS-OCT provides non-contact, high resolution cross-sectional imaging of the anterior segment structures without touching the eye. UBM uses high frequency ultrasound to generate detailed 2D images of the anterior segment, allowing visualization of structures like the iris and angle.
While both techniques allow qualitative and quantitative assessment of the anterior chamber angle and structures, AS-OCT has advantages of being non-contact, faster imaging, and less operator dependency compared to UBM. However, UBM can image deeper into the posterior iris and has greater penetration than
The document provides an overview of retinal optical coherence tomography (OCT). It discusses how OCT works using light to provide non-invasive, high resolution imaging of ocular structures. Examples of anterior segment, optic nerve, and retinal OCT scans are shown. Interpretation of macular OCT scans and quantitative thickness maps are described. Indications for retinal OCT include examining retinal layers, monitoring progression of diseases like age-related macular degeneration and diabetic macular edema, aiding treatment planning, and monitoring response to therapy. Case studies demonstrate how OCT enhanced diagnosis and treatment decisions for vitreoretinal interface disorders, retinal vascular diseases, and other retinal entities compared to other imaging tests.
Optical Coherence Tomography - principle and uses in ophthalmologytapan_jakkal
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize detailed layers and structures within the retina. OCT can be used to qualitatively and quantitatively analyze the retina, detecting various pathological features and measuring retinal thickness. Anterior segment OCT also allows high-resolution imaging of the cornea, iris, angle, and anterior chamber.
The document discusses the five layers of the cornea - epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. It describes the function of each layer. It also discusses corneal topography, which provides a 3D view of the cornea and is used to diagnose corneal conditions. Key measurements from topography include K readings to determine astigmatism and pachemetry readings to measure corneal thickness. Abnormal topography findings can indicate conditions like keratoconus, where the cornea protrudes in a cone shape. The document demonstrates how to properly perform corneal topography and pachymetry ultrasound scans.
Tomographic fundus features in Pseudoxanthoma Elasticum Abdallah Ellabban
This study analyzed optical coherence tomography (OCT) scans of 52 eyes from 27 patients with pseudoxanthoma elasticum (PXE) and compared features between those with choroidal neovascularization (CNV) secondary to angioid streaks (AS) vs CNV secondary to age-related macular degeneration (AMD). Unique lesions were more common in PXE patients, including outer retinal tubulation (ORT) seen in 70.5% of eyes with CNV secondary to AS vs 34.1% of AMD eyes, and Bruch's membrane undulation seen in 70.8% vs 11.4% respectively. ORT appeared as round or ovoid structures beneath the outer plexiform layer.
The document discusses considerations for selecting premium intraocular lenses (IOLs). It emphasizes listening to patients' desires and managing expectations. Various IOL options are suitable for different patients depending on their visual needs, personality, and ocular health factors. Careful preoperative evaluation, surgical technique, and postoperative management can help optimize outcomes and patient satisfaction.
optical coherence tomography is a new tool that makes retinal diagnosis easier. the above ppt includes a detailed and precise notes on OCT and its interpretation.
Ophthalmology Lectures ; Anterior segment OCT has been used widely in diagnosis of corneal disease, & in assessment of anterior segment surgery & keratoplasty
1. OCT imaging provides high-resolution cross-sectional images of coronary arteries and stents to assess plaque, guide stent sizing and placement, and confirm procedural success.
2. The OCT catheter is advanced to the region of interest and an automated pullback acquires images as flush media clears blood from the field of view. Images can be used to characterize plaque, measure vessel and stent dimensions, check apposition and expansion, and detect complications.
3. OCT has advantages over IVUS like superior resolution and ability to identify details like thin-cap fibroatheroma, but it also has limitations such as limited tissue penetration and the need for flush media that adds contrast load.
International Refereed Journal of Engineering and Science (IRJES)irjes
International Refereed Journal of Engineering and Science (IRJES) is a leading international journal for publication of new ideas, the state of the art research results and fundamental advances in all aspects of Engineering and Science. IRJES is a open access, peer reviewed international journal with a primary objective to provide the academic community and industry for the submission of half of original research and applications
FOCAL CHOROIDAL EXCAVATION IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY Abdallah Ellabban
Focal choroidal excavations were found in 7.8% of eyes with central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (OCT). OCT revealed that in some eyes with focal excavations, unusual choroidal tissue bridged the bottom of the excavation to the outer choroid boundary, and in some cases a suprachoroidal space was present below the excavation. Eyes with focal excavations were more myopic and had thinner subfoveal choroidal thickness than eyes without excavations. The study suggests focal excavations in CSC may form from retinal pigment epithelium retraction caused by focal scarring of choroidal connective tissue.
Multimodal evaluation of macular function in age related macularAbdallah Ellabban
- The study evaluated macular function in eyes with age-related macular degeneration (AMD) using visual acuity testing, microperimetry, and focal macular electroretinography (fmERG).
- Eyes with neovascular AMD showed marked deterioration of macular function on all tests as well as changes in the neurosensory retina.
- Eyes with large drusen only showed minimal retinal changes but decreased retinal sensitivity at the central point on microperimetry testing.
- Eyes with drusenoid pigment epithelial detachment (PED) had preserved retinal structure but significantly increased foveal thickness and decreased visual acuity, fmERG amplitudes, and retinal sensitivity,
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to capture high-resolution, cross-sectional images of the retina and anterior segment of the eye. OCT provides depth resolution on the scale of 10 microns, allowing it to visualize and measure individual layers of the retina. OCT can detect various retinal pathologies and abnormalities through qualitative and quantitative analysis of the pre-retinal, overall retinal, foveal, and macular profiles.
UBM provides high-resolution ultrasound images of ocular structures anterior to the pars plana. It was developed in the 1980s and can be used to evaluate glaucoma mechanisms and treatments. UBM allows quantification of anterior chamber angle structures and assessment of conditions like angle closure, open-angle glaucoma, and filtering surgeries. It provides useful information when the eye precludes examination by other methods due to opacity or anatomy.
Reduction of retinal senstivity in eyes with reticular pseudodrusenAbdallah Ellabban
This study evaluated the effect of reticular pseudodrusen on retinal function using multiple imaging methods in 13 eyes with reticular pseudodrusen but no other macular abnormalities. Infrared reflectance imaging detected reticular pseudodrusen within the central macula in more eyes than color fundus photography or fundus autofluorescence. Retinal sensitivity across the macula was lower in eyes with reticular pseudodrusen compared to normal eyes. The number of reticular pseudodrusen detected by different imaging modalities correlated with reduced retinal sensitivity in specific macular areas.
