Lecture slides for Medical Undergraduate teaching in Pharmacology. Study material is based on Essentials of medical pharmacology by KD tripathi and Katzung. Figures are obtained from google image search and above mentioned textbooks.
They are specific 5-HT and various degrees NE reuptake inhibition.
Venlafaxine, at lower doses (75–100 mg/day) acts as SSRI. As the dose increases it inhibit NE reuptake (& 2ry ↓ DA reuptake in prefrontal cortex, which lacks DAT→ ↑ DA).
Pharmacovigilance AND ADVERSE DRUG REACTIONS.
MONITORING REPORTING ROLE OF PHARMACIST.
CLASSIFICATION OF ADR. MECHANISM OF ADR
ROLE OF PHARMACIST IN MANAGING ADR. AUGMENTED, BIZZARE, CONTINOUS, DELAYED, END OF TREATMENT, ABCD, ABCDE.
1. Epilepsy, Seizure, Convulsion
2. Causes & Pathophysiology of Epilepsy
3. Classification and Choice of antiepileptics
4. Antiepileptics Mechanism of action of , Adverse effects, Drug interactions, General guidelines for use.
5. Recommendation to Antiepileptics and pregnancy according to RCOG 2016, SIGN 2017 guidelines
6. Treatment of status epilepticus according to American Epilepsy Society 2016 guidelines
They are specific 5-HT and various degrees NE reuptake inhibition.
Venlafaxine, at lower doses (75–100 mg/day) acts as SSRI. As the dose increases it inhibit NE reuptake (& 2ry ↓ DA reuptake in prefrontal cortex, which lacks DAT→ ↑ DA).
Pharmacovigilance AND ADVERSE DRUG REACTIONS.
MONITORING REPORTING ROLE OF PHARMACIST.
CLASSIFICATION OF ADR. MECHANISM OF ADR
ROLE OF PHARMACIST IN MANAGING ADR. AUGMENTED, BIZZARE, CONTINOUS, DELAYED, END OF TREATMENT, ABCD, ABCDE.
1. Epilepsy, Seizure, Convulsion
2. Causes & Pathophysiology of Epilepsy
3. Classification and Choice of antiepileptics
4. Antiepileptics Mechanism of action of , Adverse effects, Drug interactions, General guidelines for use.
5. Recommendation to Antiepileptics and pregnancy according to RCOG 2016, SIGN 2017 guidelines
6. Treatment of status epilepticus according to American Epilepsy Society 2016 guidelines
This presentation describes various movement disorders and its management strategies with particular focus of management of parkinson's disease. It gives basic overview of the drugs also.
It may contain a brief intoduction of disease, etiology, types of parkinson disease, clinical findings, dignosis, pathophysiology, treatment, drug classification and their mechanisms of actions.
A disorder of the central nervous system that affects movement, often including tremors.
Nerve cell damage in the brain causes dopamine levels to drop, leading to the symptoms of Parkinson's.
Parkinson's often starts with a tremor in one hand. Other symptoms are slow movement, stiffness and loss of balance.
Treatment consists of medications to increase dopamine.
Parkinsonism
It is an extra-pyramidal motor disorder characterized by rigidity, tremor and hypokinesia with secondary manifestations like defective posture and gait, mask-like face and sialorrhoea; dementia may accompany. If untreated the symptoms progress over several years to end-stage disease in which the patient is rigid, unable to move, unable to breathe properly; succumbs mostly to chest infections / embolism
Lecture slides for MBBS Undergraduate Medical students. Study material was taken from Essentials of pharmacology by KD Tripathi. Figures were searched from google.
Lecture slides for undergraduate MBBS class in Pharmacology on " Drugs for Diarrhoea" . It includes various treatment modalities which are used in the management of Diarrhoea. Basic source of information for preparing this slides is" Essentials of Pharmacology by KD tripathi, 7th Edition". Images are searched with the help of google images.
This lecture slides are prepared for Refresher course for pharmacist. Essential Medicines, Rational use of drugs and Self medication, These are the topics covered in this ppt.These slides are also useful for other medical undergraduates and post graduates students.
