Dur­ing this ses­sion we will explore cutting-edge ini­tia­tives to accel­er­ate research & devel­op­ment via Big Data, crowd­sourc­ing, tech­nolo­gies for the extended mind, and a range of data-rich per­va­sive neu­rotech­nolo­gies such as vir­tual reality. -Chair: Ali­son Fen­ney, Direc­tor of Indus­try Alliances at the Neu­rotech­nol­ogy Indus­try Orga­ni­za­tion (NIO) -Dr. Wal­ter Green­leaf, Dis­tin­guished Vis­it­ing Scholar at Stan­ford University’s Vir­tual Human Inter­ac­tion Lab -Michael Meagher, Pres­i­dent of Cogniciti -José Bar­rios, Co-Founder & CEO of Cognilab -Dr. Peter Reiner, Co-Founder, National Core for Neu­roethics at the Uni­ver­sity of British Columbia Presentation @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda

1. At the frontier of
Big Data and Brain Health

2. At the frontier of Big Data and Brain Health
Chaired by: Alison Fenney,
Director of Industry Alliances at the
Neurotechnology Industry (NIO)
Dr. Walter Greenleaf,
Distinguished Visiting Scholar
At Stanford University’s
Virtual Human Interaction Lab
Michael Meagher,
President of Cognicity
Jose Barrios
Co-Founder & CEO
Of Cognilab
Dr. Peter Reiner,
Co-Founder, National Core for Neuroethics
at the University of British Columbia
President of Cognicity

3. Transforming Healthcare
Digital Medicine
Walter Greenleaf, PhD
Stanford University - Virtual Human Interaction Lab

4. Agenda
Digital Medicine
eFormulations
Aging Populations = Significant Cost
Three Examples
Virtual Reality for Behavioral Medicine
mHealth
The Looming Crises
Hardware Opportunity

6. For 31 of the past 40 years, health care costs have
increased at a greater rate than the economy as a
whole
Health care costs constitute 18% of U.S. GDP
30% increase in personal income over the past decade
effectively eliminated by a 76% increase in health care
costs
$750B in waste
Healthcare Costs Are Growing Fast

7. 2013
99M
2050
303M
Worldwide Dementia Tsunami

8. Demographic analysis shows that there will will be substantial growth
in the proportion of aging adults within the next ten years

9. Thus, Caregiving Shortages Will Interface with a
Projected 8 Million in US With Dementia By 2025

10. Transforming HealthCare with Technology
Only One Option

11. New Technologies for Healthcare
Major Trends:
Transformation from analog to digital
Transformation from location-based and time
limited to any location, and available 24/7.
Patient focused - patient engaged in their own care
Emphasis on prevention and behavior change

12. Digital Health
Revolution
Mobile Health
Wearable
Patient centered
Leverages internet:
social, competitive, collaborative

13. Every medical device reinvented

15. HD display
Cloud computing
Internet access
Computing power
Always with you
The Transformative Power of a Smartphone
Accelerometers
Gyroscope
Magnetometers
GPS
Cameras
Infrared
Touchscreen
Finger print
Force
NFC
WiFi/Bluetooth/Ce
llular

16. The Impact of Mobile Technology on Healthcare
MOBILE DEVICES HAVE OVERTAKEN
WORLDWIDE POPULATION
More people have access to cell phones than
drinking water, electricity or a toothbrush

17. Digital Health Apps Have Arrived
In 2014, nearly 260 digital
health startups raised a record
$4.0 billion in venture capital,
equivalent to the combined
amounts raised in 2011, 2012,
and 2013

18. Digital Health Apps Have Arrived

19. The Quantified-
Self Movement:
Early Adopters

20. AliveCor Heart Monitor
$74.99

21. Ambient intelligence
Passive monitoring will enable much higher compliance
to data monitoring

22. CONNECTING HEALTHCARE DEVICES AND SENSORS TO THE NET

23. Digital Health Revolution
eFormulations for CNS Disease and Behavioral Medicine

24. eFormulations are pharmaceuticals co-packaged with unique software access codes,
allowing for combined clinical use
Patient receives a prescription for an
eFormulation including both a medication and a
software access code
Access code enables entry
to the Pear Portal, which
provides therapeutic
software that compliments
the medication
Synergistic therapeutic
effects are achieved through
concomitant use of
pharmaceuticals and
software
Continuous data
feedback from
patient and
software enables
outcomes
monitoring and
limits SAEs
Data allows clinician
decision-making support
and patient tailored “fine-
tuning” of therapeutic
approach

25. This therapeutic software has shown the ability to be as effective as
traditional psychotherapy
2
•“Computerized CBT for anxiety and
depressive disorders, especially via
the internet, has the capacity to
provide effective acceptable and
practical health care for those who
might otherwise remain untreated.”

