Uploaded byMayur Chaudhari
Antiemetics
The document discusses the mechanisms and factors involved in chemotherapy-induced nausea and vomiting, highlighting the role of the cerebral cortex, pharynx, chemoreceptor trigger zone, and vestibular nuclei. It mentions various triggers such as opioids, smell, sight, thought, and motion sickness. The document also touches upon related conditions like gastroenteritis and treatments involving 5HT3 and D2 receptor antagonists.
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Antiemetics
- 17. Cerebral Cortex Pharynx andGIT Chemoreceptor Trigger Zone Vestibular NucleiVomiting Centre (Medulla) Cancer Chemotherapy Opioids Smell Sight Thought Anticipatory Vomiting Motion Sickness Chemo and Radiotherapy Gastroenteritis 5HT3, D2, Opioids M, 5HT3,H1 M, H1 5HT3
- 43. Chemotherapy induced nauseaand vomiting
Editor's Notes
- #23 The antiemetic dose is generally much lower than antipsychotic doses. These agents should not be administered until the cause of vomiting has been diagnosed; otherwise specific treatment of conditions like intestinal obstruction, appendicitis, etc. may be delayed due to symptom relief.
- #26 - This action is independent of vagal innervation, but is stronger when vagus is intact
- #28 Dopamine (acting through D2 receptors) is an inhibitory transmitter in the g.i.t.— normally acts to delay gastric emptying when food is present in stomach. It also appears to cause gastric dilatation and LES relaxation attending nausea and vomiting
- #35 - To supplement its antiemetic action and reduce the attending dystonic reactions.
- #61 transdermal patch containing 1.5 mg of hyoscine, to be delivered over 3 days has been developed. Applied behind the pinna, it suppresses motion sickness while producing only mild side effects