skeleton of human body, skeletal system of human body, skeleton anatomy, intr...Dr Shahid Alam
skeleton of human body, skeletal system of human body, skeleton anatomy, introduction to skeleton, axial skeleton, cranium, cranial bone mnemonic for cranial bone, bone of skeleton system, 206 bones by dr shahid alam, dr shahid, shahid alam, alam
skeleton of human body, skeletal system of human body, skeleton anatomy, intr...Dr Shahid Alam
skeleton of human body, skeletal system of human body, skeleton anatomy, introduction to skeleton, axial skeleton, cranium, cranial bone mnemonic for cranial bone, bone of skeleton system, 206 bones by dr shahid alam, dr shahid, shahid alam, alam
The skeletal system includes all of the bones and joints in the body. Each bone is a complex living organ that is made up of many cells, protein fibers, and minerals. The skeleton acts as a scaffold by providing support and protection for the soft tissues that make up the rest of the body. The skeletal system also provides attachment points for muscles to allow movements at the joints. New blood cells are produced by the red bone marrow inside of our bones.
ANATOMICAL FAETURES OF BONES FOR NURSING STUDENTS .pptxWINCY THIRUMURUGAN
A long bone has two parts: the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone.
The hollow region in the diaphysis is called the medullary cavity, which is filled with yellow marrow.
The walls of the diaphysis are composed of dense and hard compact bone.
The wider section at each end of the bone is called the epiphysis (plural = epiphyses), which is filled with spongy bone.
The medullary cavity has a delicate membranous lining called the endosteum (end- = “inside”; oste- = “bone”), where bone growth, repair, and remodeling occur.The outer surface of the bone is covered with a fibrous membrane called the periosteum (peri- = “around” or “surrounding”). The periosteum contains blood vessels, nerves, and lymphatic vessels that nourish compact bone.Flat bones, like those of the cranium, consist of a layer of diploë (spongy bone), lined on either side by a layer of compact bone .Four types of cells are found within bone tissue: osteoblasts, osteocytes, osteogenic cells, and osteoclasts .Compact bone is the denser, stronger of the two types of bone tissue ,spongy bone, also known as cancellous bone, contains osteocytes housed in lacunae, but they are not arranged in concentric circles. Bones of the axial skeleton protect internal organs that includes skull (22), vertebral column (26), thoracic cage (25), ear bones (6) & Hyoid (1) TOTAL = 80
Bones of the appendicular skeleton facilitate movement with TOTAL 126 (64 in the upper & 62 in the lower) appendicular skeleton.
126+80=206.Skull bones:
The adult skull comprises 22 bones. These bones can be further classified by location:
Cranial bones: The 8 cranial bones form the bulk of your skull. They help to protect your brain.
Facial bones: There are 14 facial bones. They’re found on the front of the skull and make up the face.
Vertebral column:
The vertebral column is made up 33 bones.
Cervical vertebrae: These 7 bones are found in the head and neck.
Thoracic vertebrae: These 12 bones are found in the upper back.
Lumbar vertebrae: These 5 bones are found in the lower back.
The sacrum (5) and coccyx (4) are both made up of several fused vertebrae. Thoracic cage: The thoracic cage is made up of the sternum (breastbone) and 12 pairs of ribs.
These bones form a protective cage around the organs of the upper part, including the heart and lungs & gives attachment to muscles involved in respiration and upper limb movement.
The sternum consists of the manubrium, body of the sternum, and xiphoid process.
Ribs 1-7 are called true ribs because they attached directly to the sternum in front and vertebrae at back
Ribs 8-12 are known as false ribs.
the last two false ribs (11 & 12), have no anterior attachment, are called floating, fluctuating or vertebral ribs.
Ear bones (6):
Bones of the inner ear: Inside the temporal bone are the 3 smallest bones of the body:
Malleus
Incus
Stapes ( the smallest bone in the body) etc..
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
2. • The human skeleton consists of 206
named bones grouped into two
principal divisions:
◦ Axial skeleton
◦ Appendicular skeleton
Axial
Appendicular
3. • Each of the 206 named bones of the axial and
appendicular skeleton can
be placed in one of 6
broad classifications
based on their
embryological origins
and their anatomical
characteristics.
4. Long bones -the femur, tibia, fibula, humerus,
ulna, radius, metacarpals, metatarsals, and
phalanges.
Short bones (cube-shaped) include the carpals
& tarsals.
Flat bones-They include the cranial bones, ribs,
sternum, scapulae, and clavicles.
5. • Irregular bones include complex shapes like the
vertebrae and some facial bones.
• Sesamoid bones vary in number and
protect tendons from excessive wear:
◦ The best example is the patella.
◦ Sesamoid bones can develop fractures
due to friction, tension, and stress.
6. Sutural bones, also known as Wormian bones, are small
extra bone plates located within the sutures of cranial
bones.
