Diabetes insipidus is a condition where the body produces a large amount of dilute urine. There are three main types: central (neurogenic) diabetes insipidus caused by issues with the pituitary gland, nephrogenic diabetes insipidus caused by kidney problems, and primary diabetes insipidus related to problems with thirst regulation. Symptoms include excessive urination, excessive thirst, dry skin and fatigue. Diagnosis involves tests of urine and blood as well as imaging of the pituitary gland. Treatment depends on the type but may include vasopressin medications, thiazide diuretics, fluid management, and hypophysectomy surgery in severe cases.
The document provides information about diabetes insipidus (DI), defining it as a disorder of water metabolism caused by a deficiency of the antidiuretic hormone vasopressin. There are four main types of DI described: central DI resulting from problems with the pituitary gland or hypothalamus; nephrogenic DI caused by kidney issues; dipsogenic DI related to excessive water intake; and complete DI involving a complete absence of vasopressin. The clinical manifestations of DI include excessive thirst, urination, and water intake. Diagnostic tests evaluate urine output and concentration. Treatment focuses on vasopressin administration or derivatives to promote water reabsorption.
Pituitary disorders can be caused by too much or too little of hormones produced by the pituitary gland. Hypopituitarism is a rare disorder where the pituitary fails to secrete hormones affecting many body functions. Pituitary disorders include dwarfism caused by growth hormone deficiency, gigantism caused by excess growth hormone in children, and acromegaly caused by excess growth hormone in adults. Other disorders discussed include diabetes insipidus, a disorder of antidiuretic hormone deficiency or resistance leading to excessive thirst and urination, and SIADH, a disorder of inappropriate antidiuretic hormone secretion causing hyponatremia. Management involves hormone replacement, surgery, radiation, or drugs depending on the specific disorder.
Diabetes insipidus is a disorder caused by a deficiency of antidiuretic hormone (ADH) or the kidneys' inability to respond to ADH. This results in the excessive production of dilute urine and excessive thirst. There are several forms of diabetes insipidus, including transient DI which resolves within days, permanent DI, and nephrogenic DI which is a rare hereditary disorder. Symptoms include polyuria, polydipsia, dehydration, and electrolyte imbalances. Diagnosis involves tests like water deprivation tests and treatment focuses on ADH replacement through medications like vasopressin or desmopressin. Complications can include electrolyte imbalances, hypot
The fluid deprivation test is an important diagnostic tool used to distinguish between central diabetes insipidus and other causes of polyuria such as primary polydipsia. It involves withholding fluids from a patient for a period of time while closely monitoring urine output, osmolality, and electrolyte levels to check for an appropriate response to ADH.
kindly check this slide for nephrotic syndrome. in this slide i covered all the points regarding this topic.
if any suggestion give comment on this topic
Diabetes insipidus is an uncommon disorder that causes an imbalance of fluids in the body. This imbalance makes you very thirsty even if you've had something to drink. It also leads you to produce large amounts of urine
Hypothyroidism is a disorder where the thyroid gland does not produce enough thyroid hormone. It can be caused by autoimmune disease, over treatment of hyperthyroidism, thyroid surgery, radiation therapy, or certain medications. Common symptoms include fatigue, weight gain, dry skin, and joint and muscle pain. Diagnosis is based on blood tests measuring thyroid stimulating hormone and thyroxine levels. Treatment involves lifelong thyroid hormone replacement therapy to replicate normal thyroid function. Diet and lifestyle changes like avoiding iodine and processed foods can also help manage the condition.
Diabetes insipidus is a condition where the body produces a large amount of dilute urine. There are three main types: central (neurogenic) diabetes insipidus caused by issues with the pituitary gland, nephrogenic diabetes insipidus caused by kidney problems, and primary diabetes insipidus related to problems with thirst regulation. Symptoms include excessive urination, excessive thirst, dry skin and fatigue. Diagnosis involves tests of urine and blood as well as imaging of the pituitary gland. Treatment depends on the type but may include vasopressin medications, thiazide diuretics, fluid management, and hypophysectomy surgery in severe cases.
The document provides information about diabetes insipidus (DI), defining it as a disorder of water metabolism caused by a deficiency of the antidiuretic hormone vasopressin. There are four main types of DI described: central DI resulting from problems with the pituitary gland or hypothalamus; nephrogenic DI caused by kidney issues; dipsogenic DI related to excessive water intake; and complete DI involving a complete absence of vasopressin. The clinical manifestations of DI include excessive thirst, urination, and water intake. Diagnostic tests evaluate urine output and concentration. Treatment focuses on vasopressin administration or derivatives to promote water reabsorption.
Pituitary disorders can be caused by too much or too little of hormones produced by the pituitary gland. Hypopituitarism is a rare disorder where the pituitary fails to secrete hormones affecting many body functions. Pituitary disorders include dwarfism caused by growth hormone deficiency, gigantism caused by excess growth hormone in children, and acromegaly caused by excess growth hormone in adults. Other disorders discussed include diabetes insipidus, a disorder of antidiuretic hormone deficiency or resistance leading to excessive thirst and urination, and SIADH, a disorder of inappropriate antidiuretic hormone secretion causing hyponatremia. Management involves hormone replacement, surgery, radiation, or drugs depending on the specific disorder.
Diabetes insipidus is a disorder caused by a deficiency of antidiuretic hormone (ADH) or the kidneys' inability to respond to ADH. This results in the excessive production of dilute urine and excessive thirst. There are several forms of diabetes insipidus, including transient DI which resolves within days, permanent DI, and nephrogenic DI which is a rare hereditary disorder. Symptoms include polyuria, polydipsia, dehydration, and electrolyte imbalances. Diagnosis involves tests like water deprivation tests and treatment focuses on ADH replacement through medications like vasopressin or desmopressin. Complications can include electrolyte imbalances, hypot
The fluid deprivation test is an important diagnostic tool used to distinguish between central diabetes insipidus and other causes of polyuria such as primary polydipsia. It involves withholding fluids from a patient for a period of time while closely monitoring urine output, osmolality, and electrolyte levels to check for an appropriate response to ADH.
kindly check this slide for nephrotic syndrome. in this slide i covered all the points regarding this topic.
if any suggestion give comment on this topic
Diabetes insipidus is an uncommon disorder that causes an imbalance of fluids in the body. This imbalance makes you very thirsty even if you've had something to drink. It also leads you to produce large amounts of urine
Hypothyroidism is a disorder where the thyroid gland does not produce enough thyroid hormone. It can be caused by autoimmune disease, over treatment of hyperthyroidism, thyroid surgery, radiation therapy, or certain medications. Common symptoms include fatigue, weight gain, dry skin, and joint and muscle pain. Diagnosis is based on blood tests measuring thyroid stimulating hormone and thyroxine levels. Treatment involves lifelong thyroid hormone replacement therapy to replicate normal thyroid function. Diet and lifestyle changes like avoiding iodine and processed foods can also help manage the condition.
