Cyanosis
Cyanosis refers to a bluish color of the skin and mucous membranes resulting from an increased quantity of reduced hemoglobin/deoxyhemoglobin or abnormal hemoglobin derivatives, in the small blood vessels of those areas.
Cyanosis is a blue discoloration of the skin and mucous membranes caused by low oxygen levels in the blood. There are two main types - peripheral cyanosis, caused by reduced blood flow and seen in the extremities, and central cyanosis, caused by issues with oxygenation in the lungs or mixing of arterial and venous blood with low oxygen saturation systemically. Peripheral cyanosis can be improved by warming the skin, while central cyanosis requires treatments like oxygen therapy, surgery for congenital heart defects, intravenous fluids, or diuretics to manage fluid accumulation. The document discusses the mechanisms, causes, signs, and treatments of both peripheral and central cyanosis in detail.
This document provides an overview of cyanosis, including its definition, mechanisms, types (central, peripheral, differential), etiology, factors affecting detection, and treatment principles. Cyanosis is a bluish discoloration of the skin and mucous membranes that results from low oxygen saturation in the blood. It can be caused by issues in oxygen intake, diffusion, or circulation. The underlying etiology could be pulmonary (hypoventilation, diffusion impairment), cardiac (decreased or increased pulmonary blood flow), or a hemoglobinopathy. Detection is affected by hemoglobin level, fetal hemoglobin, and skin pigmentation. Treatment focuses on addressing the underlying condition rather than cyanosis itself, and may include oxygen therapy, warming, and intravenous
This document discusses pneumothorax, beginning with a definition and overview of types including spontaneous, traumatic, and tension pneumothorax. Risk factors are identified such as male sex, smoking, age, genetics, and lung disease. Diagnosis involves physical exam findings and imaging tests like chest x-ray and CT scan. Treatment goals are promoting lung expansion and eliminating causes, using methods such as aspiration, tube drainage, or surgery. Complications are also reviewed.
Chronic bronchitis is defined as a productive cough that lasts for three months or more per year for at least two years. Tobacco smoking is the primary cause and leads to chronic obstructive pulmonary disease in most cases. Symptoms include a chronic cough with mucus, wheezing, and shortness of breath. Treatment focuses on quitting smoking, using inhaled bronchodilators and steroids, and addressing exacerbating factors through medications, oxygen therapy, or lung transplantation in severe cases.
Cor pulmonale, or right heart failure, is caused by high blood pressure in the pulmonary artery and right ventricle due to conditions that restrict pulmonary blood flow such as chronic lung diseases. It develops when pulmonary hypertension leads to enlargement and failure of the right ventricle. Symptoms include shortness of breath, leg swelling, and fatigue. Diagnosis involves physical exam, imaging like echocardiogram and chest x-ray, and assessing pulmonary pressures. Treatment focuses on managing the underlying lung condition, giving diuretics and vasodilators, and may involve oxygen therapy or lung transplantation in severe cases.
This presentation is about the causes and mechanisms of central and peripheral cyanosis. It also contain some general information about different scenarios of cyanosis.
This document summarizes ischemic heart disease, including its definition, causes, symptoms, diagnosis, and treatment. Ischemic heart disease is caused by narrowing of the coronary arteries which reduces blood flow and oxygen to the heart. It is usually due to atherosclerosis from risk factors like smoking, diabetes, and high cholesterol. Symptoms include chest pain and shortness of breath. Diagnosis involves ECG, stress test, and angiogram. Treatment focuses on lifestyle changes, medications, angioplasty, or bypass surgery to improve symptoms and prognosis.
Pneumothorax refers to the presence of air in the pleural space and can occur spontaneously due to ruptured blebs or as a result of trauma or medical procedures. It presents clinically as reduced breath sounds, hyperresonance to percussion, and mediastinal shift. Chest x-ray or CT scan are used for diagnosis and show hypertranslucency. Treatment involves supplemental oxygen, aspiration, or chest tube placement. Physiotherapy focuses on improving ventilation and exercise tolerance. Recurrence can be prevented through procedures like pleurodesis or thoracotomy along with smoking cessation.
Cyanosis is a blue discoloration of the skin and mucous membranes caused by low oxygen levels in the blood. There are two main types - peripheral cyanosis, caused by reduced blood flow and seen in the extremities, and central cyanosis, caused by issues with oxygenation in the lungs or mixing of arterial and venous blood with low oxygen saturation systemically. Peripheral cyanosis can be improved by warming the skin, while central cyanosis requires treatments like oxygen therapy, surgery for congenital heart defects, intravenous fluids, or diuretics to manage fluid accumulation. The document discusses the mechanisms, causes, signs, and treatments of both peripheral and central cyanosis in detail.
This document provides an overview of cyanosis, including its definition, mechanisms, types (central, peripheral, differential), etiology, factors affecting detection, and treatment principles. Cyanosis is a bluish discoloration of the skin and mucous membranes that results from low oxygen saturation in the blood. It can be caused by issues in oxygen intake, diffusion, or circulation. The underlying etiology could be pulmonary (hypoventilation, diffusion impairment), cardiac (decreased or increased pulmonary blood flow), or a hemoglobinopathy. Detection is affected by hemoglobin level, fetal hemoglobin, and skin pigmentation. Treatment focuses on addressing the underlying condition rather than cyanosis itself, and may include oxygen therapy, warming, and intravenous
This document discusses pneumothorax, beginning with a definition and overview of types including spontaneous, traumatic, and tension pneumothorax. Risk factors are identified such as male sex, smoking, age, genetics, and lung disease. Diagnosis involves physical exam findings and imaging tests like chest x-ray and CT scan. Treatment goals are promoting lung expansion and eliminating causes, using methods such as aspiration, tube drainage, or surgery. Complications are also reviewed.
Chronic bronchitis is defined as a productive cough that lasts for three months or more per year for at least two years. Tobacco smoking is the primary cause and leads to chronic obstructive pulmonary disease in most cases. Symptoms include a chronic cough with mucus, wheezing, and shortness of breath. Treatment focuses on quitting smoking, using inhaled bronchodilators and steroids, and addressing exacerbating factors through medications, oxygen therapy, or lung transplantation in severe cases.
Cor pulmonale, or right heart failure, is caused by high blood pressure in the pulmonary artery and right ventricle due to conditions that restrict pulmonary blood flow such as chronic lung diseases. It develops when pulmonary hypertension leads to enlargement and failure of the right ventricle. Symptoms include shortness of breath, leg swelling, and fatigue. Diagnosis involves physical exam, imaging like echocardiogram and chest x-ray, and assessing pulmonary pressures. Treatment focuses on managing the underlying lung condition, giving diuretics and vasodilators, and may involve oxygen therapy or lung transplantation in severe cases.
This presentation is about the causes and mechanisms of central and peripheral cyanosis. It also contain some general information about different scenarios of cyanosis.
