Carving out Future Brain Health Directions + Expo Day

1. Carving Out Future Directions + Expo Day

2. Sponsors EXPO DAY

3. Source: The SharpBrains Guide to Brain Fitness (second edition)

4. Carving out Future Directions Kenneth S. Kosik, M.D. Harriman Professor of Neuroscience Co-Director, Neuroscience Research Institute University of California, Santa Barbara 1

5. De-medicalizing Cognition Successful aging Cognitive Aging MCI Not a medical issue enhancement Dementia Function Time A medical issue therapeutics 2

6. MD as gatekeeper model is not working Alternatives: Brain Shops—the health club model Virtual brain shops—mobile apps/social networks 3

7. Medical Risks – Blood Pressure – Cholesterol & Lipid Profile – Blood Sugar (Glucose) Life Style Risks – Exercise – Diet – Stress – Social Isolation – Cognitive Challenges Cognitive Health— not rocket science! Risk reduction 4

8. Empower people to look after their own health Tracking your numbers— continuous monitoring Make knowledge accessible— devices for the Brain-Computer Interface 5

9. From Information to Knowledge to Wisdom Google glass --too slow Internet --too slow Libraries too slow To become fully informed takes too long—learning is inefficient 6

10. From Information to Knowledge to Wisdom The automation of knowledge Knowledge = what we do with information Bank tellers—ATMs Super market check out--scanners & bar codes Toll booth collectors--EZpass Collectors--automatic pay in parking garages Retail stores--web-based shopping Accountants—on line taxes Social life/bars—on line dating Factory work--3D printers Pilots-computerized cockpit (driverless cars) Teachers—MOOCs Apps—navigation etc Doctors—WebMD 7

11. From Information to Knowledge to Wisdom the irreducible uncertainty of knowledge whether human or from a machine leaves us with the imperfect machine versus the imperfect human Intelligence is what we use when we don't already know what to do. Jean Piaget “the cure for imperfect automation is perfect automation” --Nicholas Carr 8

12. Critical Elements for the Future of the Brain-Computer Interface 1. Perform Neuroprediction Much of what automated knowledge and smart devices do is predict the future Main function of the brain—predict the future. Even memory is for predicting the future. Dangers of Automated Knowledge (habits): Complacency and Bias To improve automated knowledge (machines/devices)—encode more contingencies (rare events) Our ability to anticipate the future may be enhanced by a richer store of information that includes a Web-based compilation of data. 9

13. Critical Elements for the Future of the Brain-Computer Interface 2. Mine the humanities—what is a human? As we transfer more functions/behavior to technology/apps, we need to make those functions human-like. To assign human functions to machines we have to understand humans Humans evolved big brains not to understand the world, but to understand each other. --Nick Humphrey 10

14. Expo Day Agenda Sponsors Morning 8:45-9:15am. Rosetta Stone (FitBrains) 9:30-10am. Peak 10:15-10:45am. Baycrest (Cogniciti) 11-11:30am. The Arrowsmith Program 11.30am-noon. Watercooler chats Afternoon 1-1:30am. Digital Artefacts (BrainBaseline) 1:45-2:15pm. HeartMath 2:30-3pm. Sleep Genius 3:15-3:45pm. The Alzheimer’s Research and Prevention Foundation

18. Language Learning Acquisitions in 2013 and 2014 19 | ©2014 Rosetta Stone Ltd. • Closed deal in January 2014 • TMM was a France-based language learning software provider with offices in 6 countries • Its core product was an online, SaaS language learning platform covering 9 languages sold mainly to B2B clients • Extensive content and activities • 8,000+ hours of total content and over 35 different activity types • Offered tutoring, coaching, virtual classrooms, and telephone lesson to complement e-learning software • Closed deal in April 2013 • Livemocha was a Seattle-based start-up founded in 2007 • Its core product was an online language learning platform and community • ~16MM registered users • Including 1.6MM teachers, linguists, translators, and polyglots • Offered tutoring, coaching, virtual classrooms, and telephone lesson to complement e-learning software

20. Brain Fitness Acquisition in 2014 • Provider of brain-training solutions for adults and kids on the Web, iOS and Android platforms • Founded in 2007 – team based in Vancouver, Canada • One of iTunes’ top grossing education apps in 2013 • Localized in 10 languages 21 | ©2014 Rosetta Stone Ltd.

