The race to unlock one of the great mysteries of life, the structure of DNA.
Register to explore the whole course here: https://school.bighistoryproject.com/bhplive?WT.mc_id=Slideshare12202017
The race to unlock one of the great mysteries of life, the structure of DNA.
Register to explore the whole course here: https://school.bighistoryproject.com/bhplive?WT.mc_id=Slideshare12202017
This presentation is one of the series as part of the Australian Curriculum for Year 10 Science students. It covers the Biological Sciences (BS) strand of Science Understanding.
10 BS Genetics I AO covers the theme of 'Transmission of heritable characteristics from one generation to the next involves DNA and genes (ACSSU184)'.
The elaboration is describing the role of DNA as the blueprint for controlling the characteristics of organisms.
At this time; reading, listening or writing the word DNA doesn’t amaze us, we know that it is deoxyribonucleic acid. But it was not always like this. There was a time when it was a mystery; many of the scientists, researcher and workers spent their whole life in searching out what is DNA.
This is a comprehensive account of the structure of eukaryotic chromosomes. It deals with the morphology, formation, and types of chromosomes present in eukaryotic cells. The main point of interest is the folding and packaging of DNA and proteins to make chromatin.
DNA Synthesis: Bio-Synthesis world’s leading Supplier providing commercial Synthetic DNA, custom DNA synthesis services and developer of new technologies for unmodified DNA synthesis.
This presentation is one of the series as part of the Australian Curriculum for Year 10 Science students. It covers the Biological Sciences (BS) strand of Science Understanding.
10 BS Genetics I AO covers the theme of 'Transmission of heritable characteristics from one generation to the next involves DNA and genes (ACSSU184)'.
The elaboration is describing the role of DNA as the blueprint for controlling the characteristics of organisms.
At this time; reading, listening or writing the word DNA doesn’t amaze us, we know that it is deoxyribonucleic acid. But it was not always like this. There was a time when it was a mystery; many of the scientists, researcher and workers spent their whole life in searching out what is DNA.
This is a comprehensive account of the structure of eukaryotic chromosomes. It deals with the morphology, formation, and types of chromosomes present in eukaryotic cells. The main point of interest is the folding and packaging of DNA and proteins to make chromatin.
DNA Synthesis: Bio-Synthesis world’s leading Supplier providing commercial Synthetic DNA, custom DNA synthesis services and developer of new technologies for unmodified DNA synthesis.
5.1.a Contrast the functions of the DNA and protein components of ch.pdframbagra74
5.1.a Contrast the functions of the DNA and protein components of chromosomes.
5.1.b Explain why biologists initially thought that proteins were the most likely carriers of
genetic information.
5.1.c Describe how, experimentally, researchers demonstrated that DNA carries genetic
information.
5.1.d Distinguish between the bonds that link together the subunits in a single strand of DNA and
those that hold together the two strands in a DNA double helix, and summarize how these bonds
affect the behavior of the DNA molecule.
5.1.e Describe complementary base-pairing and explain how this arrangement gives rise to the
twisting, consistently proportioned, double helical structure of DNA.
5.1.f Describe the chemical differences that dictate the polarity of a DNA strand.
5.1.g Explain how the structure of DNA carries information for producing proteins.
5.1.h Explain how the structure of DNA suggests a mechanism by which genetic information can
be copied.
THE STRUCTURE OF EUKARYOTIC CHROMOSOMES
5.2.a Contrast prokaryotic and eukaryotic chromosomes in terms of structure and specialized
sequence elements.
5.2.b Describe how human chromosomes can be distinguished from one another and how such
information can be of value.
5.2.c Recall how many molecules of DNA are in each eukaryotic chromosome.
5.2.d Describe a full complement of human chromosomes in a diploid somatic cell, including sex
chromosomes.
5.2.e Define the terms "gene" and "genome."
5.2.f Describe the relationship among gene number, genome size, and organismal complexity.
5.2.g Explain why much "junk DNA" is thought to serve a biological function.
