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Neuroanatomy
Brian J. Piper, Ph.D.
Goals
• Major Brain Areas
• Neuroimaging
Spinal Cord
• Divided into regions:
   – Cervical
   – Lumbar
• Function
   – Motor
   – Sensation
Brainstem

 The Medulla [muh-
DUL-uh] is the base of
  the brainstem that
controls heartbeat and
      breathing.

   Example: SIDS
______ lobe
Match Color
Sensory Areas
2.2


        Description of 3-Dimensional Space
      • Coronal:
         – section from ear to ear, like a loaf of bread
         – most commonly used for animal research
      • Sagital:
         – section from front to back
         – mid-sagital shows brain with left and right
           cortex separated
      • Axial:
         – section that parallels horizon
         – Common for showing humans
Different Planes
Anatomical Terminology
Functions of Different Cortical Areas
•   Frontal: cognition, executive function
•   Temporal: hearing
•   Occipital: vision
•   Parietal: integration of sensory information
                    Dorsal



    Posterior                         Anterior




                    Ventral
Corpus Callosum
• Fibers that connect left and right cortex
Cerebellum
       (a mid-saggital)

      • Located below the
CC
        occipital cortex
      • Important for motor
        function
 BS
      • Site of action of alcohol
Cerebellum

     • Located below the
       occipital cortex
CC   • Important for motor
       function
BS   • Site of action of alcohol
Thalamus
    • Located in the center of
      the brain
    • Major relay center,
      information from spinal
      cord goes to thalamus,
      thalamus has many
      connections to the
      cortex
1.9




                                                  Hippocampus
                                                                    • Bilateral structure
                                                                    • Hippocampus is greek
                                                                      for seahorse
                                                                    • Essential for
                                                                      memory, especially
                                                                      spatial memory
                                                                    • Effected by long term
                                                                      alcohol exposure


http://www.bris.ac.uk/Depts/Synaptic/info/pathway/hippocampal.htm
1.2              Hippocampus: Coronal


                                    cc




Box a contains hippocampus:
         CA = cornu ammonis
         DG = dentate gyrus
         CC = corupus collosum
Amygdala


 The Amygdala [ah-MIG-
dah-la] consists of two lima
 bean-sized neural clusters
 linked to the emotions of
      fear and anger.
Brain Areas Important for
    Hormone Control
                                            Rene Descartes

                • Pineal Gland
                   – Very small subcortical structure
                   – Releases the hormone melatonin
                • Hypothalmus
                   – Hypo = “below” therefore located
                     under thalamus
                   – Regulates activity of Pituitary
                   – Pituitary communicates with
                     other endocrine glands (e.g.
                     testes)
                   – Important for steroids
Ventricles: Contain CSF




                     Abnormal Ventricles
http://www.omsi.edu/visit/life/aging/brainText.cfm
Neuroanatomy Video (1.5 min)
• http://www.youtube.com/watch?v=Li5nMsXg
  1Lk
Animal
   Research




              =


                ?
Very helpful, but ….
Hippocampus Comparison
More brains
 rat & dog
(Thalamus
C
A
            B
                                D

                                E




        L

    K                   H           F

                            G
            J       I
and sheep brain
Brain Imaging
      • Can provide information about anatomy (structure) or
        physiology (function)
      • Imaging procedures differ in their:
                – Spatial resolution: the ability to differentiate nearby brain
                  regions
                – Temporal resolution: the ability to differentiate brain
                  activity at different times




For more about brain imaging and drug abuse goto:
http://www.nida.nih.gov/NIDA_Notes/NNVol11N5/Basics.html
2.5




               Electroencephalography (EEG)
                                                                             1873-1941

• Developed by Hans
  Berger in 1929
• Electrodes are placed
  on the surface of the
  skull
• Electrical activity from
  the cortex is recorded



                             <- Click here for more info on this traacing.
        Time
1.7




        Computed Tomagraphy (EMI scan, axial)
                                                         Gr: tomos (slice) & graphein (to write).

  • Developed in the 1970’s
  • X-ray beams are passed
    through the head
  • A 2 or even 3-
    dimensional structural
    map is created




For more information about CT, goto:
http://en.wikipedia.org/wiki/Computed_axial_tomography
Positron Emission Tomography
                            (PET, another axial)
       • Radioactive material is
 1.7




         injected into the blood
       • Scanner records the
         radioactivity (positron) in
         different parts of the brain
       • Provides information about
         function
       • Very useful for research




For more detailed information about PET, goto:
http://en.wikipedia.org/wiki/Positron_emission_tomography
Functional Magnetic Resonance
2.2


                   Imaging (fMRI)
      • A cylindrical magnet
        creates a magnetic field
      • A sensor records blood
        flow and brain
        activation
Comparison of Imaging Techniques
4.7



            Measures
Procedure   Brain:
                        Advantage            Disadvantage
            Function    Excellent temporal   Measures only from brain
EEG                     resolution (msec)    surface

CT          Structure   Found in many        Some radiation exposure
                        hospitals
            Function    Wide variety of      Poor temporal resolution (min),
PET                                          Poor spatial resolution (cm)
                        uses
                                             Radiation

fMRI        Function    Good temporal      Patient cannot have
                        resolution (sec),  metal implants
                        Good spatial
                        resolution (0.5cm)
The Brain
                   Techniques to Study the Brain



         A brain lesion
        experimentally
   destroys brain tissue to
   study animal behaviors
    after such destruction.