Optic Disc and Macula Localization from Retinal Optical Coherence Tomography ...IJECEIAES
This research used images from Optical Coherence Tomography (OCT) examination as well as fundus images to localize the optical disc and macular layer of retina. The researchers utilized the OCT and fundus image to interpret the distance between macular center and optic disc in the image. The distance will express the area of macula that can be employed for further research. This distance could recognize the thickness of macula parameters diameter that will be used in localizing process of optic disc and macula. The parameters are the circle radius, the size of window’s filter, the constant value and the size of optic disc element structure as well as the size of macula. The results of this study are expected to improve the accuracy of macula detection that experience the edema.
Possible future avenues for ophthalmic imaging combining advanced techniques and deep learning. "Bubbling under the surface, and inspiration from ‘bioimaging’ in general"
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses infrared light to generate high-resolution cross-sectional images of the retina and anterior segment of the eye. OCT works by measuring the echo time and intensity of reflected light to create digital representations of tissue structures. There are two main types - time domain OCT and spectral domain OCT. OCT is useful for diagnosing and monitoring many eye conditions, such as glaucoma, age-related macular degeneration, and diabetic retinopathy. It allows detailed visualization of the retina, optic nerve, macula, and anterior segment structures.
Avaliação das alterações na curvatura anterior e posterior da Córnea, sua paquimetria, resultados visuais e refrativos após o Implante de Anel de Ferrara com o auxilio do Galilei.
1. SD-OCT examination of the cornea in dogs and cats provided accurate evaluation of each corneal layer.
2. In healthy animals, SD-OCT distinguished the epithelial, stromal, and endothelial layers and measured their thicknesses.
3. In pathological cases, SD-OCT identified features such as epithelial defects, stromal infiltrates, and thinning associated with conditions like ulcers and keratitis.
The document discusses preoperative evaluation and measurements for cataract surgery, including biometry. It covers evaluating the general health and ocular history of the patient, performing visual acuity testing, refraction, and other objective tests. It then describes methods of measuring the eye, including A-scan biometry to determine axial length using ultrasound, and optical biometry using light waves. Factors that can influence biometry measurements and techniques like keratometry are also discussed. The document concludes by covering intraocular lens power calculation and selection, noting the importance of accurate measurements and various generation of formulas used.
Optical Coherence Tomography(OCT) in posterior segment diseasesShagil Khan
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to generate high-resolution cross-sectional images of the retina and optic nerve. It provides detailed visualization of retinal structures on a microscopic scale. OCT is useful for diagnosing and monitoring various posterior segment diseases. It allows differentiation between stages of macular hole, detection of epiretinal membranes, and identification of fluid associated with neovascular age-related macular degeneration. Advances in spectral domain OCT technology have improved imaging speed and resolution, enabling clearer visualization of small retinal structures and layers.
Optical coherence tomography (OCT) is a noninvasive imaging technique that uses light waves to examine ocular structures with micrometer resolution. OCT works similarly to ultrasound but uses light instead of sound. By analyzing reflected light waves, an OCT can construct a depth profile of tissue structures. OCT provides high-resolution evaluation of retinal layers and pathology. It is useful for diagnosing and monitoring diseases like diabetic retinopathy. OCT imaging involves A-scans that are combined to form B-scans and 3D volumes. Spectral domain OCT has replaced time domain OCT due to improved sensitivity and speed. OCT is useful for classifying and monitoring diabetic macular edema and other retinal diseases.
This study evaluated 59 eyes of 54 patients who underwent implantation of intrastromal corneal ring segments (ICRS) to correct astigmatism after previous penetrating keratoplasty (PKP). The mean corrected distance visual acuity, spherical equivalent, spherical refractive error, and corneal topographic astigmatism all significantly improved after ICRS implantation. No patients lost visual acuity after the procedure. ICRS implantation effectively reduced corneal astigmatism in patients who developed astigmatism after previous PKP.
This document provides an overview of the anatomy of the anterior chamber of the eye, including its structures and clinical correlations. It discusses the anterior chamber angle and identification of its structures like the ciliary band, scleral spur, trabecular meshwork, and Schwalbe's line. Methods for grading the chamber angle like gonioscopy and Van Herick test are presented. The document also covers aqueous production and drainage system, intraocular pressure measurement, and clinical conditions like glaucoma.
The Implantable Collamer Lens (ICL) is a soft, flexible, posterior chamber phakic intraocular lens made of collagen-copolymer material called Collamer. Studies have shown ICL implantation is safe and effective for correcting myopia between -3 to -25 diopters and astigmatism up to -6 diopters. It provides stable refractive results with few complications over 4 years. Toric ICL models were found to be superior to LASIK in safety, efficacy, predictability and stability for high myopic astigmatism. The procedure is reversible and preserves corneal tissue, reducing risks compared to LASIK.
HISTORY
History regarding duration of diabetes, pastglycemic control (hemoglobin A1c), Medications used (especially insulin, oral hypoglycemics, antihypertensives, and lipid-lowering drugs), systemic history (e.g., renal disease, cardiovascular events, systemic hypertension, serum lipid levels, pregnancy)(Konno et al.,2001).
History related to drugs causing macularedema (Thiazolidinediones, fingolimod (used inMS), tamoxifen, taxanes, niacin, interferons and prostaglandin analogs).Ocular examination
Detailed patient assessment and diagnosis should include a complete ophthalmic examination, including visual acuity (preferably by a ETDRS/Log MARchart) INVESTIGATIONS OCT
All patients with DME should undergo OCT (Both Raster and radial scans). Retinal thickening (Central subfield and inner ETDRS ring thickness measurement), presence of vitreomacular adhesion or traction and morphological characteristics like presence of neurosensory detachment, cystic spaces, foveal contour should be noted(Massin et al.,2001).
The features suggestive of prognosis-like horizontal and vertical extent of IS-OS disruption, ELM disruption and hyper reflective foci (HFs)within the neurosensory retina should be noted. In the presence of gross cystoids macular edema, often it is difficult to assess these features.
Reduction in visual acuity in association with diabetic retinopathy commonly occurs from diabetic macular edema. Traditional methods of assessing DME include contact and non-contact slit-lamp biomicroscopy, indirect funduscopy, fluoresce in angiography and fundus streo-photography. However, given the relative deprival of ability of these methods to detect and to quantify DME, alternative objective methods have been applied. The introduction of OCT allows an objective evaluation of DME with effectiveness in both qualitative and quantitative description of this pathology. That is why it becomes a standard tool in the management of patients with DME .More than ten years after ETDRS, OCT greatly enhanced our ability to detect and analyse macular thickening and has brought new insights on the morphology of DME and on the presence of vitreo-retinal interface abnormalities.