Diabetes insipidus is a disorder characterized by excessive urine production and thirst due to a deficiency of antidiuretic hormone. There are two main types: central diabetes insipidus caused by issues with the pituitary gland, and nephrogenic diabetes insipidus caused by kidney problems. Symptoms include producing large volumes of dilute urine, excessive thirst, and dehydration. Treatment aims to replace ADH through medications like DDAVP, correct fluid and electrolyte imbalances, and identify and address the underlying cause of the condition.
Gigantism is a rare condition caused by excessive growth hormone production, usually from a noncancerous pituitary tumor, resulting in abnormal growth and size in children. Symptoms include increased height and size of body parts like hands and feet. Diagnosis involves blood tests to measure growth hormone levels and MRI scans to detect pituitary tumors. Treatment aims to stop growth hormone overproduction and may include surgery to remove tumors, medication to shrink tumors or block hormone effects, and gamma knife radiosurgery for tumors not accessible by traditional surgery.
1) Hypopituitarism occurs when the pituitary gland loses its ability to produce hormones, resulting in deficiencies of growth hormone, ACTH, TSH, prolactin, FSH, LH, oxytocin, and antidiuretic hormone.
2) It can be congenital due to genetic mutations or perinatal injuries, or acquired from brain damage, tumors, infections, or other causes that damage the pituitary gland.
3) Symptoms depend on which hormones are deficient but may include growth failure, hypoglycemia, delayed puberty, electrolyte imbalances, and diabetes insipidus. Treatment involves hormone replacement therapy and monitoring hormone levels.
- TSH is produced by the adenohypophysis and regulates thyroid function by stimulating iodine uptake, colloid endocytosis, and thyroid gland growth. The majority of circulating thyroid hormone is T4, with T3 making up a small percentage.
- Iodine deficiency is the most common cause of goiter and hypothyroidism worldwide. It can lead to miscarriages, stillbirths, neurological issues, and impaired intellectual function in both fetuses and newborns through adults.
- Goiters are classified based on their etiology, morphology, and size. The most common types are diffuse nontoxic goiter and multinodular goiter, which can sometimes become toxic
Nursing Management · Monitor blood sugar and use a sliding scale to treat high levels of glucose · Educate patient about diabetes · Examine feet .
Diagnosis involves measuring blood glucose levels. Ongoing specialized assessment and evaluation for complications are essential for diabetes management.
Hyperthyroidism is a hypermetabolic state caused by increased thyroid secretion. There are several types, including Graves' disease (the most common cause), toxic nodular goitre, and toxic adenoma. Clinical features include symptoms like fatigue, heat intolerance, and weight loss, as well as signs like tachycardia, eye changes, and thyroid swelling. Diagnosis involves clinical evaluation, thyroid function tests, and scans. Treatment options are antithyroid drugs, surgery, and radioactive iodine.
Diarrhea is defined as passing 3 or more loose stools per day and is the second leading cause of death in children under 5 globally. Every year around 1.5 to 2 billion cases of diarrhea occur resulting in death, with India seeing one in five child deaths due to contaminated food/water. Diarrhea is classified based on duration, clinical presentation, and physiology, and can be caused by infections, drugs, diet, surgery, or other miscellaneous factors. Management focuses on rehydration through fluid replacement, administering prescribed drugs, maintaining nutrition, and educating mothers on prevention.
This document discusses hyperthyroidism, which occurs when the thyroid gland produces excess thyroid hormones. The most common cause is Graves' disease, which is an autoimmune disorder. Symptoms include nervousness, heat intolerance, rapid pulse, and weight loss. Diagnosis involves thyroid function tests, ultrasound, and radioactive iodine uptake scan. Treatment options include antithyroid medications, radioactive iodine therapy, and surgery to remove part or all of the thyroid gland. Complications can include myxedema if the condition is not treated or becomes over-treated.
Hyperthyroidism refers to overactivity of the thyroid gland resulting in excessive secretion of thyroid hormones. The thyroid gland produces thyroid hormones which regulate metabolism. Common causes of hyperthyroidism include Graves' disease, multinodular goiter, and thyroiditis. Signs and symptoms include nervousness, palpitations, heat intolerance, tremors, and weight loss. Diagnosis involves thyroid function tests and scans. Treatment options include anti-thyroid medications, radioactive iodine, and surgery. Nursing care focuses on managing nutrition, activity tolerance, risk for injury, hyperthermia, and social interaction issues.
Nephrotic syndrome is the most common presentation of glomerular injury in children, characterized by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. It has an incidence of 2 children per 100,000, most commonly affecting males between ages 2-7. Nephrotic syndrome is classified as either primary, usually minimal change nephrotic syndrome which accounts for 75-80% of cases, or secondary which has identifiable causes such as infections, drugs, or other diseases. Treatment involves dietary management, medications, fluid balance monitoring, and parental education to manage the condition.
This document provides an overview of hypopituitarism, including its anatomy, etiology, clinical features, diagnosis, and treatment. Hypopituitarism is a clinical syndrome of deficiency in pituitary hormone production and secretion that can result from disorders of the pituitary gland, hypothalamus, or surrounding structures. Common causes include tumors, trauma, infections, infiltrative disorders, and genetic mutations. Clinical features vary depending on which hormones are deficient but may include fatigue, weight changes, dry skin, and visual disturbances. Diagnosis involves hormonal blood tests and dynamic testing. Treatment is lifelong hormone replacement therapy to mimic normal hormone levels.
This document discusses examinations for endocrine disorders. It describes different types of endocrine disorders based on hormone levels and tests to dynamically suppress or stimulate hormones. Various examination methods are outlined, including laboratory tests to measure hormone levels and functional tests like stimulatory and inhibitory tests. Imaging methods like ultrasonography, CT, MRI, and scintigraphy are described for localizing endocrine tumors or complications. Specific tests are detailed for evaluating pituitary, thyroid, and adrenal function.