26. Therapeutic software is currently the hottest area for development of
new CNS therapies
2
•Many groups are currently developing apps,
virtual environments, and games to diagnose
and treat CNS disorders
•By playing NeuroRacer, adults 60 to 85 years
old improved multitasking and cognition
versus control subjects, attaining levels
mirroring 20-year-old participants
•Cognitive and performance gains persisted
for more than 6 months
•Brain function of trained older brains
resembled younger brains

27. Medical Applications
of Virtual Reality
Technology
Digital Health Revolution

28. Now is the time for VR
VR technology is now affordable, scalable and
accessible to the marketplace.
The VR category is attracting interest and investments
from major players.
Facebook - Oculus
Samsung - GearVR
Sony - Project Morpheus
Microsoft - HoloLens

29. Rapidly
becoming the
standard for
training…
…and soon to
be part of the
standard of care
Surgical Training
Preoperative Planning & Image Guided surgery

30. Medical VR Can Address Several Key Problems
Annual cost of problems in the U.S. alone:
WEIGHT
LOSS
$289B
SMOKING
CESSATION
$528B
ADDICTION
$181B
CHRONIC
PAIN
$635B
POST
TRAUMATIC
STRESS
$300B
Stroke & TBI
$86B
Alcoholism
$223B
Autism
$126B

31. Academic research has proven Virtual Reality can effectively treat a wide
variety of mental health disorders – ranging from addictions to PTSD

32. Phobia and anxiety disorders
Post-traumatic stress disorder (PTSD)
Developmental disabilities
Depression
Drug and alcohol abuse
Anger management
Eating disorders
Attention disorders
Learning disabilities
Neuro-cognitive disorders
Virtual environments are used clinically to treat several
important behavioral health problems

33. Proven ability to change attitudes and behavior after “being” one’s
future self.

34. Neuroscience Rationale
It is necessary to activate the associated
brain system to enable neuro-plasticity
Repetition is required
Attention drives Cholinergic system
Novelty drives Noradrenergic/Serotonergic system
Reward drives Dopaminergic system

35. Commodity Priced TeleMedicine Platform

36. Big Data Opportunity
Objective data
Behavior and activities
Linked to intervention
Population trends

37. For More Information:
WalterG@Stanford.edu
Walter Greenleaf, PhD
Stanford University - Virtual Human Interaction Lab

38. 38
SharpBrains Summit
Michael Meagher, CEO Cogniciti,
mmeagher@cogniciti.com
Brain Health
Powered By
Science

39. 39
When I was a boy . . .
Me My GrandfatherMy Mother

40. 40
Today
Two Generations Going Strong

41. 41
We now need to bring proactive care to
We now need to
bring proactive
care to
Brain
Health
A key ingredient
to getting this done:
The right early-
warning test

42. 42
Home Care Clinical
Research

43. 43
Cogniciti Brain Health Assessment
20 Minutes
to Complete
Private &
Confidential
Free
Scientifically
Validated by
Baycrest

44. 44
“Is my
memory
normal or
should I
see my
doctor?”

45. 45
Tests sensitive to changes with age

46. 46
How you perform
vs. your peers
Yes/no answer to
whether your brain
health is normal
Results stored so that
you can track
changes over time
Real-time report for test takers

47. 47
Strong consumer
response
from a single media
release
132,000
94,000
37,000
Site Visits
Site Visitors
Completed
Assessments

48. 48
2014
• Original study
• 361 healthy adults ages 50-
79
• 87% tests started were fully
completed
• Reliability: test-retest 0.72
• Validity: positive correlations
of performance with age
• Cut-off: 2% of test takers
below normal
The Science
2015
• From general public test
takers
• 23,000 adults ages 50-79
• Results very similar to our
controlled 2014 study

49. 49
The benefits of proactive
cognitive assessment to
Home Care
Patients
Family
Caregivers
Healthcare
Professionals
Healthcare
Funders
Better manage their
cognitive health
More effectively
support their loved
ones
Move from reactive
to proactive care
Better control
escalating costs of
cognitive care

50. 50
We’ve designed the study to measure
impacts
3 months
Plan,
Develop,
Train
6 months
Test Administration,
Patient Follow Up
3 months
Gather
Data,
Analysis
Double-blind study 750 – 1,000 adults
Patient experience survey
Professional experience survey
Input patient
user panel
Economic
evaluation

51. 51
Cogniciti assessment and
Clinical
Research
Proactively attract
Cogniciti test completers
to memory-focused
research studies
Research Benefits
Save recruitment
time and cost

52. 52
We have begun our work . . .
Research collaboration
underway with a major
pharmaceutical firm
Cracked code of
converting test
completers to
research registrants
Objective 5%
Actual 19%

53. 53
What’s next . . .
Home Care
Clinical
Research
Find a U.S. firm to join us in studying the
patient outcomes and healthcare savings
of proactively cognitively assessing
older adults in home.
Find our next pharma/research
memory-related research firm with a
strong interest in lowering its
cost/time of volunteer recruitment.

54. Jose Barrios, CEO
Cognilab Technologies
Better Cognitive Models are Essential to
our Digital Healthcare Future

59. WEIRD

60. WEIRD

61. WEIRD

63. Crowdsourcing

67. months

68. “Most low- and middle-income countries have only one
child psychiatrist for every 1 to 4 million people.”
- World Health Organization

69. Population Growth, % (per annum)

70. Technologies of the
extended mind
Peter B. Reiner
National Core for Neuroethics
University of British Columbia

74. the extended mind

78. CALM
TECHNOLOGY

81. Technologies of the
extended mind

82. Thanks, and see you tomorrow!
Sponsors

83. THE OPPORTUNITY

84. How can consumers and professionals
harness this opportunity to better monitor
and enhance brain health, and to improve
work and life?
• LinkedIn Group
• #sharpbrains2015
• Watercooler chats
• Session @ Expo Day
THE CHALLENGE

85. To learn more, visit sharpbrains.com