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ADH- Anti diuretic hormone
CENTRAL DIABETES INSIPIDUS
Central diabetes insipidus is the most common type of diabetes
insipidus. It’s caused by damage to the pituitary gland or
hypothalamus. This damage means ADH cannot be produced,
stored, or released normally. Without ADH, large amounts of
fluid are released into the urine.
Central diabetes insipidus is multiple caused :
head trauma
conditions that cause brain swelling
brain tumors
surgery affecting the pituitary gland or hypothalamus
loss of blood supply to the pituitary gland
rare genetic conditions
Nephrogenic diabetes insipidus
Nephrogenic diabetes insipidus can be genetic or acquired.
Certain genetic mutations can damage the kidneys, leaving
them unable to respond to ADH.
Other possible causes of the kidney damage — and
nephrogenic diabetes insipidus — include:
medications, such as lithium or tetracycline (achromycin V)
blockage of the urinary tract, which includes obstruction of
the ureters (which carry urine from the kidney to the bladder)
electrolyte imbalances, such as too much calcium or not
enough potassium
chronic kidney disease, on rare occasions
DIPSOGENIC DIABETES INSIPIDUS
Is caused by dysfunction of the thirst
mechanism in the hypothalamus. This
dysfunction can cause to feel excessively
thirsty and drink too much liquid.
Dipsogenic diabetes insipidus has also been
associated with certain medications and
conditions, including mental health
conditions.
GESTATIONAL DIABETES INSIPIDUS
Gestational diabetes insipidus only occurs during
pregnancy.
It can take place when an enzyme made by
the placenta destroys a person’s ADH. The placenta plays
an important role in the exchange of nutrients and waste
products between the fetus and the mother.
Gestational diabetes insipidus can also occur when
increased levels of prostaglandin, a hormone-like
chemical, makes the kidneys less sensitive to ADH.
The condition should resolve after pregnancy.
Kidney infection (pyelonephritis) is a type of urinary tract
infection (UTI) that generally begins in your urethra or
bladder and travels to one or both of your kidneys
WATER DEPRIVATION TEST
You’ll be asked to stop drinking water for a specified
period of time before the water deprivation test.
You’ll then give blood and urine samples, and your
doctor will measure changes in:
blood sodium levels
blood osmolality levels, which indicate whether
dissolved particles (such as minerals and chemicals)
are present
blood levels of ADH
urine output
urine composition
body weight
URINE SPECIFIC GRAVITY TEST
A urine test is a painless way for your healthcare
provider to check your health and test for
abnormalities. One thing your healthcare provider
may check for in your urine sample test, or urinalysis,
is specific gravity.
A urine specific gravity test compares the density of
urine to the density of water. This quick test can help
determine how well your kidneys are diluting your
urine.
MRI
During an MRI, a machine takes an image of
brain tissue using magnets and radio waves.
doctor will then look at these images to see if
there’s any brain tissue damage that’s
causing symptoms.
doctor will also look closely at images of
hypothalamus or pituitary gland for any
damage or abnormalities.
Gestational diabetes insipidus treatment
Gestational diabetes insipidus does not typically
require treatment. Desmopressin may be
prescribed for severe gestational diabetes
insipidus.
diabetic-insipidus-OM.pdf
diabetic-insipidus-OM.pdf
diabetic-insipidus-OM.pdf
diabetic-insipidus-OM.pdf
diabetic-insipidus-OM.pdf

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diabetic-insipidus-OM.pdf

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  • 11. CENTRAL DIABETES INSIPIDUS Central diabetes insipidus is the most common type of diabetes insipidus. It’s caused by damage to the pituitary gland or hypothalamus. This damage means ADH cannot be produced, stored, or released normally. Without ADH, large amounts of fluid are released into the urine. Central diabetes insipidus is multiple caused : head trauma conditions that cause brain swelling brain tumors surgery affecting the pituitary gland or hypothalamus loss of blood supply to the pituitary gland rare genetic conditions
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  • 13. Nephrogenic diabetes insipidus Nephrogenic diabetes insipidus can be genetic or acquired. Certain genetic mutations can damage the kidneys, leaving them unable to respond to ADH. Other possible causes of the kidney damage — and nephrogenic diabetes insipidus — include: medications, such as lithium or tetracycline (achromycin V) blockage of the urinary tract, which includes obstruction of the ureters (which carry urine from the kidney to the bladder) electrolyte imbalances, such as too much calcium or not enough potassium chronic kidney disease, on rare occasions
  • 14. DIPSOGENIC DIABETES INSIPIDUS Is caused by dysfunction of the thirst mechanism in the hypothalamus. This dysfunction can cause to feel excessively thirsty and drink too much liquid. Dipsogenic diabetes insipidus has also been associated with certain medications and conditions, including mental health conditions.
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  • 16. GESTATIONAL DIABETES INSIPIDUS Gestational diabetes insipidus only occurs during pregnancy. It can take place when an enzyme made by the placenta destroys a person’s ADH. The placenta plays an important role in the exchange of nutrients and waste products between the fetus and the mother. Gestational diabetes insipidus can also occur when increased levels of prostaglandin, a hormone-like chemical, makes the kidneys less sensitive to ADH. The condition should resolve after pregnancy.
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  • 19. Kidney infection (pyelonephritis) is a type of urinary tract infection (UTI) that generally begins in your urethra or bladder and travels to one or both of your kidneys
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  • 29. WATER DEPRIVATION TEST You’ll be asked to stop drinking water for a specified period of time before the water deprivation test. You’ll then give blood and urine samples, and your doctor will measure changes in: blood sodium levels blood osmolality levels, which indicate whether dissolved particles (such as minerals and chemicals) are present blood levels of ADH urine output urine composition body weight
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  • 31. URINE SPECIFIC GRAVITY TEST A urine test is a painless way for your healthcare provider to check your health and test for abnormalities. One thing your healthcare provider may check for in your urine sample test, or urinalysis, is specific gravity. A urine specific gravity test compares the density of urine to the density of water. This quick test can help determine how well your kidneys are diluting your urine.
  • 32. MRI During an MRI, a machine takes an image of brain tissue using magnets and radio waves. doctor will then look at these images to see if there’s any brain tissue damage that’s causing symptoms. doctor will also look closely at images of hypothalamus or pituitary gland for any damage or abnormalities.
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  • 37. Gestational diabetes insipidus treatment Gestational diabetes insipidus does not typically require treatment. Desmopressin may be prescribed for severe gestational diabetes insipidus.