This document provides an overview of the endocrine system and pituitary gland. It discusses that the endocrine system and nervous system control body systems through hormone secretion. It describes the different types of hormones and how they are regulated. It focuses on disorders of the pituitary gland including hypopituitarism, Cushing's syndrome, acromegaly, gigantism, Sheehan's syndrome, and pituitary tumors. It also discusses diabetes insipidus and Syndrome of Inappropriate Antidiuretic Hormone. Nursing diagnoses and management are mentioned for various endocrine disorders.
Hypothyroidism is a disorder that occurs when the thyroid gland does not make enough thyroid hormone to meet the body’s needs.
Hyperthyroidism is a disorder that occurs when the thyroid gland makes more thyroid hormone than the body needs.
This document discusses hyperthyroidism and its management. It begins with definitions of hyperthyroidism and thyrotoxicosis. It then discusses the prevalence, anatomy, physiology and causes of hyperthyroidism. The clinical manifestations involving multiple body systems are explained in detail. Diagnostic tests including blood tests, ultrasound and radioactive iodine uptake scans are outlined. Finally, the medical management including antithyroid drugs, radioactive iodine therapy and surgery are summarized.
Simmonds disease is a chronic deficiency of function of the pituitary gland, a form of hypopituitarism, that leads to atrophy of many of the viscera, including the heart, liver, spleen, kidneys, thyroid, adrenals, and gonads. The disease results in emaciation and death if left untreated.
Nephrotic syndrome is a kidney disorder characterized by protein in the urine, low blood albumin levels, high blood lipids, and swelling. It is caused by damage to the glomerular capillary membrane in the kidney. Clinically, it presents with edema, proteinuria, hyperlipidemia, and hypoalbuminemia. Treatment involves fluid restriction, diuretics, corticosteroids, and ACE inhibitors to control symptoms and manage complications like infection, atherosclerosis, and renal failure. Prognosis depends on the underlying cause, with minimal change disease having a good prognosis if it responds to steroids.
The document discusses hyperthyroidism, also known as thyrotoxicosis, which is a condition caused by an overactive thyroid gland producing excessive thyroid hormones. The main causes of hyperthyroidism are Graves' disease, toxic nodular goiter, thyroiditis, and pituitary tumors. The document outlines the signs and symptoms of hyperthyroidism, diagnostic tests, and treatment options including antithyroid medications, radioactive iodine therapy, surgery, and management of complications.
This document discusses renal disorders and diabetes insipidus. It defines renal disorders as kidney damage that prevents proper blood filtration. Glomerulonephritis is described as kidney disease involving damage to glomeruli, which can cause problems removing waste. Diabetes insipidus causes excessive urine production from either a lack of antidiuretic hormone or kidney resistance to it. The causes, symptoms, diagnosis, and treatment of both conditions are outlined.
Discussion #1
Diabetes Insipidus
Antidiuretic Hormone (ADH) is synthesized in the hypothalamus and secreted by the posterior pituitary. Its role plays part in the body’s osmotic balance, blood pressure regulation, and kidney function. ADH affects the ability of the kidney to reabsorb water and in addition induces expression of water transport proteins in the late distal tubule and collecting duct to increase water reabsorption (Cuzzo & Lappin, 2018). Diabetes Insipidus occurs with a decreased or absent ADH causing symptoms such as polyuria and polydipsia. Three types of diabetes insipidus include: neurogenic, nephrogenic, and polydipsic (McCance & Huether, 2014).
Neurogenic DI is the most commen and caused by insufficient amounts of ADH. Damage to the pituitary gland or hypothalamus from surgery, a tumor, a head injury or an illness can cause neurogenic diabetes insipidus by affecting the usual production, storage, and release of ADH (McCance & Huether, 2014).
Nephrogenic DI is often idiopathic. It occurs when there's a defect in the kidney tubules. The defect may be due to an inherited disorder or a chronic kidney disorder (McCance & Huether, 2014).
Polydipsic DI can cause production of large amounts of diluted urine. The underlying cause is drinking an excessive amount of fluids that is caused by damage to the thirst-regulating mechanism in the hypothalamus. The condition has also been linked to mental illness (McCance & Huether, 2014).
“DI must be distinguished from other polyuric states, including diabetes mellitus. The basic criteria for the diagnosis of DI include polyuria, polydipsia, low urine specific gravity (<1.010), low urine osmolality (<200 mOsm/kg), hypernatremia, high serum osmolality (300 mOsm or more depending on adequate water intake), and continued diuresis despite a serum sodium level of 145 mEq/L or greater” (McCance & Huether, p. 720).
Treatment for neurogenic diabetes insipidus includes increasing water intake or desmopressin (DDAVP).This medication replaces the missing anti-diuretic hormone and decreases urination. Treatment for nephrogenic diabetes insipidus includes stopping initial cause if medication induced or treatment with thiazide diuretics. Treatment for polydipsic diabetes insipidus includes decreasing fluid intake (McCance & Huether, 2014).
A red flag symptom requiring urgent treatment of diabetes insipidus would include passing large amounts of dilute urine. This can cause severe electrolyte disturbances and intravascular depletion leading to shock (McCance & Huether, 2014).
Discussion #2
Diabetes insipidus (DI) is a rare condition that occurs when your kidneys are not able to conserve water. DI is not related to diabetes mellitus, which is often referred to simply as diabetes. That means you can have DI without having diabetes. In fact, the condition can occur in anyone.
DI results in extreme thirst and frequent urination of dilute and odorless urine. There are several types of DI, and they can often .
Diabetes insipidus is a disorder characterized by excessive urine production and thirst due to a deficiency of antidiuretic hormone. There are two main types: central diabetes insipidus caused by issues with the pituitary gland, and nephrogenic diabetes insipidus caused by kidney problems. Symptoms include producing large volumes of dilute urine, excessive thirst, and dehydration. Treatment aims to replace ADH through medications like DDAVP, correct fluid and electrolyte imbalances, and identify and address the underlying cause of the condition.
Gigantism is a rare condition caused by excessive growth hormone production, usually from a noncancerous pituitary tumor, resulting in abnormal growth and size in children. Symptoms include increased height and size of body parts like hands and feet. Diagnosis involves blood tests to measure growth hormone levels and MRI scans to detect pituitary tumors. Treatment aims to stop growth hormone overproduction and may include surgery to remove tumors, medication to shrink tumors or block hormone effects, and gamma knife radiosurgery for tumors not accessible by traditional surgery.
1) Hypopituitarism occurs when the pituitary gland loses its ability to produce hormones, resulting in deficiencies of growth hormone, ACTH, TSH, prolactin, FSH, LH, oxytocin, and antidiuretic hormone.