PERIOCULAR RECOGNITION USING REDUCED FEATURESijcsit
Biometrics is science of measuring and statistically analyzing biological data. Biometric system establishes identity of a person based on unique physical or behavioural characteristic possessed by an individual.Behavioural biometrics measures characteristics which are acquired naturally over time. Physical biometrics measures inherent physical characteristics on a n individual. Over the last few decades enormous attention is drawn towards ocular biometrics. Cues provided by ocular region have led to exploration of newer traits. Feasibility of periocular region as a useful biometric trait has been explored recently. With the promising results of preliminary examination, research towards periocular region is currently gaining lot of prominence. Researchers have analyzed various techniques of feature extraction and classification in the periocular region. The current paper investigates the effect of using Lower Central Periocular Region (LCPR) for identification. The results obtained are comparable with those acquired for the entire periocular region with an advantage of reduced periocular area
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
1. Three-Dimensional Tomographic Features of
Dome-Shaped Macula by Swept-Source
Optical Coherence Tomography
ABDALLAH A. ELLABBAN, AKITAKA TSUJIKAWA, AKIKO MATSUMOTO, KENJI YAMASHIRO, AKIO OISHI,
SOTARO OOTO, ISAO NAKATA, YUMIKO AKAGI-KURASHIGE, MASAHIRO MIYAKE, HUSSEIN S. ELNAHAS,
TAREK M. RADWAN, KHALED A. ZAKY, AND NAGAHISA YOSHIMURA
PURPOSE: To study the tomographic and pathomorpho-logic
features of dome-shaped maculas with swept-source
optical coherence tomography (OCT).
DESIGN: Prospective, cross-sectional study.
METHODS: The macular area of 51 highly myopic eyes
(35 patients) with dome-shaped maculas was studied with
swept-source OCT at 1050 nm. Three-dimensional
(3-D) data sets were obtained with raster scanning
covering a 12 3 8-mm2 area; 3-D images of the posterior
pole were constructed by autosegmentation of the retinal
pigment epithelium (RPE).
RESULTS: In all reconstructed 3-D images of the
RPE, 2 outward concavities were seen within the poste-rior
staphyloma and a horizontal ridge was formed
between these 2 concavities. In 42 of these eyes, this
horizontal ridge was band shaped. The vertical OCT
section through the fovea showed a convex configura-tion
of RPE, but the horizontal section showed an
almost flat RPE line. In 9 eyes, 3-D images showed
a typical dome-shaped convexity within the staphyloma.
OCT scans showed no outward protrusions in the
external scleral surface, but marked scleral thinning
was seen consistent with the 2 outward concavities of
the RPE. The sclera of the fovea (518.6 ± 97.6 mm)
was significantly thicker than that in all 4 quadrants
of the parafoveal area (range, 277.2 to 360.3 mm;
P .001).
CONCLUSIONS: In highly myopic eyes with a dome-shaped
macula, a horizontal ridge is formed within the
posterior staphyloma by uneven thinning of the
sclera. (Am J Ophthalmol 2013;155:320–328.
2013 by Elsevier Inc. All rights reserved.)
HIGH MYOPIA IS ONE OF THE LEADING CAUSES OF
visual disturbance worldwide and is particularly
prevalent in Asians.1–3 Axial elongation of the
globe leads to complex changes in the topography of the
posterior pole, with concomitant thinning of the retina,
choroid, and sclera and subsequent development of
macular pathologic features.4–6 Posterior staphyloma,
which is one of the characteristic features of high
myopia, has been reported to be associated with various
vision-threatening complications, including choroidal
neovascularization, macular holes, schisis, chorioretinal
atrophy, and visual field defects.4–6 Using fundus
examination, Curtin classified posterior staphyloma in
eyes with high myopia into 10 types.4
Based on optical coherence tomography (OCT),
a dome-shaped macula was first described by Gaucher
and associates as an unexpected finding in myopic staphy-loma
and was characterized as an inward convexity of the
macula that occurred in highly myopic eyes within the
concavity of a posterior staphyloma.7 They suggested that
the dome-shaped macula may be the result of changes in
choroidal thickness or to changes in scleral shape in highly
myopic eyes. Subsequently, Imamura and associates, by
using enhanced depth imaging OCT, reported that the
dome-shaped macula is the result of a localized variation
in thickness of the sclera in the macular area.8,9
However, the mechanisms that underlie this unusual
tomographic feature remain unknown. In addition, most
cases of dome-shaped macula in these previous reports
were examined by only unidirectional OCT scans.7,8,10,11
So far, little information is available on the topography
of the posterior pole in eyes with a dome-shaped macula.
With the advances in OCT in the last decade, several
retinal pathologic characteristics have been identified in
highly myopic eyes.12–19 However, imaging of highly
myopic eyes with conventional OCT systems has several
difficulties. Recent OCT generation has used swept-source
laser as a light source.20–27 The swept-source OCT
at a longer wavelength allows deeper tissue penetration
into the choroid and even sclera, especially in highly
myopic eyes. Additionally, the higher imaging speed, larger
scan window, and lower sensitivity roll-off with depth allow
for larger scans and the production of 3-dimensional (3-D)
Supplemental Material available at AJO.com
Accepted for publication Aug 21, 2012.
From the Department of Ophthalmology and Visual Sciences, Kyoto
University Graduate School of Medicine, Kyoto, Japan (A.A.E., A.T.,
A.M., K.Y., A.O., S.O., I.N., Y.A.-K., M.M., N.Y.); the Department of
Ophthalmology, Suez Canal University, Faculty of Medicine, Ismailia,
Egypt (A.A.E., H.S.E., T.M.R., K.A.Z.); and Topcon Corporation,
Tokyo, Japan (A.M.).
Inquiries to Akitaka Tsujikawa, Department of Ophthalmology
and Visual Sciences, Kyoto University Graduate School of
Medicine, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: tujikawa@kuhp.
kyoto-u.ac.jp
320 0002-9394/09/$36.00
http://dx.doi.org/10.1016/j.ajo.2012.08.007
2013 BY ELSEVIER INC. ALL RIGHTS RESERVED.
2. FIGURE 1. Parameters associated with the dome-shaped macular configuration as measured from a multiaveraged vertical section
obtained with swept-source optical coherence tomography. At the fovea, 3 parameters were measured: retinal thickness (blue
line), choroidal thickness (yellow line), and scleral thickness (dashed white double arrow). The height of the inward bulge of the
retinal pigment epithelium (red double arrow) was measured above the tangent plane (red dashed line) at the bottom of the posterior
pole. At points 2000 mm superior and 2000 mm inferior to the fovea, the choroidal (yellow line) and scleral (dashed white double
arrow) thicknesses were measured. In the horizontal scan, choroidal and scleral thicknesses also were measured at 2000 mm temporal
and nasal to the fovea. White arrowheads indicate the outer scleral border.
images of the posterior pole. In the study described herein,
we examined eyes with a dome-shaped macula using swept-source
OCT at a longer wavelength to study the pathomor-phologic
features of the dome-shaped macula by 3-D
imaging and to elucidate its association with macular
complications.