This document summarizes ischemic heart disease, including its definition, causes, symptoms, diagnosis, and treatment. Ischemic heart disease is caused by narrowing of the coronary arteries which reduces blood flow and oxygen to the heart. It is usually due to atherosclerosis from risk factors like smoking, diabetes, and high cholesterol. Symptoms include chest pain and shortness of breath. Diagnosis involves ECG, stress test, and angiogram. Treatment focuses on lifestyle changes, medications, angioplasty, or bypass surgery to improve symptoms and prognosis.
Pneumothorax refers to the presence of air in the pleural space and can occur spontaneously due to ruptured blebs or as a result of trauma or medical procedures. It presents clinically as reduced breath sounds, hyperresonance to percussion, and mediastinal shift. Chest x-ray or CT scan are used for diagnosis and show hypertranslucency. Treatment involves supplemental oxygen, aspiration, or chest tube placement. Physiotherapy focuses on improving ventilation and exercise tolerance. Recurrence can be prevented through procedures like pleurodesis or thoracotomy along with smoking cessation.
This document discusses ischemic heart disease and angina. It defines ischemic heart disease as a condition where there is inadequate blood supply and oxygen to the heart muscle. Angina is described as chest pain or discomfort caused by an imbalance between the heart's oxygen supply and demand. The document outlines the causes, types, risk factors, diagnosis, and management of angina through lifestyle modifications and medications like aspirin to control symptoms and reduce health risks.
The document discusses acute respiratory distress syndrome (ARDS), a life-threatening lung condition that prevents sufficient oxygen from entering the blood. ARDS can result from direct or indirect lung injury and causes fluid buildup in the lungs, reduced lung compliance, and impaired gas exchange. Symptoms include difficulty breathing, low blood oxygen levels, and abnormal breath sounds. Treatment focuses on supportive care in the ICU, including mechanical ventilation, supplemental oxygen, medications, and positioning strategies to improve ventilation.
This document discusses pleural effusions, which are collections of fluid in the pleural space. Pleural effusions are usually secondary to other diseases rather than primary. There are two main types - transudative effusions which occur without inflammation from conditions like heart failure, and exudative effusions which occur with inflammation from things like infections or cancer. Diagnosis involves chest imaging and analyzing fluid obtained via thoracentesis. Treatment focuses on resolving the underlying cause as well as draining fluid to relieve symptoms. Nursing care centers around maintaining normal breathing patterns and monitoring for complications.
Normally, the pleural space contains a small amount of fluid (5 to 15 mL), which acts as a lubricant that allows the pleural surfaces to move without friction.
But if fluid builds up from either increased production or inadequate removal pleural effusion results.
Pleural effusion B/L or unilateral (parapneumonic process)
Refers to any significant collection of fluid within pleural space.
Any imbalance in formation, absorption lead accumulation of pleural fluid. Common condition:
CHF
Bacterial pneumonia
Malignancy(chest tumor)
Pulmonary embolism
Pleura effusion is a condition refers to a collection of fluid in the pleural space. It is almost secondary to other conditions.
Emphysema is a type of chronic obstructive pulmonary disease that involves damage to the alveoli in the lungs, making it difficult to breathe. It can be caused by long-term exposure to irritants like cigarette smoke or air pollution. Symptoms include shortness of breath and coughing. Diagnosis involves physical exams, imaging tests, and pulmonary function tests. While the lung damage cannot be reversed, treatment focuses on reducing symptoms through medications, oxygen therapy, lung surgery, and transplants in severe cases.
Chronic bronchitis is defined as a persistent cough with mucus production for at least three months in a year for two consecutive years. It is primarily caused by long-term irritation and inflammation of the airways due to cigarette smoke or other inhaled chemicals. Chronic bronchitis can progress to more severe lung diseases like COPD or lung cancer and, if left untreated, may result in heart failure or respiratory infections. The pathology involves damage to the airways, thickening of the mucus membranes, and increased mucus production.
Bronchiectasis is a chronic lung condition characterized by abnormal dilation of the bronchi. It can be caused by airway obstruction, pulmonary infections, genetic disorders like cystic fibrosis, or idiopathic factors. Symptoms include persistent cough with large amounts of sputum, hemoptysis, and clubbing of the fingers. Diagnosis is made through chest imaging like HRCT. Treatment focuses on clearing secretions through postural drainage, chest physiotherapy, antibiotics, bronchodilators, and smoking cessation. Nursing management centers on helping patients perform breathing exercises and techniques to clear pulmonary secretions.
This document discusses pulmonary thromboembolism (PE), which refers to blood clots (thrombi) traveling from deep veins to the lungs. Most clots originate in the lower extremities. Risk factors include inherited conditions, surgery, trauma, immobilization, cancer and pregnancy. PE can cause hypoxemia and pulmonary hypertension. Diagnosis involves clinical assessment, D-dimer testing, chest imaging like CT pulmonary angiogram (gold standard), ventilation-perfusion scanning and echocardiogram. Treatment aims to relieve symptoms and prevent complications like right heart strain.
Dyspnea, or shortness of breath, is a common symptom that can be caused by many cardiac and pulmonary conditions. A thorough diagnostic evaluation of dyspnea involves taking a detailed patient history, conducting a physical exam, and obtaining initial tests like an electrocardiogram, chest x-ray, and blood tests to evaluate for conditions involving the heart, lungs, blood, and other potential causes and to guide further testing if needed. Grading scales are used to characterize the severity of a patient's dyspnea. The pathophysiology of dyspnea involves an imbalance between the perceived need to breathe and the ability to breathe.
This document provides information about acute respiratory distress syndrome (ARDS), including its pathophysiology, clinical manifestations, diagnosis, treatment, nursing care, and complications. ARDS is a respiratory failure condition caused by lung injury and results in increased permeability of the alveolar-capillary membrane. It progresses through exudative, proliferative, and fibrotic phases. Treatment involves supportive care, mechanical ventilation, positioning strategies, and managing complications such as nosocomial pneumonia and renal failure.
Clubbing, also known as Hippocrates fingers, is the bulbous enlargement of the fingertips and nails. It is caused by proliferation of subcutaneous tissues due to chronic hypoxemia from conditions like lung diseases, heart diseases, and liver or gastrointestinal diseases. Examination involves comparing the fingernails to look for reduced or absent diamond-shaped spaces, indicating clubbing. While clubbing itself has no treatment, addressing the underlying condition can potentially reverse it over time.
Lung abscess is a localized area of lung destruction caused by infection, typically by aspiration of oropharyngeal bacteria. It appears on imaging as a cavity containing air-fluid levels. The infection can start as necrotizing pneumonia that progresses to microabscesses and larger cavitary lesions over time. Risk factors include dental/sinus infections, impaired swallowing, or pre-existing lung disease. Treatment involves antibiotics targeting common aerobic and anaerobic bacteria. Therapy typically lasts 4-6 weeks until imaging shows resolution, though surgery may be needed for large or resistant abscesses. Complications can include empyema, bronchopleural fistula, or distant infections if not properly treated.