2) It can be congenital due to genetic mutations or perinatal injuries, or acquired from brain damage, tumors, infections, or other causes that damage the pituitary gland.
3) Symptoms depend on which hormones are deficient but may include growth failure, hypoglycemia, delayed puberty, electrolyte imbalances, and diabetes insipidus. Treatment involves hormone replacement therapy and monitoring hormone levels.
- TSH is produced by the adenohypophysis and regulates thyroid function by stimulating iodine uptake, colloid endocytosis, and thyroid gland growth. The majority of circulating thyroid hormone is T4, with T3 making up a small percentage.
- Iodine deficiency is the most common cause of goiter and hypothyroidism worldwide. It can lead to miscarriages, stillbirths, neurological issues, and impaired intellectual function in both fetuses and newborns through adults.
- Goiters are classified based on their etiology, morphology, and size. The most common types are diffuse nontoxic goiter and multinodular goiter, which can sometimes become toxic
Nursing Management · Monitor blood sugar and use a sliding scale to treat high levels of glucose · Educate patient about diabetes · Examine feet .
Diagnosis involves measuring blood glucose levels. Ongoing specialized assessment and evaluation for complications are essential for diabetes management.
Hyperthyroidism is a hypermetabolic state caused by increased thyroid secretion. There are several types, including Graves' disease (the most common cause), toxic nodular goitre, and toxic adenoma. Clinical features include symptoms like fatigue, heat intolerance, and weight loss, as well as signs like tachycardia, eye changes, and thyroid swelling. Diagnosis involves clinical evaluation, thyroid function tests, and scans. Treatment options are antithyroid drugs, surgery, and radioactive iodine.
Diarrhea is defined as passing 3 or more loose stools per day and is the second leading cause of death in children under 5 globally. Every year around 1.5 to 2 billion cases of diarrhea occur resulting in death, with India seeing one in five child deaths due to contaminated food/water. Diarrhea is classified based on duration, clinical presentation, and physiology, and can be caused by infections, drugs, diet, surgery, or other miscellaneous factors. Management focuses on rehydration through fluid replacement, administering prescribed drugs, maintaining nutrition, and educating mothers on prevention.
This document discusses hyperthyroidism, which occurs when the thyroid gland produces excess thyroid hormones. The most common cause is Graves' disease, which is an autoimmune disorder. Symptoms include nervousness, heat intolerance, rapid pulse, and weight loss. Diagnosis involves thyroid function tests, ultrasound, and radioactive iodine uptake scan. Treatment options include antithyroid medications, radioactive iodine therapy, and surgery to remove part or all of the thyroid gland. Complications can include myxedema if the condition is not treated or becomes over-treated.
Hyperthyroidism refers to overactivity of the thyroid gland resulting in excessive secretion of thyroid hormones. The thyroid gland produces thyroid hormones which regulate metabolism. Common causes of hyperthyroidism include Graves' disease, multinodular goiter, and thyroiditis. Signs and symptoms include nervousness, palpitations, heat intolerance, tremors, and weight loss. Diagnosis involves thyroid function tests and scans. Treatment options include anti-thyroid medications, radioactive iodine, and surgery. Nursing care focuses on managing nutrition, activity tolerance, risk for injury, hyperthermia, and social interaction issues.
Nephrotic syndrome is the most common presentation of glomerular injury in children, characterized by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. It has an incidence of 2 children per 100,000, most commonly affecting males between ages 2-7. Nephrotic syndrome is classified as either primary, usually minimal change nephrotic syndrome which accounts for 75-80% of cases, or secondary which has identifiable causes such as infections, drugs, or other diseases. Treatment involves dietary management, medications, fluid balance monitoring, and parental education to manage the condition.
This document provides an overview of hypopituitarism, including its anatomy, etiology, clinical features, diagnosis, and treatment. Hypopituitarism is a clinical syndrome of deficiency in pituitary hormone production and secretion that can result from disorders of the pituitary gland, hypothalamus, or surrounding structures. Common causes include tumors, trauma, infections, infiltrative disorders, and genetic mutations. Clinical features vary depending on which hormones are deficient but may include fatigue, weight changes, dry skin, and visual disturbances. Diagnosis involves hormonal blood tests and dynamic testing. Treatment is lifelong hormone replacement therapy to mimic normal hormone levels.
This document discusses examinations for endocrine disorders. It describes different types of endocrine disorders based on hormone levels and tests to dynamically suppress or stimulate hormones. Various examination methods are outlined, including laboratory tests to measure hormone levels and functional tests like stimulatory and inhibitory tests. Imaging methods like ultrasonography, CT, MRI, and scintigraphy are described for localizing endocrine tumors or complications. Specific tests are detailed for evaluating pituitary, thyroid, and adrenal function.
This document provides an overview of the endocrine system and pituitary gland. It discusses that the endocrine system and nervous system control body systems through hormone secretion. It describes the different types of hormones and how they are regulated. It focuses on disorders of the pituitary gland including hypopituitarism, Cushing's syndrome, acromegaly, gigantism, Sheehan's syndrome, and pituitary tumors. It also discusses diabetes insipidus and Syndrome of Inappropriate Antidiuretic Hormone. Nursing diagnoses and management are mentioned for various endocrine disorders.
Hypothyroidism is a disorder that occurs when the thyroid gland does not make enough thyroid hormone to meet the body’s needs.
Hyperthyroidism is a disorder that occurs when the thyroid gland makes more thyroid hormone than the body needs.
This document discusses hyperthyroidism and its management. It begins with definitions of hyperthyroidism and thyrotoxicosis. It then discusses the prevalence, anatomy, physiology and causes of hyperthyroidism. The clinical manifestations involving multiple body systems are explained in detail. Diagnostic tests including blood tests, ultrasound and radioactive iodine uptake scans are outlined. Finally, the medical management including antithyroid drugs, radioactive iodine therapy and surgery are summarized.
Simmonds disease is a chronic deficiency of function of the pituitary gland, a form of hypopituitarism, that leads to atrophy of many of the viscera, including the heart, liver, spleen, kidneys, thyroid, adrenals, and gonads. The disease results in emaciation and death if left untreated.