METHODS
THE INSTITUTIONAL REVIEW BOARD AND ETHICS
Committee of Kyoto University approved this prospective
study, which adhered to the tenets of the Declaration of
Helsinki. Written informed consent for research participa-tion
was obtained from each subject before examination.
In the current prospective cross-sectional study, we
examined 51 eyes (35 patients) with high myopia who
demonstrated a dome-shaped macular configuration within
the posterior staphyloma. The macular area of the study
subjects was examined using a prototype swept-source
OCT at Kyoto University Hospital between the beginning
of September 2010 and the end of February 2012. The diag-nosis
of a dome-shaped macula was based on the OCT find-ings
of an inward bulge inside the chorioretinal posterior
concavity of the macular area, according to the description
of Gaucher and associates.7 This unusual feature of the
macula in eyes with a dome-shaped macula is especially
clear on the vertical scans,7 and performing long vertical
scans has been recommended to discern specific features.28
In the current study, we recruited patients with highly
myopic eyes with a dome-shaped macula on the basis of
the presence of an inward bulge of the retinal pigment
epithelium (RPE) of more than 50 mm on vertical sections
of OCT (Figure 1) above a presumed line tangent to the
outer surface of RPE at the bottom of the posterior staphy-loma.
High myopia was defined as a refractive error of 6.0
diopters or more, an axial length of 26.5 mm or more, or
both. Eyes were excluded if they had a pre-existing ocular
disease or if they had a history of ocular surgery, other
than cataract surgery. The original refractive errors were
used for eyes that underwent cataract surgery. The type of
posterior staphyloma was determined by location and size
according to the classification of Curtin.4 In the current
study, eyes with an inferior posterior staphyloma (type V)
were excluded. All eyes of our patients had a posterior
staphyloma of type I, II, III, or IX.
All subjects underwent a comprehensive ocular exami-nation,
including autorefractometry (ARK1; Nidek, Gama-gori,
Japan), best-corrected visual acuity measurement with
a 5-m Landolt chart, axial length measurement using ocular
biometry (IOLMaster; Carl Zeiss Meditec, Jena, Germany),
slit-lamp examination, intraocular pressure measurement,
dilated color fundus photography (TRC50LX; Topcon
Corp, Tokyo, Japan), and swept-source OCT examination.
All eyes with macular complications underwent simulta-neous
fluorescein angiography and indocyanine green angi-ography
using Spectralis HRAþOCT (Heidelberg
Engineering, Heidelberg, Germany). Eyes with poor images
resulting from opaque media (eg, cataracts or corneal
opacity) were excluded from the study.
SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY
AND SCAN PROTOCOLS: The prototype swept-source
OCT (Topcon Corp) used in the current study has been
described previously.20,21 In brief, this swept-source OCT
VOL. 155, NO. 2 THREE-DIMENSIONAL FEATURES OF DOME-SHAPED MACULA 321
3. uses a light source of a wavelength-sweeping laser centered
at 1050 nm, with a repetition rate of 100 000 Hz. This OCT
system has a depth of 2.6 mm in the scan window. Swept-source
OCT examinations of the eligible subjects were
performed by trained examiners (A.A.E., A.M.) after pupil
dilation.
In each subject, multiaveraged horizontal and vertical
raster scans of 12 mm were obtained. Fifty single images,
where each image consisted of 1024 A-scans, were regis-tered
and averaged by software to create a multiaveraged
single image. The vertical scan was centered on the fovea,
whereas the horizontal scan was centered on the midpoint
between the fovea and optic disc.
3-D imaging data sets were acquired by using a raster
scan protocol of 512 (horizontal) 3 128 (vertical) A-scans
per data set in 0.8 seconds. Each raster scan consisted of
128 B-scans and covered an area of 12 3 8 mm2 centered
on the fovea. Centration was confirmed by internal fixa-tion
and by a built-in camera within the swept-source
OCT system. To improve the signal-to-noise ratio, each
image was despeckled by the weighted moving averaging
of three consecutive original B-scans. In each image, the
RPE line was determined using the built-in automated
segmentation-modifying tool, with manual corrections if
necessary. 3-D images were constructed to represent the
curvature of the posterior pole.
CHOROIDAL AND SCLERAL THICKNESS MEASUREMENT
PROTOCOL: Using the multiaveraged OCT images, we
measured the choroidal and scleral thicknesses at the
center of the fovea and at surrounding parafoveal regions
at 2000 mm superiorly, inferiorly, temporally, and nasally,
respectively. Retinal thickness was defined as the distance
between the vitreoretinal interface and the outer border of
the RPE; choroidal thickness was defined as the distance
between the outer border of the RPE line and the chorioscl-eral
interface; scleral thickness was defined as the distance
between the chorioscleral interface and outer scleral
border. Retinal, choroidal, and scleral thicknesses at the
fovea were calculated as the average of the measurements
in the vertical and horizontal OCT images at the fovea.
We also measured the height of the inward bulge of the
RPE above a presumed line tangent to the RPE at the
bottom of the posterior staphyloma (Figure 1).
The outer surface of the sclera was identified carefully in
the OCT scans from retro-ocular structures such as epis-cleral
tissue, the Tenon capsule, inferior oblique aponeu-rosis,
or orbital fat. Scleral tissues were identified by their
lamellar morphologic features, continuity of the outer
surface of the sclera within the 7 raster lines in the vertical
and horizontal scans, and high reflectivity values. The
outer border of the sclera at the fovea exceeded the scan
window in 2 eyes, and the outer scleral border was not
clearly visible in 3 eyes. In these 5 eyes, we used the greatest
measurable scleral thickness. In the parafoveal region, the
scleral thickness could be identified in all eyes.