31. Fit Brains Overview • Fit Brains provides fun and engaging brain training activities for all ages, from children to older adults, that can be played anytime, anywhere. Targets six major brain areas: Memory, Concentration, Problem Solving, Visuospatial, Processing Speed and Language • Founded in 2007 and acquired by Rosetta Stone in January 2014 • In 2013 and 2014 Fit Brains Trainer consistently ranked in the Top 10 among the iTunes Top Grossing Apps - Education category • 11MM+ users since launch; 32,000+ ratings on iTunes averaging ~4.5 stars • Localized into 10 languages: EN, FR, IT, DE, ES, JA, KO, CH, PT & RU • High user retention rate – significantly better than the average app (as tracked by Flurry Analytics) and even better than the average weather app (i.e., the top performing category in the App Store) 32 | ©2014 Rosetta Stone Ltd.

32. Fit Brains Key Product Features • Currently 61 brain activities each with multiple levels of skill per activity, and an adaptive learning system that scales challenges to each user to ensure mental stimulation by introducing new content and challenge mechanics • Diversity of brain areas trained – Fit Brains covers six (6) major brain areas -- Memory, Focus, Logic, Speed, Language and Visual • Best cross platform compatibility – iOS, Android, Amazon Kindle, and HTML5 website means it is accessible on any tablet or smart phone via native apps and/or mobile device browsers (unlike other products that rely upon Flash for their websites and are accessible only via computer browsers) • Customization for B2B clients – Fit Brains can customize both the content and the reporting / dashboards for each client 33 | ©2014 Rosetta Stone Ltd.

35. ENJOY BECOMING BETTER EVERY DAY Roy Zahut Lead Scientist

36. MEET PEAK

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38. CORE COMPONENTS EXERCISES MOTIVATION DATA

39. EXERCISES THAT FIT YOU 20+ games Adaptive difficulty

40. MOTIVATION Bringing cognitive trainig to the hands of those who need it

41. DATA User Context Exercise

42. PEAK INSIGHTS 49 WE ARE CREATING A DASHBOARD FOR YOUR BRAIN

43. BETTER WORKING HABITS 50

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45. DID I FAIL MY EXAM BECAUSE OF AN ATTENTION DEFICIT? DO I HAVE THE BRAIN OF AN ENGINEER? INSIGHTS WHAT KIND OF DIET HELPS ME BE MOST ALERT?

46. DOES PHYSICAL FITNESS HAVE AN EFFECT ON MEMORY? SHOULD I BE WORRIED ABOUT A SUDDEN COGNITIVE DECLINE? INSIGHTS AM I SHARPER AFTER 6 HOURS OF SLEEP?

47. LET’S WORK TOGETHER 54 SCIENTISTS AND DEVELOPERS TRACKERS AND SENSORS DESIGN PARTNERS SCIENCE@PEAK.NET

48. SharpBrains Summit 2014 Michael Meagher, President Cogniciti Inc. mmeagher@cogniciti.com 519-851-9899 CONFIDENTIAL Pg 55

49. Cogniciti We are in the business of . . . Commercializing the brain health science of Baycrest and other leading healthcare institutes. Our owners – 2 non-profits – Baycrest: a world leader for cognitive neuroscience related to memory and aging. – MaRS Discovery District: Canada’s leading centre for innovation and entrepreneurship. CONFIDENTIAL Pg 56

50. Focus on Boomers and Seniors 100 million ages 50 – 79 in North America 1. Engage Adults . . . in preventative brain-health care that works 2. Improve patient outcomes . . . through the earlier detection of cognitive issues 3. Speed new treatments . . . by providing a research-validated cognitive measurement tool CONFIDENTIAL Pg 57