Nephrotic syndrome is a kidney disorder characterized by protein in the urine, low blood albumin levels, high blood lipids, and swelling. It is caused by damage to the glomerular capillary membrane in the kidney. Clinically, it presents with edema, proteinuria, hyperlipidemia, and hypoalbuminemia. Treatment involves fluid restriction, diuretics, corticosteroids, and ACE inhibitors to control symptoms and manage complications like infection, atherosclerosis, and renal failure. Prognosis depends on the underlying cause, with minimal change disease having a good prognosis if it responds to steroids.
The document discusses hyperthyroidism, also known as thyrotoxicosis, which is a condition caused by an overactive thyroid gland producing excessive thyroid hormones. The main causes of hyperthyroidism are Graves' disease, toxic nodular goiter, thyroiditis, and pituitary tumors. The document outlines the signs and symptoms of hyperthyroidism, diagnostic tests, and treatment options including antithyroid medications, radioactive iodine therapy, surgery, and management of complications.
This document discusses renal disorders and diabetes insipidus. It defines renal disorders as kidney damage that prevents proper blood filtration. Glomerulonephritis is described as kidney disease involving damage to glomeruli, which can cause problems removing waste. Diabetes insipidus causes excessive urine production from either a lack of antidiuretic hormone or kidney resistance to it. The causes, symptoms, diagnosis, and treatment of both conditions are outlined.
Discussion #1
Diabetes Insipidus
Antidiuretic Hormone (ADH) is synthesized in the hypothalamus and secreted by the posterior pituitary. Its role plays part in the body’s osmotic balance, blood pressure regulation, and kidney function. ADH affects the ability of the kidney to reabsorb water and in addition induces expression of water transport proteins in the late distal tubule and collecting duct to increase water reabsorption (Cuzzo & Lappin, 2018). Diabetes Insipidus occurs with a decreased or absent ADH causing symptoms such as polyuria and polydipsia. Three types of diabetes insipidus include: neurogenic, nephrogenic, and polydipsic (McCance & Huether, 2014).
Neurogenic DI is the most commen and caused by insufficient amounts of ADH. Damage to the pituitary gland or hypothalamus from surgery, a tumor, a head injury or an illness can cause neurogenic diabetes insipidus by affecting the usual production, storage, and release of ADH (McCance & Huether, 2014).
Nephrogenic DI is often idiopathic. It occurs when there's a defect in the kidney tubules. The defect may be due to an inherited disorder or a chronic kidney disorder (McCance & Huether, 2014).
Polydipsic DI can cause production of large amounts of diluted urine. The underlying cause is drinking an excessive amount of fluids that is caused by damage to the thirst-regulating mechanism in the hypothalamus. The condition has also been linked to mental illness (McCance & Huether, 2014).
“DI must be distinguished from other polyuric states, including diabetes mellitus. The basic criteria for the diagnosis of DI include polyuria, polydipsia, low urine specific gravity (<1.010), low urine osmolality (<200 mOsm/kg), hypernatremia, high serum osmolality (300 mOsm or more depending on adequate water intake), and continued diuresis despite a serum sodium level of 145 mEq/L or greater” (McCance & Huether, p. 720).
Treatment for neurogenic diabetes insipidus includes increasing water intake or desmopressin (DDAVP).This medication replaces the missing anti-diuretic hormone and decreases urination. Treatment for nephrogenic diabetes insipidus includes stopping initial cause if medication induced or treatment with thiazide diuretics. Treatment for polydipsic diabetes insipidus includes decreasing fluid intake (McCance & Huether, 2014).
A red flag symptom requiring urgent treatment of diabetes insipidus would include passing large amounts of dilute urine. This can cause severe electrolyte disturbances and intravascular depletion leading to shock (McCance & Huether, 2014).
Discussion #2
Diabetes insipidus (DI) is a rare condition that occurs when your kidneys are not able to conserve water. DI is not related to diabetes mellitus, which is often referred to simply as diabetes. That means you can have DI without having diabetes. In fact, the condition can occur in anyone.
DI results in extreme thirst and frequent urination of dilute and odorless urine. There are several types of DI, and they can often .
Diabetes insipidus is a disorder characterized by the body's inability to conserve water, leading to excessive urine production and thirst. There are two main types: central diabetes insipidus results from inadequate production of the antidiuretic hormone vasopressin by the pituitary gland, while nephrogenic diabetes insipidus occurs when the kidneys do not respond properly to vasopressin. Symptoms include polyuria, polydipsia, and if untreated, dehydration. Diagnosis involves testing for elevated serum sodium and osmolality with low urine osmolality. Treatment focuses on fluid replacement and administration of vasopressin or thiazide diuretics depending on the type of
Chronic kidney disease (CKD) means your kidneys are damaged and can't filter blood the way they should. The disease is called “chronic” because the damage to your kidneys happens slowly over a long period of time.
This document provides information about diabetes insipidus, including its signs and symptoms, causes, types, diagnosis, and treatment. There are four main types of diabetes insipidus: nephrogenic, central, gestational, and dipsogenic. Central diabetes insipidus is caused by a lack of the antidiuretic hormone vasopressin, while nephrogenic diabetes insipidus occurs when the kidneys do not respond properly to vasopressin. Diagnosis involves tests of blood and urine as well as a water deprivation test. Treatment depends on the type but may include vasopressin supplements or medications to reduce urine production.
This document provides information about diabetes insipidus, including its signs and symptoms, causes, types, diagnosis, and treatment. There are four main types of diabetes insipidus: nephrogenic, central, gestational, and dipsogenic. Central diabetes insipidus is caused by a lack of the antidiuretic hormone vasopressin, while nephrogenic diabetes insipidus occurs when the kidneys do not respond properly to vasopressin. Diagnosis involves tests of blood and urine as well as a water deprivation test. Treatment depends on the type but may include vasopressin supplements or medications to reduce urine production.
Renal failure occurs when the kidneys are no longer able to effectively remove waste and toxins from the blood. It can be acute, developing suddenly, or chronic, developing over a longer period of time. The main causes of acute renal failure are decreased blood flow to the kidneys, direct kidney damage, and blockages preventing urine outflow. Chronic renal failure is commonly caused by poorly controlled diabetes or hypertension and can develop over months or years. Treatment involves diet, medications, dialysis, and potentially kidney transplantation to replace failed kidney function.
Nephrotic syndrome is a kidney disorder characterized by protein in the urine, swelling, and high cholesterol levels. It is caused by damage to small blood vessels in the kidneys that filter waste from the blood. Symptoms include swelling, foamy urine, weight gain, and fatigue. Treatment focuses on controlling blood pressure with medications, reducing cholesterol and swelling, and managing diet and lifestyle factors.