TABLE 1. Characteristics of Eyes With a Dome-Shaped
Macula
No. of eyes/patients 51/35
Sex (male/female) 8/27
Age (years) 65.6 6 11.3 (40 to 87)
Axial length (mm) 29.53 6 2.16 (26.16 to 34.89)
Refractive error (D) 13.69 6 5.86 (6.75 to 31.0)
Visual acuity (logMAR) 0.36 6 0.39 (0.18 to 1.40)
Intraocular pressure (mm Hg) 14.8 6 2.7 (9 to 22)
Height of inward bulgea (mm) 152.3 6 58.8 (56.0 to 294.0)
Foveal retinal thickness (mm) 190.9 6 84.9 (0.0 to 522.5)
Foveal choroidal
thickness (mm)
34.5 6 29.0 (10.0 to 117.5)
Foveal scleral thickness (mm) 518.6 6 97.6 (316.0 to 711.0)
Type of posterior staphyloma
I 18
II 26
III 3
IX 4
D ¼ diopter; logMAR ¼ logarithm of minimal angle of resolu-tion.
aThe height of the inward bulge was measured from
a presumed line tangent to the outer surface of retinal pigment
epithelium at the bottom of the posterior staphyloma in the
vertical section of optical coherence tomography.
STATISTICAL ANALYSIS: Statistical analysis was com-puted
using SPSS statistical software version 16 (SPSS Inc,
Chicago, Illinois, USA). All values are expressed as mean
6 standard deviation. The measured visual acuity was
converted to the logarithmof the minimal angle of resolution
(logMAR) units for statistical analysis. The data were
analyzed using the unpaired t test. The Fisher exact test
was used to analyze categorical variables. Choroidal and
scleral thicknesses within different regions were compared
using the 1-way analysis of variance with Tukey post hoc
analysis.AP value of less than .05was considered to be statis-tically
significant.
RESULTS
IN THE CURRENT STUDY, 51 EYES OF 35 PATIENTS (8 MEN AND
27 women) with a dome-shaped macula were studied by
swept-source OCT at a 1-mm wavelength. The characteris-tics
of the subjects are summarized in Table 1. Their
mean age was 65.6 6 11.3 years (range, 40 to 87 years).
Mean refractive error was 13.69 6 5.86 diopters
(range, 6.75 to 31.00 diopters), and mean axial length
was 29.53 6 2.16 mm (range, 26.16 to 34.89 mm). Mean
visual acuity was 0.36 6 0.39 logMAR (range, 0.18 to
1.40 logMAR). The dome-shaped macula was bilateral in
16 (45.7%) patients, and all patients were Japanese.
322 AMERICAN JOURNAL OF OPHTHALMOLOGY FEBRUARY 2013
4. FIGURE 2. Eyes with high myopia that show dome-shaped macular configuration within the posterior staphyloma. (Left) Fundus
photograph. (Middle and right) Multiaveraged vertical (middle) and horizontal (right) scans through the fovea obtained by swept-source
optical coherence tomography (OCT). (Top row) Both vertical and horizontal OCT scans show an inward convexity of
the retinal pigment epithelium (RPE) within the staphyloma. The inward bulge is seen more clearly in the vertical scan. The top
of the bulge (arrow) is located beneath the fovea. (Second row) Both vertical and horizontal OCT scans show an inward convexity
of the RPE. The top of the bulge (arrow) is located at the nasal side of the fovea. (Third through Fifth rows) Vertical OCT scans show
clearly an inward bulge of RPE within the posterior staphyloma. The top of the bulge (arrows) is located beneath the fovea. The hori-zontal
SHAPE OF INWARD PROTRUSION IN EYES WITH
DOME-SHAPED MACULAS: Multiaveraged sections with
the swept-source OCT enabled clear visualization of the
structure of the retina, choroid, and sclera. In all eyes, an
inward bulge within the posterior staphyloma was seen
clearly in the vertical sections. The height of the inward
bulge above the tangent plane was 152.3658.8 mm(range,
56.0 to 294.0 mm). In the horizontal scan, however, the
inward convexity often was detected less clearly. In some
eyes, the horizontal scan showed a flat RPE line without
any inward bulge within the staphyloma (Figure 2).
Reconstructed 3-D images revealed curvature of the RPE
in the posterior pole. In all eyes, 2 outward concavities of
RPE were seen within the posterior staphyloma, and a hori-zontal
ridge was present between these 2 concavities, which
was located at the fovea (Figure 3, Supplemental Video,
and Supplemental Figures 1 and 2). In 42 eyes (82.4 %),
the horizontal ridge was present as a band shape and the
vertical scan through the fovea showed a convex configura-tion,
but the horizontal scan showed an almost flat RPE
line. In the other 9 eyes (17.6%), 3-D imaging of the
scan shows an almost flat contour of the RPE.
VOL. 155, NO. 2 THREE-DIMENSIONAL FEATURES OF DOME-SHAPED MACULA 323
5. FIGURE 3. An eye with high myopia showing a band-shaped ridge within the posterior staphyloma. (Top left) Fundus photograph of
the right eye of a 61-year-old woman (visual acuity, 20/20). Axial length was 28.60mm and refractive error wasL12.5 diopters. The
dashed green rectangle outlines the area (12 38mm2) scanned by swept-source optical coherence tomography (OCT). (Top middle)
Three-dimensional reconstructed image obtained by the swept-source OCT showing an inward convexity of the retina in the posterior
pole. (Top right) Three-dimensional image reconstructed by segmentation of the retinal pigment epithelium (RPE) showing 2
outward concavities within the posterior staphyloma. A horizontal ridge is formed between these 2 outward concavities. (Bottom
left) A vertical 12-mm line scan showing an inward bulge of the RPE beneath the fovea. The height of the RPE line above the tangent
plane was 275 mm. The external surface of the sclera shows a rather smooth curvature (white arrowheads). The sclera shows marked
thinning at the areas of the 2 concavities and seems to be relatively thick beneath the fovea. (Bottom right) A horizontal 12-mm line
scan showing an almost flat contour of the RPE. The scleral thinning at the parafoveal area is less evident, compared with the areas of
the 2 outward concavities within the staphyloma.
FIGURE 4. An eye with high myopia that showing a dome-shaped convexity within the posterior staphyloma. (Top left) Fundus
photograph of the right eye of a 41-year-old woman (visual acuity, 20/25). Refractive error wasL14.0 diopters and the axial length
was 29.24 mm. The dashed green rectangle outlines the area (12 3 8 mm2) scanned by swept-source optical coherence tomography
(OCT). Vertical and horizontal multiaveraged scans of 12 mm were obtained along the green arrows. (Top middle) Three-dimensional
reconstructed image obtained by swept-source OCT showing an inward convexity of the retina in the posterior pole.