Lecture slides for undergraduate Medical students (MBBS) for Pharmacology class. Presentation includes some important historical milestones followed by introduction to general anesthesia. Stages of general anesthesia, Inhalational and intravenous anesthetic agents with their pros and cons and uses. Complications of general anesthesia and pre anesthetic medication is in the last part of presentation.
This slides are prepared for undergraduate medical (MBBS) class for teaching pharmacology. Materials for slides are taken from Essentials of Pharmacology, KD Tripathi 7th ed, Medical Pharmacology, SK Shrivastav and Sharma & Sharma. Pictures are obtained from google.
Presntation prepared for MBBS pharmacology teaching on Thyroid Hormones and Antithyroid drugs. These slides focuses on Thyroid hormone synthesis along with its regulation and pharmacological actions. treatment of Hypothyroidism and hyperthyroidism is covered.
Medical Undergraduate Lecture slides on Pharmacotherapy of HIV-AIDS. These slides include life cycle of HIV. Classification of available drugs based on target site. Individual Drugs with Mechanism of action, PK, AE and drug interactions. Treatment principles and guidelines for HIV-AIDS based on NACO(National Aids Control Organisation, India) Guidelines.
Lecture slides for undergraduates medical (MBBS) Students. Source material for this presentation is Essentials of Pharmacology, KD Tripathi, Katzung and Goodman and Gillman. It deals with Local anaesthetics with their mechanism of action, pharmacokinetics , adverse effects and therapeutic uses.
Presentation for Medical undergraduates for teaching pharmacology. It deals with Physiology of steroid hormones and their action along with agents which are used therapeutically with their action, adverse effects and therapeutic uses.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
6. Parkinson’s Disease
Extrapyramidal motor disorder
Progressive, Degenerative
Rigidity, tremor and Hypokinesia
Defective posture, Gait, Mask like face
Sialorrhoea, Dementia.
7. Environmental Toxins
Protein Damage
Lipid Peroxidation
DNA Damage
AgingNeuronal Metabolism
Selective Vulnerability of
neuronal cells
Free radical formation,
Oxidative stress
Excitotoxicity
Cell
death
17. Levodopa
Inactive, Precursor of Dopamine
95% converted into dopamine peripherally by
decarboxylation
Which exerts systemic action
Remaining enters brain, converted into dopamine
18. Levodopa: CNS
Symptomatic relief in Hypokinesia, rigidity and tremors
Person become more alert
Gradual Normalization of symptoms
No effect on dementia
22. Levodopa: ADRs
After Chronic Use
•Abnormal movements
•Behavioral abnormalities
•Fluctuations in Beneficial effects
•Wearing off phenomena
•On-off phenomenon
23. Wearing off (End of Dose)
Occur at later stage on chronic use
Each dose improves mobility
Rigidity and akinesia return at the end of dosing interval
24. On-OFF Phenomena
All or None response
On phase may be complicated by dyskinesia
Off phase with severe disease
28. Amount of Levodopa in CNS ↑ , so dose ↓ up to 1/4th
Systemic ADRs of Levodopa ↓
Minimization of cardiac ADRs
Minimization of on-off effect
Degree of improvement higher
30. Dopamine Agonist
Can act on striatal DA receptors
Even in advanced patient who lost ability to synthesize, Store
and Release DA
Longer acting
Exert Subtype selective activation of DA receptors
31. Bromocriptine
Potent D2 agonist, Partial agonist/antagonist at D1 receptor
Symptomatic improvement with in 30-60 minutes, last for 6-10 hours
High dose needed for monotherapy, which produces intolerable side
effects
Vomiting, Hallucinations, Hypotension, Nasal Stuffiness
Used to smoothen ‘on off’ fluctuations with l-dopa
32. Ropinirole & Pramipexole
Selective D2/D3 agonist
Pramipexole has greater affinity for D3 receptors
Used as supplementary drug to L-dopa with tolerable S/E in
advanced cases
Dose titration take 1-2 weeks
33. Ropinirole & Pramipexole
Used as monotherapy in early cases