This document discusses the four types of respiratory failure:
1) Type 1 (hypoxemic) is characterized by low oxygen levels in the blood but normal or low carbon dioxide levels, usually due to issues with ventilation/perfusion matching.
2) Type 2 (hypercapnic/ventilatory) involves low oxygen and high carbon dioxide levels due to inadequate alveolar ventilation.
3) Type 3 (peri-operative) commonly occurs after surgery due to effects of anesthesia and abdominal issues.
4) Type 4 (shock) involves intubation during resuscitation for conditions like cardiogenic, hypovolemic, or septic shock. The document then provides details on the causes, characteristics
Mitral stenosis is commonly caused by rheumatic heart disease which leads to inflammation and fusion of the mitral valve leaflets, reducing the mitral valve orifice area. Severe mitral stenosis, defined as a mitral valve area less than 1.0 cm2, can cause pulmonary hypertension, pulmonary edema, atrial fibrillation, and right heart failure as the heart tries to maintain sufficient cardiac output against the back pressure. Physical exam may reveal signs of pulmonary hypertension like a loud pulmonary component to S2, as well as a tapping apex, opening snap, and mid-diastolic rumble on cardiac auscultation. Echocardiography can determine the severity of mitral stenosis and assess
This document discusses respiratory failure, including its definition, types, causes, clinical manifestations, diagnostic evaluations, management, and complications. Respiratory failure is when the respiratory system fails to adequately oxygenate the blood or eliminate carbon dioxide. It can be classified as hypoxemic or hypercapnic. Acute respiratory failure develops rapidly over hours while chronic develops over days. Management involves treating the underlying cause, providing oxygen supplementation, monitoring vital signs, and supporting respiratory function. Complications can affect the lungs, heart, gastrointestinal system, and risk of infection.
Kindly leave your comment if you found this helpful ;)
Some of the slides, i hide it from my real presentations for my own reference. Download to see all of them.
Hemoptysis is defined as coughing up blood originating below the vocal cords. It can range from blood-streaked sputum to coughing up pure blood. The document discusses the definition, causes, differential diagnosis, diagnosis and treatment of hemoptysis. The main causes discussed are tracheobronchial diseases like bronchitis and tumors, as well as cardiovascular issues. Diagnosis involves history, examination, labs, chest imaging like CXR, CT, and procedures like bronchoscopy.
1. Interstitial lung diseases (ILDs) involve the lung parenchyma including the alveoli, capillaries, and spaces between.
2. ILDs are classified based on known causes, idiopathic forms, and granulomatous types. Idiopathic pulmonary fibrosis is the most common idiopathic form.
3. Clinical presentation involves breathlessness, cough, and reduced lung function. Investigations include chest imaging showing infiltrates and fibrosis, and lung biopsies to determine classification. Treatment focuses on removing exposures, suppressing inflammation, and palliating symptoms primarily using corticosteroids.
Gangrene occurs when tissues die due to lack of blood flow and oxygen. There are three main types: dry gangrene caused by lack of oxygen, wet gangrene caused by bacterial infection which is more dangerous, and gas gangrene caused by Clostridia bacteria. Symptoms include pain, swelling, discoloration and odor. Treatments depend on the type but may include antibiotics, surgery to improve blood flow, hyperbaric oxygen therapy, debriding dead tissue, and amputation of severely affected body parts.
Cyanosis is a bluish discoloration of the skin or mucous membranes due to excessive amounts of deoxygenated hemoglobin. It can be central or peripheral in origin. Central cyanosis occurs when oxygen saturation in arterial blood is low, such as in congenital heart defects causing right-to-left shunts. Peripheral cyanosis is caused by slowed blood flow and high oxygen extraction from normally saturated blood, as seen in cold exposure, shock, or peripheral vascular disease. Differential cyanosis may present with cyanosis isolated to certain limbs depending on anatomy. Methemoglobinemia and sulfhemoglobinemia can also cause cyanosis and require specific treatments.
A soldier stationed at a high altitude developed shortness of breath and was found to have low oxygen saturation and bluish discoloration of the tongue. This suggests central cyanosis caused by exposure to low oxygen levels at high altitude. The patient will need examination of cardiovascular and respiratory systems and treatment of hypoxemia, likely with supplemental oxygen. Central cyanosis results from low oxygen in arteries and is seen in conditions like lung disease, heart defects, or low oxygen environment like high altitude.
This document discusses ischemic heart disease and angina. It defines ischemic heart disease as a condition where there is inadequate blood supply and oxygen to the heart muscle. Angina is described as chest pain or discomfort caused by an imbalance between the heart's oxygen supply and demand. The document outlines the causes, types, risk factors, diagnosis, and management of angina through lifestyle modifications and medications like aspirin to control symptoms and reduce health risks.
The document discusses acute respiratory distress syndrome (ARDS), a life-threatening lung condition that prevents sufficient oxygen from entering the blood. ARDS can result from direct or indirect lung injury and causes fluid buildup in the lungs, reduced lung compliance, and impaired gas exchange. Symptoms include difficulty breathing, low blood oxygen levels, and abnormal breath sounds. Treatment focuses on supportive care in the ICU, including mechanical ventilation, supplemental oxygen, medications, and positioning strategies to improve ventilation.
This document discusses pleural effusions, which are collections of fluid in the pleural space. Pleural effusions are usually secondary to other diseases rather than primary. There are two main types - transudative effusions which occur without inflammation from conditions like heart failure, and exudative effusions which occur with inflammation from things like infections or cancer. Diagnosis involves chest imaging and analyzing fluid obtained via thoracentesis. Treatment focuses on resolving the underlying cause as well as draining fluid to relieve symptoms. Nursing care centers around maintaining normal breathing patterns and monitoring for complications.
Normally, the pleural space contains a small amount of fluid (5 to 15 mL), which acts as a lubricant that allows the pleural surfaces to move without friction.
But if fluid builds up from either increased production or inadequate removal pleural effusion results.
Pleural effusion B/L or unilateral (parapneumonic process)
Refers to any significant collection of fluid within pleural space.
Any imbalance in formation, absorption lead accumulation of pleural fluid. Common condition:
CHF
Bacterial pneumonia
Malignancy(chest tumor)
Pulmonary embolism
Pleura effusion is a condition refers to a collection of fluid in the pleural space. It is almost secondary to other conditions.
Emphysema is a type of chronic obstructive pulmonary disease that involves damage to the alveoli in the lungs, making it difficult to breathe. It can be caused by long-term exposure to irritants like cigarette smoke or air pollution. Symptoms include shortness of breath and coughing. Diagnosis involves physical exams, imaging tests, and pulmonary function tests. While the lung damage cannot be reversed, treatment focuses on reducing symptoms through medications, oxygen therapy, lung surgery, and transplants in severe cases.
