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Cell biology
This document provides information about an advanced cell biology course including the lecturer's contact details, textbook, course objectives, topics, and syllabus. The course will cover basic cell components and structures like the nucleus, membrane, cytoskeleton, and cell cycle. It will focus on the molecular basis of life at the cellular level and general principles and mechanisms. The first week will be an introduction and subsequent weeks will cover specific topics like transcription, signaling, and trafficking. Cells are introduced as the basic functional units of living organisms and their evolution is briefly outlined.
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Cell biology
- 1. Advanced Cell Biology 20141nd Semester Department of Animal Science Chungbuk National University 1st Lecture
- 2. Basic Information aboutCourses Lecturer : Suk Namgoong Room 443, S21-5 suknamgoong@chungbuk.ac.kr HP: 010-4103-2415 Biweekly : 1st, 3nd, 5th Thursday 9:00-12:00
- 3. Textbook and Materials Maintext : Cell biology, 2nd edition, Pollard & Earnshaw Most of lecture material will be provided as ppt at http://www.slideshare.net/suknamgoong * Book is in my Office
- 4. Course Objectives • Tounderstand the molecular basis of life at the cellular level • Focusing on general principles and molecular mechanisms. • Therefore, we assume general knowledge of Macromolecular structures and Chemical bonds, equilibrium constants, and rate constants
- 5. 1st week :Introduction 3rd week : Basic principle of Cell component/ Research Strategoes 5nd week : Nucleus, Transcription and Splicing 7nd week : Membrane and Channel 9nd week : Membrane Trafficking 11nd week : Cell Signaling 13nd week : Cytoskeleton 15nd week : Cell Cycle Syllabus
- 6. Cells Basic Functional Unitsof all living organism Mouse Embryonic Fibroblast (MEF)
- 7.
- 8. Evolution of Life Prebioticorigin of life: Details are uncertain; RNA may have dominated early biochemistry. Common ancestor of all modern cells existed ~3.5 billion years ago with about 600 genes. Life diverged from this common origin by natural selection of favorable random mutations. Lateral transfer of genes among species has contributed to genetic diversity during evolution.
- 9. Typical Eukaryotic cellswere composed with various component
- 13. Main difference withEukaryotic and Procaryotic Cells - Compartmentation by inner cell membrane Nucleus Mitochondria Lysosome
- 14. What is differencebetweeen complicated machine and living cell? Both are composed with various ‘component’ Performed as ‘defined’ task What is difference between them?
- 15. General Characteristics ofLiving Cell Self-Replication and Generation
- 16. Every cell hastheir own ‘design sheet’ as form of DNA DNA-RNA-Protein
- 17. Macromolecules (Protein, DNA)assembled with each other and forms cellular structure
- 18. In Nucleus.. DNA isreplicated in HERE Transcriptions are carried out in HERE Splicing are carried out in HERE
- 19. ER Most Protein synthesis(Translation) happen in ER Proteins were transported via ER and Golgi to their destination
- 20. Membrane / Cell-To-CellJunction
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- 23. Chemical Principle ofCell Biology Water Proteins Nucleic Acids DNA RNA Carbohydrate Lipids
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- 26. Post-translational modification ofamino acid Important for regulation of proteins
- 27. Amino Acids =Polypeptides Covalent Bonds (공유결합)
- 28. Secondary Structure (HydrogenInteractions)
- 29. Three-dimensional Structure ofProtein determine their functions What is main driving force for Three-dimensional structure of Protein folding?
- 30. Main driving forcefor tertiary structure formation : Van der waals interactions Most protein are in water Hydrophilic (charged, polar) amino acid residues tend to be in protein surface Hydrophobic residues avoids water (core packing)
- 31. Three-dimensional Structure ofProtein (and macromocules) determine their functions
- 32. To Understand howcomplicate machine works, You should know the shape and function of each component
- 33. To Understand deeplyfunction of a specific component, you need to know about structure of functions
- 34. These approach arealso same in proteins Cas9-sgRNA-DNA Complex (Nureki et al., Cell 2014)
- 35. Some proteins havemultiple conformations
- 36. It is difficultto understand how horse can run with this single frame of picture.. But if we have series of still images of horse running, we can figure out how horse can run..
- 38. To understand howto protein do their jobs, we need Series of ‘snapshot’ structure. GDP or GTP mediated Conformational change of Rab28 GTPase
- 39.
- 40. DNA conformation: mostcommonly a double helix with complementary TA and GC base pairs. Encode genetic information in sequence.
- 41. RNA structures takeon highly diverse conformations, including helical regions with complementary base pairs. Structural RNA : Hammerhead ribozyme
- 42. Molecular Crowding :Cell is very packed..
- 43. Not like this CellularTransport inside Cells More likely this It will cost lots of energe for sure.