Lower chances of motor fluctuations and dyskinesia in
comparison to L-dopa
Slower rate of neuronal degeneration in clinical studies
Alternative to L-Dopa for longer symptom free life
35. Ropinirole & Pramipexole: S/E
Nausea
Dizziness, Hallucinations
Postural hypotension
Episodes of day time sleep
Patients advised not drive
36. MAO-B Inhibitor: Selegiline
Selective, Irreversible MAO-B Inhibitor
Retard intracerebral degradation of dopamine
In low doses does not interfere with peripheral metabolism of
dietary amines
Less chances of accumulation of CAs and hypertensive reactions
37. MAO-B Inhibitor: Selegiline
Mild action as monotherapy
With L-dopa, attenuates motor fluctuations, ↓ ‘wearing off’
20-30% reduction in L-dopa dose
Advanced cases with ’on-off’ effect not improved
Worsening of dyskinesia, mental confusion and hallucinations
38. Selegiline: Adverse effects
Postural hypotension, Nausea, confusion
Accentuation of L-dopa induced involuntary movements and
psychosis
Insomnia and agitation due to metabolism into amphetamine
Contraindicated in epilepsy
40. Rasagiline
5 time potent, longer acting
Not metabolised to amphetamine
Does not produce excitatory side effects
Some evidence of neuro protective effects
42. Entacapone, Tolcapone
Selective, reversible inhibitors of COMT
Prevent metabolism of L-dopa by COMT peripherally
Preserve DA formed in striatum
Enhance therapeutic effect of L-dopa
43. Entacapone, Tolcapone
Smoothen ‘wearing off’
Increase ‘on’ time, decrease ‘off’ time
Improves daily activities
Dose of L-dopa can be decreased
Not given for early cases
44. Entacapone, Tolcapone: A/Es
Worsening of L-dopa A/Es
Nausea, Vomiting, Dyskinesia, Postural Hypotension, Hallucinations
Diarrhoea
Orange yellow discoloration of urine
Acute fatal hepatitis and Rhabdomyolysis: Tolcapone
45. NMDA antagonist: Amantadine
Rapidly acting, lower efficacy than L-dopa
Tolerance develops in months and efficacy is lost
Promotes presynaptic synthesis and release of DA in brain,
Has some anticholinergic property
Inhibit NMDA glutamate receptors
46. Amantadine
Can be used in mild cases
Short course to supplement L-dopa
Supress motor fluctuations and abnormal movements
S/Es – Insomnia, restlessness, confusion, nightmares, Anticholinergic
effects
Livedo reticularis – Local release of Cas, edema of ankles
47. Central anticholinergics
Higher central: peripheral anticholinergic ration
Reduce the unbalanced cholinergic activity
Efficacy is lower than Levodopa
Only drug effective in drug induced parkinsonism
Trihexyphenidyl, Procyclidine, Promethazine
48. Central anticholinergics
10-25 % improvement symptomatically for 4-8 hours
Tremor is well controlled than rigidity, Hypokinesia not affected
Sialorrhoea controlled by peripheral action
Monotherapy in mild cases or when L-dopa is contraindicated
Combined with L-dopa to reduce the dose
49. Central Anticholinergics
S/E – similar to atropine
Impairment of memory, confusion and blurred vision in elderly
Urinary retention in elderly males
50. No drug can alter basic pathology of disease
Drugs used to provide symptomatic relief, additional happier and
productive life
In case of mild cases – anticholinergics or Selegiline
Ropinirole/ Pramipexole in early cases in young patients
Selegiline can be combined with L-dopa to overcome ‘ wearing off’
phenomena
51. L-dopa+ Decarboxylase is standard therapy,
Combination reduces early complications not late
Start with lower dose and titration in 2-3 months
Benefit last for 2-3 years before decline
Subsequently ‘wearing off’ is seen, dyskinesia appear
Drug holiday not practised now
52. L-dopa alone used only in patients who develop intolerable
dyskinesia
Amantadine used for brief period of exacerbation
Ropinirole/ Pramipexole – to supplement L-dopa in late cases to
smoothen ‘on off’, to reduce the dose and dyskinesia
Entacapone in advanced cases with L-dopa+ carbidopa –
Prolong action and smoothen ‘on off’ fluctuations
Editor's Notes
first clear medical description was written in 1817 by James Parkinson.