Chronic bronchitis is defined as a persistent cough with mucus production for at least three months in a year for two consecutive years. It is primarily caused by long-term irritation and inflammation of the airways due to cigarette smoke or other inhaled chemicals. Chronic bronchitis can progress to more severe lung diseases like COPD or lung cancer and, if left untreated, may result in heart failure or respiratory infections. The pathology involves damage to the airways, thickening of the mucus membranes, and increased mucus production.
Bronchiectasis is a chronic lung condition characterized by abnormal dilation of the bronchi. It can be caused by airway obstruction, pulmonary infections, genetic disorders like cystic fibrosis, or idiopathic factors. Symptoms include persistent cough with large amounts of sputum, hemoptysis, and clubbing of the fingers. Diagnosis is made through chest imaging like HRCT. Treatment focuses on clearing secretions through postural drainage, chest physiotherapy, antibiotics, bronchodilators, and smoking cessation. Nursing management centers on helping patients perform breathing exercises and techniques to clear pulmonary secretions.
This document discusses pulmonary thromboembolism (PE), which refers to blood clots (thrombi) traveling from deep veins to the lungs. Most clots originate in the lower extremities. Risk factors include inherited conditions, surgery, trauma, immobilization, cancer and pregnancy. PE can cause hypoxemia and pulmonary hypertension. Diagnosis involves clinical assessment, D-dimer testing, chest imaging like CT pulmonary angiogram (gold standard), ventilation-perfusion scanning and echocardiogram. Treatment aims to relieve symptoms and prevent complications like right heart strain.
Dyspnea, or shortness of breath, is a common symptom that can be caused by many cardiac and pulmonary conditions. A thorough diagnostic evaluation of dyspnea involves taking a detailed patient history, conducting a physical exam, and obtaining initial tests like an electrocardiogram, chest x-ray, and blood tests to evaluate for conditions involving the heart, lungs, blood, and other potential causes and to guide further testing if needed. Grading scales are used to characterize the severity of a patient's dyspnea. The pathophysiology of dyspnea involves an imbalance between the perceived need to breathe and the ability to breathe.
This document provides information about acute respiratory distress syndrome (ARDS), including its pathophysiology, clinical manifestations, diagnosis, treatment, nursing care, and complications. ARDS is a respiratory failure condition caused by lung injury and results in increased permeability of the alveolar-capillary membrane. It progresses through exudative, proliferative, and fibrotic phases. Treatment involves supportive care, mechanical ventilation, positioning strategies, and managing complications such as nosocomial pneumonia and renal failure.
Clubbing, also known as Hippocrates fingers, is the bulbous enlargement of the fingertips and nails. It is caused by proliferation of subcutaneous tissues due to chronic hypoxemia from conditions like lung diseases, heart diseases, and liver or gastrointestinal diseases. Examination involves comparing the fingernails to look for reduced or absent diamond-shaped spaces, indicating clubbing. While clubbing itself has no treatment, addressing the underlying condition can potentially reverse it over time.
Lung abscess is a localized area of lung destruction caused by infection, typically by aspiration of oropharyngeal bacteria. It appears on imaging as a cavity containing air-fluid levels. The infection can start as necrotizing pneumonia that progresses to microabscesses and larger cavitary lesions over time. Risk factors include dental/sinus infections, impaired swallowing, or pre-existing lung disease. Treatment involves antibiotics targeting common aerobic and anaerobic bacteria. Therapy typically lasts 4-6 weeks until imaging shows resolution, though surgery may be needed for large or resistant abscesses. Complications can include empyema, bronchopleural fistula, or distant infections if not properly treated.
This document discusses the four types of respiratory failure:
1) Type 1 (hypoxemic) is characterized by low oxygen levels in the blood but normal or low carbon dioxide levels, usually due to issues with ventilation/perfusion matching.
2) Type 2 (hypercapnic/ventilatory) involves low oxygen and high carbon dioxide levels due to inadequate alveolar ventilation.
3) Type 3 (peri-operative) commonly occurs after surgery due to effects of anesthesia and abdominal issues.
4) Type 4 (shock) involves intubation during resuscitation for conditions like cardiogenic, hypovolemic, or septic shock. The document then provides details on the causes, characteristics
Mitral stenosis is commonly caused by rheumatic heart disease which leads to inflammation and fusion of the mitral valve leaflets, reducing the mitral valve orifice area. Severe mitral stenosis, defined as a mitral valve area less than 1.0 cm2, can cause pulmonary hypertension, pulmonary edema, atrial fibrillation, and right heart failure as the heart tries to maintain sufficient cardiac output against the back pressure. Physical exam may reveal signs of pulmonary hypertension like a loud pulmonary component to S2, as well as a tapping apex, opening snap, and mid-diastolic rumble on cardiac auscultation. Echocardiography can determine the severity of mitral stenosis and assess
This document discusses respiratory failure, including its definition, types, causes, clinical manifestations, diagnostic evaluations, management, and complications. Respiratory failure is when the respiratory system fails to adequately oxygenate the blood or eliminate carbon dioxide. It can be classified as hypoxemic or hypercapnic. Acute respiratory failure develops rapidly over hours while chronic develops over days. Management involves treating the underlying cause, providing oxygen supplementation, monitoring vital signs, and supporting respiratory function. Complications can affect the lungs, heart, gastrointestinal system, and risk of infection.
Kindly leave your comment if you found this helpful ;)
Some of the slides, i hide it from my real presentations for my own reference. Download to see all of them.
Hemoptysis is defined as coughing up blood originating below the vocal cords. It can range from blood-streaked sputum to coughing up pure blood. The document discusses the definition, causes, differential diagnosis, diagnosis and treatment of hemoptysis. The main causes discussed are tracheobronchial diseases like bronchitis and tumors, as well as cardiovascular issues. Diagnosis involves history, examination, labs, chest imaging like CXR, CT, and procedures like bronchoscopy.
1. Interstitial lung diseases (ILDs) involve the lung parenchyma including the alveoli, capillaries, and spaces between.
2. ILDs are classified based on known causes, idiopathic forms, and granulomatous types. Idiopathic pulmonary fibrosis is the most common idiopathic form.
3. Clinical presentation involves breathlessness, cough, and reduced lung function. Investigations include chest imaging showing infiltrates and fibrosis, and lung biopsies to determine classification. Treatment focuses on removing exposures, suppressing inflammation, and palliating symptoms primarily using corticosteroids.
