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At the fron­tier of Big Data and Brain Health

Dur­ing this ses­sion we will explore cutting-edge ini­tia­tives to accel­er­ate research & devel­op­ment via Big Data, crowd­sourc­ing, tech­nolo­gies for the extended mind, and a range of data-rich per­va­sive neu­rotech­nolo­gies such as vir­tual reality.

-Chair: Ali­son Fen­ney, Direc­tor of Indus­try Alliances at the Neu­rotech­nol­ogy Indus­try Orga­ni­za­tion (NIO)
-Dr. Wal­ter Green­leaf, Dis­tin­guished Vis­it­ing Scholar at Stan­ford University’s Vir­tual Human Inter­ac­tion Lab
-Michael Meagher, Pres­i­dent of Cogniciti
-José Bar­rios, Co-Founder & CEO of Cognilab
-Dr. Peter Reiner, Co-Founder, National Core for Neu­roethics at the Uni­ver­sity of British Columbia

Presentation @ The 2015 SharpBrains Virtual Summit

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At the fron­tier of Big Data and Brain Health

  1. 1. At the frontier of Big Data and Brain Health
  2. 2. At the frontier of Big Data and Brain Health Chaired by: Alison Fenney, Director of Industry Alliances at the Neurotechnology Industry (NIO) Dr. Walter Greenleaf, Distinguished Visiting Scholar At Stanford University’s Virtual Human Interaction Lab Michael Meagher, President of Cognicity Jose Barrios Co-Founder & CEO Of Cognilab Dr. Peter Reiner, Co-Founder, National Core for Neuroethics at the University of British Columbia President of Cognicity
  3. 3. Transforming Healthcare Digital Medicine Walter Greenleaf, PhD Stanford University - Virtual Human Interaction Lab
  4. 4. Agenda Digital Medicine eFormulations Aging Populations = Significant Cost Three Examples Virtual Reality for Behavioral Medicine mHealth The Looming Crises Hardware Opportunity
  5. 5. For 31 of the past 40 years, health care costs have increased at a greater rate than the economy as a whole Health care costs constitute 18% of U.S. GDP 30% increase in personal income over the past decade effectively eliminated by a 76% increase in health care costs $750B in waste Healthcare Costs Are Growing Fast
  6. 6. 2013 99M 2050 303M Worldwide Dementia Tsunami
  7. 7. Demographic analysis shows that there will will be substantial growth in the proportion of aging adults within the next ten years
  8. 8. Thus, Caregiving Shortages Will Interface with a Projected 8 Million in US With Dementia By 2025
  9. 9. Transforming HealthCare with Technology Only One Option
  10. 10. New Technologies for Healthcare Major Trends: Transformation from analog to digital Transformation from location-based and time limited to any location, and available 24/7. Patient focused - patient engaged in their own care Emphasis on prevention and behavior change
  11. 11. Digital Health Revolution Mobile Health Wearable Patient centered Leverages internet: social, competitive, collaborative
  12. 12. Every medical device reinvented
  13. 13. HD display Cloud computing Internet access Computing power Always with you The Transformative Power of a Smartphone Accelerometers Gyroscope Magnetometers GPS Cameras Infrared Touchscreen Finger print Force NFC WiFi/Bluetooth/Ce llular
  14. 14. The Impact of Mobile Technology on Healthcare MOBILE DEVICES HAVE OVERTAKEN WORLDWIDE POPULATION More people have access to cell phones than drinking water, electricity or a toothbrush
  15. 15. Digital Health Apps Have Arrived In 2014, nearly 260 digital health startups raised a record $4.0 billion in venture capital, equivalent to the combined amounts raised in 2011, 2012, and 2013
  16. 16. Digital Health Apps Have Arrived
  17. 17. The Quantified- Self Movement: Early Adopters
  18. 18. AliveCor Heart Monitor $74.99
  19. 19. Ambient intelligence Passive monitoring will enable much higher compliance to data monitoring
  21. 21. Digital Health Revolution eFormulations for CNS Disease and Behavioral Medicine
  22. 22. eFormulations are pharmaceuticals co-packaged with unique software access codes, allowing for combined clinical use Patient receives a prescription for an eFormulation including both a medication and a software access code Access code enables entry to the Pear Portal, which provides therapeutic software that compliments the medication Synergistic therapeutic effects are achieved through concomitant use of pharmaceuticals and software Continuous data feedback from patient and software enables outcomes monitoring and limits SAEs Data allows clinician decision-making support and patient tailored “fine- tuning” of therapeutic approach
  23. 23. This therapeutic software has shown the ability to be as effective as traditional psychotherapy 2 •“Computerized CBT for anxiety and depressive disorders, especially via the internet, has the capacity to provide effective acceptable and practical health care for those who might otherwise remain untreated.”
  24. 24. Therapeutic software is currently the hottest area for development of new CNS therapies 2 •Many groups are currently developing apps, virtual environments, and games to diagnose and treat CNS disorders •By playing NeuroRacer, adults 60 to 85 years old improved multitasking and cognition versus control subjects, attaining levels mirroring 20-year-old participants •Cognitive and performance gains persisted for more than 6 months •Brain function of trained older brains resembled younger brains
  25. 25. Medical Applications of Virtual Reality Technology Digital Health Revolution