5.2.h Compare the roles played by centromeres, telomeres, and replication origins.
5.2.i Explain the organization and attachments that keep interphase chromosomes from
becoming extensively entangled.
5.2.j Describe the structure and function of the nucleolus.
5.2.k Contrast the extents of compression in interphase and mitotic chromosomes.
5.2.l Compare the roles played by non-histone proteins and histone proteins (including histone
H1) in the packaging of chromatin.
5.2.m Distinguish between a nucleosome and a nucleosome core particle.
5.2.n Explain how histone proteins are able to bind tightly to DNA.
THE REGULATION OF CHROMOSOME STRUCTURE
5.3.a Explain how chromatin-remodeling complexes and histone-modifying enzymes regulate
the accessibility of DNA.
5.3.b Explain why a cell might decondense a particular segment of DNA.
5.3.c Contrast euchromatin and heterochromatin in terms of structure, gene activity, and location
along an interphase chromosome.
5.3.d Explain how heterochromatin is established and spreads.
5.3.e Explain how heterochromatin participates in gene silencing and provide an example..
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Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Search and Society: Reimagining Information Access for Radical FuturesBhaskar Mitra
The field of Information retrieval (IR) is currently undergoing a transformative shift, at least partly due to the emerging applications of generative AI to information access. In this talk, we will deliberate on the sociotechnical implications of generative AI for information access. We will argue that there is both a critical necessity and an exciting opportunity for the IR community to re-center our research agendas on societal needs while dismantling the artificial separation between the work on fairness, accountability, transparency, and ethics in IR and the rest of IR research. Instead of adopting a reactionary strategy of trying to mitigate potential social harms from emerging technologies, the community should aim to proactively set the research agenda for the kinds of systems we should build inspired by diverse explicitly stated sociotechnical imaginaries. The sociotechnical imaginaries that underpin the design and development of information access technologies needs to be explicitly articulated, and we need to develop theories of change in context of these diverse perspectives. Our guiding future imaginaries must be informed by other academic fields, such as democratic theory and critical theory, and should be co-developed with social science scholars, legal scholars, civil rights and social justice activists, and artists, among others.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
De-mystifying Zero to One: Design Informed Techniques for Greenfield Innovati...
Chapter 16
1. Chapter 16-The Molecular Basis of Inheritance-Review
OBJECTIVES
DNA as the Genetic Material
1. Explain why researchers originally thought protein was the genetic material.
2. Summarize the experiments performed by the following scientists that provided evidence
that DNA is the genetic material:
a. Frederick Griffith
b. Oswald Avery, Maclyn McCarty, and Colin MacLeod
c. Alfred Hershey and Martha Chase
d. Erwin Chargaff
3. Explain how Watson and Crick deduced the structure of DNA and describe the evidence they
used. Explain the significance of the research of Rosalind Franklin.
4. Describe the structure of DNA. Explain the quot;base-pairing rulequot; and describe its significance.
DNA Replication and Repair
5. Describe the semiconservative model of replication and the significance of the experiments
by Matthew Meselson and Franklin Stahl.
6. Describe the process of DNA replication. Note the structure of the many origins of replication
and replication forks and explain the role of DNA polymerase. 7. Explain what energy source
drives the polymerization of DNA.
8. Define quot;antiparallelquot; and explain why continuous synthesis of both DNA strands is not
possible.
9. Distinguish between the leading strand and the lagging strand.
10. Explain how the lagging strand is synthesized even though DNA polymerase can add
nucleotides only to the 3' end.
11. Explain the roles of DNA ligase, primer, primase, helicase, and the single-strand binding
protein.
12. Explain why an analogy can be made comparing DNA replication to a locomotive made of
DNA polymerase moving along a railroad track of DNA.
Evolution, Unity, and Diversity
13. Explain the roles of DNA polymerase, mismatch repair enzymes, and nuclease in DNA
proofreading and repair.
14. Describe the structure and functions of telomeres. Explain the significance of telomerase to
healthy and cancerous cells.