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ANTIEMETICS
WHAT IS ANTIEMICS?
• “emesis” (medical
term for vomiting)
• Are typically used to
treat motion sickness,
stomach flu, side
effects of
chemotherapy, and
TWO MAJOR CENTRAL
CENTERS
•Chemoreceptor Trigger Zone (CTZ)
lies near the medulla oblongata that
communicates with vomiting center to
initiates vomiting.
Kinds of receptor:
* 5 ht
* Dopamine d2
Vomiting Center
causes vomiting
when stimulated
TYPES OF
ANTIEMTICS
5-HT3 Receptor Antagonists
•block serotonin receptors in
the central nervous
system and gastrointestinal tract.
However, they can also
cause constipation or diarrhea, d
ry mouth, and fatigue.
EXAMPLES 5-HT3 RECEPTOR
ANTAGONIST
•Dolasetron (Anzemet)
•Granisetron(Kytril, Sancuso)
•Ondansetron (Zofran)
•Tropisetron (Setrovel, Novaban)
•Palonosetron (Aloxi)
•Mirtazapine (Remeron)
DOPAMINE ANTAGONIST
•act in the brain and used to treat
nausea associated with
radiation sickness and general
anesthetics. Side effects include
muscle spasms and
restlessness.
TYPES OF DOPAMINE ANTAGONIST
Prokinetic Drugs
•Is a type of drug which enhances gastrointestinal motility.
They are used to relieve gastrointestinal symptoms such
as abdominal discomfort, bloating, constipation, heart
burn, nausea and vomiting
EXAMPLES:
•Metoclopramide
•Domperidone
TYPES OF DOPAMINE ANTAGONIST
Neuroleptics (Antipsychotics)
•are a class of psychiatric medication primarily used to
manage psychosis (including delusions, hallucinations,
or disordered thought), principally for schizophrenia
and bipolar disorder, and are increasingly being used in
the management of non-psychotic disorders.
EXAMPLE:
•Chlorpromazine
NK1 RECEPTOR ANTAGONIST
•Orally
•Used in prevention of acute
and delayed chemotherapy-
induced nausea and
vomiting and for prevention
of postoperative nausea and
vomiting.
EXAMPLES NK1 RECEPTOR
ANTAGONIST
•Aprepitant (Emend)
•Casopitant
ANTIHISTAMINES/ H1 RECEPTOR
ANTAGONIST
•are effective in many conditions,
including motion sickness,
morning sickness in pregnancy,
and to combat opioid nausea.
•Promethazine: severe morning
sickness of pregnancy (if only
essential).
EXAMPLES ANTIHISTAMINES/ H1
RECEPTOR ANTAGONIST
•Cyclizine
•Diphenhydramine (Benadryl)
•Dimenhydrinate (Gravol,
Dramamine)
•Doxylamin
CANNABINOIDS
•are used in patients
with cachexia, cytotoxic
nausea, and vomiting, or who
are unresponsive to other
agents. These may cause
changes in perception,
dizziness, and loss of
coordination.
EXAMPLES OF CANNABINOIDS
• Cannabis
• Dronabinol
SIDE EFFECTS:
• euphoria, dysphoria, sedation,
hallucination
BENZODIAZEPINES
•are a class of medications that work
in the central nervous system and
are used for a variety of medical
conditions.
•Used as sedative-hypnotics for
sleep, adjuncts to anesthesia to
induce relazation and amnesia, to
reduce anxiety, panic disorders, to
treat or prevent seizures, for alcohol
withdrawal and muscle relazant.
EXAMPLES OF
BENZODIAZEPINES:
• Midazolam
• Lorazepam
ANTICHOLINERGICS
•An anticholinergic agent is a
substance that blocks the
neurotransmitter
acetylcholine in
the central and
the peripheral nervous
STEROIDS
•Dexamethasone (Decadron)
is given in low dose at the
onset of a general
anesthetic is an effective
antiemetic. The specific
mechanism of action is not
MECHANISM
OF ACTION

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