(Top right) Three-dimensional image reconstructed by segmentation of the retinal pigment epithelium (RPE) showing the typical
dome-shaped convexity within the staphyloma. (Bottom left) Vertical 12-mm line scan clearly showing an inward bulge of the
RPE beneath the fovea. The height of the bulge of the RPE line above the tangent plane is 163 mm. The external surface of the sclera
is seen clearly (white arrowheads), and the sclera shows uneven thinning in the posterior pole, being relatively thick beneath the
fovea. (Bottom right) A horizontal 12-mm line scan also shows an inward convexity in the posterior pole.
RPE showed a typical dome-shaped convexity within the
staphyloma (Figure 4), and both vertical and horizontal
OCT scans showed a convex configuration. Of these 9
(17.6%) eyes, the top of the convexity was located beneath
the fovea in 7 (13.7%) eyes and was most prominent at the
nasal side of the fovea in 2 (3.9%) eyes.
In 2 patients, one eye showed the typical dome-shaped
convexity and the other eye showed a band-shaped ridge.
There were no significant differences in axial length,
refractive error, or choroidal thickness at the fovea or
the height of the inward bulge between these 2 types.
However, the foveal scleral thickness was significantly
324 AMERICAN JOURNAL OF OPHTHALMOLOGY FEBRUARY 2013
6. thicker in eyes with a dome-shaped convexity (598.3 6
76.8 mm) than in eyes with a band-shaped ridge (501.5 6
93.6 mm; P ¼ .006).
THICKNESS OF THE SCLERA IN DOME-SHAPED
MACULAS: Table 2 shows thickness of the choroid and of
the sclera in the posterior pole. The choroid showed gener-alized
thinning of the entire posterior pole (34.5629.0 mm
in the fovea). In OCT scans, no outward protrusions were
seen in the external surface of the sclera. However, the
sclera in the posterior pole showed an uneven thickness
consistent with the 2 outward concavities of RPE within
the staphyloma. The OCT sections showed marked scleral
thinning. In the fovea, the sclera was relatively thick
(518.6 6 97.6 mm) compared with parafoveal areas in all
4 quadrants (range, 277.2 to 360.3 mm; P .001, respec-tively).
In addition, the scleral thickness was reduced
more markedly in the superior and inferior parafoveal areas
than in the nasal or temporal parafoveal areas. The scleral
thickness at 2000 mm superiorly and inferiorly was signifi-cantly
less than that nasally (P.001 and P ¼.001, respec-tively).
MACULAR COMPLICATIONS: Table 3 shows the macular
complications seen in our patients. Of the 51 eyes with
dome-shaped macula, a full-thickness macular hole was
seen in only 1 patient (1.9%). Extrafoveal retinal schisis
was seen in 9 eyes (17.6%), but foveal schisis was seen in
only 1 eye (1.9%). Twenty-one eyes (41.2%) showed
choroidal neovascularization (CNV). Of these 21eyes, 12
had been treated with anti-vascular endothelial growth
factor agents, 4 had received photodynamic therapy, and
2 had received photodynamic therapy combined with
anti-vascular endothelial growth factor agents.
Table 4 shows the comparison between eyes with CNV
and eyes without CNV in the current study subjects. Visual
acuity was significantly poorer in eyes with CNV (0.53 6
0.42 logMAR) than in eyes without CNV (0.24 6 0.32
logMAR; P ¼ .007), but there were no differences in axial
length, refractive error, or retinal, choroidal, or scleral
thicknesses at the fovea between these 2 groups. However,
the mean height of the inward bulge was significantly less
in eyes with CNV (131.0 6 51.7 mm) than in eyes without
CNV (167.3 6 59.5 mm; P ¼ .028).
DISCUSSION
WITH THE USE OF A LIGHT SOURCE AT THIS LONGER WAVE-length,
the current swept-source OCT allows high-contrast,
long-penetration imaging of the entire choroid
and sclera. When eyes with high myopia are scanned
with a conventional OCT, the obtained images often are
partially inverted or folded because of the limit of the
scan window. The tunable laser source of the swept-source
OCT has a lower signal decay versus depth
compared with the existing spectral-domain OCT systems.
Having a long scan window depth, the swept-source OCT
used in the current study allows entire line scans of 12 mm,
even in highly myopic eyes with posterior staphyloma. In
addition, high-speed scanning coupled with the high sensi-tivity
allowed high density scanning of the macular area
(12 3 8 mm2). By segmentation of the RPE line by means
of the automated built-in software, we constructed 3-D
images of the curvature of the posterior pole in eyes with
a dome-shaped macula.
The dome-shaped macula was first described by Gaucher
and associates in 2008 as an inward bulge of the macula in
highly myopic eyes within the concavity of posterior staph-yloma.
7 However, there is no precise definition of the
dome-shaped macula. Originally, the authors reported
that this unusual feature of the macular profile is especially
clear on vertical scans,7 and Coco and associates recom-mended
performing long vertical scans to identify this
TABLE 2. Choroidal and Scleral Thickness Within the
Macular Area in Eyes With a Dome-Shaped Macula
Choroidal Thickness,
mm (P Valuea)
Scleral Thickness,
mm (P Value,a P Valueb)
Subfovea 34.5 6 29.0 518.6 6 97.6 (NA, .001)
Parafovea at
2000 mm
superiorly
49.8 6 37.8 (.065) 277.2 6 97.1 ( .001, .001)
Parafovea at
2000 mm
inferiorly
40.1 6 30.4 (.869) 284.9 6 91.1 ( .001, .001)
Parafovea at
2000 mm
temporally
39.0 6 29.7 (.940) 306.0 6 97.3 ( .001, .040)
Parafovea at
2000 mm
nasally
17.8 6 13.0 (.035) 360.3 6 93.5 ( .001, NA)
NA ¼ not applicable.
aP values, compared with the values in the fovea.
bP values, compared with the values in the nasal area (1-way
analysis of variance with Tukey post hoc analysis).