Diabetes insipidus is a condition where the kidneys are unable to conserve water due to a lack of antidiuretic hormone (ADH). There are several types of diabetes insipidus. Central diabetes insipidus is caused by damage to the hypothalamus or pituitary gland which prevents proper ADH production and release. Nephrogenic diabetes insipidus occurs when the kidneys do not respond correctly to ADH due to defects in the renal tubules. Symptoms include excessive thirst and urination. Diagnosis involves tests to measure urine and plasma osmolality during water deprivation. Treatment depends on the type, with desmopressin administered for central diabetes insipidus
Nephrotic syndrome is a kidney disorder characterized by protein in the urine, low protein levels in the blood, high cholesterol levels, and swelling. It is caused by damage to the glomeruli in the kidneys, which normally filter blood and prevent protein from entering the urine. Common causes include minimal change disease, focal segmental glomerulosclerosis, and diseases that damage the kidneys like diabetes or lupus. Treatment focuses on controlling symptoms through medications and lifestyle changes like a low-salt diet. Nursing management monitors for issues like fluid balance, nutrition, fatigue, and infection risk.
The document discusses the structure and function of the kidney and nephron. It summarizes how the kidneys filter blood to remove waste and regulate water and electrolyte balance. It then presents a case study of a patient experiencing acute renal failure and discusses lab results, symptoms, and treatment options like dialysis.
Renal failure occurs when the kidneys are unable to remove waste and regulate fluids and electrolytes. This leads to the accumulation of waste in the blood and disruption of other body functions. There are two main types - acute renal failure, which develops rapidly over hours to days, and chronic kidney disease, which progresses over months to years. The main symptoms include leg swelling, fatigue, vomiting and confusion. Treatment focuses on fluid balance, electrolyte control, and renal replacement therapy such as dialysis. Prognosis depends on age and treatment.
This document discusses acute renal failure, including its pathophysiology, symptoms, causes, diagnosis, complications, and treatments. Acute renal failure is when the kidneys suddenly fail to filter waste from the blood over a few hours or days. Symptoms include decreased urine output, swelling, fatigue, trouble breathing, and confusion. It can be caused by low blood pressure, bleeding, infection, liver or heart failure, NSAIDs, or kidney diseases. Diagnosis involves urine and blood tests and imaging. Treatments include dialysis, a low potassium diet, exercise, and medications.
Chronic kidney disease (CKD) affects 10% of the worldwide population. CKD progresses more slowly in women than men but women are less aware and often start dialysis late or not at all. CKD causes loss of kidney function over several years as the kidneys lose their ability to filter waste from the blood and control blood pressure. While there is no cure for CKD, treatments can help manage symptoms and slow disease progression.
This document provides an overview of diabetes insipidus (DI), including defining the condition as a deficiency of antidiuretic hormone resulting in excessive thirst and urine production. It discusses the objectives of teaching about DI, risk factors, types of DI, clinical manifestations involving polyuria and polydipsia, pathophysiology of increased serum osmolality, assessment, management involving vasopressin replacement and fluid conservation, nursing management, monitoring, self-care, and references research studies on DI.
Diabetes insipidus is a rare disease characterized by excessive production of dilute urine and excessive thirst. There are four main types: central diabetes insipidus caused by problems with the pituitary gland; nephrogenic diabetes insipidus caused when the kidneys do not respond to vasopressin; dipsogenic diabetes insipidus caused by damage to the body's thirst regulation system; and gestational diabetes insipidus which occurs in some pregnant women when the placenta destroys vasopressin. Gestational diabetes insipidus is usually treated with desmopressin nasal spray to manage urine control, while dipsogenic diabetes insipidus has no specific treatment.
Glycosuria, polyuria, and polydipsia are related conditions involving sugar in the urine, excessive urine production, and excessive thirst, respectively. Glycosuria is typically caused by diabetes but can also occur during pregnancy or with certain diseases. Polyuria is usually due to diabetes, kidney problems, medications, or excessive fluid intake. Polydipsia is often a symptom of diabetes or conditions causing fluid loss that triggers thirst. Testing of urine and blood can help identify underlying causes like diabetes, infections, or renal issues. Treatment focuses on managing the cause when possible.
This document provides information on acute kidney failure (ARF), including its definition, risk factors, pathophysiology, diagnosis, and nursing care considerations. ARF occurs when the kidneys are unable to excrete waste from the body due to high levels of toxins. It is characterized by three phases: onset, maintenance, and recovery. Nursing interventions focus on monitoring fluid balance, electrolytes, output, diet, and preventing infections to support the patient's recovery.
Acute renal failure occurs when the kidneys are unable to excrete waste products from the body, causing them to accumulate in the blood. It can be caused by conditions that decrease renal blood flow or damage the kidneys. Patients are classified as oliguric, excreting less than 500mL of urine per day, or nonoliguric, excreting more than 500mL daily. Risk factors include advanced age, diabetes, heart or liver disease. Diagnosis involves urine and blood tests to check kidney function and imaging tests in some cases. Treatment focuses on treating the underlying cause, managing fluid balance and electrolytes, and dialysis in severe cases.
Otalgia, or ear pain, can be caused by infections, tumors, or other issues that affect the ear, face, neck or throat. Diagnostic tests like dental x-rays, CT/MRI scans, audiograms and vestibular tests help identify the underlying cause. Treatment depends on the cause but may include antibiotics, antivirals, analgesics, steroids or surgery. Accurately diagnosing the source of referred ear pain is important for successful management.
Poisoning can occur through accidental or intentional means. Common causes include medication overdoses, food contamination, carbon monoxide inhalation, and insect bites or stings. Signs and symptoms vary depending on the type of poison but can include nausea, vomiting, diarrhea, dizziness, confusion and loss of consciousness. Treatment involves assessing airway, breathing and circulation, identifying the poison, administering activated charcoal or induced vomiting when appropriate, giving oxygen and antidotes if available, and providing supportive care to treat symptoms and prevent further complications. The goal is to limit absorption of the poison, enhance elimination, and support organ function until the toxic effects resolve.
This document discusses public relations in the context of nursing. It provides definitions of public relations from various experts and outlines the key roles and functions of public relations, including learning public desires, advising the public, ensuring contact between the public and organizations, and informing the public of available facilities. The document also discusses the nurse's role in promoting good public relations through courteous service, adequate information provision to patients, and ensuring optimal patient care. Maintaining a welcoming reception, prompt emergency services, and deploying guides are some efforts highlighted to maintain good public relations in hospitals.