Gangrene occurs when tissues die due to lack of blood flow and oxygen. There are three main types: dry gangrene caused by lack of oxygen, wet gangrene caused by bacterial infection which is more dangerous, and gas gangrene caused by Clostridia bacteria. Symptoms include pain, swelling, discoloration and odor. Treatments depend on the type but may include antibiotics, surgery to improve blood flow, hyperbaric oxygen therapy, debriding dead tissue, and amputation of severely affected body parts.
Cyanosis is a bluish discoloration of the skin or mucous membranes due to excessive amounts of deoxygenated hemoglobin. It can be central or peripheral in origin. Central cyanosis occurs when oxygen saturation in arterial blood is low, such as in congenital heart defects causing right-to-left shunts. Peripheral cyanosis is caused by slowed blood flow and high oxygen extraction from normally saturated blood, as seen in cold exposure, shock, or peripheral vascular disease. Differential cyanosis may present with cyanosis isolated to certain limbs depending on anatomy. Methemoglobinemia and sulfhemoglobinemia can also cause cyanosis and require specific treatments.
A soldier stationed at a high altitude developed shortness of breath and was found to have low oxygen saturation and bluish discoloration of the tongue. This suggests central cyanosis caused by exposure to low oxygen levels at high altitude. The patient will need examination of cardiovascular and respiratory systems and treatment of hypoxemia, likely with supplemental oxygen. Central cyanosis results from low oxygen in arteries and is seen in conditions like lung disease, heart defects, or low oxygen environment like high altitude.
This document defines and classifies different types of cyanosis, including central cyanosis resulting from reduced oxygen saturation in the blood or abnormal hemoglobins, and peripheral cyanosis caused by slowed blood flow. It outlines approaches to evaluating a patient with cyanosis, including determining the timing of onset, differentiating central and peripheral cyanosis, checking for clubbing, and performing blood tests like arterial blood gases, oximetric studies, and spectroscopic or electrophoretic examination of hemoglobin. Treatment involves addressing the underlying cause, managing symptoms by warming affected areas, and providing oxygenation.
This document discusses cyanosis, defined as a bluish discoloration of the skin and mucous membranes due to low oxygen saturation in the blood. It describes two main types of cyanosis - peripheral and central cyanosis. Peripheral cyanosis is caused by low oxygen saturation at the venous end of capillaries and affects the extremities. Central cyanosis involves decreased oxygen saturation in arterial blood and affects more central areas. Causes, signs, and treatments are provided for each type. Investigations like pulse oximetry, blood gases, and hyperoxia testing are also summarized to differentiate between cardiac and pulmonary causes of cyanosis.
This document discusses the relationship between blood disorders and lung complications. It covers several topics:
1. Anemia can cause dyspnea, decreased carbon monoxide transfer factor, and complications like autoimmune hemolytic anemia which are associated with conditions like fibrosing alveolitis.
2. Sickle cell disease increases risks of pneumonia, acute chest syndrome, pulmonary edema, and chronic pulmonary disease/pulmonary hypertension.
3. Thalassemia major is associated with hypoxemia, reduced lung volumes and flow rates, diminished diffusing capacity, and pulmonary hypertension.
Cyanosis refers to a bluish color of the skin and mucous membranes caused by increased amounts of reduced hemoglobin in small blood vessels. It is usually seen in the lips, nail beds, ears, and cheeks. Cyanosis can be central, meaning it is caused by low oxygen saturation in the blood, or peripheral, caused by slowed blood flow and increased oxygen extraction in tissues. Central cyanosis is suggested by cyanosis of both the skin and mucous membranes, while peripheral cyanosis spares the mucous membranes and can be alleviated by warming the skin. Determining the type of cyanosis and evaluating for conditions affecting respiration or circulation can help identify the underlying cause.
Approach to Cyanosis [Paediatrics presentation for medical (MBBS) students]Rushali Riah
This is the presentation on 'Approach to Cyanosis' for Paediatrics under MBBS curriculum. It focuses of peripheral, central, and differential cyanosis along with their history/examination findings, investigations, and treatment. Good luck!
This document discusses cyanosis, defined as a bluish discoloration of the skin and mucous membranes due to high amounts of deoxygenated hemoglobin in the blood. Cyanosis can be central, occurring in the tongue and oral cavity due to low oxygen saturation in the lungs, or peripheral, occurring in the extremities due to reduced blood flow and oxygen extraction. Causes of central cyanosis include congenital heart defects and lung diseases, while peripheral cyanosis can be caused by exposure to cold, heart failure, or shock. Mixed cyanosis involves both central and peripheral features. Diagnosis involves blood tests and imaging exams, while treatment focuses on the underlying condition causing the cyanosis.
This document discusses alveolar hemorrhage syndromes. It begins by defining alveolar hemorrhage and describing the underlying disruption of the alveolar capillary basement membrane that causes bleeding into the alveolar spaces of the lungs. The main causes discussed include both autoimmune causes like Goodpasture's syndrome and systemic lupus erythematosus as well as non-autoimmune causes like infections, coagulopathies, and pulmonary embolism. Clinical presentation, diagnostic tools, pathology patterns, and treatments are described for different types of alveolar hemorrhage syndromes.
This document discusses cyanosis, which refers to a bluish discoloration of the skin and mucous membranes due to poorly oxygenated blood in the circulation. Central cyanosis occurs when deoxygenated blood enters the systemic circulation due to a heart defect or lung disease. Common causes of cyanosis include congenital heart defects, lung diseases, methemoglobinemia, and anemia. The differential diagnosis and workup involves differentiating cardiac from pulmonary etiologies using physical exam findings, oxygen saturation testing, blood gases, imaging, and echocardiography. Emergency management of cyanotic spells focuses on increasing systemic vascular resistance through positioning, oxygen, fluids, morphine, phenylephrine, or beta blockers. Long
This document discusses cyanosis, defined as a bluish or purple discoloration of the skin and mucous membranes due to increased deoxygenated hemoglobin in the blood. There are two main types: peripheral cyanosis, which occurs locally in cold areas due to vasoconstriction; and central cyanosis, which results from imperfect oxygenation in the lungs or a mixing of venous and arterial blood when oxygen saturation falls below 80-85%. Central cyanosis is best seen on the tongue. The document goes on to discuss causes of central cyanosis like birth asphyxia or heart defects, and the differences between central and peripheral cyanosis.
Hyperviscosity syndrome (HVS) occurs when increased levels of proteins, cells, or other components in the blood cause it to become abnormally viscous or thick. This leads to reduced blood flow and organ damage. HVS is diagnosed based on clinical signs and symptoms along with laboratory tests showing elevated blood viscosity. Treatment involves reducing the cause of viscosity, typically through plasmapheresis to remove excess proteins in multiple myeloma or Waldenstrom macroglobulinemia. Prompt treatment is needed to prevent organ damage and vision loss from HVS.
This document provides guidance on evaluating and treating cyanosis in neonates. Key points include:
- Cyanosis can be central, peripheral or differential based on its mechanism and location. A thorough history, physical exam, pulse oximetry and diagnostic testing is needed to determine the cause.