TABLE 3. Complications in the Eyes With a Dome-Shaped
Macula
Choroidal neovascularization 21 (41.2%)
Serous retinal detachment 3 (5.9%)
Diffuse chorioretinal atrophy 15 (29.4%)
Patchy chorioretinal atrophy 4 (7.8%)
Lamellar macular hole 3 (5.9%)
Full-thickness macular hole 1 (1.9%)
Foveal schisis 1 (1.9%)
Extrafoveal retinal schisis 9 (17.6%)
VOL. 155, NO. 2 THREE-DIMENSIONAL FEATURES OF DOME-SHAPED MACULA 325
7. feature.28 Based on these previous reports, we used numer-ical
data for the presence of an inward bulge of the RPE of
more than 50 mm on the vertical OCT section above
a presumed line tangent to the RPE at the bottom of the
posterior staphyloma. On vertical scans, the height of the
inward bulge ranged from 56.0 to 294.0 mm. On horizontal
scans, however, the inward convexity often was detected
less clearly, and only 9 eyes showed an inward bulge of
more than 50 mm. A recent report by Coco and associates
supports our current findings: when eyes with dome-shaped
macula were examined with OCT, an inward bulge of the
macula was detected on both vertical and horizontal scans
in 9 eyes, but only on the vertical scan in 26 eyes.28
In reconstructed 3-D images of the RPE, 2 outward
concavities were seen within the posterior staphyloma,
and a horizontal ridge was formed between these 2 concav-ities
in all eyes. Unexpectedly, this horizontal ridge was
present in the typical dome-shaped convexity in only 9 of
51 eyes; the remaining 42 eyes showed a band-shaped ridge
that extended horizontally from the optic disc through the
fovea. However, statistical analysis showed no major differ-ence
between the 2 types of protrusion. In addition, 2 of our
patients showed a band-shaped ridge in 1 eye and a dome
shaped convexity in the other eye. A dome-shape
convexity that generally is recognized as a dome-shaped
macula may be a variant of the more common band-shaped
ridge between a pair of outward concavities within
the posterior staphyloma.
Recently, Moriyama and associates studied the topog-raphy
of highly myopic eyes with high-resolution MRI.29
Although 3-D MRI reconstructs the shape of the vitreous
cavity, it does contribute to our understanding of the entire
shape of eyeballs with high myopia. Those authors reported
that 63.3% of eyes with high myopia had more than 1 protru-sion
on the vitreous cavity and that eyes with 3 protrusions
showed the dome-shaped macula appearance on OCT
sections. These eyes had 1 nasal protrusion and 1 temporal
protrusion that was divided into 2 parts, superior and infe-rior,
separated by the macula. Their observation supports
our current finding of 2 outward concavities of the RPE
within the posterior staphyloma. However, we could not
confirm the presence of the nasal concavity in our patients
because it was sometimes beyond the limit of our scan. In
9 eyes with a dome-shaped convexity, the top of the
convexity was located under the fovea in 7 eyes and was
most prominent at the nasal side of the fovea in 2 eyes.
The third outward concavity on the nasal side may
contribute to formation of the dome-shaped convexity on
the horizontal ridge.
In our patients, no outward protrusions were seen in the
external surface of the sclera, although 2 outward concavi-ties
of RPE were seen within the posterior staphyloma.
Imamura and associates suggested that the dome-shaped
macula is the result of relatively localized variations in the
thickness of the sclera beneath the macula.8 Consistent
with their report, the foveal scleral thickness in our patients
was significantly greater than that of the parafoveal regions
in all 4 quadrants. In addition, OCT sections showed
marked scleral thinning, consistent with 2 outward concav-ities
within the staphyloma. In our patients, scleral thick-ness
at the fovea (518.6 6 97.6 mm) was in between data
obtained from enucleated normal eyes (0.94 6 0.18 mm)
and OCT measurements of highly myopic eyes (281 6
85 mm).8,30 However, the scleral thickness within the
2 outer concavities within the staphyloma (range, 277.2
to 284.9 mm) was similar to that of highly myopic eyes.
Curtin classified posterior staphylomas in eyes with high
myopia into 10 types.4 Type I and type II staphylomas are
reported to be most common in the Japanese population,
with type I being seen in 23.4% and type II being seen in
52.7% of individuals with high myopia.31 In younger
patients with high myopia, posterior staphyloma is detected
rarely. The development of posterior staphyloma at an
older age often is accompanied by scleral thinning. In
eyes with high myopia, the location of the ectatic change
can vary between individuals,4 and the posterior staphy-loma
has been shown not only to deepen with age, but
also to change its shape over time.31 Thus, we postulate
that such asymmetric expansion of the eyeball could lead
to the formation of the dome-shaped macular configuration
within the staphyloma. This asymmetric expansion may be
TABLE 4. Characteristics of the Eyes With Dome-Shaped
Macula With or Without Choroidal Neovascularization
Eyes Without
Choroidal
Neovascularization
Eyes With
Choroidal
Neovascularization P Value
No. of eyes (%) 30 (58.8%) 21 (41.2%)
Sex (male/female) 9/21 2/19 .098a
Age (years) 65.5 6 12.4 65.8 6 10.0 .936b
Axial length (mm) 29.60 6 2.13 29.45 6 2.24 .816b
Refractive error (D) 13.61 6 6.26 14.06 6 5.35 .806b
Visual acuity
(logMAR)
0.24 6 0.32 0.53 6 0.42 .007b
Foveal retinal
thickness (mm)
190.1 6 62.0 191.9 6 111.6 .943b
Foveal choroidal
thickness (mm)
38.5 6 32.8 28.8 6 21.8 .212b
Foveal scleral
thickness (mm)
518.0 6 109.7 519.4 6 79.6 .958b
Height of the
inward bulgec
(mm)
167.3 6 59.5 131.0 6 51.7 .028b
D ¼ diopters; logMAR ¼ logarithm of minimal angle of resolu-tion.
aFisher exact test.
bUnpaired t test.
cHeight of the inward bulge was measured from the presumed
line tangent to the outer surface of retinal pigment epithelium at
the bottom of the posterior staphyloma on vertical optical coher-ence
tomography scans.
326 AMERICAN JOURNAL OF OPHTHALMOLOGY FEBRUARY 2013
8. secondary to a difference in structural strength of the sclera
at the fovea because of either a regional difference in the
biochemical structure of scleral lamellae or because of orga-nization
of the collagen bundles that make the central part
of the sclera in eyes with a dome-shaped macula mechani-cally
stronger than are the upper or lower regions.
Although the mechanism of myopic CNV remains
controversial, several factors have been reported to pose
a risk for development of CNV, such as lacquer cracks,
patchy atrophy, choroidal thinning, dysfunction of
choroidal circulation, and posterior staphyloma protru-sion.
32–37 In the current study, CNV was present in
41.2% of eyes, and the height of the inward bulge in eyes
without CNV was significantly greater than that in eyes
with CNV, although the reason for this finding is
uncertain. In eyes with a greater dome-shaped macula,
however, the change in the foveal contour from concave
to convex within the incurvation of the posterior staphy-loma
may ameliorate the overall protrusion of the staphy-loma
or may alter the mechanical damage induced by
lacquer cracks, resulting in a decreased risk of CNV.