Jean-Martin Charcot was particularly influential in refining and expanding this early description and in disseminating information internationally about Parkinson's disease. He separated Parkinson's disease from multiple sclerosis and other disorders characterized by tremor, and he recognized cases that later would likely be classified among the Parkinsonism-plus syndromes.
- Extrapyramidal motor disorder characterized by rigidity, tremor and Hypokinesia with secondary manifestations like defective posture and gait, mask like face and Sialorrhoea and dementia.
Functional circuitry between the cortex, basal ganglia, and thalamus. The major neurotransmitters are indicated. In Parkinson’s disease, there is degeneration of the pars compacta of the substantia nigra, leading to overactivity in the indirect pathway (red) and increased glutamatergic activity by the subthalamic nucleus.
Striatum receive Excitatory Glu input from motor cortex and modulatory Dopaminergic input from SN-PC. Balancing Cholinergic interneurons in striatum
Output from Stritum to GP I and SN-PR via direct and indirect pathway. Direct pathway releases GABA while dominant indirect pathway hay GABA (Inhibitory) and Glu (Excitatory) relay.
Degenrative lesion in SN-PC decreases dopaminergic input to the striatum leading to imbalance between DA and Ach and producing Hypokinesia, Rigidity and tremor.
Direct pathway facilitates BG output to the thalamus and motor areas
Indirect pathway disinhibits the STN and in turn inhibits thalamus and motor areas.
BG plays a important role in planning and programming of movement by selecting and inhibiting specific motor strategies.
BG plays a role in some cognitive processes in awareness of body orientation in space, ability to adapt behaviour as task requirements change and motivation
Loss of dopamine results in an overactive indirect pathway that is thought to underlie Akinesia and Rigidity.
Underactive direct pathway is responsible for Bradykinesia.
Posture, Gait, Handwriting, Speech, Facial expression, Mood and self-care gradually normalize
some patients this progresses to excitement— frank psychosis may occur. Embarrassingly disproportionate increase in sexual activity has also been noted
Dopamine decrease central sympathetic outflow
Gradual tolerance develops to both cardiac stimulant and hypotensive actions.
AbN Movt – fascial tics, grimacing, tounge thrusting, Choreoathetoid movt, - develops within months.
Behavioral AbN – Mild anxiety, Nightmares, Depression, Mania, Hallucination, Confusion, Psychosis
Fluctuation in motor fn – after 2-5 yrs of therapy.
Increasing the dose and frequency can give relief but limited by development of dyskinesia
Reflection of progression of disease
Neurons loss ability to store and release DA
Dose fractionation and frequent administration tends to diminish this for a time.
Pyridoxine – nullify therapeutic effect by enhancing per. Decarboxylation
Phenothiazines, butyrophenones and Metoclopramide
Mao Inhibitors – HTN crisis can occur due to inhibition of peripheral DA
AntiHTN – Postural Hypotension
Atropine – Retard absorption,More time available for per degradation
Two isoenzyme forms of MAO, termed MAO-A and MAO-B are recognized; both are present in peripheral adrenergic structures and intestinal mucosa, while the latter predominates in the brain and blood platelets.
clinical benefits derived from selegiline are short lived (6–26 months).
Based on the hypothesis that oxidation of DA and/or environmental toxins (MPTP-like) in the striatum by MAO to free radicals was causative in parkinsonism, it was proposed that early therapy with selegiline might delay progression of the disorder. However, no difference in the course of the disease has been detected on follow up of selegiline treated patients in large multicentric studies