                                             Hubel (1990)
2 Min Funny Neuroanatomy Overview
http://www.youtube.com/watch?v=XAurv6mAWKM
What plane?




 Sarah Tappon, 8/5/2009
Sarah Tappon, 8/5/2009
What is the impact of …?

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Introductory Psychology: Brain

  • 2. Goals • Major Brain Areas • Neuroimaging
  • 3. Spinal Cord • Divided into regions: – Cervical – Lumbar • Function – Motor – Sensation
  • 4. Brainstem The Medulla [muh- DUL-uh] is the base of the brainstem that controls heartbeat and breathing. Example: SIDS
  • 5.
  • 6.
  • 10. 2.2 Description of 3-Dimensional Space • Coronal: – section from ear to ear, like a loaf of bread – most commonly used for animal research • Sagital: – section from front to back – mid-sagital shows brain with left and right cortex separated • Axial: – section that parallels horizon – Common for showing humans
  • 13. Functions of Different Cortical Areas • Frontal: cognition, executive function • Temporal: hearing • Occipital: vision • Parietal: integration of sensory information Dorsal Posterior Anterior Ventral
  • 14. Corpus Callosum • Fibers that connect left and right cortex
  • 15. Cerebellum (a mid-saggital) • Located below the CC occipital cortex • Important for motor function BS • Site of action of alcohol
  • 16. Cerebellum • Located below the occipital cortex CC • Important for motor function BS • Site of action of alcohol
  • 17. Thalamus • Located in the center of the brain • Major relay center, information from spinal cord goes to thalamus, thalamus has many connections to the cortex
  • 18. 1.9 Hippocampus • Bilateral structure • Hippocampus is greek for seahorse • Essential for memory, especially spatial memory • Effected by long term alcohol exposure http://www.bris.ac.uk/Depts/Synaptic/info/pathway/hippocampal.htm
  • 19. 1.2 Hippocampus: Coronal cc Box a contains hippocampus: CA = cornu ammonis DG = dentate gyrus CC = corupus collosum
  • 20. Amygdala The Amygdala [ah-MIG- dah-la] consists of two lima bean-sized neural clusters linked to the emotions of fear and anger.
  • 21. Brain Areas Important for Hormone Control Rene Descartes • Pineal Gland – Very small subcortical structure – Releases the hormone melatonin • Hypothalmus – Hypo = “below” therefore located under thalamus – Regulates activity of Pituitary – Pituitary communicates with other endocrine glands (e.g. testes) – Important for steroids
  • 22. Ventricles: Contain CSF Abnormal Ventricles
  • 24. Neuroanatomy Video (1.5 min) • http://www.youtube.com/watch?v=Li5nMsXg 1Lk
  • 25. Animal Research = ? Very helpful, but ….
  • 29. C A B D E L K H F G J I
  • 31. Brain Imaging • Can provide information about anatomy (structure) or physiology (function) • Imaging procedures differ in their: – Spatial resolution: the ability to differentiate nearby brain regions – Temporal resolution: the ability to differentiate brain activity at different times For more about brain imaging and drug abuse goto: http://www.nida.nih.gov/NIDA_Notes/NNVol11N5/Basics.html
  • 32. 2.5 Electroencephalography (EEG) 1873-1941 • Developed by Hans Berger in 1929 • Electrodes are placed on the surface of the skull • Electrical activity from the cortex is recorded <- Click here for more info on this traacing. Time
  • 33. 1.7 Computed Tomagraphy (EMI scan, axial) Gr: tomos (slice) & graphein (to write). • Developed in the 1970’s • X-ray beams are passed through the head • A 2 or even 3- dimensional structural map is created For more information about CT, goto: http://en.wikipedia.org/wiki/Computed_axial_tomography
  • 34. Positron Emission Tomography (PET, another axial) • Radioactive material is 1.7 injected into the blood • Scanner records the radioactivity (positron) in different parts of the brain • Provides information about function • Very useful for research For more detailed information about PET, goto: http://en.wikipedia.org/wiki/Positron_emission_tomography
  • 35. Functional Magnetic Resonance 2.2 Imaging (fMRI) • A cylindrical magnet creates a magnetic field • A sensor records blood flow and brain activation
  • 36. Comparison of Imaging Techniques 4.7 Measures Procedure Brain: Advantage Disadvantage Function Excellent temporal Measures only from brain EEG resolution (msec) surface CT Structure Found in many Some radiation exposure hospitals Function Wide variety of Poor temporal resolution (min), PET Poor spatial resolution (cm) uses Radiation fMRI Function Good temporal Patient cannot have resolution (sec), metal implants Good spatial resolution (0.5cm)
  • 37. The Brain Techniques to Study the Brain A brain lesion experimentally destroys brain tissue to study animal behaviors after such destruction. Hubel (1990) 2 Min Funny Neuroanatomy Overview http://www.youtube.com/watch?v=XAurv6mAWKM
  • 38. What plane? Sarah Tappon, 8/5/2009
  • 40. What is the impact of …?