It is interesting to note that, although extrafoveal
retinal schisis was present in 9 eyes, only 1 eye had foveal
schisis without either foveal detachment or macular hole
formation. Although, in the population of the current
study, the mean spherical equivalent and axial length
were relatively high, the incidence of foveoschisis was
lower than in previous reports.15,38 The bulge in eyes
with a dome-shaped macula may act as a macular
buckle-like mechanism, indenting the fovea similar to
a macular exoplant or Ando plomb device,39–41 and thus
may prevent or alleviate tractional forces over the fovea,
thereby preventing schisis or detachment.
The current study had some limitations. All measure-ments
of choroidal and scleral thicknesses were carried
out manually using a built-in caliper. In addition, all study
subjects were Japanese. Because the distribution of type of
posterior staphyloma in Japanese persons is different from
that in white persons,31 further studies in other ethnic
groups are necessary. Furthermore, the current study is
cross-sectional, so additional longitudinal studies are
needed to elucidate clearly the scleral changes in the
formation of a dome-shaped macular configuration in
eyes with high myopia. Very recently, Coco and associates
postulated the concept of macular bending, defined as
a smooth macular elevation found in OCT in patients
with high myopia related to either a dome-shaped macula
or the border of inferior staphyloma.28 In the current
study, eyes with inferior staphyloma (type V) were
excluded. Although we believe that these eyes are
different from those with a typical dome-shaped macula,
other authors have suggested that these may be
variants.10,28
Gaucher and associates reported that all eyes with
a dome-shaped macula have a posterior staphyloma of
type I or II, and Imamura and associates suggested that
a dome-shaped macula is a novel posterior anatomic char-acteristic
of some highly myopic eyes and is not a specific
subtype of posterior staphyloma.7,8 In the current study,
eyes with a dome-shaped macula had either posterior
staphyloma type I, II, or, less frequently, III, or IX,
whereas type V was excluded. We believe that the
dome-shaped macula is not related to the type of staphy-loma,
but rather is related to an anatomic or structural
change within the sclera and can occur in eyes with
any type of staphyloma.
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST
and the following were reported. Ms Matsumoto is an employee of the Topcon Corporation; Dr Yoshimura receives financial support from the Topcon
Corporation, Nidek, and Canon and is a consultant to Nidek. Publication of this article was supported in part by Grant-in-Aid for Scientific Research
no. 21592256 from the Japan Society for the Promotion of Science, Tokyo, Japan; and by the Japan National Society for the Prevention of Blindness,
Tokyo, Japan. Involved in Conception and design of study (A.A.E., A.T., A.M., H.S.E., T.M.R., K.A.Z., N.Y.); Data collection (A.A.E., A.M., K.Y.,
A.O., S.O., I.N., Y.A.-K., M.M.); Analysis and interpretation of data (A.A.E., A.T., A.M., K.Y., A.O., S.O., I.N., Y.A.-K., M.M., H.S.E., T.M.R.,
K.A.Z.); Writing of article (A.A.E., A.T.); Critical revision of article (A.A.E., A.T., A.M., K.Y., A.O., S.O., I.N., Y.A.-K., M.M., H.S.E., T.M.R.,
K.A.Z., N.Y.); and Final approval of article (A.A.E., A.T., A.M., K.Y., A.O., S.O., I.N., Y.A.-K., M.M., H.S.E., T.M.R., K.A.Z., N.Y.).
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328 AMERICAN JOURNAL OF OPHTHALMOLOGY FEBRUARY 2013
10. Biosketch
Abdallah A. Ellabban, MD, graduated from the Suez Canal University (Egypt) and obtained hisMDin 2003. He completed
a residency program and obtained a masters degree in ophthalmology from the Suez Canal University in 2007. Dr Ellabban
is now in a PhD program in the Department of Ophthalmology and Visual Sciences at Kyoto University (Japan) under the
supervision of Professor Nagahisa Yoshimura.
VOL. 155, NO. 2 THREE-DIMENSIONAL FEATURES OF DOME-SHAPED MACULA 328.e1
11. SUPPLEMENTAL FIGURE 1. An eye with high myopia showing a band-shaped ridge within the posterior staphyloma. (Top left)
Fundus photograph of the right eye of a 42-year-old man (visual acuity, 20/40). Axial length was 29.19 mm and refractive error
wasL15.5 diopters. The dashed green rectangle outlines the area (12 3 8 mm2) scanned by swept-source optical coherence tomog-raphy
(OCT). (Top middle) Three-dimensional reconstructed image obtained by swept-source OCT showing an inward convexity of
the retina at the posterior pole. (Top right) Three-dimensional image of retinal pigment epithelium (RPE) showing 2 outward concav-ities
within the posterior staphyloma. A horizontal ridge is formed between these 2 concavities. (Bottom left) Vertical 12-mm line
scan showing an inward bulge of the RPE beneath the fovea. The height of elevation of the RPE line above the tangent plane is
277 mm. The external surface of the sclera shows a rather smooth curvature (white arrowheads). The sclera shows marked thinning
in the areas of the 2 concavities and seems to be relatively thick beneath the fovea. (Bottom right) Horizontal 12-mm line scan
showing that the contour of the RPE is almost flat. The scleral thinning at the parafoveal area is less evident compared with the areas
of the 2 outer concavities within the staphyloma.
SUPPLEMENTAL FIGURE 2. An eye with high myopia showing a band-shaped ridge within the posterior staphyloma. (Top left)
Fundus photograph of the right eye of a 62-year-old woman (visual acuity, 20/20). Refractive error wasL12.5 diopters. The dashed
green rectangle outlines the area scanned by swept-source optical coherence tomography (OCT). (Top middle) Three-dimensional
reconstructed image obtained by swept-source OCT showing an inward convexity of the retina at the posterior pole. (Top right)
Three-dimensional image of retinal pigment epithelium (RPE) showing 2 outward concavities within the staphyloma, with a hori-zontal
ridge between these 2 concavities. (Bottom left) Vertical 12-mm line scan showing an inward bulge of the RPE beneath the
fovea. The height of elevation of the RPE line above the tangent plane is 95 mm. The external surface of the sclera shows a rather
smooth curvature (white arrowheads). The sclera shows marked thinning at the areas of the 2 concavities and seems to be relatively
thick beneath the fovea. (Bottom right) Horizontal 12-mm line scan showing an almost flat contour of the RPE. The scleral thinning
at the parafoveal area is less evident than within areas of the 2 outward concavities.
328.e2 AMERICAN JOURNAL OF OPHTHALMOLOGY FEBRUARY 2013