- Causes can be non-cardiac such as lung issues or methemoglobinemia, or cardiac such as transposition of the great arteries, tetralogy of Fallot, or ductal-dependent lesions.
- Treatment focuses on stabilizing the infant until the specific cause is determined and any necessary procedures or surgery can be done, using prostaglandins to maintain ductal patency in duct-dependent lesions when
Thrombosis is the formation of a blood clot (thrombus) inside a blood vessel or heart chamber. There are three main types of thrombi based on composition and location. Thrombosis occurs due to endothelial injury, abnormal blood flow, and hypercoagulability. Thrombi form at sites of injury or turbulence in arteries and heart chambers, and at sites of stasis in veins. Microscopically, thrombi appear laminated with alternating pale and dark layers. Thrombosis can occur in any blood vessel and lead to complications such as embolism if parts of the thrombus break off.
Anemia can be seen in the emergency department both as a primary pathological process or secondary to both medical and surgical diseases. Moreover, acute anemia can occur in children who have been otherwise healthy, who have systemic disease, or who have known hematologic disorders. Anemia may indicate a disorder with a single hematopoietic cell line (eg, red blood cells) or may be associated with changes in multiple cell lines indicative of bone marrow involvement, immunologic disease, peripheral destruction of erythrocytes, or sequestration of cells. Independent of the etiology, prompt diagnosis is predicated on understanding the classifications of anemia, the associated presenting symptoms, and the proper ordering and interpretation of laboratory studies. This article will discuss the evaluation, proper classification, differential diagnosis, and initial management of acute anemia using cases representative of those that might be seen in the pediatric emergency department.
Hepatopulmonary syndrome (HPS) is characterized by liver disease, intrapulmonary vasodilation, and impaired oxygenation. It is caused by an imbalance of vasodilator and vasoconstrictor agents produced by the damaged liver that cause widespread pulmonary vasodilation. This leads to ventilation-perfusion mismatching and hypoxemia. While no medical treatments are effective, liver transplantation can completely resolve HPS.
Chronic glomerulonephritis is a kidney disorder caused by slow, cumulative damage and scarring of the glomeruli, or tiny blood filters in the kidneys, usually due to inflammation. This results in reduced kidney function over time and can ultimately lead to kidney failure if left untreated. The condition is diagnosed based on abnormal urine or blood tests and kidney imaging and confirmed via kidney biopsy. Treatment focuses on slowing disease progression with medications and managing symptoms like high blood pressure, while dialysis or kidney transplant may be needed in severe cases of kidney failure.
The document discusses various diagnostic tests and procedures. It begins by outlining the phases of diagnostic testing as pre-test, intra-test, and post-test phases. It then describes specific tests like the complete blood count, which measures components of blood, and serum electrolyte testing, which evaluates electrolyte levels important for various body functions. The document provides details on normal ranges and clinical implications of results for these common lab investigations.
This document provides an overview of anaemia, including its definition, causes, risk factors, pathophysiology, classification, clinical manifestations, diagnostic tests, medical management, and nursing care. Key points include:
- Anaemia is a reduction in red blood cells, haemoglobin, or hematocrit, causing tissue hypoxia. It can be caused by blood loss, decreased red blood cell production, or increased red blood cell destruction.
- Common causes include iron, vitamin B12, or folate deficiencies, blood loss, bone marrow disorders, and haemolytic disorders.
- Signs and symptoms vary depending on severity but can include pallor, fatigue, weakness, and shortness of breath.
- Diagnostic
GENERAL PHYSICAL EXAMINATION OF GIT, RS,.pptxPreethamK15
This document provides details on performing a general physical examination of the gastrointestinal system, respiratory system, cardiovascular system, and central nervous system. Some key findings include:
- Increased weight can indicate non-alcoholic steatohepatitis (NASH) while decreased weight can indicate malignancy.
- Clubbing of the fingers can indicate primary biliary cirrhosis, inflammatory bowel disease, or hepatocellular carcinoma.
- Edema of the legs pitting over 40 seconds indicates congestive heart failure, pericarditis, or tricuspid valve disorders.
- Features of respiratory failure include tachycardia, cyanosis, low blood pressure, and asterixis in type 2 respiratory failure
This is a concise presentation on the pathology of endometrial cancer based on the latest WHO female genital tumors latest edition, 5th edition
prepared on April 2022
- Hydatidiform mole is a benign tumor of the placenta that has malignant potential. It is more common in Asian women and those over 35.
- Complete moles are diploid and paternal in origin, while partial moles are triploid with both paternal and maternal chromosomes. Complete moles have no fetus while partial moles may have an abnormal fetus.
- Diagnosis is made through ultrasound showing cystic spaces and very high HCG levels. Management involves surgical evacuation followed by monitoring of HCG levels to detect malignant changes, as 20% of complete moles may develop into gestational trophoblastic neoplasia.
This document summarizes the key mediators involved in the inflammatory response. It discusses how chemical mediators called cytokines, chemokines, lipids like prostaglandins and leukotrienes, amines such as histamine, peptides, complement proteins, and nitric oxide are released from cells to coordinate and regulate inflammation. These mediators act through receptors on target cells to produce effects like increased vascular permeability, leukocyte migration, pain, and fever responses. The document also outlines the innate and acquired immune responses mediated by cells like phagocytes, natural killer cells, and antibodies.
1. Psoriasis is a chronic, inflammatory skin disease characterized by well-defined, red, scaly plaques located over extensor surfaces and scalp.
2. It has a genetic predisposition and can be triggered by environmental factors such as trauma, infection, drugs, and stress.
3. Treatment involves topical therapies for mild disease and systemic therapies such as phototherapy, retinoids, methotrexate, and biological agents for more severe disease.
This document discusses hypertensive disorders in pregnancy, specifically pre-eclampsia. It defines pre-eclampsia and lists risk factors. Diagnosis involves high blood pressure and proteinuria. Classification ranges from mild to severe. Complications for the mother include seizures, stroke, liver or kidney damage. Management involves controlling blood pressure, preventing seizures with magnesium sulfate, and delivering the baby to resolve symptoms. Close monitoring of the mother and baby postpartum is important.
This document summarizes various parasitic infestations and their clinical features. It discusses papular urticaria caused by sensitivity to insect antigens, scabies caused by the mite Sarcoptes scabiei, and different types of pediculosis caused by head lice, body lice, and crab lice. It also mentions other conditions like myiasis, pulicosis, tungiasis, cimicosis, blister beetle dermatitis, spider bites, demodicidosis, larva migrans, leishmaniasis, and lymphatic filariasis. For each condition, it provides details on the causative organism, clinical manifestations, distribution of lesions
This document summarizes several neurocutaneous disorders including neurofibromatosis type 1 and 2, tuberous sclerosis, and Sturge-Weber syndrome. It describes the neurological, cutaneous, and other system involvement for each disorder including common symptoms such as seizures, tumors, and skin lesions. Diagnostic criteria involving clinical findings are provided. The summary focuses on the key features and manifestations across body systems involved in these genetic neurocutaneous conditions.
