The document discusses pre-invasive and invasive lesions of the cervix, including normal cervix, cervical intraepithelial neoplasia (CIN), and cervical cancer. It covers carcinogenic factors like human papillomavirus that can lead to CIN I, CIN II, CIN III, and eventual cancer. Screening tools like Pap smears and management approaches for each stage of CIN and cancer are also summarized.

1. Pre-invasive & Invasive Lesions of the Cervix http://crisbertcualteros.page.tl

2. Normal Cervix Cancer Cervical Intraepithelial Neoplasia (CIN) Carcinogenic Factors CIN I CIN II CIN III Carcinogenesis

8. Carcinogenesis Normal Cervix Cancer Cervical Intraepithelial Neoplasia (CIN) Carcinogenic Factors CIN I CIN II CIN III

9. Human Papilloma Virus

11. HPV E3 E1 E2 E4 E5 E6 E7 L1 L2 Human Genome p53 pRB Viral Genome Integration

12. E6 p53 DNA Repair Programmed Cell Death (Apoptosis) Viral Oncoprotein – Host Regulatory Protein Complex

13. E7 pRB Viral Oncoprotein – Host Regulatory Protein Complex S G2 M G1 G0 cell cycle

16. Normal CANCER INITIATOR PROMOTER Carcinogenesis

19. Cervical Intraepithelial Neoplasia

38. Colposcopy

40. Colposcopy of the Cervix

47. Cervical Carcinoma

65. Stage III A Stage III B Extension to the LOWER 3rd of Vagina Extension to the PELVIC WALL

66. Surgical Management

71. Multimodality Treatment

82. Follow-Up