The document discusses disorders of water and electrolyte metabolism. It covers homeostasis of water and electrolytes, common electrolyte imbalances seen in disease, and key mechanisms that regulate fluid and electrolyte balance in the body, including thirst, antidiuretic hormone, aldosterone, and osmoreceptors.
Concepts of acid base balance and its disorders are very important for practice of medicine.It is for the benefit of medical and students of allied fields.
Concepts of acid base balance and its disorders are very important for practice of medicine.It is for the benefit of medical and students of allied fields.
Basic Intravenous Therapy 3: Fluids And Electrolytes, Balance and Imbalance, ...Ronald Magbitang
Lecture Presentation in Basic Intravenous Therapy Seminar, discussion on Body Fluids and Electrolytes, Normal Values and the Imbalances, the symptomatology and treatment and precautions, and, finally the different types of commonly available, utilized IVF in clinics
fluid and electrolyte imbalance
normal physiology of fluid regulation
FLUID IMBALANCES- fluid volume excess, fluid volume deficit, third spacing,
ELECTROLYTE IMBALANCES- hypo and hypernatremia, hypo and hyperkalemia, hypo and hypercalcemia
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
"Impact of front-end architecture on development cost", Viktor TurskyiFwdays
I have heard many times that architecture is not important for the front-end. Also, many times I have seen how developers implement features on the front-end just following the standard rules for a framework and think that this is enough to successfully launch the project, and then the project fails. How to prevent this and what approach to choose? I have launched dozens of complex projects and during the talk we will analyze which approaches have worked for me and which have not.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
21. Osmosis When a bottle bottomed with a semi-permeable membrane is filled with 3% salt solution and put into a glass of water, the water in the glass will move into the bottle, this phenomenon is call osmosis. Osmosis make the salt solution rising and solution stops rising when weight of column equals osmotic pressure.
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24. fewer same more Particle concentration compared with intracellular fluid Swell & burst no alteration wrinkle or shrivel Response of cell placed in solution 0.45% NaCl 0.9% NaCl 3% NaCl Distilled water 5% glucose 20% glucose Representative solution <280 280-310 >310 Osmolality (mmol/L) hypotonic isotonic hypertonic
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31. The vascular organ of the lamina terminalis (OVLT) contains osmoreceptive neurons – also the subfornical organ (SFO) and the median preoptic n. (MnPO) Osmoreceptors stimulate AVP secretion and thirst These cells project to the paraventricular nuclei ( PVN) and supraoptic nuclei ( SON) to produce AVP secretion
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33. Thirst is inhibited by decreased plasma osmolality (OVLT receptors) and by increased blood pressure (hypervolemia) Thirst is triggered by increased plasma osmolality (OVLT receptors) , decreased plasma volume, and increased plasma Ang Ⅱ which is caused by decreased plasam volume. (angiotensin II in SFO). Thirst precisely regulate the volume and osmolality of ECF
37. The signal pathway following V2 receptor stimulation by ADH AC: adenylate cyclase; BLM: basolateral membrane; AM: apical membrane; V2: vasopressin receptor; PKA: protein kinase A tubule
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39. ADH is more sensitive to the change of osmotic pressure. 1-2% change of osmotic pressure will change the production of ADH. At first, when blood volume is not markedly decrease, ADH will not be increased. When blood volume is decreased >10%, ADH will be increased At this time, the decrease of blood volume may be life-threatening. ADH released BP/Blood volume + Stretch receptor + Plasma osmotic pressure + Osmoreceptor + Plasma osmotic pressure - Osmoreceptor - ? maintenance of body fluid volume has priority over maintenance of body fluid osmolality.
55. Classification of disorders of water and sodium metabolism ECF volume Hypervolemia Normovolemia Hypovolemia Disorders of water metabolism with normal serum sodium concentration Hypovolemic hyponatremia (Hypotonic dehydration) Isotonic dehydration Hypovolemic hypernatremia (Hypertonic dehydration) Normal Hypervolemic hyponatremia (Water intoxication) Edema Hyponatremia Hypernatremia Dehydration : an excessive loss of body fluid. Serum sodium concentration Normovolemic hyponatremia (SIADH, Rest osmostat) Normovolemic hypernatremia (Upward resetting of hypothalamus osmolar set-point) Hypervolemic hypernatremia (Sodium intoxication) (<130mmol/L) (130-150mmol/L) (>150mmol/L)
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58. Diabetes Insipidus Central diabetes insipidus is characterized by decreased secretion of antidiuretic hormone (ADH) that results in polyuria and polydipsia by diminishing the patient's ability to concentrate urine. Nephrogenic diabetes insipidus is characterized by a decrease in the ability to concentrate urine due to a resistance to ADH action in the kidney.
59. Osmotic diuresis Increased blood glucose ↑ Glomerular filtration of glucose ↑ Osmotic pressure of renal tubular fluid ↓ Water reabsorption Osmotic diuresis H 2 O reabsorption ↑ glucose filtration Osmotic diuresis ↑ Osmolality -
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62. Principles of Therapy: Treating the primary disease Supplying 5%-10% Glucose Adding a small amount of NaCl solution Adding K + properly
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67. Principles of Therapy: Treating the primary disease Supplying 5%Glocose normal saline or 0.9% NaCl solution
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70. Isotonic dyhydration Hypertonic dehydration Hypotonic dehydration Insensible water loss Treated inappropriately with pure water
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77. Alterations of metabolism and function hyponatremia-> water shifting into cells-> brain cell edema-> CNS dysfunction
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81. Effects of hypernatremia on the brain. Brain shrinkage within minutes of development of hypertonicity.Rapid adaptation in few hrs. Rapid correction results in cerebral edema
82. Effects of hyponatremia on the brain and adaptive responses. Brain swelling occurs in minutes of developing hypotonicity, Partial restoration in hrs, normalization of brain vol in days. Overly aggressive correction of Na can lead to irreversible brain damage
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88. Classification of disorders of water and sodium metabolism ECF volume Hypervolemia Normovolemia Hypovolemia Disorders of water & sodium metabolism with normal serum sodium concentration Hypotonic dehydration Isotonic dehydration Hypertonic dehydration Normal Water intoxication Edema Hyponatremia Hypernatremia Dehydration : an excessive loss of body fluid. Serum sodium concentration SIADH Rest osmostat Upward resetting of hypothalamus osmolar set-point Sodium intoxication (<130mmol/L) (130-150mmol/L) (>150mmol/L)