This document discusses Mullerian anomalies/defects, which range from agenesis to duplication of the tubes, uterus, cervix and upper vagina. It covers the classification system used (AFS), incidence, etiology, genetics, embryogenesis, clinical features, diagnosis using imaging modalies like HSG, USG and MRI, and management of various anomalies like unicornuate uterus, didelphys, bicornuate, septate and arcuate uterus. Complications in reproduction from each anomaly and outcomes of treatments like metroplasty are also summarized. Diethylstilbestrol exposure related abnormalities are briefly discussed.
Toxoplasma gondii is a coccidian parasite transmitted through contact with infected cat feces or consumption of undercooked meat. It typically causes mild or asymptomatic infections but can cause severe brain and eye damage in fetuses, infants, and immunocompromised individuals. Strongyloides stercoralis is a nematode transmitted through skin contact with soil. It resides in the small intestine and can cause chronic diarrhea but also disseminate and cause potentially fatal infections in malnourished or immunosuppressed individuals. Both parasites are diagnosed through examination of infected tissues and confirmed with serological tests.
The jugular venous pulse reflects right atrial pressure and is best examined in the right internal jugular vein. It normally displays three positive waves and two negative troughs related to atrial filling and emptying. Abnormalities can indicate conditions that elevate or lower right atrial pressure such as heart failure, tamponade, constriction. Specific wave changes suggest problems like tricuspid regurgitation or stenosis. The jugular venous pulse is a useful physical exam finding for cardiovascular assessment.
Heart murmurs can be produced by turbulence in blood flow caused by abnormalities in heart valves or structures. A murmur is described by its timing in the cardiac cycle, location, intensity, quality, and radiation pattern.
A mid-systolic murmur is the most common murmur and can be caused by ventricular outflow obstructions like aortic stenosis, dilation of the aorta/pulmonary trunk, accelerated flow, or innocent murmurs from normal anatomical variations. Diastolic murmurs include early diastolic murmurs like aortic regurgitation and high-pressure pulmonary regurgitation, and mid-diastolic murmurs caused by stenosis of the mitral or tricuspid valves. Flow murmurs
The document describes the development of the male and female reproductive systems from the indifferent stage through sexual differentiation. It covers the development of the gonads (testes and ovaries), genital ducts, and external genitalia. Some key points include:
- The gonads initially develop as indifferent gonads before differentiating into testes or ovaries depending on the presence of the SRY gene on the Y chromosome.
- The genital ducts also initially develop in an indifferent stage before the mesonephric ducts develop into male structures like the epididymis and vas deferens, while the paramesonephric ducts develop into female structures like the uterus and fallopian tubes.
- External
This document discusses chronic osteomyelitis, including its causes, pathology, presentations, examinations, investigations, differential diagnoses, and treatments. It can develop following acute osteomyelitis or be caused by tuberculosis or fungi. Pathology involves spread of pus within bone leading to bone death and cavities. Presentations include discharging sinuses and bone fragments. Investigations include x-rays showing bone changes and cultures of pus. Surgical treatments aim to remove dead bone and tissue. Complications include exacerbations, growth abnormalities, and fractures. It also discusses Garre's osteomyelitis and Brodie's abscess as specific types.
Forceps delivery is an operative vaginal delivery procedure that uses obstetric forceps to assist in the extraction of the fetal head. Forceps have curved blades that fit around the fetal head to allow the operator to apply gentle traction. Forceps delivery is indicated when there are signs of fetal distress, prolonged second stage of labor, or maternal medical complications. Risks include laceration, hemorrhage, and injuries to the mother or baby. Proper technique and only performing the procedure when fully trained can help minimize risks.
This document provides information on face presentation during childbirth. It defines face presentation as a cephalic presentation with the fetus in a complete extended attitude and the presenting part being the face. The two types of face presentation are primary (presenting before labor) and secondary (caused by extension during labor). The main positions are left and right mentoanterior and mentoposterior. Face presentation has a higher risk of complications compared to vertex presentation such as prolonged labor and increased need for operative delivery. The management involves allowing labor to progress for mentoanterior positions but cesarean section is usually needed for persistent mentoposterior.
E. coli is a normal flora in the gut but can cause several infections. It is the most common cause of urinary tract infections and can lead to different types of gastroenteritis depending on the strain. Some strains like EHEC O157:H7 can cause hemorrhagic colitis and potentially fatal hemolytic uremic syndrome in young children and the elderly. E. coli is also known to cause neonatal meningitis, wound infections after surgeries, and sepsis.
The brain receives a high blood supply to meet its metabolic demands. Arterial blood reaches the brain through the internal carotid and vertebral arteries, forming the circle of Willis at the base of the brain before branching into smaller vessels. Venous blood drains from the brain into internal jugular veins. Disruption of blood flow to the brain through cerebrovascular accidents like stroke can cause rapid loss of consciousness or permanent brain damage. Cerebrospinal fluid produced by choroid plexuses circulates within ventricles and around the brain and spinal cord, carrying nutrients and waste products.
This document discusses genetic diseases and abnormal fetal development. It begins with definitions of genetic terms like genetic code, chromosomes, genes, and cell division. It then discusses abnormal fetal development including malformations, deformations, and disruptions caused by chromosomal abnormalities, genetic defects, and environmental factors. The document ends by covering perinatal pathology including birth defects and metabolic disorders.
This document provides information on thalassemia, a group of genetic disorders that result in reduced hemoglobin production and anemia. It discusses the different types of thalassemia including alpha and beta thalassemia. Alpha thalassemia is caused by genetic deletions of the alpha globin genes and has varying severity from silent carrier to Hemoglobin H Disease to Bart's Hydrops Fetalis Syndrome. Beta thalassemia results from mutations in the beta globin genes and includes forms ranging from silent carrier to beta thalassemia minor to intermedia to major. Laboratory tests outlined can help diagnose and differentiate types of thalassemia based on red blood cell morphology, hemoglobin analysis and iron studies.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
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TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
2. Definition
Cyanosis refers to a bluish color of the skin
and mucous membranes resulting from
an increased quantity of reduced
hemoglobin/deoxyhemoglobin or
abnormal hemoglobin derivatives, in the
small blood vessels of those areas.
3. Mechanism of Cyanosis
• Absolute increase of amount of reduced
hemoglobin in blood, > 50g/L (capillary)
• Nonfunctional hemoglobin such as
methemoglobinor sulfhemoglobin is
present in blood.