  26. 26. Now is the time for VR VR technology is now affordable, scalable and accessible to the marketplace. The VR category is attracting interest and investments from major players. Facebook - Oculus Samsung - GearVR Sony - Project Morpheus Microsoft - HoloLens
  27. 27. Rapidly becoming the standard for training… …and soon to be part of the standard of care Surgical Training Preoperative Planning & Image Guided surgery
  28. 28. Medical VR Can Address Several Key Problems Annual cost of problems in the U.S. alone: WEIGHT LOSS $289B SMOKING CESSATION $528B ADDICTION $181B CHRONIC PAIN $635B POST TRAUMATIC STRESS $300B Stroke & TBI $86B Alcoholism $223B Autism $126B
  29. 29. Academic research has proven Virtual Reality can effectively treat a wide variety of mental health disorders – ranging from addictions to PTSD
  30. 30. Phobia and anxiety disorders Post-traumatic stress disorder (PTSD) Developmental disabilities Depression Drug and alcohol abuse Anger management Eating disorders Attention disorders Learning disabilities Neuro-cognitive disorders Virtual environments are used clinically to treat several important behavioral health problems
  31. 31. Proven ability to change attitudes and behavior after “being” one’s future self.
  32. 32. Neuroscience Rationale It is necessary to activate the associated brain system to enable neuro-plasticity Repetition is required Attention drives Cholinergic system Novelty drives Noradrenergic/Serotonergic system Reward drives Dopaminergic system
  33. 33. Commodity Priced TeleMedicine Platform
  34. 34. Big Data Opportunity Objective data Behavior and activities Linked to intervention Population trends
  35. 35. For More Information: Walter Greenleaf, PhD Stanford University - Virtual Human Interaction Lab
  36. 36. 38 SharpBrains Summit Michael Meagher, CEO Cogniciti, Brain Health Powered By Science
  37. 37. 39 When I was a boy . . . Me My GrandfatherMy Mother
  38. 38. 40 Today Two Generations Going Strong
  39. 39. 41 We now need to bring proactive care to We now need to bring proactive care to Brain Health A key ingredient to getting this done: The right early- warning test
  40. 40. 42 Home Care Clinical Research
  41. 41. 43 Cogniciti Brain Health Assessment 20 Minutes to Complete Private & Confidential Free Scientifically Validated by Baycrest
  42. 42. 44 “Is my memory normal or should I see my doctor?”
  43. 43. 45 Tests sensitive to changes with age
  44. 44. 46 How you perform vs. your peers Yes/no answer to whether your brain health is normal Results stored so that you can track changes over time Real-time report for test takers
  45. 45. 47 Strong consumer response from a single media release 132,000 94,000 37,000 Site Visits Site Visitors Completed Assessments
  46. 46. 48 2014 • Original study • 361 healthy adults ages 50- 79 • 87% tests started were fully completed • Reliability: test-retest 0.72 • Validity: positive correlations of performance with age • Cut-off: 2% of test takers below normal The Science 2015 • From general public test takers • 23,000 adults ages 50-79 • Results very similar to our controlled 2014 study
  47. 47. 49 The benefits of proactive cognitive assessment to Home Care Patients Family Caregivers Healthcare Professionals Healthcare Funders Better manage their cognitive health More effectively support their loved ones Move from reactive to proactive care Better control escalating costs of cognitive care
  48. 48. 50 We’ve designed the study to measure impacts 3 months Plan, Develop, Train 6 months Test Administration, Patient Follow Up 3 months Gather Data, Analysis Double-blind study 750 – 1,000 adults Patient experience survey Professional experience survey Input patient user panel Economic evaluation
  49. 49. 51 Cogniciti assessment and Clinical Research Proactively attract Cogniciti test completers to memory-focused research studies Research Benefits Save recruitment time and cost
  50. 50. 52 We have begun our work . . . Research collaboration underway with a major pharmaceutical firm Cracked code of converting test completers to research registrants Objective 5% Actual 19%
  51. 51. 53 What’s next . . . Home Care Clinical Research Find a U.S. firm to join us in studying the patient outcomes and healthcare savings of proactively cognitively assessing older adults in home. Find our next pharma/research memory-related research firm with a strong interest in lowering its cost/time of volunteer recruitment.
  52. 52. Jose Barrios, CEO Cognilab Technologies Better Cognitive Models are Essential to our Digital Healthcare Future
  53. 53. WEIRD
  54. 54. WEIRD
  55. 55. WEIRD
  56. 56. Crowdsourcing
  57. 57. months
  58. 58. “Most low- and middle-income countries have only one child psychiatrist for every 1 to 4 million people.” - World Health Organization
  59. 59. Population Growth, % (per annum)
  60. 60. Technologies of the extended mind Peter B. Reiner National Core for Neuroethics University of British Columbia
  61. 61. the extended mind
  63. 63. Technologies of the extended mind
  64. 64. Thanks, and see you tomorrow! Sponsors
  66. 66. How can consumers and professionals harness this opportunity to better monitor and enhance brain health, and to improve work and life? • LinkedIn Group • #sharpbrains2015 • Watercooler chats • Session @ Expo Day THE CHALLENGE
  67. 67. To learn more, visit