Diabetic foot ulcers are a major complication of diabetes and a leading cause of non-traumatic lower extremity amputations. They result from an interaction of neuropathy, abnormal foot biomechanics, peripheral arterial disease, and poor wound healing in diabetes patients. Ulcers are classified based on their depth and degree of ischemia. Treatment involves strict glycemic control, antibiotic treatment of infections, wound care including debridement and dressings, and offloading pressures on the foot. Prevention relies heavily on patient education regarding foot care, protective footwear, and monitoring for early signs of infection or other issues.