This document discusses advanced maternal age and the risks associated with pregnancy after age 35. It notes that while most women over 35 have healthy pregnancies, the risks of complications like preeclampsia, premature birth, and genetic disorders increase with age. Specifically, the risk of Down syndrome rises with maternal age. The document also outlines various prenatal tests that can assess the health of the fetus and screen for potential issues.
practical application of genetics in nursing OM VERMA 2022 slide.pdfOM VERMA
This document discusses genetics and its application in nursing. It defines genetics as the study of heredity and variation in traits from one generation to the next. Genetic nurses perform risk assessments and educate families about genetic conditions. Some key applications of genetics in nursing include genetic testing and counseling, newborn screening to prevent conditions like PKU, and managing care for patients with genetic disorders. The impact on families can include social stigma, discrimination, lowered self-esteem, stress, and lack of opportunities for those with physical or mental health issues resulting from genetic conditions.
Neural tube defects and the role of folic acid in Lowering the Risk.pdfOM VERMA
1) Neural tube defects occur when the neural tube fails to close properly during early embryonic development, resulting in defects of the brain and spinal cord like anencephaly, encephalocele, and spina bifida.
2) Risk factors include genetic factors, maternal folic acid deficiency, obesity, use of some antiepileptic drugs, and environmental exposures. Tests like AFP, ultrasound, amniocentesis, and fetal karyotyping can help diagnose neural tube defects.
3) While neural tube defects cannot be cured, management may include surgery, folate supplementation, and ensuring proper prenatal nutrition to help prevent recurrence in future pregnancies.
MULTIPLE ALLOTS ( ALLELES ) AND BLOOD GROUPS OM VERMA 2023.pdfOM VERMA
This document discusses alleles, multiple alleles, and blood grouping. It explains that alleles are pairs of genes that control the same trait and occupy the same locus on a chromosome. Multiple alleles refer to three or more alleles for a particular gene. The ABO blood group system in humans is provided as an example of multiple alleles, with the alleles being IA, IB, and i. Phenotypes and genotypes are shown for the different blood groups. Examples of blood group inheritance from parents to children are also presented.
MENDALIAN THEORY OF INHERITANCE AND MULTIPLE BLOOD ALLOTS AND BLOOD GROUPS 20...OM VERMA
This document discusses Mendelian inheritance and genetics. It covers Mendel's laws of dominance, segregation, and independent assortment. It also discusses multiple alleles and uses blood groups as an example. The blood group system has multiple alleles (A, B, AB, O) that are inherited according to Mendelian principles and determine a person's blood type phenotype based on their genotype. Punnett squares can predict offspring genotypes and phenotypes from genetic crosses between parents with different alleles.
Maternal prenatal and genetic influences on development of defect and disease...OM VERMA
Maternal infections during pregnancy can increase the risk of preterm birth and serious health complications in newborns, including specific organ damage, developmental delay, and even death. Several genetic conditions can also affect fetal development, such as phenylketonuria, tuberous sclerosis complex, myotonic dystrophy, cystic fibrosis, and Turner syndrome. Maternal infections and genetic factors are two categories of conditions that can impact the health of the mother and fetus.
MATERNAL AGE,MATERNAL DRUG THERAPY PRENATAL TEST AND DIAGNOSIS.pdfOM VERMA
This document discusses prenatal testing and diagnosis. It begins with an introduction to maternal age and risks associated with advanced maternal age such as preeclampsia and genetic disorders. It then describes various prenatal tests including amniocentesis, which analyzes amniotic fluid; chorionic villus sampling, which analyzes placental tissue; and non-invasive options like cell-free DNA screening from a blood sample and triple screening tests. The document outlines both invasive procedures that obtain fetal tissues and non-invasive procedures to screen for potential issues.
This document discusses infertility, including definitions, types, risk factors, and causes in both males and females. For males, common causes discussed include abnormal sperm parameters like low count or motility, genetic factors, infections, environmental exposures, lifestyle factors, and medical conditions. For females, common causes discussed include ovulation disorders, uterine or cervical abnormalities, fallopian tube damage, endometriosis, adhesions, and cancer/treatments. Tests for diagnosing infertility include physical exams, ultrasounds, hormone tests, and procedures like hysteroscopy, HSG, and laparoscopy. Treatments mentioned include fertility drugs and in vitro fertilization.
1. Inborn errors of metabolism are rare genetic disorders that prevent the body from properly breaking down food into energy due to defects in metabolic enzymes.
2. There are three main metabolic genetic defects: phenylketonuria (PKU), galactosemia, and cystic fibrosis. PKU and galactosemia result from the inability to metabolize specific sugars or amino acids, while cystic fibrosis is caused by a defective gene that disrupts ion transport in epithelial cells.
3. The disorders cause abnormal accumulation of metabolites, damage to organs like the brain, liver, and lungs, and symptoms ranging from vomiting and diarrhea to chronic lung disease and malnutrition.
Huntington's disease is a rare, inherited disease that causes the progressive breakdown of nerve cells in the brain. It is caused by a faulty gene that results in parts of the brain becoming gradually damaged over time. The main symptoms are movement disorders, cognitive decline, and psychiatric problems. Mental illness refers to conditions that affect mood, thinking, and behavior, including depression, anxiety, schizophrenia, and addictive behaviors. There are many contributing factors including genetics, brain chemistry, life experiences, and environment. Left untreated, mental illness can cause disability and physical health complications.
Hematological disorders involve problems with red blood cells, white blood cells, platelets, and the bone marrow. Common hematological disorders include anemia, bleeding disorders like hemophilia, blood clots, and blood cancers. Hemoglobin is composed of heme and globin proteins and carries oxygen in red blood cells. Disorders of hemoglobin can be qualitative from abnormal hemoglobin proteins or quantitative from reduced hemoglobin production. Examples of qualitative disorders include sickle cell disease and thalassemia, which involves impaired globin chain production. Hemophilia is a bleeding disorder caused by deficiencies in clotting factors VIII or IX. Untreated hemochromatosis results in iron accumulation that can damage organs like the liver
genetic testing inneanates and childern.pdfOM VERMA
This document discusses genetic testing in neonates and children. It covers several topics:
1. Congenital anomalies which are abnormalities present at birth that can be caused by genetic factors like single gene defects or chromosomal disorders, as well as environmental factors.
2. Developmental delay which refers to a child not gaining skills at the expected rate and can be caused by genetic conditions, brain injuries, infections or prenatal exposure to toxins.