◦ These are found as
isolated examples, and
although unusual, they
are not rare.
7. Bones have characteristic surface markings -
structural features adapted for specific functions.
There are two major types of surface markings:
◦ Depressions and openings
Allow the passage of blood vessels and nerves
Form joints
◦ Processes
Projections or outgrowths that form joints
Serve as attachment points for ligaments and tendons
8. • While a process is any projection of bone (large or
small), a spinous process is a slender projection
from a vertebrae.
• A foramen is an opening in
bone through which blood
vessels and/or
nerves pass.
9. • If a bony process is large, round, and articular, it
might be called a condyle. The condyles of the
humerus are the Trochlea and the Capitulum.
• An epicondyle is a
bony protuberance
above a condyle.
• A fossa is a shallow
depression in bone.
10. • A tubercle is a small rounded projection.
• A tuberosity is a large bony prominence
that is not articular.
11. • A meatus is a tube-like canal. The external
auditory
meatus is a good example.
• The trochanters are two very
large bony projections on the femur.
12.
13.
14. • There are 80 bones in the central
(axial) skeleton, comprising:
◦ Skull
◦ Vertebral column (including the
sacrum)
◦ Ribs
◦ Sternum
15. The skull protects and supports the brain and
special sense organs.
Besides forming the large cranial cavity, the
skull also forms several smaller cavities.
◦ Nasal cavity
◦ Orbits (eye sockets)
◦ Paranasal sinuses
◦ Small cavities which house organs involved in
hearing and equilibrium
19. • A suture is a “seam” – an immovable joint
between bones of the skull.
Coronal Suture
Lambdoidal
Suture
Squamous Suture
20. • Of the 8 cranial bones that fit together to form
the braincase, the sphenoid bone is the
“keystone”.
◦ Like the keystone of a roman arch, the sphenoid is
the “center brick” that balances the outward thrust of
the other bones.
Representation
of a Roman Arch
21. The rest of the braincase bones are dependent for support on
the sphenoid bone (with its greater and lesser wings).
The Sphenoid bone
23. • Besides protecting the brain, the skull provides
a framework for:
◦ Attachment of muscles that move various parts of the
head
◦ Attachment for muscles that produce facial
expressions
• The facial bones form the framework of the
face and provide support for the entrances to
the digestive and respiratory systems.
24. • The spine is composed of a series of bones
called vertebrae.
• Vertebrae typically consist of:
◦ A body (weight bearing)
◦ A pedicle and lamina
forming the vertebral arch
(surrounds the spinal cord)
◦ Several processes (points
of attachment for muscles)
25. There are 7 cervical vertebrae
in the neck region labeled C1-
C7 .
There are 12 thoracic
vertebrae that articulate with
the ribs (T1-T12).
There are 5 lumbar vertebrae
that support the lower back
labeled L1-L5 .
The sacrum and coccyx are
single bones that result from
the fusion of several
vertebrae.
26. From the cervical region to
the sacrum, each vertebra
has a large central hole, or
vertebral foramen in which
the spinal cord can travel.
At each segmental level,
on both the right and left
sides, an intervertebral
foremen is formed for the
exiting spinal nerves.
27. • A tough fibrocartilage intervertebral disc is found
between the bodies of adjacent vertebrae.
28. • When viewed from the front, a normal adult
vertebral column appears straight.
• When viewed from the side,
it has four slight bends which
constitute the normal spinal
curvatures.
29. • Various conditions may exaggerate the normal
spinal curves, sometimes causing severe
disability.
30. • The cervical vertebrae comprise the bony
spine in the neck:
◦ C1 is called the Atlas because it holds up the head
the way the Titan of Greek mythology supported the
world.
◦ C2 is called the Axis because it provides a pivot,
allowing the head to turn on the neck.
31. • Without these first
two specialized
cervical vertebra,
the head-on-neck
range of motion
would be very
limited.
32. • The thoracic cage is the final part of the axial
skeleton.
• In addition to the thoracic vertebrae, it is
formed from:
◦ The sternum
◦ The thoracic vertebrae and their intervertebral discs
◦ The ribs and costal cartilages
• Its functions are to enclose and protect the
organs in the thoracic and abdominal cavities:
◦ Provide support for the bones of the upper limbs
◦ Play a role in breathing
33. • The sternum or “breastbone” is located
anteriorly in the center of the thoracic wall.
◦ Consists of the manubrium, body, xiphoid process
• The 12 pairs of ribs give structural support to
the sides of the thoracic cavity.
• The costal (having to do with the ribs)
cartilages are bars of hyaline cartilage
connecting the sternum to the ribs.
◦ Contribute to the elasticity of the thoracic cage
34.
35.
36. • The upper 7 rib pairs are called true ribs
because they attach “directly” to the
sternum (with just a small piece of costal
cartilage).