4. reduced hemoglobin in blood
desaturation of oxygen
• Arterial desaturation of oxygen:5%
• Venous desaturation of oxygen:30%
• Capillary desaturation of oxygen:average of both
• SaO2:66% reduced Hb 50g/L
5. Mean capillary concentration of reduced
hemoglobin exceeds 50 g/L. It is the
absolute rather than the relative
increase.
6. 15
5
20
5 5 5
0
5
10
15
20
Total Hb
R-Hb
Normal Polycythemia Anemia
g/dl
Mechanisms of Cyanosis
Caused by absolute increase of amount of reduced
Hb in blood, usually > 5g/dl (capillary)
The higher the hemoglobin concentration,
The greater tendency toward cyanosis.
7. severe anemia
• the relative amount of reduced hemoglobin
in the venous blood may be very large
• the absolute quantity of reduced
hemoglobin may still be small
8. polycythemia
• patients with marked polycythemia tend to
be cyanotic at higher levels of SaO2 than
patients with normal hematocrit
9. Clinical Classification & Etiology
• True Cyanosis (increased amount of reduced Hb)
— Central Type
— Peripheral Type
— Mixed Type
• Cyanosis due to abnormal Hb derivatives
— Methemoglobinemia
— Sulfhemoglobinemia
10. Central cyanosis is caused by decreased
SaO2(increased amount of reduced Hb)
11. Central cyanosis only occurs when the oxygen
saturation of arterial blood is less than 85%.
12. Cause of decreased SaO2
• Parenchymal lung disease
• Right to left cardiac shunt - congenital
cyanotic heart disease
• Decreased PO2 of inspired air - high altitude
• Hypoventilation
13. Parenchymal lung disease
• Airway obstruction,pneumonia,massive pulmonary
embolism, pulmonary edema ,chronic airflow
obstruction emphysema
• Seriously impaired pulmonary function, through
perfusion of unventilated or poorly ventilated areas
of the lung or alveolar hypoventilation,resulting in
decresed alveolar PO2 and SaO2
14. • Congenital cardiac lesion : tetralogy of Fallot (the
combination of ventricular septal defect and
pulmonary outflow tract obstruction ).
• Pulmonary arteriovenous fistulae :congenital or
acquired, solitary or multiple, microscopic or
massive.
Shunting of systemic venous blood into the
arterial circuit
the presence and severity of cyanosis
depend on the size of the shunt relative to the systemic flow as
well as on the Hb-O2 saturation of the venous blood.
17. • At 2500 m the FIO2 is about 120 mmHg, the
alveolar PO2 is approximately 80 mmHg, and the
SaO2 is nearly normal
• At 3500 m the FIO2 and alveolar PO2 are about 85
and 50 mmHg, respectively, and the SaO2 is only
about 75%.
• Cyanosis is marked in a further ascent to 3500 m.
The reason :the S shape of the Hb-O2 dissociation
curve.
Decreased PO2 of inspired air
19. Peripheral cyanosis is due to poor peripheral
circulation and increased oxygen consumption in
peripheral tissue.
20. Peripheral Cyanosis
Caused by increased oxygen consumption in
peripheral tissue.
Vasoconstriction
Low cardiac output
Exposure to cold air or water
Slowing of blood flow
Right heart failure
21. Peripheral cyanosis
• Congestive peripheral cyanosis
right-side heart failure, constrictive pericarditis, local venous diseases.
slowing of blood flow
abnormally great extraction of O2 from normally saturated arterial
blood.
• Ischmic peripheral cyanosis.
Ischemic peripheral cyanosis is often seen in severe shock.
Arterial obstruction or constriction.
vasoconstriction and diminished peripheral blood flow
22. Mixed Cyanosis
Clinical differentiation between central and
peripheral cyanosis may not always be
simple, and in conditions such as
cardiogenic shock with pulmonary edema
there may be a mixture of both types.
23. Possible causes of mixed cyanosis
• all causes of central cyanosis may
lead to peripheral cyanosis
• low cardiac output e.g. heart failure
24. Cyanosis due to abnormal Hb derivatives
Central cyanosis may be simulated by
methaemoglobulinaemia and
sulphaemoglobulinaemia.
25. Methemoglobinemia
• Hereditary: very rare
• Acquired: >30g/L in blood
- intake or exposure to some drugs or
chemicals, such as sulfa drugs, nitrite
salt. “ enterogenic cyanosis ”
Spectroscope is helpful to diagnose
methemoglobinemia.
28. Possible clinical features include
----central cyanosis
• the warm mucous membranes are blue, for
example the tongue, the inside of the lips
• central cyanosis increases immediately on
exercise which is not the case for peripheral
cyanosis
• there is polycythaemia with an abnormally
high haemoglobin and haematocrit
• clubbing is often seen in patients with
central cyanosis
29. Possible clinical features include
----peripheral cyanosis
• Cool skin and mucous membrance
• Site (lower extremities,fingers)
• Diminish after massage
30. Note that the absolute
discriminating feature between
central and peripheral cyanosis is
obtained from testing the oxygen
saturation of arterial blood.
31. Differentiation of central as opposed to
peripheral
Cyanosis Skin temp. Massage or warming
Central Warm No change
Peripheral Cool Cyanosis fades
32. Possible clinical features include
----abnormal hemoglobin
Acquired Methemoglobinemia
• Acutely develop after intaking drugs or chemicals
(often severe)
• Not relieved after oxygen therapy
• Blood remains brown after being mixed and
exposed to air
• Fades after infusion of methylene blue or
administration of large dosage of vitamin C
34. Certain features are important in arriving at
the cause of cyanosis
• History (age, gender, family disease history)
• Clinical differentiation of central as opposed to
peripheral cyanosis
• The presence or absence of clubbing of the digits
• Determination of PaO2 tension and SaO2
• Spectroscopic and other examinations of the blood
for abnormal types of hemoglobin (critical in the
differential diagnosis of cyanosis)
35. History
• particularly the onset (cyanosis present
since birth is usually due to congenital heart
disease)
• possible exposure to drugs or chemicals that
may produce abnormal types of hemoglobin
36. Lab tests
• Determination of arterial oxygen saturation
• Oximetric studies
• physical or radiographic examination ,
echocardiography right heart catherixation and
angiocardiography
• Spectroscope
37. • The combination of cyanosis and clubbing is
frequent in patients with congenital heart disease
and right-to-left shunting and is seen occasionally
in persons with pulmonary disease such as lung
abscess or pulmonary arteriovenous fistulae.
• In contrast, peripheral cyanosis or acutely
developing central cyanosis is not associated with
clubbed digits
Clubbing
38. • Cyanosis + Dyspnea
Disorders of respiratory or cardiovascular system
• Cyanosis with mild or no dyspnea
Methemoglobinemia
Sulfhemoglobinemia: Spectroscopy helpful
• Cyanosis + clubbing
Severe, long duration