3. Dysmorphism which means abnormal body shape or features and can involve conditions like wide or narrow eye spacing.
The document also discusses genetic screening techniques like cytogenetic, biochemical and molecular testing to detect chromosome, protein or DNA abnormalities that can cause
The document discusses the Human Genome Project and gene therapy. The Human Genome Project was a 13-year international scientific research project that aimed to map all the genes of the human genome. Its goals included identifying and sequencing all human genes. Gene therapy involves introducing normal genes into a person's cells to treat genetic diseases or other diseases. There are two main types - somatic cell therapy, which treats the individual patient, and germline cell therapy, which can affect future generations. Common methods of gene therapy delivery include viral and non-viral vectors such as liposomes. Potential applications include treating cancers, Alzheimer's, and hereditary diseases.
This document discusses advanced maternal age and the risks associated with pregnancy after age 35. It notes that while the majority of women over 35 have healthy pregnancies, the risks of complications like preeclampsia, premature birth, and genetic disorders increase with age. Specifically, the risk of Down syndrome rises with maternal age. The document also outlines several prenatal testing options, both invasive and non-invasive, that can detect genetic abnormalities and other potential problems. These include amniocentesis, chorionic villus sampling, cell-free DNA screening, and triple screening tests.
REVIEW OF CELLULAR DIVISION MITOSIS AND MEIOSIS 2023.pdfOM VERMA
Mitosis and meiosis are two types of cell division. Mitosis produces genetically identical daughter cells through equational division to support growth and repair. Meiosis produces gametes through reductional division, resulting in four haploid daughter cells with half the number of chromosomes. It has two divisions: Meiosis I separates homologous chromosomes and Meiosis II separates sister chromatids. The process involves prophase I with leptotene, zygotene, pachytene, diplotene and diakinesis stages, followed by metaphase I, anaphase I and telophase I. Meiosis II is similar to mitosis.
sex linked inheritance error of transmission.pdfOM VERMA
This document discusses sex-linked inheritance and errors in transmission (mutations). It begins by introducing sex-linked inheritance, which was first discovered by Thomas Morgan in experiments with fruit flies. It describes how males have one X and one Y chromosome, while females have two X chromosomes. The X chromosome contains more genes than the Y chromosome.
It then describes two types of sex-linked inheritance: X-linked dominant and X-linked recessive. X-linked dominant will cause the condition in both males and females, while X-linked recessive mostly affects males, but can also affect females.
The document goes on to define gene mutations as changes in the nitrogen base sequence of DNA. It lists several types of errors
1. The document discusses the eugenics movement and genetic counseling. Eugenics aims to improve the human species through selective breeding by encouraging reproduction among genetically advantageous individuals and discouraging it among genetically disadvantaged individuals.
2. Genetic counseling involves obtaining a family history, establishing a diagnosis, discussing genetic testing options, providing risk assessments, discussing options available to patients, and long-term follow-up support. Nurses play an important role in genetic counseling by educating patients and the public.
3. Legal and ethical issues in genetic counseling include obtaining informed consent, allowing for informed choice, respecting patient autonomy, and maintaining confidentiality. The goal of genetic counseling is to allow patients to make their own independent
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
11. CENTRAL DIABETES INSIPIDUS
Central diabetes insipidus is the most common type of diabetes
insipidus. It’s caused by damage to the pituitary gland or
hypothalamus. This damage means ADH cannot be produced,
stored, or released normally. Without ADH, large amounts of
fluid are released into the urine.
Central diabetes insipidus is multiple caused :
head trauma
conditions that cause brain swelling
brain tumors
surgery affecting the pituitary gland or hypothalamus
loss of blood supply to the pituitary gland
rare genetic conditions
12.
13. Nephrogenic diabetes insipidus
Nephrogenic diabetes insipidus can be genetic or acquired.
Certain genetic mutations can damage the kidneys, leaving
them unable to respond to ADH.
Other possible causes of the kidney damage — and
nephrogenic diabetes insipidus — include:
medications, such as lithium or tetracycline (achromycin V)
blockage of the urinary tract, which includes obstruction of
the ureters (which carry urine from the kidney to the bladder)
electrolyte imbalances, such as too much calcium or not
enough potassium
chronic kidney disease, on rare occasions
14. DIPSOGENIC DIABETES INSIPIDUS
Is caused by dysfunction of the thirst
mechanism in the hypothalamus. This
dysfunction can cause to feel excessively
thirsty and drink too much liquid.
Dipsogenic diabetes insipidus has also been
associated with certain medications and
conditions, including mental health
conditions.
15.
16. GESTATIONAL DIABETES INSIPIDUS
Gestational diabetes insipidus only occurs during
pregnancy.
It can take place when an enzyme made by
the placenta destroys a person’s ADH. The placenta plays
an important role in the exchange of nutrients and waste
products between the fetus and the mother.
Gestational diabetes insipidus can also occur when
increased levels of prostaglandin, a hormone-like
chemical, makes the kidneys less sensitive to ADH.
The condition should resolve after pregnancy.
17.
18.
19. Kidney infection (pyelonephritis) is a type of urinary tract
infection (UTI) that generally begins in your urethra or
bladder and travels to one or both of your kidneys
20.
21.
22.
23.
24.
25.
26.
27.
28.
29. WATER DEPRIVATION TEST
You’ll be asked to stop drinking water for a specified
period of time before the water deprivation test.
You’ll then give blood and urine samples, and your
doctor will measure changes in:
blood sodium levels
blood osmolality levels, which indicate whether
dissolved particles (such as minerals and chemicals)
are present
blood levels of ADH
urine output
urine composition
body weight
30.
31. URINE SPECIFIC GRAVITY TEST
A urine test is a painless way for your healthcare
provider to check your health and test for
abnormalities. One thing your healthcare provider
may check for in your urine sample test, or urinalysis,
is specific gravity.
A urine specific gravity test compares the density of
urine to the density of water. This quick test can help
determine how well your kidneys are diluting your
urine.
32. MRI
During an MRI, a machine takes an image of
brain tissue using magnets and radio waves.
doctor will then look at these images to see if
there’s any brain tissue damage that’s
causing symptoms.
doctor will also look closely at images of
hypothalamus or pituitary gland for any
damage or abnormalities.
33.
34.
35.
36.
37. Gestational diabetes insipidus treatment
Gestational diabetes insipidus does not typically
require treatment. Desmopressin may be
prescribed for severe gestational diabetes
insipidus.