37. • The bottom 5 pairs of ribs (and this number
can vary from one individual to another) are
called
false ribs.
◦ They attach indirectly to the
sternum with an elongated piece
of costal cartilage…
◦ … or not at all (ribs 11 and 12
are called floating ribs.)
39. The 126 bones of the appendicular
skeleton are primarily concerned
with movement.
◦ As “appendages” to the central
skeleton, these bones include those of
the upper and lower limbs (including
the girdles that attach them to the
axial skeleton).
40. Based on the position of its major joints and
component bones, the upper limb is divided
into the shoulder, arm, forearm, and hand:
◦ The shoulder is the area of upper limb attachment to
the trunk.
◦ The arm is the part of the upper limb between the
shoulder and the elbow joint.
◦ The forearm is between the elbow and the wrist.
◦ The hand is distal to the wrist.
The Upper Limb
41. The bones of the shoulder
(pectoral) girdle include
the scapula and the
clavicle.
◦ The shoulder joint also
incorporates the upper part
of the humerus.
44. The clavicle is “S” shaped:
◦ The medial end articulates with the manubrium
of the sternum forming the sternoclavicular joint.
◦ The lateral end articulates with the acromion
forming the acromioclavicular joint.
45. The only bone in the arm is the humerus. The
head of the humerus has two projections:
◦ The greater tubercle lies more laterally.
◦ The lesser tubercle lies more anteriorly.
◦ Between the tubercles lies the
intertubercular groove or sulcus
(bicipital groove) where the long
head of the biceps brachii tendon
is located.
46. The two bones of the forearm
are the radius and ulna:
◦ The radius is lateral (in anatomic
position) and widens distally.
◦ The more medial ulna widens
proximally into the Olecranon
process, a large prominence we feel
as the tip of the elbow.
The Forearm
47. The diaphysis (shaft) of the radius and ulna
are connected by an interosseus membrane.
There is a proximal radioulnar joint and a
distal radioulnar joint.
◦ Proximally, the head of the radius articulates with
the radial notch of the ulna.
◦ Distally, the head of the ulna articulates with the
ulnar notch of the radius.
The Forearm
50. The hand is composed of
the wrist, the palm, and the
fingers.
◦ The wrist, or carpus, is made
up of 8 carpal bones arranged
in two rows.
◦ The palm of the hand has 5
metacarpal bones .
The Hand
51. ◦ Each finger, with the exception of the thumb or 1st
digit, is composed of 3 phalanges:
• proximal phalanx
• middle phalanx
• distal phalanx
The joints of the hand
include the carpometacarpal,
metacarpophalangeal, and
interphalangeal joints.
The Hand
52. The lower limb is directly anchored to the axial skeleton by
a sacroiliac joint which links the pelvic bone to the sacrum
The gluteal region (the major bones forming the hip girdle),
thigh, leg, and foot.
◦ The gluteal region is between the iliac crest and hip
joint.
◦ The thigh is between the hip and the knee joint.
◦ The leg is between the knee and the ankle.
◦ The foot is distal to the ankle.
The Lower Limb
53. In the gluteal region, the
pelvic girdle is made up
of two os coxae, or hip
bones.
◦ Each coxal (hip) bone
consists of 3 bones that
fuse together:
• Ileum
• Ischium
• Pubis
The Pelvic Girdle
54. On the right and left sides, the os coxae are
joined posteriorly to the sacrum, and
anteriorly to one another at the pubic
symphysis (made of fibrocartilage).
◦ The free part of the lower
limb below the
hip joint is
composed of 30
different bones.
The Pelvic Girdle
55. The ilium is the largest of the three hip bones -
it forms the superior lateral prominence of the
pelvis (iliac crest):
◦ Consists of a superior ala and inferior body which
forms the acetabulum
(the socket for the head
of the femur)
◦ Greater sciatic notch
allows passage of the
sciatic nerve.
The Pelvic Girdle
56. The ischium constitutes the inferior and
posterior part of the hip bone.
◦ Its most prominent feature is the ischial tuberosity -
the part that meets
the chair when
you are sitting.
The Pelvic Girdle
57. The pubis is the anterior and inferior part of
the hip bone.
◦ It has superior and inferior rami and a body.
The Pelvic Girdle
58. The pelvic brim is a line from the sacral
promontory to the upper part of the pubic
symphysis.
◦ The false pelvis lies above this line. It contains
no pelvic organs except the urinary bladder
(when full) and the
uterus during
pregnancy.
The Pelvic Girdle
59. The true pelvis is the bony pelvis inferior to the
pelvic brim. It has an inlet, an outlet and a
cavity.
◦ The pelvic axis
is the path of
childbirth
during the first
and second
stages of labor.
The Pelvic Girdle
60. Compared to the female pelvis, the male pelvis:
Male Pelvis Female Pelvis