51. Cogniciti Brain Health Assessment CONFIDENTIAL Pg 58

52. 150 days ago we launched in Canada CONFIDENTIAL Pg 59

53. Then continues with tests chosen for their sensitivity to changes in cognition with age CONFIDENTIAL Pg 60

54. CONFIDENTIAL Pg 61

55. Cogniciti online report for test takers CONFIDENTIAL Pg 62

56. Cogniciti sample report for doctors CONFIDENTIAL Pg 63

57. Cogniciti online brain health info site CONFIDENTIAL Pg 64

58. Task now: put the Assessment to work • Our Goal: Broaden distribution – Searching for: organization looking to attract/engage adults in their 50’s and 60’s • Our Goal: Speed development new treatments – Searching for: pharma/other manufacturer that needs a validated measurement tool for research and development • Our Goal: Improve patient outcomes affordably – Searching for: healthcare funders who want a cognitive assessment tool designed to reach large groups at low cost CONFIDENTIAL Pg 65

59. Arrowsmith Program Arrowsmith Program refers both to the Arrowsmith Program methodology and our affiliated organizations that make the Arrowsmith Program available to public and private schools in Canada, United States, Australia and New Zealand. The Arrowsmith Program was founded over 30 years ago on early neuroscience research. For over 3 decades, the Arrowsmith Program has been strengthening the learning capacities of students, making them confident and independent learners.

60. Who is the Arrowsmith Program designed for? Presenting with a diagnosed specific learning difficulty OR Struggling to learn academic/social skills Average to above average intelligence Having any combination of 19 learning dysfunctions Mild to Severe learning difficulties

61. Arrowsmith Program Around the World

62. Licensing Model Established schools for 5 years or more Student population of 100 students 1 year agreement 10:1 student ratio 10 student commitment Accommodate for students to participate in four 40 minute cognitive periods every day Minimum 1 teacher certified in Arrowsmith methodology

63. Arrowsmith Certification 3 week intensive teacher training - Foundational understanding of neuroplasticity - Principles of the Arrowsmith Program - Exercise methodology - Student data collection, tracking, and problem solving - Assessment protocols - Advocacy Ongoing mandatory professional development

64. Implementation Model

65. Program Types Full Time Program - 4 to 8 cognitive exercise periods per day - 3 to 4 years in length Part Time Program - eligible after 2 years - 1 to 3 cognitive exercises two to four days a week - 4 hours of cognitive work each week

66. Completed Research • There have been a range of Outcome Studies completed • Academic Skills and Learning Outcomes document • Latest outcome study by Kemp-Koo, University of Saskatchewan, Saskatoon in 2013 • Document available on website under ‘Research’ tab at http://www.arrowsmithschool.org

67. Current Research Cognitive and Achievement Studies • University of Calgary, Brain Gain Lab – Dr Brad Hale • Woodcock Johnson Tests of Cognitive and Achievements Ability • Annual Conferences for American Psychological Association and Canadian Psychological Association

68. Current Research Brain Imaging Studies A Brain on Clocks: fMRI scan of student engaged in the Arrowsmith Program Clocks exercise as part of the University of British Columbia research study being conducted on Eaton Arrowsmith School students under the direction of Dr. Lara Boyd.

69. Research at UBC – Dr. Boyd Brain Behaviour Lab

70. Research at SIU – Dr. Greg Rose Centre for Integrated Research in Cognitive & Neural Sciences

71. How Can I Engage? Book The Woman Who Changed Her Brain, Barbara Arrowsmith-Young Articles When Learning Disabilities Disguise Themselves - Huffington Post How the Brain Learns: What lessons are there for teaching? - Australian Council for Educational Research (ACER) Videos 60 Minutes Australia TEDx Toronto Talk Websites www.arrowsmithschool.org www.barbaraarrowsmithyoung.com

72. Barbara Arrowsmith Young’s Vision My vision is of a world in which no child ever struggles with a learning disability, no child is ever stigmatized as having one, and no child experiences the ongoing emotional pain of living with a learning disability. My vision is for all schools to become places where children can go to strengthen their brains so they can learn effectively and efficiently. Cognitive exercises, using the principles of neuroplasticity, will become an integral part of each school’s curriculum. In this way, learning problems can be addressed early, as part of a regular curriculum, and student without cognitive deficits will all benefit from cognitive stimulation. (The Woman Who Changed Her Brain, page 216)

73. Contact Us: info@arrowsmithprogram.ca

74.  To learn more, visit SharpBrains.com