Biochemistry
of Lipids
Biochemistry and Molecular
Biology
Fatty Acids
Fatty Acids
Fatty Acids
      e.g. palmitic Acid is abbreviated as 16:0




                                                  C16
C1




      e.g. oleic Acid is abbreviated as 18:1D9
Fatty Acids




Lauric Acid                            Glucose

MW: 200                                MW: 180
solubility in H2O: 0.063 mg g-1        solubility in H2O: 1,100 mg g-1
(solubility in benzene: 2.60 mg g-1)
Fatty Acids
Some FAs and their common names…

14:0   myristic acid
16:0   palmitic acid
18:0   stearic acid
18:1   cisD9 oleic acid
18:2   cisD9,12 linoleic acid
18:3   cisD9,12,15 -linonenic acid
20:4   cisD5,8,11,14 arachidonic acid
20:5   cisD5,8,11,14,17 eicosapentaenoic acid
Fatty Acids



                  Oleic Acid




                               Linolenic acid
       Linoleic acid
Fatty Acids
e.g.     Fatty Acid            Melting Point (oC)

12:0                    44.2
14:0                    53.9
16:0                    63.1
18:0                    69.8
18:1                    13.4
18:2(D9,12)              1.5
18:3(D9,12,15)        - 11.0
Fatty Acids
Isomerism
              H                 Cl
 Trans or E         C       C
              Cl                H
                    H                H

                        C   C
 Cis or Z
                   Cl                Cl
Fatty Acids
Triacylglycerides




                        Glycerol




alcohol   carboxylic acid          ester
Triacylglycerides
Triacylglycerides

    Ester Link




                 Fatty Acid




Glycerol
Triacylglycerides
                     FA1
                                 Diglyceride
     G
                     FA2




                           FA1

                 G
 Triglycerides             FA2

                           FA3
Triacylglycerides
Triglycerides
Triglycerides




 Adipocytes
Triglycerides
Triglycerides
Energy from fat
Phospholipids
The four phosphlipids
Cholesterol
Fluid Mosaic Model
Fat in the blood
Vitamins

biochemistry of lipids